CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (137,018)	$ (90,393)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(16,861)	(17,561)
Non-cash interest expense	6,405	7,529
Change in fair value of development derivative liability	0	(33,427)
Non-cash research and development expense	0	4,951
Stock-based compensation	10,019	20,961
Depreciation and amortization	2,302	3,730
Deferred income tax expense	(1,812)	0
Impairment of other property, plant and equipment	13,200	0
Impairment of goodwill	76,501	0
Amortization of premiums (discounts), net and other non-cash transactions	(3,129)	1,276
Changes in operating assets and liabilities:
Accounts receivable	2,986	(7,728)
Inventory	(1,033)	422
Operating leases, net	(1,786)	1,787
Other assets	5,591	2,864
Accounts payable	(8,920)	2,998
Accrued expenses	1,640	14,167
Net cash used in operating activities	(51,915)	(88,424)
Cash flows from investing activities:
Purchases of investments	(107,012)	(93,493)
Maturities of investments	148,043	227,974
Purchases of property, plant and equipment	(433)	(4,203)
Net cash provided by investing activities	40,598	130,278
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	0	188
Cash receipts from development derivative liability	0	750
Net cash provided by financing activities	0	938
Effect of foreign exchange rates on cash and cash equivalents	45	(17)
Net increase (decrease) in cash and cash equivalents	(11,272)	42,775
Cash and cash equivalents at beginning of period	88,227	25,218
Cash and cash equivalents at end of period	$ 76,955	$ 67,993