CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Total revenue	$ 21,585	$ 28,330	$ 46,407	$ 51,977
Operating costs and expenses:
Cost of goods sold	5,115	7,667	10,430	13,423
Research and development	42,740	101,313	149,993	196,917
General and administrative	20,521	29,555	47,860	61,234
Restructuring, impairment and other costs of terminated program	106,045	0	107,520	0
Total operating costs and expenses	174,421	138,535	315,803	271,574
Loss from operations	(152,836)	(110,205)	(269,396)	(219,597)
Non-operating income (expense):
Change in fair value of development derivative liability	0	(2,713)	33,427	(4,312)
Non-cash interest expense on liabilities related to the sales of future royalties	(7,228)	(13,089)	(14,757)	(26,385)
Interest income and other income (expense), net	1,096	845	1,491	2,257
Total non-operating income (expense), net	(6,132)	(14,957)	20,161	(28,440)
Loss before provision for income taxes	(158,968)	(125,162)	(249,235)	(248,037)
Provision for income taxes	100	357	226	449
Net loss	$ (159,068)	$ (125,519)	$ (249,461)	$ (248,486)
Basic net loss per share (in dollars per share)	$ (0.85)	$ (0.69)	$ (1.34)	$ (1.37)
Diluted net loss per share (in dollars per share)	$ (0.85)	$ (0.69)	$ (1.34)	$ (1.37)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	186,800	182,698	186,323	182,038
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	186,800	182,698	186,323	182,038
Product sales
Revenue:
Total revenue	$ 5,312	$ 7,846	$ 11,000	$ 12,641
Non-cash royalty revenue related to the sales of future royalties
Revenue:
Total revenue	16,264	20,456	33,825	39,254
License, collaboration and other revenue
Revenue:
Total revenue	$ 9	$ 28	$ 1,582	$ 82