Exhibit 99.2

Nasdaq: SFNC 4 th Quarter 2022 Earnings Presentation Contents 5 Q4 Highlights 6 Q4 Results Overview 12 Loans 16 Deposits, Liquidity, Securities, Interest Rate Sensitivity & Capital 21 Credit Quality 25 Key Takeaways 27 Appendix

2 Forward - Looking Statements and Non - GAAP Financial Measures Forward - Looking Statements . Certain statements by Simmons First National Corporation (the “Company”, which where appropriate includes the Company’s wholly - owned banking subsidiary, Simmons Bank) contained in this presentation may not be based on historical facts and should be considered "forward - looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 . These forward - looking statements may be identified by reference to a future period(s) or by the use of forward - looking terminology, such as "anticipate," “believe,” “continue,” "estimate," "expect," "foresee,“ “indicate,” “plan,” “potential,” “project,” “target,” "may," "might," "will," "would," "could,“ “should,” “likely” or "intend," future or conditional verb tenses, and variations or negatives of such terms or by similar expressions . These forward - looking statements include, without limitation, statements relating to the Company’s future growth ; business strategies ; product development ; revenue ; expenses (including interest expense and non - interest expenses) ; assets ; loan demand (including loan growth, loan capacity, and other lending activity) ; asset quality ; profitability ; earnings ; critical accounting policies ; accretion ; net interest margin ; noninterest revenue ; the Company's common stock repurchase program ; adequacy of the allowance for credit losses ; income tax deductions ; credit quality ; level of credit losses from lending commitments ; net interest revenue ; interest rate sensitivity (including, among other things, the potential impact of rising rates) ; loan loss experience ; liquidity ; capital resources ; future economic conditions and market risk ; interest rates ; the expected benefits, milestones, timelines, and costs associated with the Company’s merger and acquisition strategy and activity ; the Company’s ability to recruit and retain key employees ; increases in, and cash flows associated with, the Company’s securities portfolio ; legal and regulatory limitations and compliance and competition ; anticipated loan principal reductions ; plans for investments in and cash flows from securities ; projections regarding securities investments ; the interest rate sensitivity estimates noted on slide 19 ; digital bank initiatives ; and dividends . Readers are cautioned not to place undue reliance on the forward - looking statements contained in this presentation in that actual results could differ materially from those indicated in or implied by such forward - looking statements due to a variety of factors . These factors include, but are not limited to, changes in the Company's operating or expansion strategy ; the availability of and costs associated with obtaining adequate and timely sources of liquidity ; the ability to maintain credit quality ; the effect of steps the Company takes in response to the COVID - 19 pandemic ; the pace of recovery when the pandemic subsides and the heightened impact it has on many of the risks described herein ; the effects of the pandemic on, among other things, the Company’s operations, liquidity, and credit quality ; changes in general market and economic conditions ; increased unemployment ; labor shortages ; possible adverse rulings, judgments, settlements and other outcomes of pending or future litigation ; the ability of the Company to collect amounts due under loan agreements ; changes in consumer preferences and loan demand ; effectiveness of the Company's interest rate risk management strategies ; laws and regulations affecting financial institutions in general or relating to taxes ; the effect of pending or future legislation ; the ability of the Company to repurchase its common stock on favorable terms ; the ability of the Company to successfully manage and implement its acquisition strategy and integrate acquired institutions ; difficulties and delays in integrating an acquired business or fully realizing cost savings and other benefits of mergers and acquisitions ; changes in interest rates, deposit flows, real estate values, and capital markets ; increased inflation ; customer acceptance of the Company's products and services ; changes or disruptions in technology and IT systems (including cyber threats, attacks and events) ; changes in accounting principles relating to loan loss recognition (current expected credit losses, or CECL) ; the benefits associated with the Company’s early retirement program ; political crises, war, and other military conflicts (including the ongoing military conflict between Russia and Ukraine) or other major events, or the prospect of these events ; increased competition ; changes in governmental policies ; loss of key employees ; and other risk factors . Other relevant risk factors may be detailed from time to time in the Company's press releases and filings with the U . S . Securities and Exchange Commission, including, without limitation, the Company’s Form 10 - K for the year ended December 31 , 2021 . Any forward - looking statement speaks only as of the date of this presentation, and the Company undertakes no obligation to update these forward - looking statements to reflect events or circumstances that occur after the date of this presentation . Annualized, pro forma, projected and estimated numbers are used for illustrative purpose only, are not forecasts and may not reflect actual results . Non - GAAP Financial Measures . This presentation contains financial information determined by methods other than in accordance with U . S . generally accepted accounting principles (“GAAP”) . The Company’s management uses these non - GAAP financial measures in their analysis of the Company’s performance . These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax - exempt, as well as exclude from net income (including on a per share diluted basis), pre - tax, pre - provision earnings, net charge - offs, income available to common shareholders, non - interest income, and non - interest expense certain income and expense items attributable to merger activity (primarily including merger - related expenses and Day 2 CECL provisions), gains and/or losses on sale of branches, net branch right - sizing initiatives, loss on redemption of trust preferred securities and gain on sale of intellectual property . In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets . The Company further presents certain figures that are exclusive of the impact of Paycheck Protection Program (“PPP”) loans, deposits and/or loans acquired through acquisitions, mortgage warehouse loans, and/or energy loans, or gains and/or losses on the sale of securities . The Company’s management believes that these non - GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, as well as normalize for tax effects, the effects of the PPP, and certain other effects . Management, therefore, believes presentations of these non - GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non - GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods . These non - GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non - GAAP performance measures that may be presented by other companies . Where non - GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the appendix to this presentation .

94% 6% Arkansas Kansas $2.6B 1 Total Deposits 83 branches 35% 22% 17% 16% 9% 1% Arkansas Texas Tennessee Missouri Oklahoma Kansas $22.2B 2 Total Deposits 230 branches 3 Simmons Bank: The culmination of a deliberate growth strategy… 1903 - 2012 Since 2012, we have dramatically improved our growth profile through geographic diversification, building brand awareness… A firm foundation Geographic transformation Building brand awareness $3.5 $4.4 $4.6 $7.6 $8.4 $15.1 $16.5 $21.3 $22.4 $24.7 $27.5 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 Metropolitan National Bank Delta Trust & Banking Corporation Trust Company of the Ozarks Community First Bancshares, Inc . Liberty Bancshares, Inc. Citizens National Bank Hardeman County Investment Company, Inc . First Texas BHC Southwest Bancorp, Inc. Reliance Bancshares, Inc. Landrum Company Triumph Bancshares, Inc . Landmark Community Bank Spirit of Texas Bancshares, Inc. 2022 Korn Ferry Tour Tournament of the Year Will Zalatoris Team Simmons Bank 2022 FEDEX St. Jude Championship Winner 2021 PGA Tour Rookie of the Year Ground - breaking support for female student athletes at 10 universities across our six - state footprint Memphis, TN Little Rock, AR Union City, TN Simmons Bank Plaza at Dickies Arena Fort Worth, TX On March 23, 1903 , Simmons National Bank opens for business in Pine Bluff, AR Total deposits collected on Day 1 were $3,338.22 In 1909, Simmons paid its first cash dividend to shareholders On October 16, 1992, shares of Simmons First National Corporation begin trading on the NASDAQ stock exchange Figures presented in acquisition timeline represent total assets (in billions) of SFNC as of December 31 of each respective y ear (1) Total deposits and branch data as of June 30, 2012, based on FDIC Summary of Deposits filing (2) Total deposits as of June 30, 2022, based on FDIC Summary of Deposits filing, branch data as of December 31, 2022

Simmons Bank’s first fully digital account origination solutions that generally require no human intervention on the bank’s side from beginning to end, while offering a streamlined and engaging opening process A fast, safe and easy way to send money to friends, family and other people you trust, regardless of where they bank 1 4 … that sets a strong foundation for the next stage … substantial investments in leading edge technology and digital banking, while creating a well - defined culture… Strong foundation for the next stage Technology/Digital enhancements that sets a strong foundation for 2023 and beyond Simmons Bank Mobile App… like having a bank in your pocket 4.8 out of 5 star rating on IOS app store A $100 million, multi - year project that began in 2018 to upgrade customer - facing and back - office IT systems so that they compete both now and well into the future A well - defined corporate culture Coin Checking and Savings Zelle and Zelle related marks are wholly owned by Early Warning Services, LLC and are used herein under license (1) U.S. checking or savings account required to use Zelle ®. Transactions between enrolled consumers typically occur in minutes. (2) Deposit market share ranking based on S&P Global Market Intelligence information based on FDIC Summary of Deposits repo rt as of June 30, 2022 (3) Based on research performed by Dividend Power Deposit Market Share 2 2 nd in Arkansas 8 th in Tennessee 9 th in Missouri 11 th in Oklahoma $0.38 $0.38 $0.40 $0.42 $0.44 $0.46 $0.48 $0.50 $0.60 $0.64 $0.68 $0.72 $0.76 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 1 of only 24 U.S. companies that have paid dividends for 100+ years 3 Organic Growth Better Bank Initiative P eople P rocesses S ystems Culture defines who we are at Simmons Bank. It provides parameters for our behaviors, values and attitudes and sets expectations for the ways we interact with others. This has been our story for more than 100 years as we’ve built a legacy around doing right by our team, customers and communities. Established the Simmons First Foundation in 2014

5 Q4 22 and FY 22 Highlights Q 4 net income $83.3M FY22 earnings of $256.4M 1 Q 4 earnings per share $0.65 Q4 adjusted EPS of $0.64 (1) 1 Net income up 3 % QoQ and up 73 % YoY EPS up 3 % QoQ and up 55 % YoY ROA of 1 . 22 % , ROE of 10 . 27 % and ROTCE ( 1 ) of 19 . 29 % Q 4 total revenue of $237.7M FY22 revenue +13% 2 Record revenue of $ 887 . 4 million reported in FY 22 , up 13 % YoY . Positive operating leverage results in 13 % increase in FY 22 pre - provision net revenue . Pre - provision net revenue (1) $95.2M in Q4 FY22 PPNR (1) +13% QoQ loan growth + 3 % to $16.1B Unfunded commitments $5B 3 Solid balance sheet growth with loans up 3 % and deposits up 2 % linked quarter . NPL ratio of 37 basis points unchanged on a linked quarter basis . Net charge - offs for FY 22 total 9 bps and NPL coverage ratio remains healthy at 334 % NPL coverage ratio at 334% NPAs/total assets at 23 bps Book value per share +3% vs Q3 22 and Tangible BVPS (1) +6% 4 Regulatory capital ratios increase on a linked quarter basis and remain significantly above “well - capitalized” guidelines . Equity to asset ratio + 25 bps 11.9% at 12/31/22 TCE ratio (1) up +31 bps to 7% QoQ = 4Q22 vs 3Q22 YoY = 4Q22 vs 4Q21 (1) Non - GAAP measures that management believes aids in the discussion of results. See Appendix for Non - GAAP reconciliation

Q4 22 Results Overview

Summary Income Statement FY $ in millions, except per share data Q4 22 Q3 22 Q4 21 Q3 22 Q4 21 2022 Net interest income 193.0 193.6 153.1 - 26 717.3 Noninterest income, excluding securities gain (loss) (1) 44.7 43.0 46.9 4 (5) 170.3 Total revenue, excluding securities gain (loss) (1) 237.7 236.6 200.0 - 19 887.7 Noninterest expense 142.6 138.9 141.6 3 1 566.7 Pre-provision net revenue (1) 95.2 97.7 58.4 (3) 63 320.9 Gain (loss) on sale of securities (0.1) (0.0) (0.3) NM NM (0.3) Provision for (recapture of) credit losses on loans 0.0 0.1 (1.3) NM NM 14.1 Provision for income taxes 11.8 17.0 11.2 (30) 6 50.1 Net income $ 83.3 $ 80.6 $ 48.2 3 % 73 % $256.4 Diluted EPS $ 0.65 $ 0.63 $ 0.42 3 % 55 % $2.06 Impact of certain items: Day 2 CECL provision $ - $ - 22.7$ 33.8$ Merger related costs - 1.4 13.6 22.5 Branch right sizing costs 1.1 1.2 1.6 3.6 Loss from early retirement of TruPS - 0.4 - 0.4 Gain on sale of intellectual property - (0.8) - (0.8) Gain on insurance settlement (4.1) - - (4.1) Donation to Simmons First Foundation - - - 1.7 Tax effect (2) 0.8 (0.6) (9.9) (14.9) Total impact on earnings ($2.2) $ 1.7 $ 28.0 $ 42.2 Adjusted pre-provision net revenue (1) $ 92.2 $ 100.0 $ 73.7 (8) % 25 % $ 344.3 Adjusted net income (1) $ 81.1 $ 82.3 $ 76.3 (1) 6 % $ 298.6 Adjusted diluted EPS (1) $ 0.64 $ 0.64 $ 0.67 - (4)% $ 2.40 % Change vs 7 Q4 22 and FY 22 Financial Highlights Note: Numbers may not add due to rounding NM – not meaningful (1) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation (2) Effective tax rate of 26.135% Q4 Highlights (Comparisons reflect Q4 22 vs Q3 22) Net Interest Income • Loan growth ( $ 535 million) outpaced cash flow from securities portfolio ( $ 185 million principal) • Decline in noninterest bearing and interest bearing transaction accounts ( $ 342 million) • Those dynamics required increased wholesale funding in the quarter, which drove increase in deposit costs and impacted net interest income growth • Strategic decision to extend the duration of certain wholesale deposit maturities to reduce funding cost rate sensitivity . Noninterest Income • Increase in noninterest income reflects gain on insurance settlement, offset by continued decline in mortgage lending income and decline in wealth management fees due to seasonal items that benefited the prior quarter Noninterest Expense • Increase in noninterest expense reflects increase in FDIC deposit and state banking assessments, full - year tax credit amortization recorded in the fourth quarter and the impact of certain incentive compensation accrual adjustments recorded in the prior quarter Provision for Income Taxes • Decrease in provision for income taxes reflects benefit of tax credits recorded in the fourth quarter

8 Net Interest Income and Margin (FTE) FTE – Fully taxable equivalent using an effective tax rate of 26.135% PPP – Paycheck Protection Program (1) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation (2) Adjusted loan yield excludes the impact of accretion and PPP $158.7 $151.2 $191.2 $199.8 $199.8 4Q21 1Q22 2Q22 3Q22 4Q22 Net Interest Income $ in millions; FTE +26% Δ in Interest Income (FTE) ex PPP & Accretion Δ in Interest Expense Δ in Accretion & PPP Contribution Net Interest Income Evolution $ in millions; FTE Net Interest Margin FTE (%) 2.86 2.76 3.24 3.34 3.31 3.24 3.23 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 NIM NIM excluding PPP and accretion(1) 4.58 4.34 4.54 4.86 5.40 1.74 1.86 2.08 2.29 2.68 0.17 0.14 0.18 0.47 1.02 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Loan Yield (FTE) Securities (FTE) Cost of Deposits Adjusted Loan Yield (1) (2) Loan, Securities & Deposits Yield/Rate FTE (%) Q4 Highlights (Comparisons reflect Q4 22 vs Q3 22) Net interest income (FTE) was flat on a linked quarter basis. Key highlights include: • 4% increase in average loans • +54 bp increase in loan yield and +39 bp increase in securities yield. Loan yield excluding PPP and accretion at 5.29% (1) , up 56 bps • Period end loan balance of $16.1 billion vs $15.9 billion average balance for the quarter, coupled with consistent balance of unfunded commitments provides a catalyst for future growth • Strategic decision in the quarter to extend the duration of certain wholesale deposit maturities to reduce funding cost rate sensitivity (required prefunding cost to carry for portion of Q4) • $1.4 million decrease in accretion income and PPP loans interest income Remaining balance of purchase accounting accretion at 12/31/22 was $22.0 million Q3 22 Q4 22

FY YoY $ in millions Q4 22 Q3 22 Q4 21 Q3 22 Q4 21 2022 % Change Service charges on deposit accounts $11.9 $12.6 $ 11.9 (5) % - % $ 46.5 8 % Wealth management fees 8.2 8.6 8.0 (5) 1 31.9 2 Debit and credit card fees 7.8 7.7 7.5 2 5 31.2 10 Mortgage lending income 1.1 2.6 5.0 (56) (77) 10.5 (52) Bank owned life insurance 3.0 2.9 2.8 3 7 11.1 25 Other service charges and fees 2.0 2.1 1.8 (3) 15 7.6 (1) Other 6.6 6.7 6.9 (1) (4) 27.4 (15) 40.6 43.0 43.8 (6) (7) 166.3 (4) Gain (loss) on sale of securities (0.1) - (0.3) NM NM (0.3) NM Gain on insurance/legal settlement 4.1 - 3.1 NM NM 4.1 NM Total noninterest income $44.6 $43.0 $46.6 4 % (4)% $170.1 (11) % Adjusted noninterest income (1) $40.6 $42.7 $46.6 (5) % (13)% $165.8 (11) % % Change vs 23.3% 22.5% 17.8% 18.2% 18.8% 23.5% 22.5% 17.9% 18.1% 17.4% Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Noninterest Income/Total Revenue Adjusted Noninterest Income, excludingsecurities gain (loss)/Adjusted Total Revenue(1) Noninterest Income to Total Revenue $16.2 $14.6 $12.4 $13.4 $13.8 $16.3 $14.6 $12.5 $13.3 $12.6 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Noninterest Income per Employee Adjusted Noninterest Income, excluding securities gain (loss) per Employee(1) Noninterest Income Per Employee (FTE) ($ in thousands) $69.4 $64.9 $69.7 $73.8 $73.5 $69.5 $64.9 $69.8 $73.7 $72.2 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Revenue per Employee Adjusted Revenue per Employee(1) Revenue Per Employee (FTE) ($ in thousands) 9 Noninterest Income Note: Numbers may not add due to rounding NM – not meaningful FTE – Full - time equivalent (1) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Q4 Highlights (Comparisons reflect Q4 22 vs Q3 22) • Noninterest income totaled $ 44 . 6 million, up 4 % • Included in Q 4 results was a $ 4 . 1 million gain from an insurance settlement related to a weather - related event • Decrease in adjusted noninterest income primarily due to continued decline in mortgage lending income that is consistent with industry trends given current market environment • Expected decline in wealth management fees given market conditions and inclusion of seasonal items in the prior quarter • The year - over - year decline in noninterest income reflects a decrease in gain on sale of securities, coupled with an industry driven decline in mortgage lending income . Most other fee - based business lines reported year - over - year increases

FY YoY $ in millions Q4 22 Q3 22 Q4 21 Q3 22 Q4 21 2022 % Change Salaries and employee benefits $73.0 $71.9 $63.8 2 % 14 % 287.0 17 % Occupancy expense, net 11.6 11.7 11.0 - 5 44.3 14 Furniture and equipment 5.4 5.4 4.7 - 14 20.7 4 Deposit insurance 3.7 3.3 2.1 12 75 11.6 66 OREO and foreclosure expense 0.4 0.2 0.6 108 (39) 1.0 (53) Donation to Simmons First Foundation - - - - - 1.7 NM Other 48.5 45.1 45.7 8 6 178.0 16 Merger related costs and certain items - 1.4 13.6 NM NM 22.5 41 Total noninterest expense $142.6 $138.9 $141.6 3 % 1 % $566.7 17 % Adjusted noninterest expense (1) $141.4 $136.4 $126.4 4 % 12 % $539.1 15 % % Change vs 2,877 2,893 3,233 3,206 3,236 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Employees (FTE) 69.0% 66.4% 67.8% 57.2% 58.3% 59.5% 63.0% 56.7% 54.4% 57.0% Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Efficiency Ratio Adjusted Efficiency Ratio (1) Efficiency Ratio 2.29% 2.07% 2.34% 2.07% 2.10% 2.05% 2.02% 2.03% 2.03% 2.08% Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Noninterest Expense Adjusted Noninterest Expense (1) Noninterest Expense as a Percentage of Total Average Assets 10 Noninterest Expense Note: Numbers may not add due to rounding NM – not meaningful FTE – full - time equivalent QoQ = 4Q22 vs 3Q22 YoY = 4Q22 vs 4Q21 (1) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Q4 Highlights • Noninterest expense comparisons on a YOY basis are impacted by the acquisitions of Spirit of Texas Bancshares, Inc . (April 2022 ), Landmark Community Bank (October 2021 ) and Triumph Bancshares, Inc . (October 2021 ) • The increase in noninterest expense on a QoQ basis was driven by an increase in : • FDIC deposit and state bank assessments up approximately $ 0 . 8 million • Full - year tax credit amortization ( $ 1 . 2 million) • The impact of certain incentive compensation accrual adjustments recorded in the prior quarter

Digital: Significant growth and enhancements implemented throughout the year Zelle and Zelle related marks are wholly owned by Early Warning Services, LLC and are used herein under license 11 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Zelle ® Volume (transactions) 66% 70% +59% +50% +30% +21% +274% Q4 21 Q4 22 Avg Deposit Balance per Mobile Acct +14% Q4 21 Q4 22 Mobile Deposit Dollars +20% Q4 21 Q4 22 Branch Transactions Digital Transactions Customer Transactions by Channel 66% 70% 70% +17% Digital Launched Credit Score Manager in Q4 Credit Report Score Factors Credit Alerts Score Simulator Debt Analysis Credit Score Manager allows customers to: • View their credit score in detail • Gain insight into factors that contribute to their credit score • Receive alerts when changes to their score takes place • Utilize an interactive tool to see how future actions might affect their credit score • Track their debt balances, monthly payments and calculate debt to income

Loan Portfolio

13 Loan Portfolio: Well - diversified, granular portfolio with no significant concentrations (1) Total loans excluding credit card portfolio and mortgage warehouse Data shown above as of December 31, 2022. By State Loan Portfolio – Geographic diversification 33% 18% 16% 11% 5% 2% 15% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Top 10 MSA’s % of Total Loans 1 Dallas - Plano - Irving 10.4% Houston - Sugarland - Baytown 8.0% Memphis 6.4% Nashville - Davidson - Murfreesboro 5.9% Fort Worth - Arlington 5.6% Little Rock - North Little Rock - Conway 5.5% St. Louis 3.8% Fayetteville - Springdale - Rogers 3.4% Oklahoma City 2.2% Jonesboro, AR 2.0% Office Portfolio (non - owner occupied) 48% 13% 12% 10% 4% 13% Texas Arkansas Tennessee Missouri Oklahoma Other By State Key Statistics At 12/31/22 NPL Ratio 0.00% Past Due 30+ Days 0.00% Average Loan Size $2.2M Median Loan Size $0.5M Number of loans <$1M 64% Retail (non - owner occupied) 45% 11% 11% 11% 5% 17% Texas Arkansas Tennessee Missouri Oklahoma Other By State Key Statistics At 12/31/22 NPL Ratio 0.12% Past Due 30+ Days 0.00% Average Loan Size $1.9M Median Loan Size $0.9M Number of loans <$1M 52% Construction - Land Development 45% 9% 15% 4% 3% 24% Texas Arkansas Tennessee Missouri Oklahoma Other By State Key Statistics At 12/31/22 NPL Ratio 0.02% Past Due 30+ Days 0.10% Average Loan Size $1.1M Median Loan Size $0.2M Number of loans <$1M 81% $1.0B $1.0B $2.6B $15.8B 1

$2,943 $3,428 $4,473 $5,138 $5,000 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Unfunded Commitments $ in millions Mortgage Warehouse / PPP Agricultural 14 Loan portfolio: Solid growth that was geographically widespread PPP – Paycheck Protection Program Corporate Banking includes the following units: Corporate CRE, Public Sector Banking, Commercial Finance, Equipment Financing , A sset Based Lending, Institutional Banking and Mortgage Warehouse Total loans at 12/31/22 Total loans at 9/30/22 $(37) $(58) $28 $79 $110 $195 $218 $535 Linked Quarter Loan Growth $ in millions Total Loans RE - Commercial RE - Construction Commercial RE – Single Family Loan Growth by Core Banking Units Linked quarter percent change Metro Banking Community Banking Corporate Banking +8% Loan Portfolio Waterfall $ in millions Consumer & Other - % +4% Funded loan /advances Paydowns /payoffs +3% 78% variable rate • 70% tied to Prime • 28% tied to SOFR

+101 bps $340 $503 $766 $750 $824 $455 $392 $484 $484 $929 $838 $1,077 $542 $460 $467 $493 $619 $776 $1,114 $552 $270 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Opportunity Proposal Ready to Close $1,291 $2,314 $2,364 $3,015 $1,480 $1,549 $1,122 15 Loan pipelines: Steadfastly focused on disciplined pricing and underwriting standards (1) Quarterly amounts adjusted for Illinois branches sold in 2021 Rate Ready to Close 3.77% 3.47% 3.28% 3.43% 4.45% 5.84% 6.85% Commercial Loan Pipeline by Category $ in millions $274 $242 $291 $219 $223 $183 $127 $120 $97 $108 $99 $58 $36 $21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Mortgage Closed Loan Volume Mortgage Pipeline Volume Mortgage Loan Volume $ in millions Q4 Highlights – Mortgage Loan Volume • Mortgage originations in Q 4 22 : • 81 % purchase • 19 % refinance Q4 Highlights – Commercial Loan Pipeline • Commercial loan pipeline continues to reflect impact of rising rates and macro economic environment • Focused on maintaining prudent underwriting standards and pricing discipline

Deposits, Liquidity, Securities, Interest Rate Sensitivity and Capital

0.65% 1.41% 0.47% 1.02% 2.20% 3.65% 0.00% 0.75% 1.50% 2.25% 3.00% 3.75% Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Interest Bearing Deposits Cost of Deposits Avg Fed Funds Rate Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Noninterest Bearing Interest Bearing Transactions Time Deposits 17 Deposits: Strategic decision in Q4 to extend the duration of certain wholesale deposits Source: Average Fed Funds rate based on data from www.macrotrends.net (1) Deposit beta calculated as change in cost of deposits from Q4 21 to Q4 22 divided by the change in quarterly average Fed era l Funds Effective rate for Q4 21 vs Q4 22. $19.4 $19.4 Evolution of Funding Rates Q4 Highlights • Total deposits increased 2 % on a linked quarter basis • Strategic decision to extend the duration of select wholesale deposits ; brokered CDs added in Q 4 range from 6 - 12 months maturities • Weighted average maturity of wholesale deposits increase to 8 . 4 months at 12 / 31 / 22 compared to 6 . 8 months at 9 / 30 / 22 $22.0 $22.1 +2% $924 $(183) $(140) $(202) $399 Linked Quarter Deposit Growth $ in millions Total Deposits Noninterest Bearing Transaction Accounts Interest Bearing Transaction Accounts Time Deposits Deposit Mix $ in billions $22.5 Brokered Deposits (money market & CDs) 24% deposit beta during this cycle (1)

18 Liquidity: Significant sources of liquidity Cash and Cash Equivalents + Variable Rate Securities $ in millions Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Cash & Cash Equivalents Variable Rate Securities $3,527 $4,103 $3,606 $3,286 $3,150 $3,132 $2,321 $1,910 $1,824 At December 31, 2022 Par Value Yield (FTE) (1) Effective Duration AFS HTM Fixed Rate Municipal $2,979 3.18% 11.81 37% 63% MBS/CMO 2,855 1.98 4.79 59 41 Treasury/Agency 582 2.34 8.79 17 83 Corporate 471 4.29 4.49 42 58 Other 177 3.31 4.35 48 52 Variable Rate 1,142 4.33 0.00 100 - Total $ 8 , 205 2.93% 6.56 53% 47% Securities Portfolio Summary $ in millions Q4 Highlights • Solid liquidity as cash position returns to more normalized level, aided by variable rate securities • Securities portfolio is expected to generate approximately $ 160 – $ 180 million in quarterly cash flow based on scheduled principal maturities • Cash flows from securities portfolio are expected to help fund future loan growth • Nominal change in effective duration - from 6 . 47 at 9 / 30 / 22 to 6 . 56 at 12 / 31 / 22 ; effective yield ( 1 ) increased 22 bps • Including $ 1 B matched swap on fixed rate securities, effective duration is 5 . 84 at 12 / 31 / 22 FTE – fully taxable equivalent using an effective tax rate of 26.135% NA – not available (1) Effective yield of securities portfolio at 12/31/22, excludes AOCI impact of HTM transfers made during Q2 22 (2) Source: S&P Global Market Intelligence. Represents peer median loan to deposit ratio. Peer group includes ABCB, AUB, OZ K, BOKF, CADE, CBSH, FBK, HWC, HTLF, HOMB, IBTX, ONB, PNFP, PB, RNST, SSB, SNV, TRMK, UMBF, UCBI $3,180 5,442 1,982 Additional Liquidity Sources $ in millions Unpledged securities FHLB borrowing availability Fed Funds lines and Fed Discount Window Total at 12.31.22 $10,604 Loan to Deposit Ratio 90% 76% 67% 62% 60% 62% 62% 69% 70% 72% Q4 19 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Q3 22 Q4 22 Peer Median 2 89% 80% 75% 72% 71% 69% 69% 74% 79% NA

19 Interest Rate Sensitivity Balance Sheet Interest Rate Sensitivity Over the next 12 months (estimated) (0.49)% 0.40% 0.81% D50 bps U25 bps U50 bps Estimated net interest income sensitivity given immediate, parallel shift in interest rates across the yield curve with a static balance sheet Immediate increase in interest rates Loan Portfolio At December 31, 2022 43% 57% Variable Rate Loans Fixed Rate Loans Fixed vs Variable Rate 32% 68% No Floor Not At Floor Floor Status – Variable Rate Loans 51% 21% 6% 22% Daily Within 3Mo 4 to 12 Mo Over 12 Mo Variable Rate Loans – Rate Reset Date (0.29)% 0.34% 0.67% Gradual increase in interest rates* Estimated net interest income sensitivity given gradual, parallel shift in interest rates across the yield curve with a static balance sheet Fair Value Hedges At December 31, 2022 * Assumptions used in balance sheet interest rate sensitivity estimates under a gradual increase in interest rates include th e f ollowing: Down 50 bps scenario – 25 bp decrease in September and 25 bp decrease in December Up 25 bps scenario – 25 bp increase in February Up 50 bps scenario – 25 bp increase in February and 25 bp increase in March Approximately $1.1 billion principal of fixed rate loans maturing over the next 12 months at a weighted average rate of 4.86% Entered into a 2 - year forward starting swap in September 2021 to convert designated AFS securities from fixed interest rates to variable interest rates based on federal funds effective rate . Instrument Hedged Asset Notional Fair Value Weighted Avg Pay Rate Receive Rate 2 - yr Forward Starting Swap Fixed Rate Callable AFS Securities $1.0 Billion $105 Million 1.21% Federal Funds Effective (currently 4.33%) Spread based on current rates 3.12% D50 bps U25 bps U50 bps

20 Capital: Focused on tangible book value and maintaining strong regulatory capital levels (1) Q4 22 data as of December 31, 2022, 3Q 22 data as of September 30, 2022, and Q4 21 data as of December 31, 2021 (2) Non - GAAP measure that management believes aids in the discussion of results. See Appendix for Non - GAAP reconciliation (3) Based on January 12, 2023, closing stock price of $22.99. 9.1% 9.2% 9.3% 4Q 21 Q3 22 4Q 22 W ELL C APITALIZED 5.0% Tier 1 Leverage Ratio (1) 13.8% 11.7% 11.9% Q4 21 Q3 22 Q4 22 CET1 Capital Ratio (1) W ELL C APITALIZED 6.5% 13.8% 11.7% 11.9% Q4 21 Q3 22 Q4 22 Tier 1 Risk - Based Capital Ratio (1) 16.8% 14.1% 14.2% 4Q 21 Q3 22 Q4 22 Total Risk - Based Capital Ratio (1) W ELL C APITALIZED 10.0% W ELL C APITALIZED 8.0% $28.82 $24.87 $25.73 Q4 21 Q3 22 Q4 22 Book Value Per Common Share (1) +3% $17.71 $13.51 $14.33 Q4 21 Q3 22 Q4 22 +6% Tangible Book Value Per Common Share (1) (2) $0.40 $0.42 $0.44 $0.46 $0.48 $0.50 $0.60 $0.64 $0.68 $0.72 $0.76 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 113 consecutive years 30 - 35% targeted payout ratio 3.3% dividend yield (3) Proven Dividend Record Share Repurchase Program The Company did not repurchase any shares during Q4 22 under the 2022 Program authorized by the Board in January 2022

Credit Quality

22 Credit Quality: Key credit quality metrics remain at historically low - levels and reflect… Source: S&P Global Market Intelligence 2017 – 2021 (1) As of December 31, for each respective year shown above; quarterly data as of the end of the quarter for each respectiv e p eriod (2) Net charge - offs to average loans for the full - year for each respective year shown above; quarterly annualized data for eac h respective quarter Annual Trend 12/31/22 12/31/21 Change NPL / Loans 0.37% 0.57% (20) bps Nonperforming Loans (in millions) $58.9 $68.6 $(9.7) NPA / Assets 0.23% 0.31% (8) bps Nonperforming Assets (in millions) $62.5 $76.3 $(13.8) Past Due 30+ Days / Loans 0.18% 0.11% 7 bps Net Charge - offs / Average Loans 0.09% 0.13% (4) bps NPL Coverage Ratio 334% 300% 34 bps ACL / Loans 1.22% 1.71% (49) bps Total Loans (in millions) $16,142 $12,013 $4,129 … prudent underwriting standards and strategic decision in 2019 to de - risk certain elements of acquired loan portfolios 0.81% 0.67% 0.65% 0.96% 0.57% 0.53% 0.42% 0.37% 0.37% 2017 2018 2019 2020 2021 Q1 22 Q2 22 Q3 22 Q4 22 Annual Nonperforming loans / loans (1) Strategic decision to de - risk certain elements of the loan portfolio through planned run - off of particular acquired non - relationship credits Quarterly Nonperforming assets / total assets (1) 0.83% 0.64% 0.55% 0.64% 0.31% 0.29% 0.26% 0.23% 0.23% 2017 2018 2019 2020 2021 Q1 22 Q2 22 Q3 22 Q4 22 Annual Quarterly Net charge - offs to average loans (2) 0.31% 0.21% 0.24% 0.45% 0.13% 0.22% 0.02% 0.00% 0.13% 2017 2018 2019 2020 2021 Q1 22 Q2 22 Q3 22 Q4 22 Annual Quarterly K ey Credit Metrics : ▪ Average FICO Scores 754 ▪ Balance Weighted Average FICO Score 744 ▪ Line Utilization 21% 1.61% 1.64% 1.86% 1.60% 1.40% 1.39% 1.55% 1.30% 1.52% 2017 2018 2019 2020 2021 Q1 22 Q2 22 Q3 22 Q4 22 Credit card portfolio net charge - off ratio (2) Annual Quarterly 9 bps for 2022 Acquired loans accounted for 6 bps of the 13 bps of total net charge - offs reported during Q4 22. While reported as net charge - offs, they were offset by a PCD adjustment 144 bps for 2022

23 ACL: Reflects improved asset quality metrics and Moody’s economic forecast ACL – Allowance for Credit Losses on Loans (1) ALLL for 2017 – 2019 and ACL 2020 – 2022 (2) As of December 31, for each respective year shown above; quarterly data as of the end of the quarter for each respectiv e p eriod $ in millions ACL ACL / Loans ACL as of 9/30/21 $ 202.5 1.87% Q4 21 Recapture of Provision (24.0) Day 2 CECL Provision (Landmark/Triumph) 22.7 Q4 21 Net Charge - Offs (9.3) Day 1 PCD Allowance (Landmark/Triumph) 13.4 ACL as of 12/31/21 $ 205.3 1.71% Q1 22 Recapture of Provision (19.9) Q1 22 Net Charge - Offs (6.5) ACL as of 3/31/22 $ 178.9 1.49% Q2 22 Provision - Day 2 CECL Provision (Spirit) 30.3 Q2 22 Net Charge - Offs (0.7) Day 1 PCD Allowance (Spirit) 4.1 ACL as of 6/30/22 $ 212.6 1.41% Q3 22 Provision (15.9) Q3 22 Net Charge - Offs (0.2) Day 1 PCD Allowance Adjustment (Spirit) 1.1 ACL as of 9/30/22 $ 197.6 1.27% Q4 22 Provision - Q4 22 Net Charge - Offs (5.1) Day 1 PCD Allowance Adjustment (Spirit) 4.5 ACL as of 12/31/22 $ 197.0 1.22% Allowance for Credit Losses on Loans and Loan Coverage Reserve for Unfunded Commitments $ in millions As of 12/31/21 As of 3/31/22 As of 6/30/22 As of 9/30/22 As of 12/31/22 Unfunded Commitments $2,943 $3,428 $4,473 $5,138 $5,000 Reserve $22.4 $22.4 $25.9 $41.9 $41.9 Reserve / Unfunded Balance 0.8% 0.7% 0.6% 0.8% 0.8% ACL METHODOLOGY AS OF 12/31/22: ▪ Qualitative allocation: 0.31% ▪ Quantitative allocation: 0.91% ▪ Moody’s September 2022 scenarios with management’s weighting: Baseline (62%) / S1 (8%) / S2 (30%) ▪ Total credit coverage / total commitments: 1.13% ACL/ALLL (1) / Loans (%) and ACL/ALLL ($) (2) $ in millions $42 $57 $68 $220 $238 $205 $179 $213 $198 $197 0.39% 0.48% 0.46% 1.52% 1.85% 1.71% 1.49% 1.41% 1.27% 1.22% 0.00% 0.20% 0.40% 0.60% 0.80% 1.00% 1.20% 1.40% 1.60% 1.80% 2.00% $0 $25 $50 $75 $100 $125 $150 $175 $200 $225 $250 2017 2018 2019 1/1/20 CECL Adoption 2020 2021 Q1 22 Q2 22 Q3 22 Q4 22

24 Company Ratings Rating Disclaimer: The ratings provided by Moody’s Investors Service, Kroll Bond Rating Agency and BauerFinancial are subject to review or withdrawal by Moody’s Investors Service, Kroll Bond Rating Agency and BauerFinancial , respectively, at any time and are not recommendations to buy, sell or hold securities. Each rating should be evaluated independently of any other rat ing. These ratings are provided for informational purposes only and are solely the opinions of the rating agencies. Long - Term Issuer Rating Baa2 Subordinated Debt Baa2 Outlook Stable Simmons First National Corporation Short - Term Deposit Rating P - 1 Long - Term Deposit Rating A2 Short - Term Counterparty Risk Rating P - 2 Long - Term Counterparty Risk Rating Baa1 Long - Term Issuer Rating Baa2 Baseline Credit Assessment baa1 Outlook Stable Simmons Bank Moody’s Investors Service assigned first - time ratings to Simmons First National Corporation and Simmons Bank on January 12, 2023 Senior Unsecured Debt BBB+ Subordinated Debt BBB Short - Term Debt K2 Long - Term Ratings Stable Simmons First National Corporation Deposit A - Short - Term Deposit K2 Short - Term Debt K2 Senior Unsecured Debt A - Subordinated Debt BBB+ Long - Term Rating Stable Simmons Bank Kroll Bond Rating Agency ratings shown above were reaffirmed on March, 4, 2022 5 STARS (superior) Star rating as of January 16, 2023

Key Takeaways

26 Key Takeaways 1 Strong foundation for the next stage centered on “Better Bank Initiative” that focuses on P eople, P rocesses and S ystems 2 Capital position provides a strong foundation to support future organic growth while also focusing on growing tangible book value per share 3 Credit quality metrics remain at historical lows and reflect the strength of our markets, our conservative credit culture and our strategic decision in 2019 to de - risk certain elements of acquired loan portfolios 4 Focused on organic balance sheet growth while maintaining disciplined loan and deposit pricing strategies designed to grow revenue and produce positive operating leverage

Appendix

28 Breakout: Loan portfolio by Category as of September 30, 2022 as of December 31, 2022 $ in millions Balance $ % of Total Loans Balance $ % of Total Loans Classified $ Nonperforming $ ACL % Unfunded Commitment $ Unfunded Commitment Reserve Total Loan Portfolio Consumer - Credit Card 193 1% 197 1% 1 1 2.7% - Consumer - Other 181 1% 153 1% - - 1.4% 28 Real Estate - Construction 2,372 15% 2,567 16% 4 3 1.4% 3,022 Real Estate - Commercial 7,250 46% 7,468 46% 106 15 1.3% 292 Real Estate - Single - family 2,467 16% 2,546 16% 27 23 0.7% 328 Commercial 2,512 16% 2,622 16% 27 17 1.3% 1,213 PPP 12 - 9 - - - - - Mortgage Warehouse 129 1% 95 1% - - 0.2% - Agriculture 264 2% 206 1% 1 - 0.3% 116 Other 227 1% 279 2% - - 1.5% 1 Total Loan Portfolio 15,607 100% 16,142 100% 166 59 1.22% 5,000 0.8% Loan Concentration (Holding Company Level) : C&D 82% 87% CRE 253% 259% Select Loan Categories (excluding PPP) Retail 1,480 9% 1,479 9% 9 4 2.1% 219 Nursing / Extended Care 337 2% 341 2% - - 1.1% 5 Healthcare 493 3% 501 3% 1 - 0.8% 171 Multifamily 883 6% 1,004 6% 9 - 0.7% 1,076 Hotel 867 6% 822 5% 66 7 1.4% 42 Restaurant 480 3% 505 3% 3 2 0.9% 35 NOO Office 993 6% 973 6% 4 - 2.3% 111 Energy 55 - 53 - 3 3 2.7% 6

29 Non - GAAP Reconciliations Q4 Q1 Q2 Q3 Q4 YTD YTD $ in thousands, except per share data 2021 2022 2022 2022 2022 2022 2021 Calculation of Adjusted Earnings Net Income $ 48,238 $ 65,095 $ 27,454 $ 80,603 $ 83,260 $ 256,412 $ 271,156 Certain items Merger related costs 13,591 1,886 19,133 1,422 35 22,476 15,911 Branch right sizing, net 1,648 909 380 1,235 1,104 3,628 (906) Day 2 CECL provision 22,688 - 33,779 - - 33,779 22,688 Donation to Simmons First Foundation - - 1,738 - - 1,738 - Loss from early retirement of TruPS - - - 365 - 365 - Gain on sale of intellectual property - - - (750) - (750) - Gain on insurance settlement - - - - (4,074) (4,074) - Gain on sale of branches - - - - - - (5,316) Tax effect⁽¹⁾ _ (9,913) _ (731) _ (14,382) _ (594) _ 768 (14,939) (8,462) Certain items, net of tax ____ 28,014 2,064 40,648 1,678 (2,167) 42,223 23,915 Adjusted earnings (non - GAAP) $ _76,252 $ 67,159 $ 68,102 $ 82,281 $ 81,093 $ 298,635 $ 295,071 Calculation of Earnings and Adjusted Earnings per Diluted Share Net Income $ 48,238 $ 65,095 $ 27,454 $ 80,603 $ 83,260 $ 256,412 $ 271,156 Less: Preferred stock dividend 8 _ - _ - _ - _ - _ - _ 47 Earnings available to common shareholders $ _48,230 $ 65,095 $ 27,454 $ 80,603 $ 83,260 $ 256,412 $ 271,109 Diluted earnings per share $ 0.42 $ 0.58 $ 0.21 $ 0.63 $ 0.65 $ 2.06 $ 2.46 Adjusted earnings (non - GAAP) $ 76,252 $ 67,159 $ 68,102 $ 82,281 $ 81,093 $ 298,635 $ 295,071 Less: Preferred stock dividend 8 - - - - - 47 Adjusted earnings available to common shareholders (non - GAAP) $ _76,244 $ 67,159 $ 68,102 $ 82,281 $ 81,093 $ 298,635 $ 295,024 Adjusted diluted earnings per share (non - GAAP) $ 0.67 $ 0.59 $ 0.53 $ 0.64 $ 0.64 $ 2.40 $ 2.68 (1) Effective tax rate of 26.135%

Q4 Q1 Q2 Q3 Q4 YTD YTD $ in thousands 2021 2022 2022 2022 2022 2022 2021 Calculation of Pre - Provision Net Revenue (PPNR) Net interest income $ 153,081 $ 145,606 $ 185,099 $ 193,585 $ 193,026 $ 717,316 $ 591,532 Noninterest income 46,601 42,218 40,178 43,023 44,647 170,066 191,815 Less: Gain (loss) on sale of securities (348) (54) (150) (22) (52) (278) 15,498 Less: Noninterest expense 141,597 128,417 156,813 138,943 142,575 566,748 483,589 Pre - Provision Net Revenue (PPNR) (non - GAAP) $ 58,433 $ 59,461 $ 68,614 $ 97,687 $ 95,150 $ 320,912 $ 284,260 Calculation of Adjusted Pre - Provision Net Revenue Pre - Provision Net Revenue (PPNR) (non - GAAP) $ 58,433 $ 59,461 $ 68,614 $ 97,687 $ 95,150 $ 320,912 $ 284,260 Plus: Merger related costs 13,591 1,886 19,133 1,422 35 22,476 15,911 Plus: Branch right sizing costs 1,648 909 380 1,235 1,104 3,628 (906) Plus : Loss from early retirement of TruPS - - - 365 - 365 - Plus: Donation to Simmons First Foundation - - 1,738 - - 1,738 - Less: Gain on sale of branches - - - - - - (5,316) Less: Gain on sale of intellectual property - - - (750) - (750) - Less: Gain on insurance settlement - - - - (4,074) (4,074) - Adjusted Pre - Provision Net Revenue (non - GAAP) $ 73,672 $ 62,256 $ 89,865 $ 99,959 $ 92,215 $ 344,295 $ 293,949 30 Non - GAAP Reconciliations Calculation of Book Value and Tangible Book Value per Share Total common stockholders' equity $ 3,248,841 $ 2,961,607 $ 3,259,895 $ 3,157,151 $ 3,269,362 Intangible assets: Goodwill (1,146,007) (1,147,007) (1,310,528) (1,309,000) (1,319,598) Other intangible assets (106,235) (102,748) (137,285) (133,059) (128,951) Total intangible assets (1,252,242) (1,249,755) (1,447,813) (1,442,059) (1,448,549) Tangible common stockholders' equity (non - GAAP) $ 1,996,599 $ 1,711,852 $ 1,812,082 $ 1,715,092 $ 1,820,813 Shares of common stock outstanding 112,715,444 112,505,555 128,787,764 126,943,467 127,046,654 Book value per common share $ 28.82 $ 26.32 $ 25.31 $ 24.87 $ 25.73 Tangible book value per common share (non - GAAP) $ 17.71 $ 15.22 $ 14.07 $ 13.51 $ 14.33

31 Non - GAAP Reconciliations Q4 Q1 Q2 Q3 Q4 YTD YTD $ in thousands, except number of employees (FTE) 2021 2022 2022 2022 2022 2022 2021 Calculation of Total Revenue Excluding Securities Gain (Loss) and Adjusted Total Revenue Net Interest Income (GAAP) $ 153,081 $ 145,606 $ 185,099 $ 193,585 $ 193,026 $ 717,316 $ 591,532 Noninterest Income (GAAP) 46,601 42,218 40,178 43,023 44,647 170,066 191,815 Total Revenue 199,682 187,824 225,277 236,608 237,673 887,382 783,347 Less: Gain (loss) on sales of securities (348) (54) (150) (22) (52) (278) 15,498 Total Revenue, excluding securities gain (loss) (non - GAAP) $ 200,030 $ 187,878 $ 225,427 $ 236,630 $ 237,725 $ 887,660 $ 767,849 Total Revenue, excluding securities gain (loss) (non - GAAP) $ 200,030 $ 187,878 $ 225,427 $ 236,630 $ 237,725 $ 887,660 $ 767,849 Less: Branch right sizing income 2 - (88) (65) - (153) 369 Less: Gain on sale of branches - - - - - - 5,316 Less: Gain on sale of intellectual property - - - 750 - 750 - Less: Loss from early retirement of TruPS - - - (365) - (365) - Less: Gain on insurance settlement - - - - 4,074 4,074 - Adjusted Total Revenue (non - GAAP) $ 200,028 $ 187,878 $ 225,515 $ 236,310 $ 233,651 $ 883,354 $ 762,164 Employees (FTE) 2,877 2,893 3,233 3,206 3,236 Total Revenue per Employee (FTE) $ 69.41 $ 64.92 $ 69.68 $ 73.80 $ 73.45 Adjusted Total Revenue per Employee (FTE) $ 69.53 $ 64.94 $ 69.75 $ 73.71 $ 72.20 FTE – Full time equivalent Calculation of Adjusted Noninterest Income Noninterest Income (GAAP) $ 46,601 $ 42,218 $ 40,178 $ 43,023 $ 44,647 $ 170,066 $ 191,815 Less: Branch right sizing income 2 - (88) (65) - (153) 369 Less: Gain on sale of branches - - - - - - 5,316 Less: Gain on sale of intellectual property - - - 750 - 750 - Less: Loss from early retirement of TruPS - - - (365) - (365) - Less: Gain on insurances settlement - ____ - - - 4,074 4,074 - Adjusted Noninterest Income (non - GAAP) $ 46,599 $ 42,218 $ 40,266 $ 42,703 $ 40,573 $ 165,760 $ 186,130 Adjusted Noninterest Income (non - GAAP) $ 46,599 $ 42,218 $ 40,266 $ 42,703 $ 40,573 $ 165,760 $ 186,130 Less: Gain (loss) on sale of securities (348) _(54) _(150) _ (22) (52) (278) 15,498 Adjusted Noninterest Income, excluding securities gains (losses) (non - GAAP) $ 46,947 $ 42,272 $ 40,416 $ 42,725 $ 40,625 $ 166,038 $ 170,632

32 Non - GAAP Reconciliations Calculation of Adjusted Noninterest Expense Noninterest Expense (GAAP) $ 141,597 $ 128,417 $ 156,813 $ 138,943 $ 142,575 $ 566,748 $ 483,589 Less: Merger related costs 13,591 1,886 19,133 1,422 35 22,476 15,911 Less: Branch right sizing expense 1,650 909 292 1,170 1,104 3,475 (537) Less: Donation to Simmons First Foundation - - 1,738 - - _ 1,738 - Adjusted Noninterest Expense (non - GAAP) $ 126,356 $ 125,622 $ 135,650 $ 136,351 $ 141,436 $ 539,059 $ 468,215 Calculation of Noninterest Expense to Average Assets Average total assets $ 24,698,022 $ 24,826,199 $ 26,769,032 $ 26,868,731 $ 27,180,575 Noninterest expense to average total assets 2.29% 2.07% 2.34% 2.07% 2.10% Adjusted noninterest expense to average assets (non - GAAP) 2.05% 2.02% 2.03% 2.03% 2.08% FTE – Full time equivalent Q4 Q1 Q2 Q3 Q4 YTD YTD $ in thousands 2021 2022 2022 2022 2022 2022 2021 Calculation of Noninterest Income Excluding Securities Gain (Loss) Noninterest Income (GAAP) $ 46,601 $ 42,218 $ 40,178 $ 43,023 $ 44,647 $ 170,066 $ 191,815 Less: Gain (loss) on sale of securities (348) _(54) _(150) _ (22) (52) (278) 15,498 Noninterest Income, excluding securities gains (losses) (non - GAAP) $ 46,949 $ 42,272 $ 40,328 $ 43,045 $ 44,699 $ 170,344 $ 176,317 Calculation of Noninterest Income to Total Revenue Noninterest Income to Total Revenue 23.34% 22.48% 17.83% 18.18% 18.79% Adjusted Noninterest Income, excluding securities gain (loss) to Adjusted Total Revenue (non - GAAP) (reconciliation shown on page 31) 23.47% 22.50% 17.92% 18.08% 17.39% Noninterest Income per Employee $ 16.20 $ 14.59 $ 12.43 $ 13.42 $ 13.80 Adjusted Noninterest Income per Employee (FTE) $ 16.32 $ 14.61 $ 12.50 $ 13.33 $ 12.55

33 Non - GAAP Reconciliations Q4 Q1 Q2 Q3 Q4 $ in thousands 2021 2022 2022 2022 2022 Calculation of Efficiency Ratio and Adjusted Efficiency Ratio Noninterest Expense (efficiency ratio numerator) $ 141,597 $ 128,417 $ 156,813 $ 138,943 $ 142,575 Total Revenue $ 199,682 $ 187,824 $ 225,277 $ 236,608 $ 237,673 Fully taxable equivalent adjustment ___ _ _5,579 ____ __ 5,602 ___ _ _6,096 ___ _ _6,203 ___ _ _6,770 Efficiency ratio denominator $ 205,261 $ 193,426 $ 231,373 $ 242,811 $ 244,443 Efficiency ratio (based on GAAP figures) 68.98% 66.39% 67.77% 57.22% 58.33% Adjusted Noninterest Expense (non - GAAP) (reconciliation shown on page 32) $ 126,356 $ 125,622 $ 135,650 $ 136,351 $ 141,436 Less: Other real estate and foreclosure expense 576 343 142 168 350 Less: Amortization of intangible assets ___ __ 3,486 ____ __ _3,486 ___ _ _4,096 ___ __ 4,225 ___ __ 4,108 Adjusted efficiency ratio numerator (non - GAAP) $ 122,294 $ 121,793 $ 131,412 $ 131,958 $ 136,978 Adjusted Total Revenue (non - GAAP) (reconciliation shown on page 31) $ 200,028 $ 187,878 $ 225,515 $ 236,310 $ 233,651 Fully taxable equivalent adjustment ___ _ _5,579 ____ __ 5,602 ___ _ _6,096 ___ _ _6,203 ___ _ _6,770 Adjusted efficiency ratio denominator non - GAAP) $ 205,607 $ 193,480 $ 231,611 $ 242,513 $ 240,421 Adjusted Efficiency Ratio (non - GAAP) 59.48% 62.95% 56.74% 54.41% 56.97% Fully taxable equivalent adjustment using an effective tax rate of 26.135%

34 Non - GAAP Reconciliations Q3 Q4 $ in thousands 2022 2022 Calculation of Net Interest Margin Net Interest Income $ 193,585 $ 193,026 Plus: taxable equivalent adjustment ________6,203 ________6,770 Net Interest Income – fully taxable equivalent 199,788 199,796 Less: Accretion (5,834) (4,473) Less: PPP interest income _______(191) _______(103) Net Interest Income – fully taxable equivalent excluding PPP interest income $ 193,763 $ 195,220 Average Earning Assets $ 23,745,097 $ 23,970,128 Less: PPP loans (average) (18,179) (11,325) Average Earning Assets, excluding PPP loans $ 23,726,918 $ 23,958,803 Net Interest Margin 3.34% 3.31% Net Interest Margin – excluding accretion and PPP interest income 3.24% 3.23% Calculation of Loan Yield Loan interest income (FTE) $ 187,851 $ 216,782 Less: Accretion on acquired loans (5,261) (4,464) Less: PPP interest income ________(191) ________(103) Adjusted Loan Interest Income (FTE) $ 182,399 $ 212,215 Average loans $ 15,320,833 $ 15,929,957 Less: PPP loans (average) (18,179) (11,325) $ 15,302,654 $ 15,918,632 Loan yield (FTE) 4.86% 5.40% Loan yield (FTE) – excluding accretion and PPP interest income 4.73% 5.29% Q3 FTE - Fully taxable equivalent adjustment using an effective tax rate of 26.135% Q3 Q4 $ in thousands 2022 2022 Calculation of Tangible Common Equity (TCE) Total stockholders’ equity $ 3,157,151 $ 3,269,362 Less: Preferred stock ________ - _______ _ - Total common stockholders’ equity $ 3,157,151 $ 3,269,362 Total assets $ 27,076,074 $ 27,461,061 Less: Intangible assets (1,442,059) (1,448,549) Total tangible assets $ 25,634,015 $ 26,012,512 Common equity to total assets 11.66% 11.91% Tangible common equity to tangible common assets (non - GAAP) 6.69% 7.00% Calculation of Return on Tangible Common Equity Net income $ 83,260 Less: Preferred dividend _______ _ - Net income available to common stockholders $ 83,260 Net income available to common stockholders $ 83,260 Less: Amortization of intangible assets, net of taxes 3,035 Adjusted net income available to common stockholders (non - GAAP) $ 86,295 Average common stockholders’ equity $ 3,214,912 Less: Average intangible assets 1,440,353 Average tangible common stockholders’ equity (non - GAAP) $ 1,774,559 Return on average common equity 10.27% Return on average tangible common equity (non - GAAP) 19.29%

Nasdaq: SFNC 4 th Quarter 2022 Earnings Presentation Contents 5 Q4 Highlights 6 Q4 Results Overview 12 Loans 16 Deposits, Liquidity, Securities, Interest Rate Sensitivity & Capital 21 Credit Quality 25 Key Takeaways 27 Appendix