Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Cash flows from operating activities:
Net loss	$ (41,097)	$ (36,034)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash interest expense on liability related to sale of future royalties	1,815
Stock-based compensation	4,234	4,802
Depreciation and amortization	3,480	3,856
Impairment of long-lived assets	1,675
Other non-cash transactions	295	309
Changes in operating assets and liabilities:
Accounts receivable	(5,865)	22,942
Inventory	(1,452)	(4,446)
Other assets	4,305	(1,199)
Accounts payable	(1,290)	(2,895)
Accrued compensation	(4,620)	(1,572)
Accrued expenses	1,094	1,961
Accrued clinical trial expenses	773	1,505
Deferred revenue	3,226	(2,555)
Other liabilities	(1,191)	(1,544)
Net cash used in operating activities	(34,618)	(14,870)
Cash flows from investing activities:
Purchases of investments	(102,023)	(372,723)
Maturities of investments	151,964	113,235
Sales of investments		61,368
Purchases of property and equipment	(1,516)	(3,765)
Net cash provided by (used in) investing activities	48,425	(201,885)
Cash flows from financing activities:
Payments of capital lease obligations	(566)	(459)
Proceeds from sale of future royalties, net of transaction costs	119,589
Issuance of common stock, net of issuance costs	479	221,958
Net cash provided by financing activities	119,502	221,499
Effect of exchange rates on cash and cash equivalents	(136)	(14)
Net increase in cash and cash equivalents	133,173	4,730
Cash and cash equivalents at beginning of period	15,312	17,755
Cash and cash equivalents at end of period	$ 148,485	$ 22,485