Stock-Based Compensation (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Total stock-based compensation expense
Total stock-based compensation	$ 18,885	$ 17,399	$ 10,326
Cost of goods sold [Member]
Total stock-based compensation expense
Total stock-based compensation	1,266	915	295
Research and development [Member]
Total stock-based compensation expense
Total stock-based compensation	7,944	7,218	3,377
General and administrative [Member]
Total stock-based compensation expense
Total stock-based compensation	$ 9,675	$ 9,266	$ 6,654