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Stock-Based Compensation - Stock Option Activity Under Equity Incentive Plans (Detail) (Stock Options [Member], USD $)
In Thousands, except Per Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Stock Options [Member]
 
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]  
Number of Shares, Outstanding, Beginning balance 20,655us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Options granted 7,713us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Options exercised (4,852)us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Options forfeited and canceled (1,521)us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Outstanding, Ending balance 21,995us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Vested and Expected to Vest 21,338us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Number of Shares, Exercisable 13,007us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Outstanding, Beginning balance $ 9.06us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Options granted $ 13.96us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Options exercised $ 9.43us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Options forfeited and Canceled $ 11.89us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Outstanding, Ending balance $ 10.50us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Vested and expected to vest $ 10.41us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Exercise Price per Share, Exercisable $ 8.90us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Weighted-Average Remaining Contractual Life, Outstanding 4 years 11 months 16 days
Weighted-Average Remaining Contractual Life, Vested and expected to Vest 4 years 10 months 21 days
Weighted-Average Remaining Contractual Life, Exercisable 3 years 5 months 19 days
Aggregate Intrinsic Value, Outstanding $ 112,549us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Aggregate Intrinsic Value, Vested and expected to Vest 111,071us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember
Aggregate Intrinsic Value, Exercisable $ 85,839nktr_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockOptionsExercisableIntrinsicValue
/ us-gaap_AwardTypeAxis
= us-gaap_EmployeeStockOptionMember