-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Ff9D3YBYGD8RW+1Xfim1fDG+vO6tOdyOy68K7QFSY5hE4AD1q515gndSNK7kpAIG
 qp5YphZN5k+nNTXZ1gQzHQ==

<SEC-DOCUMENT>0001005477-03-002207.txt : 20030728
<SEC-HEADER>0001005477-03-002207.hdr.sgml : 20030728
<ACCEPTANCE-DATETIME>20030728134957
ACCESSION NUMBER:		0001005477-03-002207
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030707
FILED AS OF DATE:		20030728

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IMMUNE RESPONSE CORP
		CENTRAL INDEX KEY:			0000817785
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				330255679
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		5935 DARWIN COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
		BUSINESS PHONE:		6194317080

	MAIL ADDRESS:	
		STREET 1:		5935 DARWIN COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KIMBERLIN KEVIN
		CENTRAL INDEX KEY:			0000904841

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31732
		FILM NUMBER:		03805542

	BUSINESS ADDRESS:	
		STREET 1:		SPENCER TRASK SECURITIES INC
		STREET 2:		535 MADISON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		2123555565
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>edgar123.xml
<DESCRIPTION>AMENDMENT TO FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0201</schemaVersion>

    <documentType>4/A</documentType>
    <periodOfReport>2003-07-07</periodOfReport>
    <dateOfOriginalSubmission>2003-07-11</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000817785</issuerCik>
        <issuerName>IMMUNE RESPONSE CORP</issuerName>
        <issuerTradingSymbol>IMNR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000904841</rptOwnerCik>
            <rptOwnerName>KIMBERLIN KEVIN</rptOwnerName>
        </reportingOwnerId>

        <reportingOwnerAddress>
            <rptOwnerStreet1>535 MADISON AVENUE18TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
        <isDirector>1</isDirector>
        <isOfficer>0</isOfficer>
        <isTenPercentOwner>1</isTenPercentOwner>
        <isOther>0</isOther>
    </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>

        <securityTitle>
            <value>Common Stock, par value $.0025 per share</value>
        </securityTitle>

        <transactionDate>
            <value>2003-07-07</value>
        </transactionDate>
    <transactionCoding>
        <transactionFormType>4</transactionFormType>
        <transactionCode>P</transactionCode>
        <equitySwapInvolved>0</equitySwapInvolved>
    </transactionCoding>
        <transactionAmounts>

            <transactionShares>
                <value>2662332</value>
            </transactionShares>

            <transactionPricePerShare>
                <value>1.33</value>
            </transactionPricePerShare>

            <transactionAcquiredDisposedCode>
                <value>A</value>
            </transactionAcquiredDisposedCode>
        </transactionAmounts>
        <postTransactionAmounts>

            <sharesOwnedFollowingTransaction>
                <value>9483139</value>
                <footnoteId id="F1"/>
            </sharesOwnedFollowingTransaction>
        </postTransactionAmounts>
        <ownershipNature>

            <directOrIndirectOwnership>
                <value>I</value>
            </directOrIndirectOwnership>

            <natureOfOwnership>
                <value>See Notes</value>
                <footnoteId id="F2"/>
                <footnoteId id="F3"/>
                <footnoteId id="F4"/>
            </natureOfOwnership>
        </ownershipNature>
        </nonDerivativeTransaction>

    </nonDerivativeTable>
    <derivativeTable>
        <derivativeTransaction>

        <securityTitle>
            <value>Class A warrants</value>
        </securityTitle>

        <conversionOrExercisePrice>
            <value>1.33</value>
        </conversionOrExercisePrice>

        <transactionDate>
            <value>2003-07-07</value>
        </transactionDate>
    <transactionCoding>
        <transactionFormType>4</transactionFormType>
        <transactionCode>X</transactionCode>
        <equitySwapInvolved>0</equitySwapInvolved>
    </transactionCoding>
        <transactionAmounts>

            <transactionShares>
                <value>1774888</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </transactionShares>

            <transactionPricePerShare>
                <value>2360601</value>
            </transactionPricePerShare>

            <transactionAcquiredDisposedCode>
                <value>A</value>
            </transactionAcquiredDisposedCode>
        </transactionAmounts>

        <exerciseDate>
            <value>2002-12-10</value>
        </exerciseDate>

        <expirationDate>
            <value>2003-07-07</value>
        </expirationDate>
        <underlyingSecurity>

            <underlyingSecurityTitle>
                <value>Common Stock Class B Warrants</value>
            </underlyingSecurityTitle>

            <underlyingSecurityShares>
                <value>1774888</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </underlyingSecurityShares>
        </underlyingSecurity>
        <postTransactionAmounts>

            <sharesOwnedFollowingTransaction>
                <value>24606788</value>
                <footnoteId id="F7"/>
                <footnoteId id="F8"/>
            </sharesOwnedFollowingTransaction>
        </postTransactionAmounts>
        <ownershipNature>

            <directOrIndirectOwnership>
                <value>I</value>
            </directOrIndirectOwnership>

            <natureOfOwnership>
                <value>See Notes</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </natureOfOwnership>
        </ownershipNature>
        </derivativeTransaction>

        <derivativeTransaction>

        <securityTitle>
            <value>8% Convertible Debenture due 2005</value>
        </securityTitle>

        <conversionOrExercisePrice>
            <value>1.4570</value>
        </conversionOrExercisePrice>

        <transactionDate>
            <value>2003-07-07</value>
        </transactionDate>
    <transactionCoding>
        <transactionFormType>4</transactionFormType>
        <transactionCode>H</transactionCode>
        <equitySwapInvolved>0</equitySwapInvolved>
    </transactionCoding>
        <transactionAmounts>

            <transactionShares>
                <value>2611709</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </transactionShares>

            <transactionPricePerShare>
                <value>3805260.27</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </transactionPricePerShare>

            <transactionAcquiredDisposedCode>
                <value>D</value>
            </transactionAcquiredDisposedCode>
        </transactionAmounts>

        <exerciseDate>
            <value>2003-06-10</value>
        </exerciseDate>

        <expirationDate>
            <value>2003-07-07</value>
        </expirationDate>
        <underlyingSecurity>

            <underlyingSecurityTitle>
                <value>Common Stock</value>
            </underlyingSecurityTitle>

            <underlyingSecurityShares>
                <value>2611709</value>
            </underlyingSecurityShares>
        </underlyingSecurity>
        <postTransactionAmounts>

            <sharesOwnedFollowingTransaction>
                <value>21995079</value>
                <footnoteId id="F7"/>
                <footnoteId id="F8"/>
            </sharesOwnedFollowingTransaction>
        </postTransactionAmounts>
        <ownershipNature>

            <directOrIndirectOwnership>
                <value>I</value>
            </directOrIndirectOwnership>

            <natureOfOwnership>
                <value>See Notes</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </natureOfOwnership>
        </ownershipNature>
        </derivativeTransaction>

        <derivativeTransaction>

        <securityTitle>
            <value>8% Convertible Debenture due 2005</value>
        </securityTitle>

        <conversionOrExercisePrice>
            <value>1.4570</value>
        </conversionOrExercisePrice>

        <transactionDate>
            <value>2003-07-07</value>
        </transactionDate>
    <transactionCoding>
        <transactionFormType>4</transactionFormType>
        <transactionCode>H</transactionCode>
        <equitySwapInvolved>0</equitySwapInvolved>
    </transactionCoding>
        <transactionAmounts>

            <transactionShares>
                <value>1006986</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </transactionShares>

            <transactionPricePerShare>
                <value>1467178.03</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </transactionPricePerShare>

            <transactionAcquiredDisposedCode>
                <value>A</value>
            </transactionAcquiredDisposedCode>
        </transactionAmounts>

        <exerciseDate>
            <value>2003-07-07</value>
        </exerciseDate>

        <expirationDate>
            <value>2006-07-07</value>
        </expirationDate>
        <underlyingSecurity>

            <underlyingSecurityTitle>
                <value>Common Stock</value>
            </underlyingSecurityTitle>

            <underlyingSecurityShares>
                <value>1006986</value>
            </underlyingSecurityShares>
        </underlyingSecurity>
        <postTransactionAmounts>

            <sharesOwnedFollowingTransaction>
                <value>23002065</value>
                <footnoteId id="F7"/>
                <footnoteId id="F8"/>
            </sharesOwnedFollowingTransaction>
        </postTransactionAmounts>
        <ownershipNature>

            <directOrIndirectOwnership>
                <value>I</value>
            </directOrIndirectOwnership>

            <natureOfOwnership>
                <value>See Notes</value>
                <footnoteId id="F5"/>
                <footnoteId id="F6"/>
            </natureOfOwnership>
        </ownershipNature>
        </derivativeTransaction>

    </derivativeTable>
    <footnotes>
        <footnote id="F1">This number does not include the number from Column 9 in Table II.</footnote>
        <footnote id="F2">8,750 shares of stock are held by the reporting person's spouse. 4,000 shares of common stock are held by Kimberlin Family Partners, L.P., a Colorado limited partnership, of which the reporting
person is the general partner. 448,717 shares of common stock are held by Kevin Kimberlin Partners, L.P., a Delaware limited partnership (&quot;KKP&quot;), of which the general partner is KKP Management
LLC, of which the reporting person is the managing member. 6,535,792 shares of common stock are held by Cheshire Associates LLC, of which the reporting person is a related party.</footnote>
        <footnote id="F3">2,485,880 shares of the Issuer's common stock are held collectively by Spencer Trask Private Equity Fund I, Spencer Trask Private Equity Fund II and Spencer Trask Private Equity, Accredited
Fund III, LLC (collectively, the &quot;Funds&quot;). The reporting person is approximately an 80% owner of the entity that is a 100% owner of the manager of such Funds. See Footnotes (4) and (8).</footnote>
        <footnote id="F4">The reporting person does not have any pecuniary interest in the 2,485,880 shares of the Issuer's common stock held by the Funds.</footnote>
        <footnote id="F5">On July 7, 2003, Cheshire Associates LLC, of which the reporting person is a related party, exercised 1,774,888 Class A warrants in accordance with the revised terms for certain holders of shares of
common stock and Class A warrants issued by the Issuer in connection with its December 2002 private placement. Upon exercise of the Class A warrants, Cheshire Associates LLC received
2,662,332 shares of common stock and 1,774,888 Class B warrants of the Issuer. Cheshire Associates LLC satisfied the payment of the aggregate exercise price for its exercise of the 1,774,888 Class
A warrants (i.e., 2,360,601) by means of its partial cancellation and surrender of $3,805,260.27 8% Convertible Secured Promissory Note issued by IRC in favor of Cheshire on 6/10/03.</footnote>
        <footnote id="F6">On July 7, 2003, Cheshire Associates LLC also purchased a $1,467,178.03 promissory note initially convertible into 1,006,986 shares of the Issuer's common stock. Such note was issued in
consideration for the partial cancellation and surrender of the $3,805,260.27 8% Convertible Secured Promissory Note issued by IRC in favor of Cheshire of 6/10/03.</footnote>
        <footnote id="F7">This number includes the number of shares of the Issuer's common stock underlying options, convertible notes and warrants held by the reporting person or related parties of the reporting person,
including 994,352 shares of common stock underlying the Class B warrants held by the Funds.</footnote>
        <footnote id="F8">The reporting person does not have any pecuniary interest in the 994,352 shares of the Issuer's common stock underlying the Class B warrants held by the Funds.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ KEVIN B. KIMBERLIN</signatureName>
        <signatureDate>2003-07-25</signatureDate>
    </ownerSignature>

</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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