Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Current assets:
Cash and cash equivalents	$ 39,067	$ 25,437
Short-term investments	197,959	251,757
Accounts receivable, net of allowance of nil at December 31, 2013 and 2012	2,229	5,805
Inventory	13,452	18,269
Other current assets	5,175	13,363
Total current assets	257,882	314,631
Restricted Cash	25,000	25,000
Property and equipment, net	66,974	72,215
Goodwill	76,501	76,501
Other assets	8,170	9,443
Total assets	434,527	497,790
Current liabilities:
Accounts payable	9,115	2,863
Accrued compensation	14,254	8,773
Accrued expenses	6,243	8,008
Accrued clinical trial expenses	16,905	17,500
Deferred revenue, current portion	23,664	21,896
Interest payable	6,917	7,083
Liability related to the sale of future royalties, current portion	7,000	3,000
Other current liabilities	14,123	9,414
Total current liabilities	98,221	78,537
Senior secured notes	125,000	125,000
Capital lease obligations, less current portion	8,049	11,607
Liability related to receipt of refundable milestone payment	70,000
Liability related to the sale of future royalties, less current portion	121,520	128,266
Deferred revenue, less current portion	82,384	96,551
Other long-term liabilities	19,256	10,811
Total liabilities	524,430	450,772
Commitments and contingencies
Stockholders' equity (deficit):
Preferred stock, 10,000 shares authorized, $0.0001 par value; no shares designated, issued or outstanding at December 31, 2013 and 2012
Common stock, $0.0001 par value; 300,000 authorized; 116,494 shares and 115,259 shares issued and outstanding at December 31, 2013 and 2012, respectively	11	11
Capital in excess of par value	1,643,660	1,617,744
Accumulated other comprehensive loss	(1,181)	(357)
Accumulated deficit	(1,732,393)	(1,570,380)
Total stockholders' equity (deficit)	(89,903)	47,018
Total liabilities and stockholders' equity (deficit)	$ 434,527	$ 497,790