Selected Quarterly Financial Data (Tables)

12 Months Ended

Dec. 31, 2014

Quarterly Financial Information Disclosure [Abstract]

Quarterly Financial Data

The following table sets forth certain unaudited quarterly financial data. In our opinion, the unaudited information set forth below has been prepared on the same basis as the audited information and includes all adjustments necessary to present fairly the information set forth herein. All data is in thousands except per share information.

	Fiscal Year 2014											Fiscal Year 2013
	Q1			Q2			Q3		Q4			Q1			Q2			Q3			Q4
Product sales	$	5,795		$	5,802		$	6,096	$	7,460		$	11,810		$	10,324		$	14,672		$	8,040
Total revenue	$	19,771		$	28,513		$	132,871	$	19,551		$	23,004		$	33,862		$	60,909		$	31,146
Cost of goods sold	$	7,907		$	5,108		$	9,220	$	6,298		$	11,661		$	5,011		$	12,877		$	8,960
Research and development expenses	$	38,338		$	36,702		$	34,200	$	38,494		$	45,618		$	52,230		$	43,914		$	48,248
Operating income (loss)	$	(36,402	)	$	(22,916	)	$	80,321	$	(37,488	)	$	(45,106	)	$	(32,605	)	$	(6,525	)	$	(35,894	)
Net income (loss)	$	(46,201	)	$	(32,637	)	$	70,605	$	(45,683	)	$	(55,063	)	$	(42,748	)	$	(16,543	)	$	(47,659	)
Net income (loss) per share(1)
Basic	$	(0.37	)	$	(0.26	)	$	0.55	$	(0.35	)	$	(0.48	)	$	(0.37	)	$	(0.14	)	$	(0.41	)
Diluted	$	(0.37	)	$	(0.26	)	$	0.53	$	(0.35	)	$	(0.48	)	$	(0.37	)	$	(0.14	)	$	(0.41	)

(1) Quarterly loss per share amounts may not total to the year-to-date loss per share due to rounding.