Commitments and Contingencies (Details) (USD $)	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Commitments and Contingencies (Textual) [Abstract]
Royalty expense	$ 1,800,000	$ 2,200,000	$ 3,900,000
Purchase commitments related to contract manufacturing, clinical development and certain other items	10,100,000
Securities related claims [Member]
Loss Contingencies [Line Items]
Obligations under Director and Officer Indemnifications per incident	500,000
Non-securities related claims [Member]
Loss Contingencies [Line Items]
Obligations under Director and Officer Indemnifications per incident	$ 250,000