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Cash and Investments in Marketable Securities (Tables)
3 Months Ended
Mar. 31, 2021
Fair Value Disclosures [Abstract]  
Cash and Investments in Marketable Securities, Including Cash Equivalents
Cash and investments in marketable securities, including cash equivalents, are as follows (in thousands):
Estimated Fair Value at
March 31, 2021December 31, 2020
Cash and cash equivalents$150,164 $198,955 
Short-term investments887,152 862,941 
Long-term investments96,093 136,662 
Total cash and investments in marketable securities$1,133,409 $1,198,558 
Portfolio of Cash and Investments in Marketable Securities
Our portfolio of cash and investments in marketable securities includes (in thousands):
March 31, 2021
December 31, 2020
Amortized CostGross Unrealized GainsGross Unrealized LossesFair ValueFair Value
Corporate notes and bonds$510,521 $313 $(171)$510,663 $687,469 
Corporate commercial paper478,448 35 (41)478,442 313,497 
Obligations of U.S. government agencies4,880 — 4,884 2,382 
Available-for-sale investments$993,849 $352 $(212)$993,989 $1,003,348 
Money market funds123,607 179,302 
Certificates of deposit8,254 9,623 
Cash7,559 6,285 
Total cash and investments in marketable securities$1,133,409 $1,198,558