CONDENSED CONSOLIDATED BALANCE SHEETS (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 10,338	$ 15,312
Short-term investments	308,939	225,856
Accounts receivable	3,911	4,938
Inventory	16,754	12,656
Other current assets	7,003	17,944
Total current assets	346,945	276,706
Restricted cash and long-term investments	35,022	173,768
Property and equipment, net	73,256	78,576
Goodwill	76,501	76,501
Other assets	9,728	999
Total assets	541,452	606,550
Current liabilities:
Accounts payable	2,624	3,019
Accrued compensation	12,687	12,807
Accrued expenses	6,450	6,669
Accrued clinical trial expenses	13,200	11,953
Deferred revenue, current portion	22,639	19,643
Convertible subordinated notes	0	214,955
Other current liabilities	11,870	6,486
Total current liabilities	69,470	275,532
Capital lease obligations, less current portion	12,414	14,582
Senior secured debt	125,000
Liability related to sale of future royalties, less current portion	126,746
Deferred revenue, less current portion	101,762	108,188
Other long-term liabilities	10,728	10,437
Total liabilities	446,120	408,739
Commitments and contingencies
Stockholders' equity:
Preferred stock, 10,000 shares authorized, $0.0001 par value; 3,100 shares designated Series A and no shares issued or outstanding at December 31, 2011; no shares designated, issued or outstanding at September 30, 2012
Common stock, $0.0001 par value; 300,000 authorized; 115,073 shares and 114,485 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively	11	11
Capital in excess of par value	1,612,620	1,597,428
Accumulated other comprehensive income (loss)	155	(1,103)
Accumulated deficit	(1,517,454)	(1,398,525)
Total stockholders' equity	95,332	197,811
Total liabilities and stockholders' equity	$ 541,452	$ 606,550