Restructuring, Impairment and Other Costs of Terminated Program - Restructuring Reserve Rollforward (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Mar. 31, 2022
Restructuring Reserve [Roll Forward]
Restructuring, impairment and other costs of terminated program	$ 106,045	$ 0	$ 107,520	$ 0
Employee Severance
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value					$ 32,417
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	0
Restructuring, impairment and other costs of terminated program	27,750
Payments during the period	(12,881)
Liability balance as of June 30, 2022	14,869		14,869
No service period
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value					23,588
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	0
Restructuring, impairment and other costs of terminated program	23,588
Payments during the period	(12,881)
Liability balance as of June 30, 2022	10,707		10,707
Service period required
Restructuring Cost and Reserve [Line Items]
Total severance and other termination benefits, at fair value					$ 8,829
Restructuring Reserve [Roll Forward]
Liability balance as of March 31, 2022	0
Restructuring, impairment and other costs of terminated program	4,162
Payments during the period	0
Liability balance as of June 30, 2022	$ 4,162		$ 4,162