Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2014	Dec. 31, 2013
Current assets:
Cash and cash equivalents	$ 12,365	$ 39,067
Restricted cash	25,000
Short-term investments	225,459	197,959
Accounts receivable, net of allowance of nil at December 31, 2014 and 2013	3,607	2,229
Inventory	12,952	13,452
Other current assets	8,817	5,175
Total current assets	288,200	257,882
Restricted cash		25,000
Property, plant and equipment, net	70,368	66,974
Goodwill	76,501	76,501
Other assets	6,552	8,170
Total assets	441,621	434,527
Current liabilities:
Accounts payable	2,703	9,115
Accrued compensation	5,749	14,254
Accrued expenses	6,418	6,243
Accrued clinical trial expenses	7,708	16,905
Interest payable	6,917	6,917
Capital lease obligations, current portion	4,512	3,536
Deferred revenue, current portion	24,473	23,664
Liability related to the sale of future royalties, current portion		7,000
Other current liabilities	5,567	10,587
Total current liabilities	64,047	98,221
Senior secured notes	125,000	125,000
Capital lease obligations, less current portion	4,139	8,049
Liability related to receipt of refundable milestone payment		70,000
Liability related to the sale of future royalties, less current portion	120,471	121,520
Deferred revenue, less current portion	76,911	82,384
Other long-term liabilities	14,721	19,256
Total liabilities	405,289	524,430
Commitments and contingencies
Stockholders' equity (deficit):
Preferred stock, $0.0001 par value; 10,000 shares authorized, no shares designated, issued or outstanding at December 31, 2014 and 2013, respectively
Common stock, $0.0001 par value; 300,000 authorized; 131,216 shares and 116,494 shares issued and outstanding at December 31, 2014 and 2013, respectively	13	11
Capital in excess of par value	1,824,195	1,643,660
Accumulated other comprehensive loss	(1,567)	(1,181)
Accumulated deficit	(1,786,309)	(1,732,393)
Total stockholders' equity (deficit)	36,332	(89,903)
Total liabilities and stockholders' equity (deficit)	$ 441,621	$ 434,527