Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenue:
Product sales	$ 24,864	$ 27,412	$ 30,116
Royalty revenues	10,327	7,255	5,172
License, collaboration and other revenue	36,289	124,372	36,643
Total revenue	71,480	159,039	71,931
Operating costs and expenses:
Cost of goods sold	21,891	25,667	30,948
Research and development	126,766	108,065	95,109
General and administrative	46,760	40,986	41,006
Impairment of long-lived assets	0	12,576	0
Total operating costs and expenses	195,417	187,294	167,063
Loss from operations	(123,937)	(28,255)	(95,132)
Non-operating income (expense):
Interest income	2,244	1,545	3,688
Interest expense	(10,223)	(11,174)	(12,176)
Other income (expense), net	(1,044)	827	848
Total non-operating expense, net	(9,023)	(8,802)	(7,640)
Loss before provision (benefit) for income taxes	(132,960)	(37,057)	(102,772)
Provision (benefit) for income taxes	1,018	881	(253)
Net loss	$ (133,978)	$ (37,938)	$ (102,519)
Basic and diluted net loss per share	$ (1.19)	$ (0.40)	$ (1.11)
Weighted average shares outstanding used in computing basic and diluted net loss per share	112,942	94,079	92,772