Property and Equipment

12 Months Ended

Dec. 31, 2013

Property Plant And Equipment [Abstract]

Property and Equipment

Note 4 — Property and Equipment

Property and equipment consist of the following (in thousands):

	December 31,
	2013			2012
Building and leasehold improvements	$	71,306		$	72,180
Laboratory equipment		26,621			27,145
Manufacturing equipment		23,699			20,877
Furniture, fixtures and other equipment		23,235			21,914
Depreciable property and equipment at cost		144,861			142,116
Less: accumulated depreciation		(84,148	)		(72,666	)
Depreciable property and equipment, net		60,713			69,450
Construction-in-progress		6,261			2,765
Property and equipment, net	$	66,974		$	72,215

Building and leasehold improvements include our manufacturing, research and development and administrative facilities and the related improvements to these facilities. Laboratory and manufacturing equipment include assets that support both our manufacturing and research and development efforts. Construction-in-progress includes assets being built to enhance our manufacturing and research and development efforts. Property and equipment includes certain assets acquired through capital leases (see Note 6).

In July 2012, we consolidated our U.S.-based research activities into our existing San Francisco facility and ceased use of and plan to sell one of our buildings located in Huntsville, Alabama that was dedicated to research activities. The announcement of this consolidation plan in March 2012 triggered the recognition of a $1.7 million impairment charge relating to these assets in the year ended December 31, 2012.

Depreciation expense, including depreciation of assets acquired through capital leases, for the years ended December 31, 2013, 2012, and 2011 was $13.0 million, $13.8 million, and $15.0 million, respectively.