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Organization and Summary of Significant Accounting Policies (Details Textual) (USD $)
 12 Months Ended
Dec. 31, 2011
years
Dec. 31, 2010
Finite-Lived Intangible Assets [Line Items]    
Outstanding convertible subordinated notes $ 214,955,000  
Organization and Summary of Significant Accounting Policies (Textual) [Abstract]    
Cash and cash equivalents, and Investment in marketable securities 414,900,000  
Indebtedness 239,900,000  
Maximum maturity term of investments in marketable securities to be considered as cash equivalents 3 months  
Maturity term of investments considered as short term

Cash, Cash Equivalents, and Investments, and Fair Value of Financial Instruments

We consider all investments in marketable securities with an original maturity of three months or less to be cash equivalents. Investments are designated as available-for-sale and are carried at fair value, with unrealized gains and losses reported in stockholders' equity as accumulated other comprehensive income (loss). The disclosed fair value related to our investments is based primarily on the reported fair values in our period-end brokerage statements. We independently validate these fair values using available market quotes and other information. Investments in securities with maturities of less than one year, or where management's intent is to use the investments to fund current operations or to make them available for current operations, are classified as short-term investments

Interest and dividends on securities classified as available-for-sale, as well as amortization of premiums and accretion of discounts to maturity, are included in interest income. Realized gains and losses and declines in value of available-for-sale securities judged to be other-than-temporary, if any, are included in other income (expense). The cost of securities sold is based on the specific identification method.

The carrying value of cash, cash equivalents, and investments approximates fair value and is based on quoted market prices.

  
Number of customers accounted for major accounts receivable 4 2
Percentage of accounts receivable customers one 26.00% 66.00%
Percentage of accounts receivable customers two 20.00% 21.00%
Percentage of accounts receivable customers three 19.00%  
Percentage of accounts receivable customers four 17.00%  
Estimated useful lives, minimum 3  
Estimated useful lives, maximum 7  
Minimum percentage of amount realized upon ultimate settlement 50.00%  
Allowance for doubtful accounts      
Development milestones payments received upon achievement 4,500,000  
Number of collaboration agreements from which development milestones achieved 2  
Recognized revenue under previous milestone revenue recognition policy 1,500,000  
Increase in revenue under milestone method of revenue recognition 3,000,000  
Increase in per share under milestone method of revenue recognition $ 0.03  
Purchase and Sale Agreement with RPI [Member]
    
Finite-Lived Intangible Assets [Line Items]    
Proceeds from sale of royalty rights 124,000,000  
Structuring transaction costs $ 4,500,000