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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KKDwWds/+EcFOz+GHZk6s2CIKwc2tL81qIvYiKzTr5kDrOOERaI/8ABkW6DNkmNl
 6WxAA/Q0dP2Az6HcUFmtAg==

<SEC-DOCUMENT>0000898432-07-001026.txt : 20071212
<SEC-HEADER>0000898432-07-001026.hdr.sgml : 20071212
<ACCEPTANCE-DATETIME>20071212160732
ACCESSION NUMBER:		0000898432-07-001026
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071206
FILED AS OF DATE:		20071212
DATE AS OF CHANGE:		20071212

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KIMBERLIN KEVIN
		CENTRAL INDEX KEY:			0000904841

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-18006
		FILM NUMBER:		071301910

	BUSINESS ADDRESS:	
		STREET 1:		SPENCER TRASK SECURITIES INC
		STREET 2:		535 MADISON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		2123555565

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORCHESTRA THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0000817785
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				330255679
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		5931 DARWIN COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
		BUSINESS PHONE:		7604317080

	MAIL ADDRESS:	
		STREET 1:		5931 DARWIN COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	IMMUNE RESPONSE CORP
		DATE OF NAME CHANGE:	19950911
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-12-06</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000817785</issuerCik>
        <issuerName>ORCHESTRA THERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>OCHTE.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000904841</rptOwnerCik>
            <rptOwnerName>KIMBERLIN KEVIN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SPENCER TRASK VENTURES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>535 MADISON AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-12-06</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>600000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3926970</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On December 6, 2007, Spencer Trask Investment Partners LLC (&quot;STIP&quot;), an affiliate of the Reporting Person, invested $150,000
 in the Issuer.  In exchange for the investment, STIP received 600,000 shares of common stock of the Issuer, as well as a
 Senior Subordinated Secured Promissory Note, due on March 6, 2008 (the &quot;STIP Note&quot;) in the principal amount of $450,000.
 The STIP Note and shares of common stock were issued pursuant to a Securities Purchase Agreement between the Issuer and
 STIP, dated as of August 28, 2007, and amended September 28, 2007, and is secured by the grant of a security interest in all
 of the assets of the Issuer pursuant to the terms of a Security Agreement, dated the same date, by the Issuer in favor of
 STIP.  The Reporting Person, the principal stockholder and a director of the Issuer, disclaims beneficial ownership of these
 securities except to the extent of his pecuniary interest therein.</footnote>
        <footnote id="F2">Does not include 125,000 shares of common stock held by Qubit Holdings, LLC (&quot;Qubit&quot;), a Delaware limited liability company
 owned by certain trusts formed for the benefit of the Reporting Person's children, as to all of which securities the
 Reporting Person disclaims both any pecuniary interest therein and any beneficial ownership, as the Reporting Person has no
 power to vote or dispose, or direct the voting or disposition, of any of the securities held by Qubit or such trusts.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Kevin Kimberlin</signatureName>
        <signatureDate>2007-12-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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