Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenue:
Total revenue	$ 23,647	$ 50,573
Operating costs and expenses:
Cost of goods sold	5,756	3,811
Research and development	95,604	108,987
General and administrative	31,679	26,217
Impairment of assets and other costs for terminated program	0	45,189
Total operating costs and expenses	133,039	184,204
Loss from operations	(109,392)	(133,631)
Non-operating income (expense):
Non-cash interest expense on liability related to sale of future royalties	(13,296)	(6,968)
Change in fair value of development derivative liability	(1,599)	0
Interest income and other income (expense), net	1,412	8,352
Interest expense	0	(6,204)
Total non-operating income (expense), net	(13,483)	(4,820)
Loss before provision for income taxes	(122,875)	(138,451)
Provision for income taxes	92	200
Net loss	$ (122,967)	$ (138,651)
Basic and diluted net loss per share (in dollars per share)	$ (0.68)	$ (0.78)
Weighted average shares outstanding used in computing basic and diluted net loss per share (in shares)	181,370	177,185
Product sales
Revenue:
Total revenue	$ 4,795	$ 3,444
Royalty revenue
Revenue:
Total revenue	0	9,719
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	18,798	9,895
License, collaboration and other revenue
Revenue:
Total revenue	$ 54	$ 27,515