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Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2011
Property and Equipment [Abstract]  
Property and equipment
                 
     December 31,  
     2011     2010  

Building and leasehold improvements

   $ 72,473      $ 73,150   

Laboratory equipment

     33,705        31,871   

Manufacturing equipment

     12,135        13,386   

Furniture, fixtures and other equipment

     20,750        22,803   
    

 

 

   

 

 

 

Depreciable property and equipment at cost

     139,063        141,210   

Less: accumulated depreciation

     (62,237     (53,994
    

 

 

   

 

 

 

Depreciable property and equipment, net

     76,826        87,216   

Construction- in-progress

     1,750        2,557   
    

 

 

   

 

 

 

Property and equipment, net

   $ 78,576      $ 89,773