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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended
Apr. 30, 2022
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Organization And Summary Of Significant Accounting Policies [Line Items]            
Cash and investments in marketable securities   $ 628,244,000   $ 628,244,000   $ 798,783,000
Accounts receivable   10,006,000   10,006,000   22,492,000
Accounts receivable, credit loss expense (reversal)   0 $ 0 0 $ 0  
Employee Severance            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Workforce termination, percentage 70.00%          
Bristol Myers Squibb Collaboration Agreement            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Accounts receivable   $ 7,400,000   $ 7,400,000   $ 21,400,000