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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TLcfExyo3gkgje6wFq6ZE5zLvnBTh8DWWMOrtvFsRxEtFykYk/HJSGmobQW/0vS6
 5Bok5zC+bcanMDcagZHcvQ==

<SEC-DOCUMENT>9999999995-09-001277.txt : 20090505
<SEC-HEADER>9999999995-09-001277.hdr.sgml : 20090505
<ACCEPTANCE-DATETIME>20090505001512
ACCESSION NUMBER:		9999999995-09-001277
CONFORMED SUBMISSION TYPE:	EFFECT
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20090504
DATE AS OF CHANGE:		20090505
EFFECTIVENESS DATE:		20090504

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HUMAN GENOME SCIENCES INC
		CENTRAL INDEX KEY:			0000901219
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				223178468
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		EFFECT
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-155769
		FILM NUMBER:		09795303

	BUSINESS ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850-3338
		BUSINESS PHONE:		3013098504

	MAIL ADDRESS:	
		STREET 1:		14200 SHADY GROVE ROAD
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
</SEC-HEADER>
<DOCUMENT>
<TYPE>EFFECT
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2009-05-04</finalEffectivenessDispDate>
        <finalEffectivenessDispTime>14:00:00</finalEffectivenessDispTime>
        <form>S-3</form>
        <filer>
            <cik>0000901219</cik>
            <entityName>HUMAN GENOME SCIENCES INC</entityName>
            <fileNumber>333-155769</fileNumber>
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