Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Current assets:
Cash and cash equivalents	$ 15,312	$ 17,755
Short-term investments	225,856	298,177
Accounts receivable, net of allowance of nil at December 31, 2011 and 2010	4,938	25,102
Inventory	12,656	7,266
Other current assets	17,944	5,679
Total current assets	276,706	353,979
Long-term investments	173,768
Property and equipment, net	78,576	89,773
Goodwill	76,501	76,501
Other assets	999	972
Total assets	606,550	521,225
Current liabilities:
Accounts payable	3,019	7,194
Accrued compensation	12,807	9,252
Accrued expenses	6,669	8,540
Accrued clinical trial expenses	11,953	12,144
Deferred revenue, current portion	19,643	20,584
Convertible subordinated notes, current portion	214,955
Other current liabilities	6,486	6,394
Total current liabilities	275,532	64,108
Convertible subordinated notes		214,955
Capital lease obligations, less current portion	14,582	17,014
Deferred revenue, less current portion	108,188	124,763
Deferred gain	3,278	4,152
Other long-term liabilities	7,159	5,571
Total liabilities	408,739	430,563
Commitments and contingencies
Stockholders' equity:
Preferred stock, 10,000 shares authorized Series A, $0.0001 par value; 3,100 shares designated; no shares issued or outstanding at either December 31, 2011 or 2010
Common stock, $0.0001 par value; 300,000 authorized; 114,485 shares and 94,517 shares issued and outstanding at December 31, 2011 and 2010, respectively	11	9
Capital in excess of par value	1,597,428	1,354,232
Accumulated other comprehensive (loss) income	(1,103)	968
Accumulated deficit	(1,398,525)	(1,264,547)
Total stockholders' equity	197,811	90,662
Total liabilities and stockholders' equity	$ 606,550	$ 521,225