Selected Quarterly Financial Data (Tables)

12 Months Ended

Dec. 31, 2011

Selected Quarterly Financial Data [Abstract]

Quarterly Financial Data

	Fiscal Year 2011												Fiscal Year 2010
	Q1			Q2			Q3			Q4			Q1			Q2			Q3			Q4
Product sales	$	2,474		$	8,641		$	7,677		$	6,073		$	1,828		$	9,398		$	5,485		$	10,700
Royalty revenues	$	2,319		$	2,367		$	2,545		$	3,095		$	1,756		$	1,756		$	1,745		$	1,999
License, collaboration and other revenue	$	6,506		$	6,323		$	16,846		$	6,614		$	29,653		$	31,409		$	30,695		$	32,615
Total revenue	$	11,299		$	17,331		$	27,068		$	15,782		$	33,237		$	42,563		$	37,925		$	45,314
Gross profit on product sales	$	(789	)	$	501		$	2,639		$	623		$	(2,468	)	$	4,509		$	(760	)	$	463
Research and development expenses	$	30,176		$	32,270		$	31,018		$	33,302		$	23,286		$	25,600		$	27,724		$	31,455
General and administrative expenses	$	11,727		$	11,185		$	12,350		$	11,498		$	9,013		$	10,207		$	10,181		$	11,585
Impairment of long lived assets	$	—		$	—		$	—		$	—		$	—		$	—		$	—		$	12,576
Total operating costs and expenses	$	45,166		$	51,595		$	48,406		$	50,250		$	36,595		$	40,696		$	44,150		$	65,853
Operating (loss) income	$	(33,867	)	$	(34,264	)	$	(21,338	)	$	(34,468	)	$	(3,358	)	$	1,867		$	(6,225	)	$	(20,539	)
Interest expense	$	2,585		$	2,570		$	2,543		$	2,525		$	2,951		$	2,909		$	2,826		$	2,488
Net loss	$	(36,034	)	$	(36,381	)	$	(24,068	)	$	(37,495	)	$	(6,130	)	$	(517	)	$	(8,711	)	$	(22,580	)
Basic and diluted net loss per share(1)	$	(0.33	)	$	(0.32	)	$	(0.21	)	$	(0.33	)	$	(0.07	)	$	(0.01	)	$	(0.09	)	$	(0.24	)

(1) Quarterly loss per share amounts may not total to the year-to-date loss per share due to rounding.