Condensed Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Sep. 30, 2014	Dec. 31, 2013
Current assets:
Cash and cash equivalents	$ 32,008	$ 39,067
Restricted cash	25,000
Short-term investments	204,635	197,959
Accounts receivable, net	46,074	2,229
Inventory	11,695	13,452
Other current assets	4,708	5,175
Total current assets	324,120	257,882
Restricted cash		25,000
Property and equipment, net	69,275	66,974
Goodwill	76,501	76,501
Other assets	7,006	8,170
Total assets	476,902	434,527
Current liabilities:
Accounts payable	5,428	9,115
Accrued compensation	13,753	14,254
Accrued expenses	7,760	6,243
Accrued clinical trial expenses	9,643	16,905
Interest payable	3,167	6,917
Deferred revenue, current portion	24,626	23,664
Other current liabilities	16,172	21,123
Total current liabilities	80,549	98,221
Senior secured notes	125,000	125,000
Capital lease obligations, less current portion	5,339	8,049
Liability related to receipt of refundable milestone payment		70,000
Liability related to sale of future royalties, less current portion	120,492	121,520
Deferred revenue, less current portion	82,902	82,384
Other long-term liabilities	15,402	19,256
Total liabilities	429,684	524,430
Commitments and contingencies
Stockholders' equity (deficit):
Preferred stock, $0.0001 par value; 10,000 shares authorized, no shares designated, issued or outstanding at September 30, 2014 or December 31, 2013, respectively
Common stock, $0.0001 par value; 300,000 authorized; 128,248 shares and 116,494 shares issued and outstanding at September 30, 2014 and December 31, 2013, respectively	12	11
Capital in excess of par value	1,789,010	1,643,660
Accumulated other comprehensive loss	(1,178)	(1,181)
Accumulated deficit	(1,740,626)	(1,732,393)
Total stockholders' equity (deficit)	47,218	(89,903)
Total liabilities and stockholders' equity (deficit)	$ 476,902	$ 434,527