Blueprint

TR-1: Standard form for notification of major holdings

NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible)

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:				ASTRAZENECA PLC
1b. Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)
Non-UK issuer
2. Reason for the notification (please mark the appropriate box or boxes with an "X")
An acquisition or disposal of voting rights							X
An acquisition or disposal of financial instruments
An event changing the breakdown of voting rights
Other (please specify):
3. Details of person subject to the notification obligation
Name				Wellington Management Group LLP
City and country of registered office (if applicable)				Boston, USA
4. Full name of shareholder(s) (if different from 3)
Name				Bank of New York (Nominees) Ltd BBH ISL NOMINEES LTD BNY (OCS) Nominees Limited BNY Mellon Nominees Limited GOLDMAN SACHS INTERNATIONAL HSBC Global Custody Nominee (UK) Limited Japan Trustee Services Bank Ltd. JP Morgan Chase Nominees Limited Mellon Nominees (UK) Ltd. Nortrust Nominees Limited ROY Nominees Limited State Street Nominees Limited VIDACOS NOMINEES LIMITED
City and country of registered office (if applicable)
5. Date on which the threshold was crossed or reached:				01/10/2019
6. Date on which issuer notified (DD/MM/YYYY):				03/10/2019
7. Total positions of person(s) subject to the notification obligation:
		% of voting rights attached to shares (total of 8.A)	% of voting rights through financial instruments (total of 8.B.1 + 8.B.2)		Total of both in % (8.A + 8.B)	Total number of voting rights of issuer
Resulting situation on the date on which threshold was crossed or reached		3.42%	2.47%		5.89%	1,311,894,438
Position of previous notification (if applicable)

8. Notified details of the resulting situation on the date on which the threshold was crossed or reached:
A: Voting rights attached to shares
Class/type of shares ISIN code (if possible)	Number of voting rights					% of voting rights
	Direct (Art 9 of Directive 2004/109/EC) (DTR5.1)	Indirect (Art 10 of Directive 2004/109/EC) (DTR5.2.1)				Direct (Art 9 of Directive 2004/109/EC) (DTR5.1)	Indirect (Art 10 of Directive 2004/109/EC) (DTR5.2.1)
GB0009895292 Ordinary Shares		44,864,077					3.42%

SUBTOTAL 8.A	44,864,077					3.42%

B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC (DTR5.3.1.1 (a))
Type of financial instrument	Expiration date	Exercise/ Conversion Period		Number of voting rights that may be acquired if the instrument is exercised/converted			% of voting rights
Depository Receipt				56,705,376 Depository Receipt shares or 28,352,661 votes on a converted basis			2.16%
Depository Receipt				6,875,371 Depository Receipt shares or 3,437,680 votes on a converted basis			0.26%
Equity Call Option	15/01/2021	01/01/1900to15/01/2021		1,137 Equity Call Option shares or 56,850 votes on a converted basis			0.00%
Equity Call Option	15/11/2019	01/01/1900to15/11/2019		476 Equity Call Option shares or 23,800 votes on a converted basis			0.00%

		SUBTOTAL 8.B.1		31,870,991			2.43%

B 2: Financial Instruments with similar economic effect according to Art. 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b))
Type of financial instrument	Expiration date	Exercise/ Conversion Period		Physical or cash settlement	Number of voting rights		% of voting rights
Equity Swap	31/01/2020	01/02/2019to31/01/2020		Cash	183,970 Equity Swap shares or 91,985 votes on a converted basis		0.01%
Equity Swap	29/05/2020	04/06/2019to29/05/2020		Cash	140,896 Equity Swap shares or 70,448 votes on a converted basis		0.01%
Equity Swap	31/03/2020	01/04/2019to31/03/2020		Cash	128,263 Equity Swap shares or 64,131 votes on a converted basis		0.00%
Equity Swap	30/04/2020	12/04/2019to30/04/2020		Cash	69,549 Equity Swap shares or 34,774 votes on a converted basis		0.00%
Equity Swap	30/06/2020	02/07/2019to30/06/2020		Cash	56,143 Equity Swap shares or 28,071 votes on a converted basis		0.00%
Equity Swap	31/08/2020	08/08/2019to31/08/2020		Cash	42,723 Equity Swap shares or 21,361 votes on a converted basis		0.00%
Equity Swap	15/05/2020	09/08/2018to15/05/2020		Cash	19,846 Equity Swap shares or 19,846 votes on a converted basis		0.00%
Equity Swap	20/05/2020	08/10/2018to20/05/2020		Cash	17,989 Equity Swap shares or 17,989 votes on a converted basis		0.00%
Equity Swap	15/05/2020	20/02/2019to15/05/2020		Cash	35,896 Equity Swap shares or 17,948 votes on a converted basis		0.00%
Equity Swap	30/04/2020	15/04/2019to30/04/2020		Cash	30,612 Equity Swap shares or 15,306 votes on a converted basis		0.00%
Equity Swap	30/04/2020	08/04/2019to30/04/2020		Cash	29,511 Equity Swap shares or 14,755 votes on a converted basis		0.00%
Equity Swap	15/05/2020	02/03/2018to15/05/2020		Cash	11,419 Equity Swap shares or 11,419 votes on a converted basis		0.00%
Equity Swap	20/05/2020	05/10/2018to20/05/2020		Cash	11,206 Equity Swap shares or 11,206 votes on a converted basis		0.00%
Index Future	01/10/2019	01/01/1900to01/10/2019		Cash	2,089 Index Future shares or 10,879 votes on a converted basis		0.00%
Equity Swap	15/05/2020	10/10/2017to15/05/2020		Cash	8,928 Equity Swap shares or 8,928 votes on a converted basis		0.00%
Equity Swap	20/05/2020	08/01/2019to20/05/2020		Cash	8,741 Equity Swap shares or 8,741 votes on a converted basis		0.00%
Equity Swap	20/05/2020	25/01/2019to20/05/2020		Cash	7,546 Equity Swap shares or 7,546 votes on a converted basis		0.00%
Equity Swap	20/05/2020	23/08/2019to20/05/2020		Cash	7,195 Equity Swap shares or 7,195 votes on a converted basis		0.00%
Equity Swap	15/05/2020	09/02/2018to15/05/2020		Cash	6,300 Equity Swap shares or 6,300 votes on a converted basis		0.00%
Equity Swap	20/05/2020	15/07/2019to20/05/2020		Cash	6,212 Equity Swap shares or 6,212 votes on a converted basis		0.00%
Equity Swap	20/05/2020	06/07/2018to20/05/2020		Cash	4,635 Equity Swap shares or 4,635 votes on a converted basis		0.00%
Equity Swap	05/05/2020	31/07/2019to05/05/2020		Cash	7,671 Equity Swap shares or 3,835 votes on a converted basis		0.00%
Equity Swap	15/05/2020	02/02/2018to15/05/2020		Cash	3,782 Equity Swap shares or 3,782 votes on a converted basis		0.00%
Equity Swap	20/05/2020	03/07/2018to20/05/2020		Cash	3,496 Equity Swap shares or 3,496 votes on a converted basis		0.00%
Equity Swap	20/05/2020	05/04/2018to20/05/2020		Cash	2,982 Equity Swap shares or 2,982 votes on a converted basis		0.00%
Equity Swap	15/05/2020	02/07/2018to15/05/2020		Cash	2,827 Equity Swap shares or 2,827 votes on a converted basis		0.00%
Equity Swap	15/05/2020	23/10/2017to15/05/2020		Cash	2,779 Equity Swap shares or 2,779 votes on a converted basis		0.00%
Equity Swap	05/05/2020	20/08/2019to05/05/2020		Cash	5,393 Equity Swap shares or 2,696 votes on a converted basis		0.00%
Equity Swap	15/05/2020	16/07/2018to15/05/2020		Cash	2,608 Equity Swap shares or 2,608 votes on a converted basis		0.00%
Equity Swap	20/05/2020	13/07/2018to20/05/2020		Cash	2,503 Equity Swap shares or 2,503 votes on a converted basis		0.00%
Equity Swap	20/05/2020	08/10/2018to20/05/2020		Cash	2,309 Equity Swap shares or 2,309 votes on a converted basis		0.00%
Equity Swap	20/05/2020	23/07/2018to20/05/2020		Cash	2,158 Equity Swap shares or 2,158 votes on a converted basis		0.00%
Exchange Traded Fund	01/10/2019	01/10/2019		Cash	378,510 Exchange Traded Fund shares or 1,948 votes on a converted basis		0.00%
Equity Swap	15/05/2020	11/06/2018to15/05/2020		Cash	1,367 Equity Swap shares or 1,367 votes on a converted basis		0.00%
Equity Swap	20/05/2020	06/04/2018to20/05/2020		Cash	1,267 Equity Swap shares or 1,267 votes on a converted basis		0.00%
Equity Swap	20/05/2020	14/09/2018to20/05/2020		Cash	1,132 Equity Swap shares or 1,132 votes on a converted basis		0.00%
Equity Swap	20/05/2020	03/08/2018to20/05/2020		Cash	1,034 Equity Swap shares or 1,034 votes on a converted basis		0.00%
Equity Swap	05/05/2020	12/08/2019to05/05/2020		Cash	1,926 Equity Swap shares or 963 votes on a converted basis		0.00%
Equity Swap	15/05/2020	14/06/2019to15/05/2020		Cash	1,593 Equity Swap shares or 796 votes on a converted basis		0.00%
Equity Swap	20/05/2020	19/03/2018to20/05/2020		Cash	773 Equity Swap shares or 773 votes on a converted basis		0.00%
Equity Swap	15/05/2020	16/05/2019to15/05/2020		Cash	1,290 Equity Swap shares or 645 votes on a converted basis		0.00%
Equity Swap	15/05/2020	27/07/2018to15/05/2020		Cash	600 Equity Swap shares or 600 votes on a converted basis		0.00%
Index Future	01/10/2019	01/01/1900to01/10/2019		Cash	96 Index Future shares or 501 votes on a converted basis		0.00%
Equity Swap	05/05/2020	15/08/2019to05/05/2020		Cash	841 Equity Swap shares or 420 votes on a converted basis		0.00%
Equity Swap	05/05/2020	13/08/2019to05/05/2020		Cash	834 Equity Swap shares or 417 votes on a converted basis		0.00%
Equity Swap	05/05/2020	02/08/2019to05/05/2020		Cash	818 Equity Swap shares or 409 votes on a converted basis		0.00%
Equity Swap	15/05/2020	26/07/2019to15/05/2020		Cash	647 Equity Swap shares or 323 votes on a converted basis		0.00%
Equity Swap	20/05/2020	25/06/2018to20/05/2020		Cash	314 Equity Swap shares or 314 votes on a converted basis		0.00%
Equity Swap	20/05/2020	21/05/2018to20/05/2020		Cash	200 Equity Swap shares or 200 votes on a converted basis		0.00%
Equity Swap	15/05/2020	08/11/2018to15/05/2020		Cash	172 Equity Swap shares or 172 votes on a converted basis		0.00%
Equity Swap	20/05/2020	03/10/2019to20/05/2020		Cash	162 Equity Swap shares or 162 votes on a converted basis		0.00%
Equity Swap	05/05/2020	13/09/2019to05/05/2020		Cash	66 Equity Swap shares or 66 votes on a converted basis		0.00%

				SUBTOTAL 8.B.2	525,159		0.04%

9. Information in relation to the person subject to the notification obligation (please mark the applicable box with an "X")
Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer.
Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entity (please add additional rows as necessary)					X
Name		% of voting rights if it equals or is higher than the notifiable threshold	% of voting rights through financial instruments if it equals or is higher than the notifiable threshold	Total of both if it equals or is higher than the notifiable threshold
Wellington Management Group LLP				5.89%
Wellington Group Holdings LLP				5.89%
Wellington Investment Advisors Holdings LLP				5.89%
Wellington Management Company LLP				5.88%

Wellington Management Group LLP				5.89%
Wellington Group Holdings LLP				5.89%
Wellington Investment Advisors Holdings LLP				5.89%
Wellington Management Global Holdings, Ltd.
Wellington Management International Ltd



10. In case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be held

11. Additional information:


Place of completion	London
Date of completion	02/10/2019

	By: /s/ Adrian Kemp
	Name: Adrian Kemp
	Title: Company Secretary