Property and Equipment - Property and Equipment (Detail) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 144,861	$ 142,116
Less: accumulated depreciation	(84,148)	(72,666)
Depreciable property and equipment, net	60,713	69,450
Construction-in-progress	6,261	2,765
Property and equipment, net	66,974	72,215
Building and Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	71,306	72,180
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	26,621	27,145
Manufacturing Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	23,699	20,877
Furniture, Fixtures and Other Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 23,235	$ 21,914