CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenue:
Product sales and royalties	$ 12,280	$ 10,222	$ 35,855	$ 26,023
License, collaboration and other	6,132	16,846	24,190	29,675
Total revenue	18,412	27,068	60,045	55,698
Operating costs and expenses:
Cost of goods sold	7,228	5,038	23,138	16,441
Research and development	34,016	31,018	102,302	93,464
General and administrative	10,068	12,350	30,750	35,262
Impairment of long-lived assets	0		1,675
Total operating costs and expenses	51,312	48,406	157,865	145,167
Loss from operations	(32,900)	(21,338)	(97,820)	(89,469)
Non-operating income (expense):
Interest income	603	622	1,865	1,583
Interest expense	(11,184)	(2,543)	(23,448)	(7,698)
Other income (expense), net	156	(717)	913	(599)
Total non-operating expense, net	(10,425)	(2,638)	(20,670)	(6,714)
Loss before provision for income taxes	(43,325)	(23,976)	(118,490)	(96,183)
Provision for income taxes	222	92	439	300
Net loss	$ (43,547)	$ (24,068)	$ (118,929)	$ (96,483)
Basic and diluted net loss per share	$ (0.38)	$ (0.21)	$ (1.04)	$ (0.86)
Weighted average shares outstanding used in computing basic and diluted net loss per share	114,915	114,413	114,699	112,435