Selected Quarterly Financial Data (Tables)

12 Months Ended

Dec. 31, 2013

Quarterly Financial Information Disclosure [Abstract]

Quarterly Financial Data

The following table sets forth certain unaudited quarterly financial data. In our opinion, the unaudited information set forth below has been prepared on the same basis as the audited information and includes all adjustments necessary to present fairly the information set forth herein. All data is in thousands except per share information.

	Fiscal Year 2013												Fiscal Year 2012
	Q1			Q2			Q3			Q4			Q1			Q2			Q3			Q4
Product sales	$	11,810		$	10,324		$	14,672		$	8,040		$	6,945		$	9,694		$	8,355		$	10,405
Total revenue	$	23,004		$	33,862		$	60,909		$	31,146		$	17,949		$	23,684		$	18,412		$	21,146
Cost of goods sold	$	11,661		$	5,011		$	12,877		$	8,960		$	8,707		$	7,203		$	7,228		$	7,290
Research and development expenses	$	45,618		$	52,230		$	43,914		$	48,248		$	35,085		$	33,201		$	34,016		$	46,373
Operating loss	$	(45,106	)	$	(32,605	)	$	(6,525	)	$	(35,894	)	$	(37,932	)	$	(26,988	)	$	(32,900	)	$	(43,381	)
Net loss	$	(55,063	)	$	(42,748	)	$	(16,543	)	$	(47,659	)	$	(41,097	)	$	(34,285	)	$	(43,547	)	$	(52,926	)
Basic and diluted net loss per share(1)	$	(0.48	)	$	(0.37	)	$	(0.14	)	$	(0.41	)	$	(0.36	)	$	(0.30	)	$	(0.38	)	$	(0.46	)

(1) Quarterly loss per share amounts may not total to the year-to-date loss per share due to rounding.