Property, Plant and Equipment - Property, Plant and Equipment (Detail) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2014	Dec. 31, 2013
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 147,866	$ 144,861
Less: accumulated depreciation	(93,807)	(84,148)
Depreciable property, plant and equipment, net	54,059	60,713
Construction-in-progress	16,309	6,261
Property plant and equipment, net	70,368	66,974
Building and Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	72,228	71,306
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	26,975	26,621
Manufacturing Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	25,212	23,699
Furniture, Fixtures and Other Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 23,451	$ 23,235