CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2013	Mar. 31, 2012
Revenue:
Product sales	$ 11,810	$ 6,945
Royalty revenues	325	3,177
Non-cash royalty revenue related to sale of future royalties	4,393
License, collaboration and other	6,476	7,827
Total revenue	23,004	17,949
Operating costs and expenses:
Cost of goods sold	11,661	8,707
Research and development	45,618	35,085
General and administrative	11,129	10,414
Impairment of long-lived assets		1,675
Total operating costs and expenses	68,408	55,881
Loss from operations	(45,404)	(37,932)
Non-operating income (expense):
Interest income	314	632
Interest expense	(4,645)	(2,548)
Non-cash interest expense on liability related to sale of future royalties	(5,543)	(1,785)
Other income (expense), net	427	660
Total non-operating expense, net	(9,447)	(3,041)
Loss before provision for income taxes	(54,851)	(40,973)
Provision for income taxes	212	124
Net loss	$ (55,063)	$ (41,097)
Basic and diluted net loss per share	$ (0.48)	$ (0.36)
Weighted average shares outstanding used in computing basic and diluted net loss per share	115,309	114,531