Property, Plant and Equipment - Property, Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 193,450	$ 188,322
Less: accumulated depreciation	(138,488)	(127,875)
Depreciable property, plant and equipment, net	54,962	60,447
Construction-in-progress	4,700	5,218
Property, plant and equipment, net	59,662	65,665
Building and leasehold improvements
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	92,977	93,097
Laboratory equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	40,121	36,623
Computer equipment and software
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	28,684	26,910
Manufacturing equipment
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	21,796	22,030
Furniture, fixtures, and other
Property, Plant and Equipment [Line Items]
Depreciable property, plant and equipment at cost	$ 9,872	$ 9,662