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Property and Equipment (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Property and equipment
Depreciable property and equipment at cost	$ 139,063	$ 141,210
Less: accumulated depreciation	(62,237)	(53,994)
Depreciable property and equipment, net	76,826	87,216
Construction-in-progress	1,750	2,557
Property and equipment, net	78,576	89,773
Building and leasehold improvements [Member]
Property and equipment
Depreciable property and equipment at cost	72,473	73,150
Laboratory equipment [Member]
Property and equipment
Depreciable property and equipment at cost	33,705	31,871
Manufacturing equipment [Member]
Property and equipment
Depreciable property and equipment at cost	12,135	13,386
Furniture, fixtures and other equipment [Member]
Property and equipment
Depreciable property and equipment at cost	$ 20,750	$ 22,803

The cumulative amount of depreciation, depletion and amortization (related to property, plant and equipment, but not including land) that has been recognized in the income statement.

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- Definition

Tangible assets that are held by an entity for use in the production or supply of goods and services, for rental to others, or for administrative purposes and that are expected to provide economic benefit for more than one year; net of accumulated depreciation. Examples include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software.

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