Income Taxes (Tables)

12 Months Ended

Dec. 31, 2014

Income Tax Disclosure [Abstract]

Loss Before (Benefit) Provision for Income Taxes

Loss before (benefit) provision for income taxes includes the following components (in thousands):

	Year Ended December 31,
	2014			2013			2012
Domestic	$	(56,414	)	$	(161,068	)	$	(174,258	)
Foreign		1,986			1,300			2,809
Loss before (benefit) provision for income taxes	$	(54,428	)	$	(159,768	)	$	(171,449	)

(Benefit) Provision for Income Taxes

The (benefit) provision for income taxes consists of the following (in thousands):

	Year Ended December 31,
	2014			2013			2012
Current:
Federal	$	—		$	—		$	(137	)
State		1			1			1
Foreign		(482	)		1,838			1,029
Total Current		(481	)		1,839			893
Deferred:
Federal		—			422			(422	)
State		—			49			(49	)
Foreign		(31	)		(65	)		(16	)
Total Deferred		(31	)		406			(487	)
(Benefit) provision for income taxes	$	(512	)	$	2,245		$	406

Income Tax Provision Related to Continuing Operations

Income tax provision related to continuing operations differs from the amount computed by applying the statutory income tax rate of 35% to pretax loss as follows (in thousands):

	Year Ended December 31,
	2014			2013			2012
U.S. federal provision (benefit)
At statutory rate	$	(19,050	)	$	(55,919	)	$	(60,007	)
State taxes		1			50			(48	)
Change in valuation allowance		11,831			55,042			47,349
Non-cash interest expense on liability related to sale of future royalties		7,311			7,808			6,320
Stock-based compensation		2,832			271			236
Foreign tax inclusion		—			—			6,510
Foreign tax differential		(17	)		(20	)		(227	)
Research credits		(2,933	)		(6,273	)		(591	)
Other		(487	)		1,286			864
(Benefit) provision for income taxes	$	(512	)	$	2,245		$	406

Significant Components of Deferred Tax Assets and Liabilities

Significant components of our deferred tax assets for federal and state income taxes are as follows (in thousands):

	December 31,
	2014			2013
Deferred tax assets:
Net operating loss carryforwards	$	423,776		$	391,385
Research and other credits		66,666			61,707
Deferred revenue		29,758			35,588
Stock-based compensation		21,948			25,962
Sale of future royalties		20,153			28,057
Capitalized research expenses		14,795			17,687
Reserves and accruals		8,288			14,685
Property, plant and equipment		8,264			8,580
Other		2,218			2,539
Deferred tax assets before valuation allowance		595,866			586,190
Valuation allowance for deferred tax assets		(595,690	)		(586,040	)
Total deferred tax assets		176			150
Total deferred tax liabilities		—			—
Net deferred tax assets	$	176		$	150

Unrecognized Tax Benefits

We have the following activity relating to unrecognized tax benefits (in thousands):

	December 31,
	2014			2013		2012
Beginning balance	$	16,363		$	14,067	$	13,576
Tax positions related to current year
Additions:
Federal		502			477		289
State		6,141			381		302
Reductions		—			—		—
Tax positions related to prior year
Additions:
Federal		—			636		37
State		5,258			—		—
Foreign		—			802		—
Reductions — foreign		(742	)		—		—
Settlements		—			—		—
Lapses in statute of limitations		—			—		(137	)
Ending balance	$	27,522		$	16,363	$	14,067