Consolidated Statements of Cash Flows - USD ($)	12 Months Ended			118 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (523,837,000)	$ (444,440,000)	$ (440,667,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(77,746,000)	(48,563,000)	(36,303,000)	$ (333,451,000)
Non-cash interest expense on liabilities related to sales of future royalties	47,313,000	30,267,000	25,044,000	244,273,000
Loss on revaluation of liability related to the sale of future royalties	24,410,000	0	0
Change in fair value of development derivative liability	8,023,000	0	0
Non-cash research and development expense	16,703,000	0	0
Stock-based compensation	94,674,000	94,261,000	99,795,000
Depreciation and amortization	14,146,000	14,182,000	13,156,000
Impairment of advance payments to contract manufacturers and equipment for terminated program	0	20,351,000	0
Amortization of premiums (discounts), net and other non-cash transactions	(6,730,000)	(3,943,000)	11,394,000
Changes in operating assets and liabilities
Accounts receivable	12,397,000	1,913,000	6,411,000
Inventory	(509,000)	(2,627,000)	(1,284,000)
Operating leases, net	2,340,000	2,743,000	13,090,000
Other assets	(2,688,000)	4,476,000	1,190,000
Accounts payable	(11,690,000)	2,382,000	12,967,000
Accrued compensation	1,203,000	4,697,000	1,530,000
Other accrued expenses	(23,524,000)	8,644,000	4,349,000
Deferred revenue	(605,000)	(5,516,000)	(16,565,000)
Net cash used in operating activities	(412,660,000)	(313,287,000)	(328,681,000)
Cash flows from investing activities:
Purchases of investments	(960,689,000)	(987,533,000)	(1,380,865,000)
Maturities of investments	1,166,951,000	1,449,304,000	1,614,036,000
Sales of investments	11,504,000	41,700,000	0
Purchases of property, plant and equipment	(14,989,000)	(7,258,000)	(26,285,000)
Net cash provided by investing activities	202,777,000	496,213,000	206,886,000
Cash flows from financing activities:
Proceeds from sale of future royalties, net of $3.8 million of transaction costs	0	146,250,000	0
Repayment of senior notes	0	(250,000,000)	0
Cash receipts from development derivative liability	3,000,000	0	0
Proceeds from shares issued under equity compensation plans	33,238,000	23,396,000	23,355,000
Net cash provided by (used in) financing activities	36,238,000	(80,354,000)	23,355,000
Effect of foreign exchange rates on cash and cash equivalents	(92,000)	20,000	(102,000)
Net increase (decrease) in cash and cash equivalents	(173,737,000)	102,592,000	(98,542,000)
Cash and cash equivalents at beginning of year	198,955,000	96,363,000	194,905,000
Cash and cash equivalents at end of year	25,218,000	198,955,000	96,363,000	$ 25,218,000
Supplemental disclosure of cash flow information:
Cash paid for interest	0	9,742,000	19,199,000
Cash paid for income taxes	325,000	539,000	555,000
Operating lease right-of-use assets recognized in exchange for lease liabilities	1,057,000	2,133,000	57,691,000
Accounts receivable recognized in exchange for long-term liabilities	$ 0	$ 4,000,000	$ 0