Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Revenue:
Product sales and royalties	$ 10,122	$ 4,793
License, collaboration and other	7,827	6,506
Total revenue	17,949	11,299
Operating costs and expenses:
Cost of goods sold	8,707	3,263
Research and development	35,085	30,176
General and administrative	10,414	11,727
Impairment of long-lived assets	1,675
Total operating costs and expenses	55,881	45,166
Loss from operations	(37,932)	(33,867)
Non-operating income (expense):
Interest income	632	432
Interest expense	(4,333)	(2,585)
Other income, net	660	134
Total non-operating expense	(3,041)	(2,019)
Loss before provision for income taxes	(40,973)	(35,886)
Provision for income taxes	124	148
Net loss	$ (41,097)	$ (36,034)
Basic and diluted net loss per share	$ (0.36)	$ (0.33)
Weighted average shares outstanding used in computing basic and diluted net loss per share	114,531	108,677