Liabilities Related to Sales of Future Royalties - Activity Within the Liability Account (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		126 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds					$ 274,000
Non-cash royalty revenue			$ 33,825	$ 39,254	(367,277)
Non-cash interest expense	$ 7,228	$ 13,089	14,757	$ 26,385	259,030
Payments to RPI					(10,000)
Loss on revaluation of liability related to the sale of future royalties					23,522
Liabilities related to the sales of future royalties – ending balance	179,275		179,275		179,275
Less: unamortized transaction costs	(2,500)		(2,500)		(2,500)
Liabilities related to the sales of future royalties, net	176,775		176,775		176,775	$ 195,427
2012 Purchase and Sale Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds					124,000
Non-cash royalty revenue					(297,507)
Non-cash interest expense					229,474
Payments to RPI					(10,000)
Loss on revaluation of liability related to the sale of future royalties					23,522
Liabilities related to the sales of future royalties – ending balance	69,489		69,489		69,489
Less: unamortized transaction costs	0		0		0
Liabilities related to the sales of future royalties, net	69,489		69,489		69,489
2020 Purchase and Sale Agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty monetization proceeds			150,000
Non-cash royalty revenue			(69,770)
Non-cash interest expense			29,556
Payments to RPI			0
Loss on revaluation of liability related to the sale of future royalties			0
Liabilities related to the sales of future royalties – ending balance	109,786		109,786		109,786
Less: unamortized transaction costs	(2,500)		(2,500)		(2,500)
Liabilities related to the sales of future royalties, net	$ 107,286		$ 107,286		$ 107,286