Property and Equipment - Property and Equipment (Detail) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2012	Dec. 31, 2011
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 142,116	$ 139,063
Less: accumulated depreciation	(72,666)	(62,237)
Depreciable property and equipment, net	69,450	76,826
Construction-in-progress	2,765	1,750
Property and equipment, net	72,215	78,576
Building and leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	72,180	72,473
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	27,145	26,290
Manufacturing equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	20,877	19,550
Furniture, fixtures and other equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 21,914	$ 20,750