CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		126 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022
Cash flows from operating activities:
Net loss			$ (249,461)	$ (248,486)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties			(33,825)	(39,254)	$ 367,277
Non-cash interest expense on liabilities related to the sales of future royalties	$ 7,228	$ 13,089	14,757	26,385	259,030
Change in fair value of development derivative liability	0	2,713	(33,427)	4,312
Non-cash research and development expense			4,951	5,795
Stock-based compensation	11,103	23,714	32,064	47,612
Depreciation and amortization			7,171	7,090
Impairment of right-of-use assets and property, plant and equipment	57,321		57,321	0
Amortization of premiums (discounts), net and other non-cash transactions			700	4,090
Changes in operating assets and liabilities:
Accounts receivable			12,486	10,018
Inventory			(1,168)	676
Operating leases, net			1,486	2,260
Other assets			7,627	11,585
Accounts payable			2,833	(2,101)
Accrued compensation			14,588	14,133
Other accrued expenses			(1,520)	(4,101)
Net cash used in operating activities			(163,417)	(159,986)
Cash flows from investing activities:
Purchases of investments			(247,014)	(527,887)
Maturities of investments			466,423	612,419
Sales of investments			0	5,035
Purchases of property, plant and equipment			(4,983)	(6,157)
Net cash provided by investing activities			214,426	83,410
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans			655	28,523
Cash receipts from development derivative liability			750	1,500
Net cash provided by financing activities			1,405	30,023
Effect of foreign exchange rates on cash and cash equivalents			(87)	(57)
Net increase (decrease) in cash and cash equivalents			52,327	(46,610)
Cash and cash equivalents at beginning of period			25,218	198,955
Cash and cash equivalents at end of period	$ 77,545	$ 152,345	77,545	152,345	$ 77,545
Supplemental disclosures of cash flow information:
Operating lease right-of-use asset recognized in exchange for lease liabilities			$ 0	$ 1,057