Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue:
Total revenue	$ 23,315	$ 1,087,717	$ 51,537	$ 1,125,735
Operating costs and expenses:
Cost of goods sold	5,018	5,522	10,458	12,168
Research and development	106,686	88,334	225,149	187,758
General and administrative	22,581	20,261	47,587	38,948
Total operating costs and expenses	134,285	114,117	283,194	238,874
Income (loss) from operations	(110,970)	973,600	(231,657)	886,861
Non-operating income (expense):
Interest expense	(5,231)	(5,385)	(10,457)	(10,725)
Non-cash interest expense on liability related to sale of future royalties	(5,975)	(4,975)	(12,040)	(9,994)
Interest income and other income (expense), net	11,989	12,105	24,472	13,676
Total non-operating income (expense), net	783	1,745	1,975	(7,043)
Income (loss) before provision for income taxes	(110,187)	975,345	(229,682)	879,818
Provision (benefit) for income taxes	(278)	3,885	(1,261)	4,150
Net income (loss)	$ (109,909)	$ 971,460	$ (228,421)	$ 875,668
Net income (loss) per share
Basic (in dollars per share)	$ (0.63)	$ 5.67	$ (1.31)	$ 5.27
Diluted (in dollars per share)	$ (0.63)	$ 5.33	$ (1.31)	$ 4.91
Weighted average shares outstanding used in computing net income (loss) per share
Basic (in shares)	174,549	171,378	174,206	166,160
Diluted (in shares)	174,549	182,291	174,206	178,281
Product sales
Revenue:
Total revenue	$ 4,346	$ 5,863	$ 8,744	$ 12,158
Royalty revenue
Revenue:
Total revenue	7,343	8,563	18,733	19,639
Non-cash royalty revenue related to sale of future royalties
Revenue:
Total revenue	9,091	9,045	17,321	15,965
License, collaboration and other revenue
Revenue:
Total revenue	$ 2,535	$ 1,064,246	$ 6,739	$ 1,077,973