Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenue:
Product sales	$ 25,152	$ 44,846	$ 35,399
Royalty revenue	329	1,148	4,874
Non-cash royalty revenue related to sale of future royalties	21,937	22,055	10,791
License, collaboration and other revenue	153,289	80,872	30,127
Total revenue	200,707	148,921	81,191
Operating costs and expenses:
Cost of goods sold	28,533	38,509	30,428
Research and development	147,734	190,010	148,675
General and administrative	40,925	40,532	41,614
Impairment of long-lived assets			1,675
Total operating costs and expenses	217,192	269,051	222,392
Loss from operations	(16,485)	(120,130)	(141,201)
Non-operating income (expense):
Interest expense	(17,869)	(18,453)	(15,489)
Non-cash interest expense on liability related to sale of future royalties	(20,888)	(22,309)	(18,057)
Interest and other income (expense), net	814	1,124	3,298
Total non-operating expense, net	(37,943)	(39,638)	(30,248)
Loss before (benefit) provision for income taxes	(54,428)	(159,768)	(171,449)
(Benefit) provision for income taxes	(512)	2,245	406
Net loss	$ (53,916)	$ (162,013)	$ (171,855)
Basic and diluted net loss per share	$ (0.42)	$ (1.40)	$ (1.50)
Weighted average shares outstanding used in computing basic and diluted net loss per share	126,873	115,732	114,820