Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2020

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2020		2019
Building and leasehold improvements	$	92,977	$	93,097
Laboratory equipment	40,121		36,623
Computer equipment and software	28,684		26,910
Manufacturing equipment	21,796		22,030
Furniture, fixtures, and other	9,872		9,662
Depreciable property, plant and equipment at cost	193,450		188,322
Less: accumulated depreciation	(138,488)		(127,875)
Depreciable property, plant and equipment, net	54,962		60,447
Construction-in-progress	4,700		5,218
Property, plant and equipment, net	$	59,662	$	65,665