Stock-Based Compensation (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Total stock-based compensation expense
Total stock-based compensation cost	$ 4,234	$ 4,802
Cost of goods sold [Member]
Total stock-based compensation expense
Total stock-based compensation cost	408	332
Research and development expense [Member]
Total stock-based compensation expense
Total stock-based compensation cost	1,923	1,969
General and administrative expense [Member]
Total stock-based compensation expense
Total stock-based compensation cost	$ 1,903	$ 2,501