Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2014

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2014			2013
Building and leasehold improvements	$	72,228		$	71,306
Laboratory equipment		26,975			26,621
Manufacturing equipment		25,212			23,699
Furniture, fixtures and other equipment		23,451			23,235
Depreciable property, plant and equipment at cost		147,866			144,861
Less: accumulated depreciation		(93,807	)		(84,148	)
Depreciable property, plant and equipment, net		54,059			60,713
Construction-in-progress		16,309			6,261
Property, plant and equipment, net	$	70,368		$	66,974