Leases - Additional Information (Detail) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 28, 2011 sqft	Sep. 30, 2009 Pfizer, Inc. [Member] sqft
Leases [Line Items]
Percentage ceiling on rent increases, annually, capital lease	3.00%
San Carlos facility capital leases, termination date	Oct. 05, 2016
Impairment charge				$ 12.6
Net book value of assets	1.0	1.4
Book value of assets, gross	2.3	2.3
Future minimum rental receipts under the San Carlos facility subleases	7.4
Operating sublease						102,283
Operating Sublease term commenced start date	August 2010
Operating Sublease term commenced period	114 months
Operating Sublease term commenced end date	January 31, 2020
Additional area included in operating sublease due to expansion of Mission Bay Facility					24,002
Operating Sublease term commenced period expansion	December 28, 2011
Operating Sublease term commenced end date expansion	January 31, 2020
Rent expense for operating leases	$ 2.9	$ 2.8	$ 2.4