Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenue:
Total revenue	$ 48,847	$ 23,315	$ 99,420	$ 51,537
Operating costs and expenses:
Cost of goods sold	5,773	5,018	9,584	10,458
Research and development	96,436	106,686	205,423	225,149
General and administrative	24,347	22,581	50,564	47,587
Impairment of assets and other costs for terminated program	0	0	45,189	0
Total operating costs and expenses	126,556	134,285	310,760	283,194
Loss from operations	(77,709)	(110,970)	(211,340)	(231,657)
Non-operating income (expense):
Interest expense	(647)	(5,231)	(6,851)	(10,457)
Non-cash interest expense on liability related to sale of future royalties	(6,691)	(5,975)	(13,659)	(12,040)
Interest income and other income (expense), net	5,191	11,989	13,543	24,472
Total non-operating income (expense), net	(2,147)	783	(6,967)	1,975
Loss before provision for income taxes	(79,856)	(110,187)	(218,307)	(229,682)
Provision for income taxes	144	99	344	236
Net loss	$ (80,000)	$ (110,286)	$ (218,651)	$ (229,918)
Basic and diluted net loss per share (in dollars per share)	$ (0.45)	$ (0.63)	$ (1.23)	$ (1.32)
Weighted average shares outstanding used in computing basic and diluted net loss per share (in shares)	178,327	174,549	177,755	174,206
Product sales
Revenue:
Total revenue	$ 5,485	$ 4,346	$ 8,929	$ 8,744
Royalty revenue
Revenue:
Total revenue	9,403	7,343	19,122	18,733
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	7,684	9,091	17,579	17,321
License, collaboration and other revenue
Revenue:
Total revenue	$ 26,275	$ 2,535	$ 53,790	$ 6,739