Property and Equipment (Tables)

12 Months Ended

Dec. 31, 2013

Property Plant And Equipment [Abstract]

Property and Equipment

Property and equipment consist of the following (in thousands):

	December 31,
	2013			2012
Building and leasehold improvements	$	71,306		$	72,180
Laboratory equipment		26,621			27,145
Manufacturing equipment		23,699			20,877
Furniture, fixtures and other equipment		23,235			21,914
Depreciable property and equipment at cost		144,861			142,116
Less: accumulated depreciation		(84,148	)		(72,666	)
Depreciable property and equipment, net		60,713			69,450
Construction-in-progress		6,261			2,765
Property and equipment, net	$	66,974		$	72,215