Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenue:
Total revenue	$ 50,573	$ 28,222
Operating costs and expenses:
Cost of goods sold	3,811	5,440
Research and development	108,987	118,463
General and administrative	26,217	25,006
Impairment of assets and other costs for terminated program	45,189	0
Total operating costs and expenses	184,204	148,909
Loss from operations	(133,631)	(120,687)
Non-operating income (expense):
Interest expense	(6,204)	(5,226)
Non-cash interest expense on liability related to sale of future royalties	(6,968)	(6,065)
Interest income and other income (expense), net	8,352	12,483
Total non-operating income (expense), net	(4,820)	1,192
Loss before provision for income taxes	(138,451)	(119,495)
Provision for income taxes	200	137
Net loss	$ (138,651)	$ (119,632)
Basic and diluted net loss per share (in dollars per share)	$ (0.78)	$ (0.69)
Weighted average shares outstanding used in computing basic and diluted net loss per share (in shares)	177,185	173,859
Product sales
Revenue:
Total revenue	$ 3,444	$ 4,398
Royalty revenue
Revenue:
Total revenue	9,719	11,390
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	9,895	8,230
License, collaboration and other revenue
Revenue:
Total revenue	$ 27,515	$ 4,204