10-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)

OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2011

Commission File Number 001-14169

HUMAN GENOME SCIENCES, INC.

(Exact name of registrant)

Delaware	22-3178468
(State of organization)	(I.R.S. employer identification number)

14200 Shady Grove Road, Rockville, Maryland 20850-7464

(address of principal executive offices and zip code)

(301) 309-8504

(Registrant’s telephone number)

Securities registered pursuant to Section 12(b) of the Act:

Title of Each Class	Name of Each Exchange on Which Registered
Common stock, par value $0.01 per share	The NASDAQ Stock Market LLC

Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.     Yes  x    No  ¨

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act.     Yes  ¨    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No  ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  x    No  ¨

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein and will not be contained, to the best of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	x	Accelerated filer	¨
Non-accelerated filer	¨	Smaller reporting company	¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ¨    No  x

The number of shares of the registrant’s common stock outstanding on January 31, 2012 was 198,981,706. As of June 30, 2011, the aggregate market value of the common stock held by non-affiliates of the registrant based on the closing price reported on the National Association of Securities Dealers Automated Quotations System was approximately $3,085,756,649.*

DOCUMENTS INCORPORATED BY REFERENCE

Portions of Human Genome Sciences, Inc.’s definitive proxy statement for the 2012 annual meeting of stockholders are incorporated by reference into Part III of this Annual Report.

* Excludes 64,914,447 shares of common stock deemed to be held by officers and directors and stockholders whose ownership exceeds five percent of the shares outstanding at June 30, 2011. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the registrant, or that such person is controlled by or under common control with the registrant.

PART I

ITEM 1. BUSINESS

This annual report on Form 10-K contains forward-looking statements, within the meaning of the Securities Exchange Act of 1934 and the Securities Act of 1933, that involve risks and uncertainties. In some cases, forward-looking statements are identified by words such as “believe,” “anticipate,” “expect,” “intend,” “plan,” “will,” “may” and similar expressions. You should not place undue reliance on these forward-looking statements, which speak only as of the date of this report. All of these forward-looking statements are based on information available to us at this time, and we assume no obligation to update any of these statements. Actual results could differ from those projected in these forward-looking statements as a result of many factors, including those identified in “Risk Factors,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere. We urge you to review and consider the various disclosures made by us in this report, and those detailed from time to time in our filings with the Securities and Exchange Commission, that attempt to advise you of the risks and factors that may affect our future results.

Overview

Human Genome Sciences, Inc. (“HGS”, the “Company”, “we”, “our” and “us”) is a biopharmaceutical company that exists to place new therapies into the hands of those battling serious disease. Our lead products are BENLYSTA^® (belimumab) for systemic lupus erythematosus (“SLE”) and raxibacumab for inhalation anthrax.

BENLYSTA was approved on March 9, 2011 by the U.S. Food and Drug Administration (“FDA”) for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. We launched BENLYSTA shortly thereafter and recognized revenue from our first BENLYSTA sales in March 2011. On July 13, 2011, the European Commission granted marketing authorization for BENLYSTA as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy. BENLYSTA is currently available in the United States, Canada and an increasing number of European countries, including Germany, Spain, Austria, Denmark, Finland, Hungary, Norway and Sweden. In addition, regulatory submissions are pending in other countries.

We are developing BENLYSTA with our partner, GlaxoSmithKline (“GSK”), under a 2006 co-development and co-commercialization agreement. In the United States we and GSK both have sales teams that are working together to commercialize BENLYSTA. In Germany, France and Spain, our team will work alongside GSK to commercialize BENLYSTA, and in the rest of the world GSK will lead local implementation of the commercialization of BENLYSTA. We recognize product sales revenue from BENLYSTA sales in the U.S., and GSK recognizes product sales revenue from sales in the rest of the world. We share profits and certain expenses with GSK on a worldwide basis. Under the agreement, we are responsible for the global supply of BENLYSTA.

We continue to deliver raxibacumab to the U.S. Strategic National Stockpile (“SNS”) for emergency use in treating inhalation anthrax. In July 2009, the U.S. Government (“USG”) exercised its option under our contract to purchase 45,000 additional doses of raxibacumab, with delivery to be completed over a three-year period. HGS expects to receive approximately $142.0 million from this second order as deliveries are completed, approximately $117.0 million of which has been recognized as revenue through December 31, 2011. In May 2009, we submitted a Biologics License Application (“BLA”) to the FDA for raxibacumab for the treatment of inhalation anthrax. We received a Complete Response Letter in November 2009, and we continue to work closely with the FDA to obtain approval. HGS will receive approximately $20.0 million from the USG if raxibacumab is licensed by the FDA.

In addition to our internal pipeline, we have substantial financial rights to two novel drugs that GSK has advanced to late-stage development. The first of these is darapladib, which was discovered by GSK based on HGS technology. In two Phase 3 trials, GSK is currently evaluating whether darapladib can reduce the risk of adverse cardiovascular events such as heart attack or stroke in patients with chronic coronary heart disease and acute coronary syndrome, respectively. The combined darapladib Phase 3

- 1 -

program spans 42 countries and has enrolled more than 28,500 patients. The second is albiglutide, for which GSK currently has eight Phase 3 trials in progress to evaluate the long-term efficacy, safety and tolerability of albiglutide as monotherapy and add-on therapy for patients with type 2 diabetes mellitus. Albiglutide was created by HGS using its proprietary albumin-fusion technology, and the product was licensed to GSK in 2004. We also have substantial financial rights to another novel drug that was discovered by GSK based on HGS technology, rilapladib, which GSK is currently evaluating in a Phase 2 trial for its effect on biomarkers and cognitive function in Alzheimer’s disease.

We are working on potential additional indications for BENLYSTA as well as additional methods of delivery. Currently, BENLYSTA is delivered by infusion at two-week intervals for the first three doses and every four weeks thereafter. In December 2011, we initiated dosing of patients in BLISS-SC, a Phase 3 trial of the subcutaneous formulation of BENLYSTA. If this trial is successful and regulatory authorities agree, the subcutaneous formulation will make it possible for patients to self-administer BENLYSTA by injection once a week. In 2012, we plan to initiate Phase 3 trials of BENLYSTA in vasculitis and active lupus nephritis.

We are also working to expand and advance our mid- and early-stage pipeline beyond BENLYSTA. A randomized Phase 2 trial is currently evaluating mapatumumab in combination with Nexavar^® (sorafenib) for the treatment of advanced hepatocellular cancer. Mapatumumab is a human monoclonal antibody to TRAIL receptor 1. In March 2011, we entered into an agreement with FivePrime Therapeutics, Inc. (“FivePrime”) to develop and commercialize HGS1036 (formerly FP-1039) for multiple cancers.

Strategic partnerships are an important driver of our commercial success. We have a co-development and co-commercialization agreement with GSK for BENLYSTA, and raxibacumab is being developed under a contract with the Biomedical Advanced Research and Development Authority (“BARDA”) of the Office of the Assistant Secretary for Preparedness and Response (“ASPR”), U.S. Department of Health and Human Services (“HHS”). Our strategic partnerships with pharmaceutical and biotechnology companies allow us to leverage our strengths and gain access to sales and marketing infrastructure, as well as complementary technologies. Some of these partnerships provide us with licensing or other fees, clinical development cost-sharing, milestone payments and rights to royalty payments as products are developed and commercialized. In some cases, we are entitled to certain commercialization, co-promotion, revenue-sharing and other product rights.

As of December 31, 2011, we had $881.4 million in cash and investments. With a strong cash position, a management team experienced in bringing products to market, an experienced drug development organization and significant capabilities in biologicals manufacturing, we believe HGS has the resources and capabilities necessary to achieve near-term commercial success while sustaining a viable pipeline that supports our long-term growth.

We are a Delaware corporation established in 1992, headquartered at 14200 Shady Grove Road, Rockville, Maryland 20850-7464. Our telephone number is (301) 309-8504. Our website address is www.hgsi.com. Information contained on our website is not a part of, and is not incorporated into, this annual report on Form 10-K. Our filings with the SEC are available without charge on our website as soon as reasonably practicable after filing. HGS, Human Genome Sciences and BENLYSTA are trademarks of Human Genome Sciences, Inc. Other trademarks referenced are the property of their respective owners.

Strategy

Over the last few years, we have made strategic decisions that have transformed HGS on multiple levels and contributed to our progress toward becoming a fully commercial biopharmaceutical company capable of generating sustainable revenues and sustainable growth into the future. Key strategies to help us achieve this goal include:

Execute the successful launch and commercialization of BENLYSTA.

With BENLYSTA now approved by the FDA, our first strategic priority is to continue our progress toward the successful global launch and commercialization of a drug that we believe represents an

- 2 -

improvement in the standard of care for systemic lupus. We have hired, trained and deployed a specialized commercial team, including sales, marketing and medical affairs, which has a high level of experience and familiarity with rheumatology, biologics and infused products. The combined HGS and GSK team, including a U.S. sales force of approximately 150, is working closely together to communicate effectively with rheumatologists and other stakeholders to ensure that appropriate patients with systemic lupus who need BENLYSTA will have access to it. HGS and GSK are also supporting physicians and patients with reimbursement and access programs.

Under the terms of our 2006 co-development and co-commercialization agreement with GSK, HGS has responsibility for the global supply of BENLYSTA. We believe we have produced sufficient BENLYSTA inventory to meet anticipated global market needs for at least one year, and we believe our large-scale manufacturing facility has sufficient capacity to provide worldwide supply for the next two to three years. However, HGS and GSK also anticipate that additional capacity will be required. In 2010, HGS entered into an agreement with Lonza Sales AG (“Lonza”) that we believe will provide the additional capacity needed, with production expected to come on-line in 2013.

Make BENLYSTA globally available so patients with need will have access.

We and GSK received marketing authorization for BENLYSTA from the European Commission in July 2011, and BENLYSTA has been launched and is currently available in the United States, Canada, Germany, Spain, Austria, Denmark, Finland, Hungary, Norway and Sweden. We expect to launch in France, Italy and other markets in 2012. In addition, regulatory submissions are pending in other countries. We have built our own commercialization team to work alongside GSK in Europe, with HGS headquarters in Switzerland and local organizations in Germany, France and Spain. Elsewhere, GSK will lead local implementation, with HGS sharing costs and profits equally with GSK.

Work to achieve the full therapeutic and commercial potential of BENLYSTA by developing it for other B-cell mediated diseases.

We believe that BENLYSTA has potential beyond its initial market entry in SLE. We are committed to achieving the full therapeutic and commercial potential of BENLYSTA, both by continuing its development for SLE, and by developing it for other B-cell mediated diseases where patients need new treatment options and we have scientific evidence supporting BENLYSTA’s therapeutic potential and commercial viability. In May 2011, GSK initiated dosing of patients in a Phase 3 trial of BENLYSTA in East Asia, to be conducted in China, Japan and South Korea. In December 2011, we initiated dosing in BLISS-SC, a Phase 3 trial of the subcutaneous formulation of BENLYSTA. Initial results from this study are expected in 2014; if it is successful and regulatory authorities agree, the subcutaneous formulation would make it possible for patients to self-administer BENLYSTA by injection once a week. In 2012, we plan to initiate Phase 3 trials of BENLYSTA in vasculitis and active lupus nephritis. In addition, small investigator-initiated clinical studies are currently ongoing in Sjögren’s syndrome and Waldenstrom’s macroglobulinaemia.

Find and develop new therapies for our late-stage pipeline.

We will pursue external opportunities to acquire high-potential innovative products, with a priority given to products that have the potential to be first-in-class or best-in class, and address large markets or markets on the verge of escalating growth. Our primary therapeutic focus is on indications in which we have special expertise and which can be commercialized with small specialty sales forces. We will be open to both biologics and small molecule opportunities. We also look forward to GSK’s continuing progress with late-stage products to which we have substantial financial rights, such as darapladib for cardiovascular disease and albiglutide for type 2 diabetes mellitus.

Continue to build a robust mid-and early-stage pipeline.

Our mid- and early-stage pipeline is important to our long-term future growth. A randomized Phase 2 trial is currently evaluating mapatumumab in combination with Nexavar (sorafenib) for the treatment of advanced hepatocellular cancer. Mapatumumab is a human monoclonal antibody to TRAIL receptor 1. In

- 3 -

March 2011, we and FivePrime Therapeutics announced a collaboration to develop and commercialize HGS1036 (formerly FP-1039) for multiple cancers. HGS1036 is a first-in-class biologic discovered by FivePrime that targets multiple fibroblast growth factor (“FGF”) ligands. FGF proteins are growth factors that play important roles in the growth and survival of a number of solid tumors. A Phase 1 study was completed in 2011, showing that HGS1036 was safe and well tolerated. In 2012, we plan to initiate Phase 1b trials of HGS1036 in combination with chemotherapy. Our new targets program is designed to increase the number of Investigational New Drugs entering our pipeline, and we have research collaborations ongoing to complement our internal efforts. We also look forward to GSK’s continued progress with rilapladib, to which we have substantial financial rights.

Remain strategically opportunistic and vigilant.

Strategically appropriate partnerships and collaborations will continue to play an important role in our future. We will continue our partnership with GSK as we explore the full potential of BENLYSTA. As we bring more products forward in the future that address large and international markets, other partnerships with leading companies may allow us to bring new therapies more quickly to patients who need them on a global basis. We will also pursue strategic acquisitions and collaborations to expand our portfolio of new drug candidates, provide access to complementary technologies, or reduce the cost and speed the early development of HGS-discovered targets.

Capitalize on our intellectual property portfolio.

We pursue patents to protect our intellectual property and have developed a significant intellectual property portfolio, with hundreds of issued patents covering genes, proteins, antibodies and proprietary technologies. We have also filed U.S. patent applications covering many additional discoveries and inventions. We will seek opportunities to monetize intellectual property assets that we do not plan to develop internally.

Build upon our core competencies in manufacturing and process development.

Our world-class manufacturing and process development capabilities represent a strategic advantage and allow us to control quality while maintaining flexibility.

Maintain a strong financial position.

A strong cash position is essential to our ability to commercialize new approved drugs, advance promising late-stage investigational therapies through Phase 3 trials, and continue to invest in our earlier-stage pipeline. We view a strong financial position as a strategic imperative. Maintaining it requires efficient operations, sound financial controls and the ability to raise funds in the public or private markets. It also requires a willingness to advance creative approaches such as our manufacturing alliance program, through which we have capitalized on our process development and manufacturing capability to generate revenues – or raxibacumab, which is sold to one customer, the U.S. Government, and to date has generated approximately $280 million.

Products and Clinical Programs

Marketed and Late-Stage Products

BENLYSTA was approved in March 2011 by the FDA for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. In July 2011, the European Commission granted marketing authorization for BENLYSTA as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy. BENLYSTA has been launched and is currently available for the treatment of SLE in an increasing number of countries. We continue to develop BENLYSTA for SLE and new indications. Raxibacumab for inhalation anthrax continues to generate revenue under our contract with the U.S. Government as we complete deliveries to the Strategic National Stockpile, and we continue to work closely with the FDA to achieve licensure.

- 4 -

BENLYSTA (belimumab)

BENLYSTA is a human monoclonal antibody and the first in a class of drugs known as BLyS-specific inhibitors. BENLYSTA inhibits the biological activity of a naturally occurring protein known as B-lymphocyte stimulator (BLyS), which was first discovered by HGS in 1996. In lupus and certain other autoimmune diseases, elevated levels of BLyS are believed to contribute to the production of autoantibodies – antibodies that attack and destroy the body’s own healthy tissues. BENLYSTA is being developed by HGS and GSK under a 2006 co-development and co-commercialization agreement (described below under “Lead Commercial Collaborations”).

In May 2011, GSK initiated dosing of patients in a Phase 3 trial of BENLYSTA in East Asia, to be conducted in China, Japan and South Korea. In December 2011, we initiated dosing in BLISS-SC, a Phase 3 trial of the subcutaneous formulation of BENLYSTA. In 2012, we plan to initiate Phase 3 trials of BENLYSTA in vasculitis and active lupus nephritis. In addition, small investigator-initiated clinical studies are currently ongoing in Sjögren’s syndrome and Waldenstrom’s macroglobulinaemia.

Raxibacumab

Raxibacumab is a human monoclonal antibody that targets and blocks Bacillus anthracis protective antigen, which research has shown to be the key facilitator of the deadly toxicity of anthrax infection. Raxibacumab represents a new way to address the anthrax threat. While antibiotics can kill the anthrax bacteria, they are not effective against the deadly toxins the bacteria produce. Raxibacumab targets anthrax toxins after they are released by the bacteria into the blood and tissues. In an inhalation anthrax attack, people may not know they are infected with anthrax until the toxins already are circulating in their blood, and it may be too late for antibiotics alone to be effective.

We are developing raxibacumab under a contract entered into in 2006 with BARDA. The U.S. Government is currently our only customer for raxibacumab and has the right to terminate our contract at any time. In 2011, HGS continued delivery of raxibacumab to the U.S. Strategic National Stockpile. In July 2009, the U.S. Government exercised its option to purchase 45,000 additional doses of raxibacumab for the Stockpile for emergency use in treating inhalation anthrax, with delivery to be completed over a three-year period. HGS expects to receive approximately $142.0 million from this second order as deliveries are completed. In 2011, we recognized $52.5 million in raxibacumab product sales revenue. Also under our contract, HGS submitted a BLA to the FDA for raxibacumab for the treatment of inhalation anthrax in May 2009. We received a Complete Response Letter in November 2009, and we continue to work closely with the FDA to obtain approval. HGS will receive approximately $20.0 million from the U.S. Government if raxibacumab is licensed by the FDA. Raxibacumab revenue accounted for 42% and 31% of our total revenue for 2011 and 2010, respectively.

Mid- and Early-Stage Pipeline

Our mid- and early-stage pipeline is important to our long-term future growth.

Mapatumumab

Mapatumumab is a human monoclonal antibody that specifically binds to TRAIL receptor 1 and causes it to induce apoptosis in cancer cells. A randomized Phase 2 trial is currently evaluating mapatumumab in combination with Nexavar (sorafenib) for the treatment of advanced hepatocellular cancer.

HGS1036

In March 2011, we and FivePrime Therapeutics entered into a collaboration to develop and commercialize HGS1036 (formerly FP-1039) for multiple cancers. HGS1036 is a first-in-class biologic discovered by FivePrime that targets multiple fibroblast growth factor (“FGF”) ligands. FGF proteins are growth factors that play important roles in the growth and survival of a number of solid tumors. A Phase 1 study was completed in 2011, showing that HGS1036 was safe and well tolerated. In 2012, we plan to initiate Phase 1b trials of HGS1036 in combination with chemotherapy.

- 5 -

HGS1029 and HGS1025

In January 2012, we announced that two early-stage products will not be developed further by HGS: HGS1029, an IAP inhibitor in Phase 1 development in patients with advanced solid and advanced lymphoid tumors, and HGS1025, a human monoclonal antibody to the CCR5 receptor that would have entered Phase 1b development in ulcerative colitis.

Products in the GSK Pipeline

HGS has financial rights to certain products in the GSK clinical development pipeline (described below under “Lead Commercial Collaborations”). GSK has advanced two of these products, darapladib and albiglutide, to Phase 3 development, and one, rilapladib, to Phase 2 development.

Darapladib

Darapladib was discovered by GSK based on our technology. It is a small-molecule inhibitor of lipoprotein-associated phospholipase-A2 (Lp-PLA₂), an enzyme associated with the formation of atherosclerotic plaques and identified in clinical trials as an independent risk factor for coronary heart disease and ischemic stroke. In two pivotal Phase 3 trials, GSK is evaluating whether darapladib can reduce the risk of adverse cardiovascular events such as heart attack or stroke in patients with chronic coronary heart disease (“CHD”) and acute coronary syndrome (“ACS”), respectively. In October 2011, GSK completed the enrollment of over 13,000 patients into the SOLID-TIMI 52 study of darapladib in patients who have suffered an ACS event. The SOLID-TIMI 52 study is one of two pivotal Phase 3 trials in the darapladib clinical program. The other study is STABILITY, which is evaluating darapladib in patients with CHD and in 2010 completed the enrollment of about 15,800 patients. The combined program spans 42 countries and has enrolled more than 28,500 patients at more than 1,500 clinical sites. HGS will receive 10% royalties on worldwide sales if darapladib is commercialized, and has a 20% co-promotion option in North America and Europe.

Albiglutide

Albiglutide is a biological product that is generated from the fusion of human albumin and modified human GLP-1 peptide. GSK’s Phase 3 program for albiglutide includes eight trials to evaluate the long-term efficacy, safety and tolerability of albiglutide as monotherapy and add-on therapy for patients with type 2 diabetes mellitus. GSK announced topline results of the first of eight Phase 3 trials in November 2011. The study, known as Harmony 7, was designed to compare once-weekly albiglutide to once-a-day liraglutide. Results showed a reduction in HbA1c from baseline of 0.78% for patients receiving albiglutide compared to a reduction of 0.99% for liraglutide. Although the pre-specified margin of non-inferiority to liraglutide was not met, albiglutide did show a statistically significant reduction in HbA1c from baseline (p<0.001). The most common adverse events observed during this study were nausea (9.9% for albiglutide versus 29.2% for liraglutide) and vomiting (5% for albiglutide versus 9.3% for liraglutide). GSK’s conclusion after review is that the data support continued progress toward registration as a possible once-weekly treatment for type 2 diabetes. GSK expects initial results from the remaining studies over the course of the next several months, and has stated that it expects to provide an update on albiglutide once a more complete view of the data is available in mid-2012. We created albiglutide using our proprietary albumin-fusion technology, and licensed it to GSK in 2004. We are entitled to fees and milestone payments that could amount to as much as $183.0 million – including $33.0 million received to date – in addition to single-digit royalties on worldwide sales if albiglutide is commercialized.

Rilapladib

Like darapladib, rilapladib is a small-molecule inhibitor of Lp-PLA2 that was discovered by GSK based on our technology. In a Phase 2 trial initiated in October 2011, GSK is evaluating the effects of rilapladib on biomarkers related to the pathogenesis and progression of Alzheimer’s disease and on cognitive function. HGS will receive 10% royalties on worldwide sales if rilapladib is commercialized, and has a 20% co-promotion option in North America and Europe.

- 6 -

Research and Development

HGS has developed core competencies in the discovery and understanding of human genes and their biological functions, and in the discovery and development of human protein and antibody drugs. Research and development expenses were $196.2 million, $196.4 million and $173.7 million for 2011, 2010, and 2009, respectively. These expenses are net of amounts reimbursed by our collaboration partners.

Human Antibody Technology

We have acquired rights to a variety of human antibody technologies, have integrated these technologies into our research and development program, and continue to collaborate with certain antibody companies. Many medical conditions are the result of an excess of a specific protein in the body, and some antibody drugs can inactivate such proteins and bring therapeutic benefits to patients. These drugs are known as antagonistic antibodies. For example, BENLYSTA is an antagonistic human monoclonal antibody.

In certain medical conditions, it may be desirable to stimulate a specific biological activity. Antibodies that stimulate biological activity are known as agonistic antibodies. Mapatumumab is an agonistic antibody that binds to TRAIL receptor 1 and triggers programmed cell death in cancer cells.

Albumin-Fusion Technology

Our albumin-fusion technology allows us to create long-acting forms of protein drugs by fusing the gene that expresses human albumin to the gene that expresses a therapeutically active protein. Our partners are actively pursuing the development of albumin-fusion drugs based on known therapeutic proteins. For example, albiglutide was created through the fusion of human albumin and glucagon-like peptide-1 (GLP-1).

Drug Development

We have built a drug development organization that has the expertise necessary to design and implement well-focused, high-quality clinical trials of multiple compounds. We seek to gather, document and analyze clinical trial data in such a way that they can be submitted to regulatory authorities and used to support BLAs at the appropriate time. We have assembled experienced teams in key strategic areas of development, including:

• Clinical Research and Biostatistics. The clinical research and biostatistics groups are responsible for the design, planning and analysis of clinical trials.

• Clinical Operations. The clinical operations group executes clinical trials and is responsible for managing clinical trial sites and ensuring that all proper procedures are followed during the collection of clinical data. The group includes our data management team.

• Project Management. Our project management team oversees the process of development of a drug from the earliest stages of research through the conduct of clinical development and regulatory filings.

• Regulatory Affairs. The regulatory affairs group manages communications with and submissions to regulatory authorities.

• Drug Safety. As our products advance in clinical testing, our drug safety group collects and analyzes information on drug experience and safety, and ensures that accurate medical information is distributed.

- 7 -

• Quality Assurance. The quality assurance group ensures compliance with all regulatory requirements for the clinical development and manufacture of our products.

• Bioanalytical Sciences. The bioanalytical sciences group develops and performs highly specialized assays that are used during monitoring of preclinical tests and clinical trials. Other assays help to ensure the quality and consistency of our products.

• Biopharmaceutical Development. The biopharmaceutical development group develops robust manufacturing processes and product formulations to support clinical studies and future commercial supply.

Strategic Collaborations

Strategic collaborations are a key aspect of our business strategy. We have a co-development and co-commercialization agreement with GSK for BENLYSTA and raxibacumab is being developed under a contract with the U.S. Government. Strategic collaborations are an important source of revenues and drug development cost-sharing. They also allow us to leverage our strengths and gain access to sales and marketing infrastructure, international distribution and complementary technologies. Other potential collaborations may provide sources of new product opportunities for in-licensing. In addition, we have assets that may be a better fit for another company than for HGS, and therefore could be out-licensed. Each of these collaborative models is of interest to HGS, and we are committed to remaining alert to new opportunities.

Lead Commercial Collaborations

GlaxoSmithKline

BENLYSTA. In 2006, we entered into an agreement with GSK for the co-development and co-commercialization of BENLYSTA. GSK is a world leader that brings global pharmaceutical development and marketing capabilities to the BENLYSTA program. Under the BENLYSTA agreement, we and GSK share Phase 3 and 4 development costs, sales and marketing expenses, and profits equally. HGS has primary responsibility for bulk manufacturing. We received an execution fee of $24.0 million under this agreement and recognized this payment ratably over the development period. We recognized $52.3 million from sales of BENLYSTA in 2011 and $3.4 million from the execution fee in 2010. The BENLYSTA agreement includes cost-sharing provisions under which we and GSK share clinical development costs. We recorded cost reimbursement from GSK under this provision of $25.1 million in 2011 and $62.0 million in 2010, which was reflected as a reduction in expenses. This agreement will expire three years after the later of (i) the expiration date of certain patent rights related to BENLYSTA and (ii) a period of 10 years after the first commercial sale of BENLYSTA. These certain patent rights are expected to expire by 2023, with the potential for later expiration that may result from any issuance of additional patent and/or patent term extensions. GSK may terminate the agreement if, upon the basis of competent scientific evidence or data regarding commercial potential, GSK determines BENLYSTA does not merit incurring additional development or marketing expenses. In addition, either party may terminate if the other party commits a material breach of the agreement or if the other party is bankrupt or insolvent.

Darapladib. In December 2008, GSK initiated Phase 3 development of darapladib, a small-molecule Lp-PLA₂ inhibitor discovered by GSK based on HGS technology. We will receive a 10% royalty on worldwide sales of darapladib if it is commercialized, and we have a 20% co-promotion option in North America and Europe. We are also entitled to receive a milestone payment if darapladib moves through clinical development into registration.

Albiglutide. In February 2009, GSK initiated a Phase 3 clinical trial program to evaluate the efficacy, safety and tolerability of albiglutide in the long-term treatment of type 2 diabetes mellitus. Albiglutide was created by HGS using its proprietary albumin-fusion technology, and the product was licensed to GSK in 2004. HGS is entitled to fees and milestone payments that could amount to as much as $183.0 million – including $33.0 million received to date. We are also entitled to single-digit royalties on worldwide sales if albiglutide is commercialized.

- 8 -

Rilapladib. In October 2011, GSK initiated a Phase 2 clinical trial of rilapladib, a small-molecule Lp-PLA₂ inhibitor discovered by GSK based on HGS technology, in Alzheimer’s disease. We will receive a 10% royalty on worldwide sales of rilapladib if it is commercialized, and we have a 20% co-promotion option in North America and Europe. We are also entitled to receive a milestone payment if rilapladib moves through clinical development into registration.

United States Government

Raxibacumab. In September 2005, we entered into a two-phase contract with BARDA to supply raxibacumab for inhalation anthrax. HHS is the lead agency for public health and medical response to man-made or natural disasters, including acts of bioterrorism. Under the first phase of the contract, we supplied 10 grams of raxibacumab to HHS for comparative in vitro and in vivo testing. In June 2006, under the second phase of the contract, the USG exercised its option to purchase raxibacumab and we agreed to manufacture and deliver 20,001 doses to the SNS. In 2009, we achieved our company’s first product sales by completing these deliveries and recognized $162.5 million in product sales and manufacturing and development services revenue. In July 2009, the USG exercised its option to purchase 45,000 additional doses of raxibacumab for the SNS for emergency use in treating inhalation anthrax, with delivery to be completed over a three-year period. HGS expects to receive approximately $142.0 million from this second order as deliveries are completed, including approximately $52.5 million and $47.2 million recognized as product sales revenue in 2011 and 2010, respectively. Also under our contract, HGS submitted a BLA to the FDA for raxibacumab for the treatment of inhalation anthrax in May 2009. We received a Complete Response Letter in November 2009, and we continue to work closely with the FDA to obtain approval. HGS will receive approximately $20.0 million from the USG if raxibacumab is licensed by the FDA. Our raxibacumab agreement can be terminated by the USG if it determines that a termination is in its interest.

Research and Technology Collaborations

HGS has a rich heritage of scientific discovery that has produced a substantial intellectual property estate and an extensive library of therapeutic and diagnostic targets. After careful review, we have selected targets for further research and potential development, with the goal of filing new INDs to develop the selected targets through co-development or research collaborations, as well as through our own internal research, including the application of antibody development technology from various collaborators.

Process Development and Manufacturing Alliances

Protein and antibody process development and manufacturing are core HGS competencies. We currently develop and produce several protein and antibody drugs in three state-of-the-art current good manufacturing practices (“cGMP”)-compliant process development and manufacturing facilities – totaling approximately 500,000 square feet. We are leveraging these capabilities to produce near-term revenue by entering into strategically appropriate process development and manufacturing alliances.

Patents and Proprietary Rights

We seek U.S. and foreign patent protection for the genes, proteins, antibodies and other molecules that we discover, license or otherwise acquire, as well as patents on therapeutic and diagnostic products and processes, screening and manufacturing technologies, and other inventions based on such genes, proteins, antibodies and other molecules. We also seek patent protection or rely upon trade secret rights to protect certain technologies which may be used to discover, characterize and manufacture genes, proteins, antibodies and other molecules and which may be used to develop novel therapeutic and diagnostic products and processes. We believe that in the aggregate, our patent applications, patents and licenses under patents owned by third parties are of material importance to our operations.

Additional information is set forth below about the patents and other proprietary rights covering our BENLYSTA and raxibacumab products. This information is based on our current assessment of patents that we own, control, or have exclusively licensed, and is subject to revision in the event of changes in the law, legal rulings affecting our patents, the issuance of additional pending patent applications, or if we become aware of new information.

- 9 -

BENLYSTA

We and our collaborator, GlaxoSmithKline, have patents and patent applications directed to compounds targeting BLyS, including BENLYSTA, in the United States and other countries. These patents and patent applications cover BENLYSTA as well as various methods of using the product. The principal patents covering BENLYSTA generally expire between 2016 and 2023 in the United States and between 2016 and 2021 in the rest of the world, subject to any available patent term extensions and supplemental protection certificates that may be obtained.

Raxibacumab

We have patents in the United States covering raxibacumab as well as various methods of treatment using the product. The U.S. patents covering raxibacumab expire between 2023 and 2026, subject to any available patent term extensions that may be obtained.

Important legal issues remain to be resolved as to the extent and scope of available patent protection for biotechnology products and processes in the U.S. and other important markets outside the U.S. We expect that litigation or administrative proceedings will likely be necessary to determine the validity and scope of certain of our and others’ proprietary rights. We are currently involved in a number of administrative proceedings and litigations relating to the validity and scope of protection of our patents and those of others, and are likely to be involved in additional proceedings that may affect directly or indirectly patents and patent applications related to our products or the products of our partners. For example, we have been involved in contested proceedings related to products based on BLyS (such as BENLYSTA). Any such lawsuit or proceeding may result in a significant commitment of resources in the future. In addition, changes in, or different interpretations of, patent laws in the U.S. and other countries may result in patent laws that allow others to use our discoveries or develop and commercialize our products or prevent us from using or commercializing our discoveries and products. We cannot assure you that the patents we obtain or the unpatented technology we hold will afford us significant commercial protection.

Our trademarks, including BENLYSTA, are important to us and are generally covered by trademark applications or registrations in the United States and in other countries. Trademark protection varies in accordance with local law, and continues in some countries for as long as the mark is used and in other countries for as long as the mark is registered. Trademark registrations are generally for fixed but renewable terms. In certain instances, we depend upon our collaborators to file and prosecute trademark applications and protect our trademark rights.

A discussion of certain risks and uncertainties that may affect our patent position and proprietary rights is set forth in the “Risk Factors” section of this Form 10-K.

Competition

General. We face intense competition from a wide range of pharmaceutical, biotechnology and diagnostic companies, as well as academic and research institutions and government agencies. Some of these competitors have substantially greater financial, marketing, research and development and human resources. Most large pharmaceutical companies have considerably more experience in undertaking clinical trials and in obtaining regulatory approval to market pharmaceutical products.

Basis of Competition. Principal competitive factors in our industry include:

• the quality and breadth of an organization’s technology;

• the skill of an organization’s employees and ability to recruit and retain skilled employees;

• an organization’s intellectual property estate;

- 10 -

• the range of capabilities, from target identification and validation to drug discovery and development to manufacturing and marketing; and

• the availability of substantial capital resources to fund discovery, development, manufacturing and commercialization activities.

We believe that the quality and breadth of our technology platform, the skill of our employees and our ability to recruit and retain skilled employees, our patent portfolio, our capabilities for research and drug development, and our capital resources are competitive strengths. However, many large pharmaceutical and biotechnology companies have significantly larger intellectual property estates than we do, more substantial capital resources than we have, and greater capabilities and experience than we do in preclinical and clinical development, sales, marketing, manufacturing and regulatory affairs.

Products. We are aware of products in research or development by our competitors that address all of the diseases we are targeting. Any of these products may compete with our products and product candidates. Our competitors may succeed in developing their products before we do, obtaining approvals from the FDA or other regulatory agencies for their products more rapidly than we do, or developing products that are more effective than our products. These products or technologies might render our technology obsolete or noncompetitive. Our competitors may also pursue generic or biosimilar versions of our products, which could adversely affect the sales and gross profits of our products. In addition, our partners are developing albumin fusion protein products, such as albiglutide, that are designed to be long-acting versions of existing products. While we believe our partners’ albumin fusion protein products may be a more attractive alternative to the existing products, the existing product in some cases has an established market that may make the introduction of our partners’ products more difficult. Competition is based primarily on product efficacy, safety, timing and scope of regulatory approvals, availability of supply, marketing and sales capability, reimbursement coverage, price and patent position.

Government Regulation

Regulations in the U.S. and other countries have a significant impact on our research, product development and manufacturing activities and will be a significant factor in the marketing of our products. All of our products require regulatory approval prior to commercialization. In particular, our products are subject to rigorous preclinical and clinical testing and other premarket approval requirements by the FDA and similar regulatory authorities in other regions. Various statutes and regulations also govern or influence the manufacturing, safety, labeling, storage, record keeping and marketing of our products. The lengthy process of seeking these approvals, and the subsequent compliance with applicable statutes and regulations, require the expenditure of substantial resources. Any failure by us to obtain, or any delay in obtaining, regulatory approvals could materially adversely affect our ability to commercialize our products in a timely manner, or at all.

Preclinical Testing. Before a drug may be clinically tested in the U.S., it must be the subject of rigorous preclinical testing. Preclinical tests include laboratory evaluation of product chemistry and animal studies to assess the potential safety and efficacy of the product and its formulations. The results of these studies must be submitted to the FDA as part of an IND, which is reviewed by the FDA before clinical testing in humans can begin.

Clinical Testing. Typically, clinical testing involves a three-phase process, which generally lasts four to seven years, and sometimes longer:

• Phase 1 clinical trials are conducted with a small number of subjects to determine the early safety profile and the pattern of drug distribution and metabolism.

• Phase 2 clinical trials are conducted with groups of patients afflicted with a specified disease in order to provide enough data to evaluate preliminary efficacy and optimal dosages statistically and to expand evidence of safety.

- 11 -

• Phase 3 clinical trials are large-scale, multi-center, comparative trials, which are designed to gather additional information for proper dosage and labeling of the drug and to demonstrate its overall safety and efficacy.

The FDA monitors the progress of each phase of testing, and may require the modification, suspension or termination of a trial if it is determined to present excessive risks to patients. The clinical trial process may be accompanied by substantial delay and expense and there can be no assurance that the data generated in these studies will ultimately be sufficient for marketing approval by the FDA.

Marketing Approvals. Before a product can be marketed and sold, the results of the preclinical and clinical testing must be submitted to the FDA for approval. This submission will be either a new drug application or a biologics license application, depending on the type of drug. In responding to a new drug application or a biologics license application, the FDA may grant marketing approval, request additional information or deny the application if it determines that the application does not provide an adequate basis for approval. We cannot assure you that any approval required by the FDA will be obtained on a timely basis, or at all.

In addition, the FDA may condition marketing approval on the conduct of specific post-marketing studies to further evaluate safety and efficacy (such as Phase 4 trials). Rigorous and extensive FDA regulation of pharmaceutical products continues after approval, particularly with respect to compliance with cGMPs, reporting of adverse effects, advertising, promotion and marketing. Discovery of previously unknown problems or failure to comply with the applicable regulatory requirements may result in restrictions on the marketing of a product or withdrawal of the product from the market as well as possible civil or criminal sanctions, any of which could materially adversely affect our business.

Other Regulation. We are also subject to various laws and regulations relating to safe working conditions, laboratory and manufacturing practices, the experimental use of animals and the use and disposal of hazardous or potentially hazardous substances used in connection with our research, including radioactive compounds and infectious disease agents. We also cannot accurately predict the extent of regulations that might result from any future legislative or administrative action.

In addition, ethical, social and legal concerns about genetic testing and genetic research could result in additional regulations restricting or prohibiting the processes we or our suppliers may use. Federal and state agencies, congressional committees and foreign governments have expressed interest in further regulating biotechnology. More restrictive regulations or claims that our products are unsafe or pose a hazard could prevent us from commercializing our products.

Foreign Regulation. We must obtain regulatory approval by governmental agencies in other countries prior to commercialization of our products in those countries. Foreign regulatory systems may be just as rigorous, costly and uncertain as in the U.S.

Possible Pricing Restrictions. The levels of revenues and profitability of biopharmaceutical companies like ours may be affected by the continuing efforts of government and third-party payers to contain or reduce the costs of health care through various means. For example, in certain foreign markets, pricing or profitability of therapeutic and other pharmaceutical products is subject to governmental control. In the U.S. there have been, and we expect that there will continue to be, a number of federal and state proposals to implement similar governmental control. While we cannot predict whether any legislative or regulatory proposals will be adopted, the adoption of such proposals could have a material adverse effect on our business, financial condition and profitability. In addition, in the U.S. and elsewhere, sales of therapeutic and other pharmaceutical products depend in part on the availability of reimbursement to the consumer from third-party payers, such as government and private insurance plans. Third-party payers are increasingly challenging the prices charged for medical products and services. We cannot assure you that any of our products will be considered cost effective or that reimbursement to the consumer will be available or will be sufficient to allow us to sell our products on a competitive and profitable basis.

- 12 -

Sources of Supply

Most raw materials and other supplies required in our business are generally available from various suppliers in quantities adequate to meet our needs. Certain materials and other supplies required for manufacturing are currently available only from single sources. We intend to identify and qualify alternative sources of supply wherever possible.

Manufacturing

We are able to manufacture multiple protein and antibody drugs for use in research, clinical and commercial activities. We produce and purify these protein and antibody drugs in three process development and manufacturing facilities that total approximately 500,000 square feet and offer both small-scale and large-scale manufacturing capabilities. We manufacture raxibacumab for supply to the Strategic National Stockpile. Under the terms of the 2006 co-development and co-commercialization agreement with GSK, HGS has responsibility for the global supply of BENLYSTA. We believe we have produced sufficient BENLYSTA inventory to meet anticipated global market needs for at least one year, and we believe our large-scale manufacturing facility has sufficient capacity to provide worldwide supply for the next two to three years. However, HGS and GSK also anticipate that additional capacity will be required. In 2010, HGS entered into an agreement with Lonza, a leader in biologics manufacturing, for the future commercial supply of BENLYSTA. This agreement will eventually triple our manufacturing capacity for BENLYSTA with U.S. production expected to come on-line by mid-2013.

Currently each of our lead products, BENLYSTA and raxibacumab, is produced at a single manufacturing site. BENLYSTA is produced at our large-scale manufacturing facility in Rockville, Maryland, and raxibacumab is produced in a separate part of our small-scale manufacturing facility, also in Rockville, Maryland. Each of these facilities is the sole source for these products. We cannot guarantee that one or more of these manufacturing plants will not encounter problems, including but not limited to loss of power, equipment failure or viral or microbial contamination, which could impact our ability to deliver adequate supply of one or more of these products to the market. We cannot assure you that we will be able in the future to consistently manufacture our products economically or in compliance with cGMPs and other regulatory requirements.

In the future, we may contract with additional third-party manufacturers or develop products with partners and use the partners’ manufacturing capabilities. When we use others to manufacture our products, we depend on those parties to comply with cGMPs and other regulatory requirements, and to deliver materials on a timely basis. These parties may not perform adequately. Any failures by these third parties may delay our development of products or the submission of these products for regulatory approval.

Marketing

BENLYSTA was approved on March 9, 2011 by the U.S. Food and Drug Administration (“FDA”) for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. We launched BENLYSTA shortly thereafter and recognized revenue from our first BENLYSTA sales in March 2011. We have hired, trained and deployed a specialized commercial team, including sales, marketing and medical affairs that has a high level of experience and familiarity with rheumatology, biologics and infused products. The combined HGS and GSK team, including a U.S. sales force of approximately 150, is working closely together to communicate effectively with rheumatologists and other stakeholders to ensure that appropriate patients with systemic lupus who need BENLYSTA will have access to it. HGS and GSK are also supporting physicians and patients with reimbursement and access programs.

On July 13, 2011, the European Commission granted marketing authorization for BENLYSTA as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy. BENLYSTA has been launched and is currently available in Canada, Germany, Spain, Austria, Denmark, Finland, Hungary, Norway and Sweden. We expect to launch in France, Italy and other markets in 2012. In addition, regulatory submissions are pending in other countries. We have built our own commercialization team to work alongside GSK in Europe, with HGS headquarters in Switzerland and local organizations in Germany, France and Spain. Elsewhere, GSK will lead local implementation, with HGS sharing costs and profits equally with GSK.

- 13 -

GSK and others also have co-marketing rights with respect to certain of our other products. For any products that we market together with partners, we will rely, in whole or in part, on the marketing capabilities of those parties. We may also contract with third parties to market certain of our products. Ultimately, we and our partners may not be successful in marketing our products. The prices for our products may be impacted by various factors, including economic analyses of the burden of the applicable disease, the perceived value of the product and third-party reimbursement policies.

Employees

As of February 1, 2012, we had approximately 1,100 full-time employees. None of our U.S. employees is subject to collective bargaining agreements. Our employees located in certain non-U.S. countries are covered by collective bargaining agreements that are prescribed by local labor law. Additionally, substantially all of our employees in Europe are covered by national labor laws which establish the rights of employees, including the amount of wages and benefits paid and, in certain cases, severance and similar benefits. We consider relations with our employees to be good.

- 14 -

Item 1A. Risk Factors

A number of risk factors could cause our actual results to differ materially from those that are indicated by forward-looking statements. Those factors include, without limitation, those listed below in addition to the other information in this Annual Report on Form 10-K. You should carefully consider these risk factors in evaluating our business because these risk factors may have a significant impact on our business, financial condition and results of operations. The risks described below are not the only risks we may face. Additional risks and uncertainties not presently apparent to us, or risks that we currently consider immaterial, could also negatively affect our business, financial condition and results of operations.

COMMERCIAL RISKS

Our near-term prospects are highly dependent on the success of BENLYSTA^®, our first FDA-approved product. To the extent we fail to successfully commercialize BENLYSTA, our business, financial condition and results of operations would be materially adversely affected and the price of our common stock would likely decline.

BENLYSTA is our first U.S. Food and Drug Administration (“FDA”) approved product. On March 9, 2011, the FDA approved BENLYSTA for the treatment of adult patients with active, autoantibody-positive systemic lupus erythematosus (“active SLE”). We believe that BENLYSTA product sales may constitute all or most of our total revenue over the next several years.

The degree of market acceptance and commercial success of BENLYSTA and our ability to generate and increase revenues will depend on a number of factors, including the following:

• the number of patients with systemic lupus erythematosus who are diagnosed with the disease, and those that may be treated with BENLYSTA;

• the safety and efficacy of BENLYSTA, our ability to provide acceptable evidence of safety and efficacy, and the perceptions in the medical community, by regulatory agencies and among insurers and other payers of BENLYSTA’s safety and efficacy, on both a short and long-term basis;

• BENLYSTA’s perceived advantages over alternative treatment methods (including relative convenience and ease of administration and prevalence and severity of any adverse events, including any unexpected adverse events of which we become aware);

• the claims, limitations, warnings and other information in BENLYSTA’s labeling;

• our establishment of an effective sales force and the ability of our sales, marketing and other representatives to accurately describe BENLYSTA consistent with its approved labeling;

• BENLYSTA’s price and perceived cost-effectiveness;

• the ability of patients and physicians and other providers to obtain and maintain sufficient coverage and reimbursement by third-party payers, including government payers;

• the receipt and maintenance of marketing approvals from the United States and foreign regulatory authorities;

• the growth of commercial sales in the United States and other countries;

• in the United States, the ability of group purchasing organizations, or GPOs (including distributors and other network providers), to sell BENLYSTA to their constituencies;

- 15 -

• the establishment and maintenance of commercial manufacturing capabilities ourselves or through third-party manufacturers, and our ability to meet commercial demand for BENLYSTA; and

• the effectiveness of our partnership with GlaxoSmithKline (“GSK”) in successfully obtaining foreign regulatory approvals and in marketing and selling BENLYSTA in both the U.S. and abroad.

Although our market research data suggests that there are approximately 200,000 patients in the U.S. who have been diagnosed with moderate-to-severe systemic lupus who may benefit most from BENLYSTA, we cannot predict the extent to which BENLYSTA will be utilized by these patients or other patients in the rest of the world or whether physicians, healthcare insurers or maintenance organizations, or the medical community in general, will accept or utilize BENLYSTA. The potential population of patients eligible for treatment with BENLYSTA may be reduced based on the limitations for use included in the approved Package Insert, including that BENLYSTA is not approved for use in patients with severe active lupus nephritis, severe active central nervous system lupus or those taking intravenous cyclophosphamide or other biologics. Our efforts to educate the medical community and third-party payers regarding the benefits of BENLYSTA will require significant resources and may not be successful in achieving our objectives. If BENLYSTA does not achieve broad market acceptance, the revenues we generate from sales will be limited and our business may not be profitable.

Data generated or analyzed with respect to BENLYSTA in clinical trials or otherwise, including with respect to adverse safety events, may result in decreased demand and lower sales or product recall, withdrawal or regulatory action.

The approval of BENLYSTA by the FDA followed completion of the Phase 3 development program for belimumab. As a condition to obtaining U.S. marketing approval of BENLYSTA, we are required to conduct additional clinical trials. The size and scope of these Phase 4 trials are significant and will be costly. The results generated in these Phase 4 trials and other emerging data about BENLYSTA could result in loss of marketing approval, changes in product labeling, or new or increased concerns about side effects or the efficacy of BENLYSTA that may decrease demand and lower sales. Foreign regulatory agencies may impose comparable post-approval requirements that require significant additional expenditures. For example, based on post-marketing surveillance, we and GSK proposed labeling amendments to FDA and the European regulatory authorities regarding hypersensitivity and infusion reactions. In Europe, GSK and the regulatory authorities have agreed upon the label changes, and GSK has also agreed to send a direct communication to European healthcare providers to inform them of these changes. We are still awaiting FDA’s comments on our proposed label changes. Post-marketing studies and other emerging data about BENLYSTA, such as adverse event reports, may result in other label changes and may adversely affect sales or result in withdrawal of BENLYSTA from the market. Furthermore, the discovery of significant problems with a product or class of products similar to BENLYSTA could have an adverse effect on the sales of BENLYSTA.

In addition, new data and information, including information about product misuse, may lead government agencies, professional societies, practice management groups or organizations involved in various diseases to publish guidelines or recommendations related to the use of BENLYSTA or place restrictions on sales. Such guidelines or recommendations may lead to lower sales of BENLYSTA.

If we are unable to obtain marketing approvals for BENLYSTA in additional jurisdictions, or if we are significantly delayed or limited in doing so, our results of operations and business will be materially and adversely affected and our stock price would likely decline.

In July 2011, we received marketing approval for BENLYSTA in both the European Union and in Canada. Regulatory applications have also been submitted and are currently under consideration in a number of other countries. Despite approval by the FDA and certain other jurisdictions, we cannot offer any assurances or predict with any certainty that other regulatory authorities will grant marketing approval for BENLYSTA, or the expected timeframe of such approvals. Furthermore, as was the case with FDA approval, other regulatory approvals, even if obtained, may be limited to specific indications, limit the type of patients in which the drug may be used, or otherwise require specific warning or labeling language, any

- 16 -

of which might reduce the commercial potential of BENLYSTA. Regulatory authorities may condition BENLYSTA marketing approval on the conduct of specific post-marketing studies to further evaluate safety and efficacy, in either particular patient populations or general patient populations or both. The results of these studies, discovery of previously unknown issues involving safety or efficacy or failure to comply with post-approval regulatory requirements, including requirements with respect to manufacturing practices, reporting of adverse effects, advertising, promotion and marketing, may result in restrictions on marketing of BENLYSTA or withdrawal of BENLYSTA from the market.

If we are unable to obtain approval for expansion of the labeled uses for BENLYSTA, we may not be able to recognize the value of the product in other indications.

BENLYSTA is a human monoclonal antibody that recognizes and inhibits the biological activity of B-lymphocyte stimulator, or BLyS, and was developed as a treatment for systemic lupus erythematosus. In March 2011, the FDA approved BENLYSTA for the treatment of active SLE. We and our partner intend to conduct new clinical trials for additional approved, or labeled, uses of BENLYSTA, such as vasculitis and other autoimmune indications and seek expansion of the labeled uses in the U.S. and in other countries. We and our partner also intend to conduct additional clinical trials for alternative delivery mechanisms. If we are not able to obtain approval for label expansion or alternative delivery mechanisms, we will have incurred significant clinical trial costs without corresponding benefits, our stock price may suffer and our business and financial condition could be materially and adversely affected.

We may be unable to maintain or to expand our commercial manufacturing capability and may be unable to obtain required quantities of our products for commercial use.

Except for raxibacumab and quantities of BENLYSTA manufactured to build our inventory of BENLYSTA in support of commercialization, we have limited experience manufacturing materials suitable for commercial use. The FDA and equivalent foreign regulatory organizations must determine that our facilities comply with cGMP requirements for commercial production to license them for a particular product. Although the FDA has licensed our facility for the manufacture of BENLYSTA, the FDA will routinely re-inspect our facilities for such compliance. We may not successfully establish sufficient manufacturing capabilities or manufacture our products economically or in continuing compliance with cGMPs and other regulatory requirements. For example, we believe that we have sufficient manufacturing capacity to supply commercial quantities of BENLYSTA for the next several years. In 2010, we entered into a manufacturing agreement with Lonza Sales AG pursuant to which Lonza will manufacture additional commercial quantities of BENLYSTA. However, this additional manufacturing capacity may not be available for 12 months or longer, if ever, due, in part, to the time required to obtain regulatory approvals for the manufacture of BENLYSTA in Lonza’s facility. If Lonza’s facility fails to obtain regulatory approval in a timely manner or at all, we may not be able to build or procure additional capacity in the required timeframe to meet commercial demand, and our revenues may accordingly be limited from BENLYSTA. Our revenues from BENLYSTA also will be limited if the demand for BENLYSTA exceeds our capacity to supply BENLYSTA to patients.

BENLYSTA is solely produced at our large-scale manufacturing facility in Rockville, Maryland and raxibacumab is solely produced at our small-scale manufacturing facility, which is also in Rockville, Maryland. We currently depend on single source vendors for certain components used in BENLYSTA and raxibacumab. Furthermore, the filling, finishing and packaging for both BENLYSTA and raxibacumab are solely performed by a single third party manufacturer. We cannot guarantee that one or more of these plants or vendors will not encounter problems, including but not limited to loss of power, equipment failure, component defects or viral or microbial contamination, which could adversely affect our ability to deliver adequate supply of one or more of these products to patients or customers.

If we or our third-party manufacturers fail to comply with regulatory requirements imposed on our manufacturing activities, it could have a material adverse effect on our business, financial condition and results of operations.

We have previously engaged third-party manufacturers or utilized our collaboration partners’ manufacturing capabilities to manufacture products and we expect to continue to do so in the future. If we

- 17 -

use others to manufacture our products, we will depend on those parties to comply with cGMPs and other regulatory requirements and to deliver materials on a timely basis. In addition, because regulatory approval to manufacture a drug is generally site-specific, the FDA and other regulatory authorities will routinely inspect our manufacturing facilities and our current and future third-party manufacturers’ facilities for compliance with cGMPs. If we or our third-party manufacturers fail to comply with applicable regulatory requirements, a regulatory agency may: issue warning letters; suspend or withdraw our regulatory approval for approved or in-market products; seize or detain products or recommend a product recall; refuse to approve pending applications or supplements to approved applications filed by us; suspend any of our ongoing clinical trials; impose restrictions or obligations on our operations, including costly new manufacturing requirements; close our facilities or those of our contract manufacturers; revoke previously granted drug approvals under certain circumstances; or impose civil or criminal penalties. Any of these actions could delay our development of products, the submission of these products for regulatory approval or result in insufficient product quantity to support commercial demand. As a result, our business, financial condition and results of operations could be seriously harmed.

We maintain high levels of inventory that decrease our liquidity and substantially increase the risk of write-offs.

We maintain inventory levels in excess of twelve months to mitigate risks such as product shortage due to higher than anticipated product demand, long lead times for manufacturing finished goods, supply interruptions for raw materials and risks of production disruptions at our sole U.S. FDA-approved manufacturing site due to contamination, equipment failure or other facility-related issues. We commit capital to maintain these high inventory levels, which prevents us from using that capital for other purposes, such as research and development, and requires us to utilize more capital than might otherwise be required. Increased inventory levels also impact our liquidity and cash flows since the inventory will not be converted to cash for more than one year. Our high inventory levels also heighten the risk of inventory obsolescence and write-offs.

Various factors may cause us to be unable to price or sell our products effectively. This could have a material adverse effect on our business, financial condition and results of operations.

Although we have priced BENLYSTA for the U.S. and certain other markets, we can provide no assurance as to the maintenance of these prices or that similar prices may be set for BENLYSTA in other markets upon foreign approvals. In the U.S. market we have priced BENLYSTA at approximately $443.00 for a 120 mg vial and approximately $1,477.00 for a 400 mg vial. Thus, the average price for an annual course of treatment in the U.S. (based on a patient weight of 161 pounds) would be approximately $35,000. U.S. sales of BENLYSTA are subject to various rebates, chargebacks and other deductions that will affect the revenue recognized from these sales. In Germany, the average price for an annual course of treatment (based on the same patient weight) would be approximately €23,000 (or approximately U.S. $30,900). The net price of BENLYSTA in Germany, subject to review by the German health insurance authorities, would be approximately €14,700 (or approximately U.S. $19,800) due to distribution and other costs and a required 16% rebate applicable to all pharmaceutical products. In Spain, the average price for an annual course of treatment (based on the same patient weight) would be approximately €12,000 (or approximately U.S. $16,100). The prices quoted above reflect an exchange rate of 1.34 dollars per euro. The price of BENLYSTA in other countries is and may be significantly lower than these prices. In addition, the prices for our products may be affected by various factors that could adversely affect our sales and profit margins, including economic analyses of the burden of the applicable disease, the perceived value of the product and third party reimbursement policies.

BENLYSTA is currently our only commercially marketed product, although we have sold raxibacumab to the U.S. Government. BENLYSTA is being marketed together with our collaborator, GSK. If we receive approval for other products that can be marketed, we may market the products either independently or together with collaborators or strategic partners. Whether we market a product independently or in collaboration with a strategic partner, we will incur significant additional expenditures and commit significant additional resources to establish and sustain the sales forces. For any products that we market together with partners, we will rely, in whole or in part, on the marketing capabilities of those parties. We may also contract with third parties to market certain of our products. We may be unable to retain an adequate number of qualified sales representatives and may encounter difficulties in retaining third parties to provide sales, marketing or distribution resources. Ultimately, we and our partners may not be successful in marketing our products.

- 18 -

Reimbursement policies or changes in health care systems and payer policies may result in a decline in our potential sales and a reduction in our expected revenue from our potential products.

The revenues and profitability of biopharmaceutical companies like ours may be affected by the continuing efforts of government and third-party payers to contain or reduce the costs of health care through various means. For example, in certain foreign markets pricing or profitability of therapeutic and other pharmaceutical products is subject to governmental control. In the United States, there have been, and we expect that there will continue to be, a number of federal and state proposals to implement similar governmental control. Recent United States legislation, rules and regulations instituted significant changes to the United States healthcare system that could have a material adverse effect on our business, financial condition and profitability. We cannot predict what effects, if any, this legislation might have on our company and our products as this legislation is implemented over the next few years, nor can we predict whether additional legislative or regulatory proposals may be adopted.

In addition, in the United States and elsewhere, sales of therapeutic and other pharmaceutical products depend in part on the availability of reimbursement and access to the consumer from third-party payers, such as government and private insurance plans. Third-party payers are increasingly challenging the prices charged for medical products and services. Third-party payers may limit access to pharmaceutical products through the use of prior authorizations and step therapy. Any reimbursement granted may not be maintained or limits on reimbursement available from third parties may reduce the demand for or negatively affect the price and profitability of those products. Payers may pursue aggressive cost cutting initiatives such as comparing the effectiveness, benefits and costs of similar treatments, which could result in lower reimbursement. For example, draft guidance issued in September 2011 by the United Kingdom (“U.K.”) National Institute for Health and Clinical Excellence (“NICE”) does not recommend BENLYSTA for patients with active SLE in England and Wales because NICE does not consider it to be a cost-effective use of National Health Service resources. Policies that decrease reimbursement would likely have a material adverse effect on our business, financial condition and results of operations. Our ability to successfully commercialize our products and product candidates and the demand for our products depend, in part, on the extent to which reimbursement and access is available from such third-party payers.

Because raxibacumab is a product whose current sole purchaser is the U.S. Government, the sale of raxibacumab faces risks in addition to the risks generally associated with the sale of biopharmaceutical products, including political considerations, government contracting requirements and government spending policies.

Raxibacumab, a human monoclonal antibody developed for use in the treatment of anthrax disease, presents risks in addition to those associated with our other products. Numerous other companies and governmental agencies are known to be developing biodefense pharmaceuticals and related products to combat anthrax disease. These competitors may have financial or other resources greater than ours, they may have easier or preferred access to the likely distribution channels for biodefense products or they may develop products judged to have greater efficacy for biodefense. In addition, since the primary purchaser of biodefense products is the U.S. Government and its agencies, the success of raxibacumab will depend on government spending priorities, policies and pricing restrictions. In the case of the U.S. Government, executive or legislative action could attempt to impose production and pricing requirements on us. In the event of extreme urgency, the government might seek to compel us or we might ourselves choose to reallocate our production in ways that may not be economically beneficial to the company.

We have entered into a two-phase contract to supply raxibacumab to the U.S. Government, which may be terminated by the U.S. Government at any time. Under the first phase of the contract, we supplied ten grams of raxibacumab to the U.S. Department of Health and Human Services (“HHS”) for comparative in vitro and in vivo testing. Under the second phase of the contract, the U.S. Government ordered 20,001 doses of raxibacumab for the U.S. Strategic National Stockpile (“SNS”) for use in the treatment of anthrax disease. We completed delivery of these doses and the U.S. Government accepted our deliveries. In July 2009, the U.S. Government agreed to purchase 45,000 additional doses. As of December 31, 2011, we have delivered approximately 37,100 doses of this second order. We, therefore, have future deliveries to make and ongoing obligations under the contract, including the obligation to seek FDA approval.

- 19 -

In November 2009, we received a Complete Response Letter from the FDA related to our Biologics License Application (“BLA”) for raxibacumab. In this letter, the FDA determined that it would not approve our BLA for raxibacumab in its present form and requested additional studies and data. Although the government has accepted shipment of raxibacumab subsequent to the receipt of the FDA’s Complete Response Letter, we cannot assure you that the government will continue to accept future shipments or place additional orders.

We will continue to face risks related to the requirements of the contract. If we are unable to meet our obligations associated with this contract, the U.S. Government will not be required to make future payments related to that order. Although we have received U.S. Government approval for two orders of raxibacumab, we cannot assure you we will receive additional orders.

In December 2011, the U.S. Government issued a Sources Sought Notice seeking information from manufacturers of anthrax antitoxin medical countermeasures. In December 2011, we responded to this notice with information on our continuing ability and willingness to supply raxibacumab to the U.S. Government. We expect the U.S. Government to issue a request for proposals related to the procurement of anthrax antitoxins, such as raxibacumab. HGS intends to respond to this request. We cannot assure you that the U.S. Government will issue the request for proposals or, if it does, whether the U.S. government will award an additional order for raxibacumab.

In late 2011, we completed the manufacture of all bulk raxibacumab required for the second order and then initiated manufacturing of bulk raxibacumab in anticipation of a third order. If the U.S. Government does not award us a third order, then we will not receive revenue from this manufacturing and will have incurred additional manufacturing expenses.

If we are unable to successfully commercialize BENLYSTA or other product candidates we develop, we may not be able to recover our investment in our research, product development, manufacturing and marketing efforts.

In March 2011, we received approval from the FDA to market BENLYSTA in the United States. We have made and continue to make substantial expenditures with respect to BENLYSTA and our product candidates. We have invested significant time and resources to isolate and study genes and determine their functions. We devote substantial resources to developing proteins, antibodies and small molecules for the treatment of human disease. Before we can commercialize a product, we must rigorously test the product in the laboratory and complete extensive animal and human clinical studies. We are also devoting substantial resources to enhancing our manufacturing capabilities and to building our commercial supply inventories of BENLYSTA to support commercialization. We have and expect to continue to devote substantial resources to maintain our marketing capability for BENLYSTA and any of our other products that are approved by the FDA or other regulatory authorities. If any product we develop is not approved for commercial sale, we may be unable to recover the large investment we have made in research, development, manufacturing and marketing efforts, and our business and financial condition could be materially adversely affected.

Our forecasting of sales of BENLYSTA may continue to be difficult due to uncertainty around the rate of adoption. If our BENLYSTA revenue projections are inaccurate and our business forecasting and planning decisions do not reflect our actual results, our business may be harmed and our stock price may be adversely affected.

Our business planning requires us to forecast demand and revenues despite numerous uncertainties. Actual results of operations may deviate materially from projected results. For example, our 2011 BENLYSTA revenue was lower than anticipated. This may have been a result of factors such as: patient and physician unfamiliarity with the new drug, perhaps exacerbated by lack of experience with new drugs for SLE; cautious prescribing behavior due to lack of reimbursement history for the product and recent examples of infused rheumatology products that were subject to widespread reimbursement delays or

- 20 -

payment refusals; a need to reorient physician treatment algorithms toward reducing SLE disease activity by addressing the underlying mechanism rather than selecting therapies for specific manifestations; confusion regarding the clinical relevance of the complex composite endpoints used in the BENLYSTA clinical trials and a broad indication, causing physicians to have difficulty in identifying appropriate patients for treatment with BENLYSTA; and a general need for physician education regarding SLE and treatment modalities due to the novelty of the treatment and the absence of a new option for the treatment of SLE for decades. The extent to which any of these factors individually or in the aggregate will continue to impact future sales of BENLYSTA is uncertain and difficult to predict. This may lead to lower than expected revenue, inefficiency in expenditures and increased difficulty in operational planning. Our expenses are relatively fixed in the short term. Shortfall in our revenue has a direct impact on our cash flow and on our business generally. In addition, fluctuations in our quarterly results can adversely affect the market price of our common stock and our ability to finance our operations.

COMPETITIVE RISKS

Our competitors may develop and market products that are, or are perceived as, less expensive, or more effective, or safer, or easier to administer or reach the market sooner. This may diminish or eliminate the commercial success of any products we may commercialize.

Key factors affecting the success of any approved product include its efficacy, safety profile, drug interactions, method and frequency of administration, pricing, reimbursement and level of promotional activity relative to those of competing products. Existing and any future competing products may provide greater therapeutic convenience or clinical or other benefits for a specific indication than our products, or may offer comparable performance at a lower cost. The introduction of more efficacious, safer, cheaper, or more convenient alternatives to our products could reduce our revenues and the value of our product development efforts or could render our technology, products or product candidates under development noncompetitive, uneconomical or obsolete.

We are aware of existing products and products in research or development by others that address the diseases we are targeting. Any of these products may compete with our product candidates. For example, a number of pharmaceutical and biotechnology companies are currently developing products targeting the same types of indications that we are targeting with BENLYSTA, and some of these competitors’ products are in clinical trials.

If we successfully develop products but those products do not achieve and maintain market acceptance, our business will not be successful. Any reduction in demand for our products as a result of a competing product could lead to reduced revenues, reduced margins, reduced levels of profitability, and loss of market share for our products. These competitive pressures could adversely affect our business and operating results.

The development and commercialization of biopharmaceutical products is highly competitive and subject to rapid technological advances. We will face competition with respect to all products we may develop or commercialize from pharmaceutical and biotechnology companies worldwide. We also expect increasing competition from governments, universities and other non-profit research organizations. These institutions conduct a significant amount of research and development in the field of biologic technologies and are increasingly aware of the commercial value of their findings. As a result, they are demanding greater patent and other proprietary rights, as well as licensing and future royalty revenues.

Many of our competitors have significantly greater financial, research and development, intellectual property estates, regulatory, manufacturing, marketing, sales and other resources than we do. As a result, our competitors may succeed in developing their products before we do and obtaining approvals from the FDA or other regulatory agencies for their products more rapidly than we do. They may be able to devote greater resources to the development, manufacture, marketing and sale of their products. They may initiate or withstand substantial price competition or otherwise more successfully market their products. Competing products or technologies might render our technology or product candidates under development noncompetitive, uneconomical or obsolete.

- 21 -

We may also face risks to our profitability and financial condition from generic drug or biosimilar manufacturers.

The United States has enacted legislation establishing a regulatory pathway for follow-on biologics, also known as biosimilars. This and similar regulatory and legislative activity in other countries may make it easier for generic drug manufacturers to manufacture and sell biological drugs similar or identical to BENLYSTA and raxibacumab which might affect the profitability or commercial viability of our products. An accelerated route to market for generic versions of small molecule drugs was established in the United States with the passage of the Hatch-Waxman Amendments in 1984, which also provides five years of exclusivity for small molecule drugs with additional exclusivity under certain circumstances. The passage of the Biologics Price Competition and Innovation Act (“BPCIA”) in March 2010 established a similar pathway for FDA approval of a follow-on biologic that provides 12 years of exclusivity for the original biologic and an additional six month exclusivity period if certain pediatric studies are conducted. The FDA recently released draft guidance regarding the implementation of this legislation, on which it is seeking public comment. The FDA may release additional guidance or regulations to implement this legislation, which may not be favorable to us. Moreover, additional legislation could adversely affect the period of exclusivity for an original biologic. For example, the Obama Administration has proposed reducing the period of exclusivity to seven years and prohibiting additional exclusivity periods for a given biologic product. The European Medicines Agency has issued guidelines for approving products through an abbreviated pathway under which more than ten biosimilars have been approved. European legislation provides ten years of exclusivity for original drugs, including biologics, and an additional one year of exclusivity for obtaining marketing approval for certain additional indications. If a generic or biosimilar version of one of our products were approved, it could have a material adverse effect on the sales and gross profits of the product and adversely affect our business and operating results.

PRODUCT DEVELOPMENT RISKS

Our product development efforts depend on new technologies, which may not prove successful.

Our development of new products may depend on the use of cutting-edge, recently discovered technologies that may not previously have been successfully utilized in existing commercial products. As a result, our product development efforts involve risks of failure inherent in the use of innovative and unproven technologies and the risks associated with drug development generally. These risks include the possibility that:

• these technologies or any or all of the molecules based on these technologies may be ineffective or toxic and, therefore, expose us to litigation or fail to receive or retain necessary regulatory clearances;

• the products, even if safe and effective, may be difficult to manufacture on a large scale or uneconomical to market;

• proprietary rights of third parties may prevent us or our collaborators from exploiting technologies or marketing products; and

• third parties may market superior or equivalent products.

We have limited experience in developing and commercializing products, and we may be unsuccessful in our efforts to develop other products or new indications for BENLYSTA that will be commercially successful.

Although we are or will be conducting human studies with respect to a number of products, including potential new indications for BENLYSTA, we may not be successful in developing or commercializing any of these products or indications. We will continue to incur substantial expenditures relating to research, development, clinical studies and manufacturing efforts relating to these products, for new products and for new indications for BENLYSTA. Our ability to develop and commercialize products based on proteins, antibodies and small molecules will depend on our abilities to:

• successfully complete laboratory testing and human studies;

- 22 -

• obtain and maintain necessary intellectual property rights to our products;

• obtain and maintain necessary regulatory approvals related to the efficacy and safety of our products;

• maintain production facilities meeting all regulatory requirements or enter into arrangements with third parties to manufacture our products on our behalf; and

• deploy sales and marketing resources appropriately, efficiently and effectively or enter into arrangements with third parties to provide these functions.

We may not be successful in developing any new products or developing BENLYSTA for new indications or obtaining required regulatory approvals. Even if regulatory approval is obtained for the commercial sale of a product or a new indication for BENLYSTA, it could take considerable time following approval, if ever, before we are likely to receive revenue from product sales or substantial royalty payments.

We are continually evaluating our business strategy and may modify this strategy in light of developments in our business and other factors.

Our ability to discover and develop new products depends on our internal research capabilities and our ability to acquire products. Although we continue to conduct research and development activities on products and have increased our activities in this area, our limited resources may not be sufficient to discover and develop new product candidates.

We continue to evaluate our business strategy and, as a result, may modify our strategy in the future. In this regard, we may, from time to time, focus our product development efforts on different products or may delay or halt the development of various products, as we and our partner Novartis did with ZALBIN in 2010. In addition, as a result of changes in our strategy, we may also change or refocus our existing drug discovery, development, commercialization and manufacturing activities. This could require changes in our facilities and personnel and restructuring various financial arrangements. We cannot assure you that any product development changes that we implement will be successful.

Clinical trials for our products are expensive and protracted and their outcome is uncertain. We must invest substantial amounts of time and money that may not yield viable products.

Conducting clinical trials is a lengthy, time-consuming and expensive process. Before obtaining regulatory approvals for the commercial sale of any product we must demonstrate through laboratory, animal and human studies that the product is both effective and safe for use in humans. We will incur substantial expense and devote a significant amount of time to conducting ongoing trials and initiating new trials.

Before clinical testing in humans can begin, a drug must be subject to rigorous preclinical testing and documentation. This documentation must be reviewed by the FDA as part of an Investigational New Drug Application (“IND”). Data obtained from tests are susceptible to varying interpretations that may delay, limit or prevent regulatory approval. Furthermore, regulatory authorities may refuse or delay approval as a result of many factors, including changes in regulatory policy during the period of product development. Even if an IND is approved, preclinical studies do not assure clinical success. Many potential drugs have shown promising results in early testing but subsequently failed to obtain necessary regulatory approvals.

Clinical trials may take many years. The time required varies substantially according to the type, complexity, novelty and intended use of the product candidate. The progress of clinical trials is monitored by both the FDA and independent data monitoring committees that may require the modification, suspension or termination of a trial if it is determined to present excessive risks to patients. Our rate of commencement and completion of clinical trials may be delayed by many factors, including:

• financial and personnel resources to conduct or complete trials;

- 23 -

• our inability to manufacture sufficient quantities of materials for use in clinical trials;

• unavailability or variability in the number and types of patients for each study;

• difficulty in maintaining contact with patients after treatment, resulting in incomplete data;

• safety issues or side effects;

• ineffectiveness of products during the clinical trials; or

• government or regulatory delays.

Data obtained from our clinical trials may not be sufficient to support an application for regulatory approval without further studies.

Studies conducted by us or by third parties on our behalf may not demonstrate sufficient effectiveness and safety to obtain the requisite regulatory approvals for these or any other potential products. For example, we had been developing ZALBIN for many years. In 2010, we and our collaboration partner Novartis decided to end further development of ZALBIN in anticipation of a Complete Response Letter from the FDA in which we expected the FDA to conclude that our existing ZALBIN data would not support approval of our BLA. Additionally, in November 2009, we received a Complete Response Letter from the FDA related to our BLA for raxibacumab. In this letter, the FDA determined that it could not approve the BLA in its present form and requested additional studies and data that would be needed prior to the FDA making a decision as to whether or not to approve the raxibacumab BLA. For raxibacumab, we may not be able to complete the requested studies or to generate the required data in a timely manner, if at all. If we do not complete the additional studies and generate the additional data within the time required by the FDA, we may be required to withdraw our existing BLA and resubmit our BLA after completion of such studies. This will start a new review cycle. Even if we can complete such studies and generate such data, the studies and data may not be sufficient for FDA approval. Even if FDA or other regulatory approval is obtained for a product candidate, it may be limited to specific indications, limit the type of patients in which the drug may be used, or otherwise require specific warnings or labeling language, any of which might reduce the commercial potential of the product.

We depend on third parties to conduct many of our clinical trials, and we may encounter delays in or lose some control over our efforts to develop products.

We are dependent on third-party research organizations to enroll qualified patients and conduct, supervise and monitor many of our clinical trials. Our reliance on these service providers does not relieve us of our regulatory responsibilities, including ensuring that our clinical trials are conducted in accordance with good clinical practice regulations and the plan and protocols contained in the relevant regulatory application. In addition, these organizations may not complete activities on schedule or may not conduct our preclinical studies or clinical trials in accordance with regulatory requirements or our trial design. If we are unable to obtain any necessary services on acceptable terms or if these service providers do not successfully carry out their contractual duties or meet expected deadlines, our efforts to obtain regulatory approvals for our product candidates may be delayed or prevented.

- 24 -

RISK FROM COLLABORATION RELATIONSHIPS AND STRATEGIC ACQUISITIONS

Our plan to use collaborations to leverage our capabilities may not be successful if we are unable to integrate our partners’ capabilities with our operations or if our partners’ capabilities do not meet our expectations.

As part of our strategy, we intend to continue to evaluate strategic partnership opportunities. In order for our future collaboration efforts to be successful, we must first identify partners whose capabilities complement and integrate well with ours. Technologies to which we gain access may prove ineffective or unsafe. Ownership of these technologies may be disputed. Our current agreements that grant us access to such technology may expire and may not be renewable or could be terminated if we or our partners do not meet our respective obligations. In addition, our partners may provide certain services for us, such as distribution services. These agreements are subject to differing interpretations and we and our partners may not agree on the appropriate interpretation of specific requirements. Our partners, among other things, may prove difficult to work with, less effective than we originally expected or unable to satisfy their financial and other commitments to us. Failure of our partners to perform as needed could place us at a competitive disadvantage.

We may not be able to generate substantial revenue from agreements with our current or future collaboration partners.

To date we have received substantial revenue from payments made under collaboration agreements with GSK and, to a lesser extent, other agreements. The research term of our initial GSK collaboration agreement and many of our other collaboration agreements expired in 2001. None of the research terms of these collaboration agreements was renewed and we may not be able to enter into additional collaboration agreements. While our partners under our initial GSK collaboration agreement have informed us that they have been pursuing research programs involving different genes for the creation of small molecule, protein and antibody drugs, we cannot assure you that any of these programs will continue or will result in any approved drugs. If our partners are unsuccessful in such research and development efforts, we will not receive any revenue from the development or commercialization of these assets.

Under our present collaboration agreements, we are entitled to certain commercialization rights, milestones and/or royalty payments based on our partners’ development of the applicable product. We may not receive revenue under these agreements if our collaborators fail to:

• develop marketable products;

• obtain regulatory approvals for products; or

• successfully market products.

Further, circumstances could arise under which one or more of our collaboration partners may allege that we breached our agreement with them and, accordingly, seek to terminate our relationship with them. Our collaboration partners may also terminate these agreements without cause or if competent scientific evidence or safety considerations do not justify moving the applicable product forward. If one or more of these agreements terminate, this could adversely affect our ability to commercialize our products and harm our business.

If one of our collaborators pursues a product that competes with our products, there could be a conflict of interest and we may not receive expected milestone or royalty payments.

Each of our collaborators is developing a variety of products, some with other partners. Our collaborators may pursue existing or alternative technologies to develop drugs targeted at the same diseases instead of using our licensed technology to develop products in collaboration with us. Our collaborators may also develop products that are similar to or compete with products they are developing in collaboration with us. If our collaborators pursue these other products instead of our products, we may not receive milestone or royalty payments.

- 25 -

Our efforts to acquire other biotechnology companies or in-license and develop additional product candidates may not be successful. This could have a material adverse effect on our business, financial condition and results of operations.

Our business strategy may include the acquisition of other biotechnology companies or in-license of additional product candidates to complement and supplement our existing product pipeline, and we may acquire such companies and in-license additional product candidates that have demonstrated positive pre-clinical and/or clinical data. We may not be successful in identifying, effectively evaluating, acquiring or in-licensing, and developing additional product candidates on appropriate terms. In addition, product in-licensing involves inherent risks, including uncertainties due to matters that may affect the successful development or commercialization of the in-licensed product as well as the possibility of contractual disagreements with regard to terms such as patent rights, license scope or termination rights. Competition for attractive product opportunities is intense and may require us to devote substantial resources, both managerial and financial, to a product opportunity. Even if we are successful in acquiring a product candidate, it may not result in a successfully developed, or commercialized, product. Moreover, the cost of acquiring other companies or in-licensing product candidates could be substantial and in order to acquire companies or new products we may need to raise additional financing, which if it involves the issuance of additional shares of our common stock would dilute existing stockholders. In March 2011, we entered into a development and commercialization agreement with FivePrime Therapeutics, Inc. (“FivePrime”) to develop a product for multiple cancers. We paid FivePrime an upfront license fee of $50 million and could be required to pay up to $445 million in future development, regulatory and commercial milestone payments. However, there can be no assurance that we will be able to develop and commercialize such a product or ever be able to recover our initial or subsequent investment in the development of this product. If we are unsuccessful in our efforts to acquire other companies or in-license and develop additional product candidates, or if we acquire or license unproductive assets, it could have a material adverse effect on the growth of our business.

In order to achieve the anticipated benefits of an acquisition, we must integrate the acquired company’s business, technology and employees in an efficient and effective manner. The successful combination of companies in a rapidly changing biotechnology industry may be more difficult to accomplish than in other industries. The combination of two companies requires, among other things, integration of the companies’ respective technologies and research and development efforts. We cannot assure you that this integration will be accomplished smoothly or successfully. The difficulties of integration may be increased by any need to coordinate geographically separated organizations and address differences in corporate cultures and management philosophies. The integration of certain operations will require the dedication of management resources and, accordingly, may temporarily distract attention from the day-to-day operations of the combined companies. The business of the combined companies may also be disrupted by employee retention uncertainty and lack of focus during integration. The inability of management to integrate successfully the operations of the two companies, in particular, the integration and retention of key personnel, or the inability to integrate successfully two technology platforms, could have a material adverse effect on our business, results of operations and financial condition.

REGULATORY AND COMPLIANCE RISKS

If we fail to comply with the extensive health care legal and regulatory requirements applicable to us, we may be subject to significant liability.

Our activities, and the activities of our agents, including some contracted third parties, are subject to extensive government regulation and oversight both in the U.S. and in foreign jurisdictions. As discussed in other risk factors, the FDA directly regulates many of our business activities, including the conduct of preclinical and clinical studies, product manufacturing, advertising and promotion, product distribution, and adverse event reporting. Additionally, our interactions in the U.S. or abroad with physicians and other potential referral sources that prescribe or purchase our products are also subject to government regulation designed to prevent health care fraud and abuse. Relevant U.S. laws include:

• the Anti-Kickback Law, which prohibits persons from, among other things, knowingly and willfully soliciting, receiving, offering or paying remuneration, directly or indirectly, in exchange for or to induce either the referral of an individual for, or the purchase, order or recommendation of, any good or service for which payment may be made under federal health care programs, such as the Medicare and Medicaid programs;

- 26 -

• federal false claims laws which prohibit individuals or entities from, among other things, knowingly presenting, or causing to be presented, claims for payment to the government or its agents that are false or fraudulent;

• laws that require transparency regarding financial arrangements with health care professionals, such as the reporting and disclosure requirements imposed by the Patient Protection and Affordable Care Act (“PPACA”) that will take effect in 2012 and state laws that are currently in effect; and

• state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws which may apply to items or services reimbursed by state health insurance programs or any third-party payer, including commercial insurers.

Moreover, recent health care reform legislation has increased the risks and consequences for some of these laws. For example, PPACA provides that the government may assert that a claim, which includes items or services resulting from a violation of the Federal Anti-Kickback Law constitutes a “false” or fraudulent claim for purposes of the Federal False Claims Act and other federal false claims statutes.

The FDA, the Office of Inspector General for the Department of Health and Human Services, the Department of Justice, states’ Attorneys General and other governmental authorities actively enforce the laws and regulations discussed above. In the U.S., pharmaceutical and biotechnology companies have been the target of numerous government prosecutions and investigations alleging violations of law, including claims asserting impermissible off-label promotion of pharmaceutical products, payments intended to influence the referral of federal or state health care business, submission of false claims for government reimbursement, or submission of incorrect pricing information.

Violations of any of the laws described above or any other applicable governmental regulations and other similar foreign laws may subject us, our employees or our agents to criminal and/or civil sanctions, including fines, civil monetary penalties, exclusion from participation in government health care programs (including Medicare and Medicaid), and the restriction or restructuring of our operations, any of which could adversely affect our ability to operate our business and our financial results. Additionally, whether or not we have complied with the law, an investigation into alleged unlawful conduct may incur significant expense, cause reputational damage, divert management time and attention, and otherwise adversely affect our business. While we have developed and instituted a corporate compliance program, we cannot guarantee that we, our employees, our consultants, contractors, or other agents are or will be in compliance with all applicable U.S. or foreign laws.

Furthermore, we expect there will continue to be federal and state laws and/or regulations, proposed and implemented, that could impact our operations and business. The extent to which future legislation or regulations, if any, relating to health care fraud abuse laws and/or enforcement, may be enacted or what effect such legislation or regulation would have on our business remains uncertain.

Our growing international operations increase our risk of exposure to potential claims of bribery and corruption.

Failure to comply with applicable legislation such as the U.S. Foreign Corrupt Practices Act and the recently enacted U.K. Bribery Act and other similar foreign laws could expose us and senior management to civil and criminal penalties, potential debarment from public procurement, and reputational damage, any of which could materially and adversely affect our business. While we have developed and instituted a corporate compliance program, we cannot guarantee that we, our employees, our consultants, contractors, or other agents are or will be in compliance with all applicable U.S. or foreign laws.

Because we are subject to extensive and changing government regulatory requirements, we may not be able to obtain regulatory approval of our product candidates in a timely manner, if at all.

Regulations in the United States and other countries have a significant impact on our research, product development and manufacturing activities and will be a significant factor in the marketing of our products. All of our products require regulatory approval prior to commercialization. In particular, our products are

- 27 -

subject to rigorous preclinical and clinical testing and other premarket approval requirements by the FDA and similar regulatory authorities in other regions, such as Europe and Asia. Various statutes and regulations also govern or influence the manufacturing, safety, labeling, storage, record keeping and marketing of our products. The lengthy process of seeking these approvals, and the subsequent compliance with applicable statutes and regulations, require the expenditure of substantial resources. Any failure by us to obtain, or any delay in obtaining, regulatory approvals could materially adversely affect our ability to commercialize our products in a timely manner, or at all.

United States Regulatory Approval. Before a product can be marketed in the United States, the results of the preclinical and clinical testing must be submitted to the FDA for approval. This submission will be either a new drug application (“NDA”) or a BLA, depending on the type of drug. In responding to an application, the FDA may grant marketing approval, request additional information or deny the application if it determines that the application does not provide an adequate basis for approval. In March 2011 we received marketing approval for BENLYSTA from the FDA. We cannot assure you that any approval required by the FDA for any other product candidates will be obtained on a timely basis, or at all.

Furthermore, regulatory approvals, even if obtained, may be limited to specific indications, limit the type of patients in which the drug may be used, or otherwise require specific warning or labeling language, any of which might reduce the commercial potential of the product and materially adversely affect our results of operations and business.

The FDA may condition marketing approval on the conduct of specific post-marketing studies to further evaluate safety and efficacy, including in particular patient populations. Rigorous and extensive FDA regulation of pharmaceutical products continues after approval, particularly with respect to compliance with cGMPs, reporting of adverse effects, advertising, promotion and marketing. Discovery of previously unknown problems or failure to comply with the applicable regulatory requirements may result in restrictions on the marketing of a product or withdrawal of the product from the market as well as possible civil or criminal sanctions, any of which could materially adversely affect our business. In addition, such post-marketing studies may be expensive, time-consuming and difficult to complete in a timely fashion, any of which may limit our ability to develop other indications of existing products as well as indications for new products.

Foreign Regulatory Approvals. We must obtain regulatory approval by governmental agencies in other countries prior to commercialization of our products in those countries. Foreign regulatory systems may be rigorous, costly and uncertain. In July 2011, we received marketing approval for BENLYSTA in both the European Union and in Canada. Regulatory applications have also been submitted and are currently under consideration in a number of other foreign countries. Foreign regulatory approvals, even if obtained, may be limited to specific indications, limit the type of patients in which the drug may be used, or otherwise require specific warning or labeling language, any of which might reduce the commercial potential of the product.

We are subject to environmental, health and safety laws that may restrict us from conducting our business in the most economically advantageous manner.

We are subject to various laws and regulations relating to safe working conditions, laboratory and manufacturing practices, the experimental use of animals, emissions and wastewater discharges, and the use and disposal of hazardous or potentially hazardous substances used in connection with our research, including radioactive compounds and infectious disease agents. We also cannot accurately predict the extent that regulations that might result from any future legislative or administrative action might affect our business. Any of these laws or regulations could cause us to incur additional expense or restrict our operations.

- 28 -

INTELLECTUAL PROPERTY RISKS

If our patents expire or are successfully challenged, our patent applications do not result in issued patents or if patent laws or the interpretation of patent laws change, our competitors may be able to obtain rights to and commercialize our discoveries or competing products.

We rely on patents to protect against exploitation of our discoveries by our competitors. For example, we and our collaborator GSK have patents and patent applications directed to compounds targeting BLyS, including BENLYSTA, in the United States and other countries. These patents and patent applications cover BENLYSTA as well as various methods of using the product. The principal patents covering BENLYSTA generally expire between 2016 and 2023 in the United States and between 2016 and 2021 in the rest of the world, subject to any available patent term extensions and supplemental protection certificates that may be obtained. While we have filed applications for certain patent term extensions and supplemental protection certificates, our applications may not be considered sufficient to meet the statutory requirements in all cases, may be subject to challenge if they do issue and may not cover all competing products. We also have patents in the United States covering raxibacumab as well as various methods of treatment using the product. The U.S. patents covering raxibacumab expire between 2023 and 2026, subject to any available patent term extensions that may be obtained. Some of the U.S. patents covering some of our products in development begin to expire in 2016. The expiration of or any successful challenges to our patents, patent applications, patent term extensions and supplemental protection certificates could allow other companies to commercialize products similar or identical to our products sooner than otherwise, which could lead to reduced revenues, reduced margins, reduced levels of profitability, and loss of market share for our products, adversely affecting our business and operating results.

Our pending patent applications, including those covering full-length genes and their corresponding proteins and antibodies, may not result in the issuance of any additional patents. Our applications may not be sufficient to meet the statutory requirements for patentability in all cases or may be subject to challenge if they do issue. Important legal issues remain to be resolved as to the extent and scope of available patent protection for biotechnology products and processes in the United States and other important markets outside the United States, such as Europe and Japan. For example, in March 2010, a U.S. district court decision involving Myriad Genetics expressed concerns regarding the patentability of isolated human genes and gene-based diagnostic methods. In July 2011, the Court of Appeals for the Federal Circuit issued its opinion in the Myriad Genetics case, upholding the patentability of isolated human genes, but finding that diagnostic method claims reciting merely “comparison” steps were unpatentable subject matter. In December 2011, this decision was appealed to the Supreme Court. Foreign markets may not provide the same level of patent protection as provided under the U.S. patent system. We expect that litigation or administrative proceedings will likely be necessary to determine the validity and scope of certain of our and others’ proprietary rights. We are currently involved in a number of litigation and administrative proceedings relating to the validity and scope of protection of our patents and those of others in the United States and the rest of the world.

In addition, the “Leahy-Smith America Invents Act,” was recently signed into law in the United States. Among other provisions, this law implements a “first inventor to file” system and provides opportunities for third parties to challenge issued patents and submit evidence to be considered by the Patent Office prior to the issuance of a patent. These changes could affect our ability to obtain patents on our inventions and provide additional opportunities for others to challenge our patents. These and other changes in, or different interpretations of, patent laws in the United States and other countries may result in patent laws that allow others to use our discoveries or develop and commercialize our products or prevent us from using or commercializing our discoveries and products.

HGS has brought three cases against Genentech, Inc. and City of Hope that are now pending before the United States District Court for the Central District of California alleging that U.S. Patent Nos. 6,331,415 (the “Cabilly II Patent”) and 7,923,221 (the “Cabilly III Patent”), related to the field of antibody production and manufacture are invalid, unenforceable, and not infringed by the manufacture, use, importation, offer for sale and sale of BENLYSTA and that Genentech violated numerous antitrust and unfair competition laws in obtaining and enforcing the Cabilly II patent. Genentech and City of Hope then filed counterclaims alleging, among other things, that the manufacture, offer for sale and sale of BENLYSTA infringes one or more claims of the Cabilly II patent. Genentech also brought a separate infringement action against HGS and others relating to the Cabilly III patent, which was consolidated with the HGS suits in the Central District of California. On September 19, 2011, the Court heard arguments on a number of outstanding motions and on September 22, 2011, entered an order staying the antitrust and

- 29 -

unfair competition suit and the Cabilly III patent suit. On October 3, 2011, Genentech and City of Hope moved to dismiss HGS’s inequitable conduct counterclaim and strike HGS’ unclean hands defense. On December 9, 2011, the Court dismissed HGS’ inequitable conduct counterclaim without prejudice, with the right to replead, and struck HGS’ unclean hands defense, without leave to amend. By separate order dated December 9, 2011, the Court stayed the Cabilly II patent case at the request of the parties. Accordingly, each of the Cabilly II and III patent actions, and the antitrust and unfair competition suit, remain stayed at this time.

Additionally, we have been involved in interference proceedings brought by the United States Patent and Trademark Office (“PTO”) and may be involved in additional interference proceedings in the future. These proceedings determine the priority of inventions and, thus, the right to a patent for technology in the U.S.

We are also involved in proceedings in connection with foreign patent filings, including opposition and revocation proceedings, and may be involved in other such proceedings in the future. For example, we are involved in European (“EP”) opposition proceedings filed by Teva regarding one of HGS’ issued EP patents covering BENLYSTA. We are also involved in EP opposition proceedings regarding an issued patent of Biogen Idec that HGS and GSK have licensed. In this opposition, the European Patent Office (“EPO”) found Biogen Idec’s claims to a method of treating autoimmune diseases using an antibody to BLyS (such as BENLYSTA), to be valid. Merck Serono SA has appealed this decision to an EPO Technical Board of Appeal, which has proposed to accelerate the proceedings and hold a hearing on October 9-10, 2012. On September 30, 2011, Eli Lilly and Company filed a revocation proceeding in the U.K. against Biogen Idec Inc. with respect to the same Biogen Idec EP patent that is on appeal at the EPO. A trial is expected in the Biogen Idec U.K. revocation proceeding beginning March 18, 2013.

We are also involved in another revocation proceeding in the U.K. brought by Eli Lilly and Company with respect to our EP patent related to BLyS compositions, including antibodies. In 2008, the U.K. High Court ruled that this patent was invalid in the U.K. Eli Lilly had also challenged this patent at the EPO, and in late 2009, an EPO Technical Board of Appeal held that the patent was valid. Nevertheless, in early 2010, the U.K. Court of Appeal disagreed with the EPO and upheld the High Court’s invalidation of the EP patent in the U.K. The U.K. Supreme Court granted HGS permission to appeal this decision and heard the appeal the week of July 18, 2011. On November 2, 2011, the Supreme Court issued a judgment in favor of HGS and allowed HGS’ appeal, dismissed Eli Lilly’s cross-appeal, awarded HGS costs, and remanded the case to the Court of Appeal to resolve the remaining issues. A hearing at the Court of Appeal has been scheduled for July 2-3, 2012. In addition, on February 1, 2012, Eli Lilly & Company filed another action against HGS at the U.K. High Court regarding this U.K. patent. In this new action, Eli Lilly seeks a declaratory judgment that any supplementary protection certificate obtained for HGS’ U.K. patent based on Lilly’s tabalumab product would be invalid.

We are also involved in opposition proceedings we and our collaborator FivePrime initiated February 10, 2012 against an EP patent of Aventis Pharma S.A. related to fibroblast growth factor (“FGF”) receptor fusion proteins.

We cannot assure you that we will be successful in any of these proceedings. Moreover, any such litigation or proceeding may result in a significant commitment of resources in the future and could force us to do one or more of the following: cease selling or using any of our products that incorporate the challenged intellectual property, which would adversely affect our revenue; obtain a license from the holder of the intellectual property right alleged to have been infringed, which license may not be available on reasonable terms, if at all; and redesign our products to avoid infringing the intellectual property rights of third parties, which may be time-consuming or impossible to do. In addition, such litigation or proceeding may allow others to use our discoveries or develop or commercialize our products. We cannot assure you that the patents we obtain or the unpatented technology we hold will afford us significant commercial protection.

- 30 -

If others file patent applications or obtain patents similar to ours, then the United States Patent and Trademark Office may deny our patent applications, or others may restrict the use of our discoveries.

We are aware that others, including universities, government agencies and companies working in the biotechnology and pharmaceutical fields, have filed patent applications and have been granted patents in the United States and in other countries that cover subject matter potentially useful or necessary to our business. Some of these patents and patent applications claim only specific products or methods of making products, while others claim more general processes or techniques useful in the discovery and manufacture of a variety of products. The risk of third parties obtaining additional patents and filing patent applications will continue to increase as the biotechnology industry expands. We cannot predict the ultimate scope and validity of existing patents and patents that may be granted to third parties, nor can we predict the extent to which we may wish or be required to obtain licenses to such patents, or the availability and cost of acquiring such licenses. To the extent that licenses are required, the owners of the patents could bring legal actions against us to claim damages or to stop our manufacturing and marketing of the affected products. We believe that there will continue to be significant litigation in our industry regarding patent and other intellectual property rights. Such litigation could consume a substantial portion of our resources.

Because issued patents may not fully protect our discoveries, our competitors may be able to commercialize products similar to those covered by our issued patents.

Issued patents may not provide commercially meaningful protection against competitors and may not provide us with competitive advantages. Other parties may challenge our patents or design around our issued patents or develop products providing effects similar to our products. In addition, others may discover uses for genes, proteins or antibodies other than those uses covered in our patents, and these other uses may be separately patentable. The holder of a patent covering the use of a gene, protein or antibody for which we have a patent claim could exclude us from selling a product for a use covered by its patent.

We rely on our collaboration partners to seek patent protection for the products they develop based on our research.

A significant portion of our future revenue may be derived from royalty payments from our collaboration partners. These partners face patent protection issues similar to those that we and other biotechnology or pharmaceutical companies face. As a result, we cannot assure you that any product developed by our collaboration partners will be patentable, and therefore, revenue from any such product may be limited, which would reduce the amount of any royalty payments. We also rely on our collaboration partners to effectively prosecute their patent applications. Their failure to obtain or protect necessary patents could also result in a loss of royalty revenue to us.

If we are unable to protect our trade secrets, others may be able to use our secrets to compete more effectively.

We may not be able to meaningfully protect our trade secrets. We rely on trade secret protection to protect our confidential and proprietary information. We believe we have acquired or developed proprietary procedures and materials for the production of proteins and antibodies. We have not sought patent protection for these procedures. While we have entered into confidentiality agreements with employees and collaborators, we may not be able to prevent their disclosure of these data or materials. Others may independently develop substantially equivalent information and processes.

Other parties may seek to cancel or revoke our trademarks and/or restrict the use of our trademarks.

Our trademarks, including BENLYSTA, are important to us and are generally covered by trademark applications or registrations in the United States and in other countries. Trademark protection varies in accordance with local law, and continues in some countries for as long as the mark is used and in other countries for as long as the mark is registered. Trademark registrations are generally for fixed but renewable terms. In certain instances, we rely on our collaborators to protect our trademark rights.

Our trademark applications may not be sufficient to meet the statutory requirements for registration in all cases or may be subject to challenge if they are registered. Other parties may seek to cancel or revoke our trademarks and/or restrict the use of our trademarks through litigation or administrative proceedings in

- 31 -

both the United States and in the rest of the world. We cannot assure you that we or our collaborators will be successful in any such proceedings. Moreover, any such litigation or proceeding may require us to modify our trademarks or rebrand our products to avoid infringing the trademark rights of third parties. This may be time-consuming and could adversely affect our revenue.

FINANCIAL AND MARKET RISKS

We are required to provide significant collateral for our letters of credit for our lease obligations and the amount of cash to provide that collateral may increase in the future.

The MEDCO financing of our small-scale manufacturing facility leases is secured by HGS letters of credit, which expire in December 2012. The amount of our required security deposits associated with these letters of credit is approximately $34.3 million. These letters of credit and cash collateral requirements increase our cost of doing business and could have an adverse impact on our overall liquidity, particularly if there was a call for a large amount of additional cash or security deposits due to an unexpectedly large downward movement in the market value of the pledged collateral. We may not be able to raise or provide the additional capital or collateral, if needed. In addition, we may be required to post additional collateral as a result of growing our business, which amounts could be significant, and may cause a significant amount of our cash to be restricted from other uses. We may not be able to raise, access or provide the additional capital as collateral, if needed which could materially adversely impact our results of operation, financial condition and cash flows.

Because of our substantial indebtedness and lease obligations, we may be unable to adjust our strategy to meet changing conditions in the future.

As of December 31, 2011, we had convertible debt of $561.7 million ($701.2 million on a face value basis) and a long-term lease financing for our large-scale manufacturing facility of $252.1 million. During 2011 we made cash interest payments on our convertible debt of $7.8 million. In addition, approximately $78.0 million aggregate principal amount of our remaining convertible subordinated debt due 2011 matured and was repaid in cash in October 2011. During 2011 we made cash payments on our long-term lease financing of $25.0 million. In addition, we have operating leases, primarily our long-term operating lease for our headquarters, for which we made cash payments of $20.0 million during 2011. Our substantial debt and long-term lease obligations will have several important consequences for our future operations. For instance:

• payments of interest on, and principal of, our indebtedness and our long-term lease obligations will be substantial and may exceed then current income and available cash;

• we may be unable to obtain additional future financing for marketing efforts, continued clinical trials, capital expenditures or other general corporate purposes;

• we may be unable to withstand changing competitive pressures, economic conditions and governmental regulations; and

• we may be unable to pursue acquisitions or in-licensing of additional product candidates or otherwise take advantage of significant business opportunities that may arise.

We may not have adequate financial resources available to repay our outstanding convertible debt at maturity.

As of December 31, 2011, we had $701.2 million in face value of convertible debt outstanding, including $206.7 million in face value of Convertible Subordinated Notes due 2012 (“2012 Notes”). The 2012 Notes are convertible into our common stock at a conversion price of approximately $17.78 per share in August 2012. Our recent stock price has been below the conversion price. If that were to remain the case through maturity, we would be required to pay the 2012 Notes in cash upon maturity. At this time we believe we will have sufficient unrestricted cash to pay the 2012 Notes in cash upon maturity, however,

- 32 -

there are other potential uses for these funds. In November 2011, we completed an offering of $494.5 million in face value of Convertible Senior Notes due 2018 (“2018 Notes”). Because it may be one or more years, if ever, before we are likely to generate significant positive cash flow from operations, we may not have enough cash, cash equivalents and marketable securities available to repay all of our convertible debt upon maturity.

To become a successful biopharmaceutical company, we may need additional funding. If we do not obtain this funding on acceptable terms, we may not be able to generate sufficient revenue to repay our debt, to continue our research and development efforts or to launch and successfully market our products.

We continue to expend substantial funds on our research and development programs and human studies on current and future product candidates. We also expect to expend significant funds to support commercial marketing activities, to acquire other biotechnology companies or in-license and develop additional product candidates, and to enhance our manufacturing capacity. We may need additional financing to fund these activities. We may not be able to obtain additional financing on acceptable terms, if at all. If we raise additional funds by issuing equity securities, equity-linked securities or debt securities, the new equity securities may dilute the interests of our existing stockholders and the new debt securities may contain restrictive financial covenants.

Our need for additional funding will depend on many factors, including, without limitation:

• the amount of revenue or cost sharing, if any, that we are able to obtain from our collaborations, any approved products, and the time and costs required to achieve those revenues;

• the timing, scope and results of preclinical studies and clinical trials;

• the size and complexity of our development programs;

• the timing and costs involved in obtaining regulatory approvals;

• the timing and costs of increasing our manufacturing capacity;

• the costs of commercializing our products, including marketing, promotional and sales costs;

• the commercial success of our products;

• our stock price;

• our ability to establish and maintain collaboration partnerships;

• competing technological and market developments;

• the costs involved in filing, prosecuting, enforcing and defending patent claims;

• the costs involved in bringing and defending against litigation; and

• scientific progress in our research and development programs.

If we are unable to raise additional funds, we may, among other things:

• delay, scale back or eliminate some or all of our research and development programs;

• delay, scale back or eliminate some or all of our commercialization activities;

• lose rights under existing licenses;

- 33 -

• relinquish more of, or all of, our rights to product candidates on less favorable terms than we would otherwise seek; and

• be unable to operate as a going concern.

Our marketable securities and restricted investments are subject to certain risks that could materially adversely affect our overall financial position.

We invest our cash in accordance with an established internal policy and customarily in instruments that historically have been highly liquid and carried relatively low risk. However, the capital and credit markets have experienced extreme volatility and disruption. Over the past several years, the volatility and disruption reached unprecedented levels. We maintain a significant portfolio of investments in marketable debt securities and restricted investments, which are recorded at fair value. Certain of these transactions expose us to credit risk in the event of default by the issuer. To seek to minimize our exposure to credit risk, we invest in securities with strong credit ratings and have established guidelines relative to diversification and maturity with the objective of maintaining safety of principal and liquidity. We do not invest in derivative financial instruments or auction rate securities, and we generally hold our investments in debt securities until maturity. In recent years, certain financial instruments, including some of the securities in which we have invested, have sustained downgrades in credit ratings and some high quality marketable securities have suffered illiquidity or events of default. Deterioration in the credit market may have an adverse effect on the fair value of our investment portfolio. Should any of our marketable securities or restricted investments lose significant value or have their liquidity impaired, it could materially and adversely affect our overall financial position by imperiling our ability to fund our operations and forcing us to seek additional financing sooner than we would otherwise. Such financing may not be available on commercially attractive terms, or at all.

Fluctuations in foreign exchange rates could adversely affect our results of operations, financial position and cash flows.

Our European subsidiaries’ operations may be subject to volatility in foreign exchange rates as those operations expand in the future. The profit split we earn from GSK from ex-U.S. BENLYSTA sales and our share of GSK’s ex-U.S. collaboration expenses are subject to foreign currency fluctuations. As the ex-U.S. BENLYSTA profit split and expenses increase, our foreign currency exposure may become more material and could adversely affect our business, results of operations, financial condition or cash flows.

We are not currently profitable and might never become profitable.

We have a history of losses and expect to continue to incur substantial losses and negative operating cash flow, and we might never achieve or maintain profitability.

OTHER BUSINESS RISKS

We may be subject to product liability or other claims from the use of BENLYSTA or other of our products that could negatively affect our future operations. We have limited product liability insurance.

Product liability and other liability risks are inherent in the testing, manufacturing, marketing and sales of biopharmaceutical formulations and products and product candidates. If the use of one or more of our products or product candidates harms people, we may be subject to costly and damaging product liability claims. This liability might result from claims made directly by patients, hospitals, clinics or other consumers, or by other companies manufacturing these products on our behalf. Our future operations may be negatively affected from litigation costs, settlement expenses, management resources and lost product sales inherent to these claims. In addition, negative publicity associated with any claims, regardless of their merit, may decrease future demand for our products. Any of these effects could have a material adverse effect on our business, financial condition and results of operations. While we will continue to attempt to take appropriate precautions, we cannot assure you that we will avoid significant product liability exposure.

- 34 -

Though we currently maintain product liability insurance, there is no guarantee that such insurance will provide adequate coverage against potential liabilities. We may not foresee requirements for, or be able to obtain or maintain adequate product liability insurance, when needed, on acceptable terms, if at all. As a result, our insurance may not provide adequate coverage against potential liabilities. Furthermore, our current and potential partners with whom we have collaborative agreements or our future licensees may not be willing to indemnify us against these types of liabilities and may not themselves be sufficiently insured or have sufficient liquidity to satisfy any product liability claims. Claims or losses in excess of any product liability insurance coverage that may be obtained by us could have a material adverse effect on our business, financial condition and results of operations.

Our success is dependent on our continued ability to attract, motivate and retain key personnel. If we lose or are unable to attract key management or other personnel, it could have a material adverse effect on our business, financial condition and results of operations.

Much of our progress to date has resulted from the particular scientific, technical and management skills of personnel available to us. Competition for qualified employees is intense among pharmaceutical and biotechnology companies. Part of being able to attract, motivate and retain key personnel is our ability to offer a competitive compensation package, including cash bonus and equity incentive awards. Our equity incentive awards are directly tied to our stock price. Because of the reduction in our stock price during 2011, the exercise price of a substantial number of equity incentive awards granted in the last several years exceeds the market price of our stock. As a result, an important component of our compensation package in the last several years has little or no retention value. In addition, our ability to offer attractive equity incentive awards in the future may be limited or nonexistent if we are unable to obtain stockholder approval to maintain a sufficient number of shares available for grant under our stock incentive plan. If we are unable to provide a compensation package that is competitive within our industry, or otherwise successfully compete to attract, motivate and retain qualified management and other highly skilled employees, this could materially adversely affect the implementation of our business strategy or delay the commercialization of our products. In January 2012 we eliminated approximately 150 positions resulting in the severance of approximately 100 employees and announced corresponding spending reductions to reflect current program and business requirements. Positions across the company were affected, including manufacturing, R&D and administration. This workforce reduction and the spending reduction efforts may negatively impact the morale of our remaining employees, which may adversely affect our ability to retain or attract qualified employees to fill necessary positions. If we are unable to retain the personnel we currently employ, or if we are unable to quickly replace necessary departing employees with new, qualified employees, our operations may suffer.

We may be unable to fulfill the terms of our contract manufacturing agreements with our customers for manufacturing process development and supply of selected biopharmaceutical products.

To more fully utilize our existing manufacturing capacity, we have entered into agreements with customers pursuant to which we have agreed to develop manufacturing processes for, and manufacture clinical and commercial supplies of, certain biopharmaceutical products, and may enter into similar agreements with other potential customers in the future. Our receipt of revenue under these agreements is dependent on our ability to successfully manufacture such products. If we are unable to develop a validated manufacturing process for such products, are unable to deliver product that meets the manufacturing specifications, or otherwise unable to deliver product in accordance with the applicable contractual provisions, we may not receive any additional payments under such agreements. Even if successful, we may not be able to enter into additional agreements with other customers. Any current or future customers may decide to discontinue the products contemplated under these agreements, and therefore we may not receive revenue from these agreements.

- 35 -

RISKS RELATED TO OWNERSHIP OF OUR COMMON STOCK

The market price of our common stock may be lower or more volatile than you expected.

Our stock price, like the stock prices of many other biotechnology companies, has been highly volatile. During the 12 months ended December 31, 2011, the closing price of our common stock has been as low as $6.64 per share and as high as $29.70 per share. Future market fluctuations may cause the market price of our common stock to be lower or more volatile than you expected.

The price and volume fluctuations in our stock may often be unrelated to our operating performance. The market price of our common stock could fluctuate widely because of:

• future announcements about our company, our competitors, or other companies engaged in drug development or sale including the results of testing, clinical trials, technological innovations or new commercial products;

• regulatory actions with respect to our potential products or regulatory approvals with respect to our competitors’ products;

• litigation or governmental action involving or affecting us;

• changes in government regulations;

• developments affecting our collaboration partners or in our relationships with our collaboration partners;

• announcements relating to health care reform or changes in reimbursement policies;

• our failure to acquire or maintain proprietary rights to the gene sequences we discover or the products we develop;

• public concern as to the safety of our products; and

• political and economic factors affecting market prices generally or our market segment or our company particularly.

In addition, the stock market in general and the NASDAQ Global Select Market and the stock of biotechnology companies in particular, have experienced extreme price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of these companies. Broad market and industry factors may negatively affect the market price of our common stock, regardless of our actual operating performance. In the past, following periods of volatility in the market price of a company’s securities, securities class action litigation has often been instituted against companies. Recently, two securities class action lawsuits were filed against HGS in federal court in Maryland. See Part 1, Item 3, “Legal Proceedings” of this report for further discussion.

The issuance and sale of shares underlying our outstanding convertible debt securities and options, as well as the sale of additional equity or equity-linked securities would dilute the holdings of our existing stockholders and may materially and adversely affect the price of our common stock.

Sales of substantial amounts of shares of our common stock or securities convertible into or exchangeable for our common stock in the public market, or the perception that those sales may occur, could cause the market price of our common stock to decline. We have used and may continue to use our common stock or securities convertible into or exchangeable for our common stock to acquire technology, product rights or businesses, or for other purposes. Our authorized capital stock consists of 400,000,000 shares of common stock, par value $0.01 per share. As of December 31, 2011, we had 198,750,531 shares of common stock outstanding. In addition, an aggregate of approximately 11,624,827 shares of our common stock are issuable upon conversion of our outstanding 2012 Notes at an

- 36 -

applicable conversion price of $17.78 per share; an aggregate of approximately 37,110,692 shares of our common stock are issuable upon conversion of our outstanding 2018 Notes at an applicable conversion price of $13.33 per share; 25,068,812 shares of our common stock are issuable upon the exercise of options outstanding as of December 31, 2011, having a weighted-average exercise price of $15.84 per share, including 4,404,965 stock options granted during 2011 with a weighted-average grant date fair value of $14.26 per share; and 375,813 shares of our common stock are issuable upon the vesting of restricted stock unit awards outstanding as of December 31, 2011. Furthermore, up to 10,298,500 shares of our common stock are potentially due to us upon settlement of our capped call option contracts in 2018. If we issue additional equity securities, including in exchange for our outstanding convertible debt or in connection with the exercise or vesting of equity awards, the price of our common stock may be materially and adversely affected and the holdings of our existing stockholders would be diluted.

Our certificate of incorporation and bylaws could discourage acquisition proposals, delay a change in control or prevent transactions that may be in your best interests.

Provisions of our certificate of incorporation and bylaws, as well as Section 203 of the Delaware General Corporation Law, may discourage, delay or prevent a change in control of our company that you as a stockholder may consider favorable and may be in your best interest. Our certificate of incorporation and bylaws contain provisions that:

• authorize the issuance of up to 20,000,000 shares of “blank check” preferred stock that could be issued by our board of directors to increase the number of outstanding shares and discourage a takeover attempt;

• limit who may call special meetings of stockholders; and

• establish advance notice requirements for nomination of candidates for election to the board of directors or for proposing matters that can be acted upon by stockholders at stockholders’ meetings.

- 37 -

ITEM 1B. UNRESOLVED STAFF COMMENTS

None.

ITEM 2. PROPERTIES

We currently lease and occupy approximately 1,020,000 square feet of laboratory, manufacturing and office space in Rockville, Maryland. Our space includes approximately 190,000 square feet of laboratory space, approximately 508,000 square feet of manufacturing and manufacturing support space and approximately 322,000 square feet of office space. This excludes a portion of our headquarters facility under lease which is currently not being utilized. In addition to our space in Rockville, Maryland, we also lease and occupy a small amount of office space in Europe.

We anticipate that existing commercial real estate or the available land located at our laboratory and office campus will enable us to continue to expand our operations in close proximity to one another. We believe that our properties are generally in good condition, well maintained, suitable and adequate to carry on our business.

ITEM 3. LEGAL PROCEEDINGS

In the ordinary course of business, we are involved in various legal proceedings, including, among others, patent oppositions, patent revocations, patent infringement litigation, securities class actions, shareholder derivative litigation and other matters incidental to our business. While it is not possible to accurately predict or determine the eventual outcome of these matters or estimate a range of loss, one or more of these matters currently pending could have a material adverse effect on our financial condition, results of operations or cash flows. The following is a description of material legal proceedings involving the company. We are vigorously defending all of the legal proceedings involving the company, including each of the legal proceedings matters listed below.

In November 2011, two securities class actions were filed in the United States District Court for the District of Maryland against HGS and a number of its current and former executive officers and directors. GSK was also named as a defendant. The complaints were filed by alleged purchasers of HGS common stock during 2009 and 2010 and allege violations of securities laws during that time period. In addition, three shareholder derivative actions were filed during December 2011 and January 2012 in the United States District Court for the District of Maryland by current shareholders, purportedly on behalf of the company, and are related to essentially the same allegations made in the securities class actions. It is possible that additional suits will be filed with respect to these same matters. We believe the allegations in the foregoing complaints are without merit and intend to vigorously defend these claims.

ITEM 4. MINE SAFETY DISCLOSURES

None.

- 38 -

PART II

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

Our common stock is traded on the NASDAQ Global Market under the symbol HGSI. The following table presents the quarterly high and low closing prices as quoted by NASDAQ.

	High		Low
2011
First Quarter	$	29.03	$	23.85
Second Quarter	$	29.70	$	24.54
Third Quarter	$	24.96	$	11.49
Fourth Quarter	$	13.98	$	6.64
2010
First Quarter	$	32.68	$	25.76
Second Quarter	$	33.30	$	22.46
Third Quarter	$	30.18	$	21.84
Fourth Quarter	$	29.79	$	23.60

As of January 31, 2012, there were 578 holders of record of our common stock. We have never declared or paid any cash dividends. We do not anticipate declaring or paying cash dividends for the foreseeable future, in part because existing lease agreements prohibit such dividends. Instead, we will retain our earnings, if any, for the future operation and expansion of our business.

The following graph compares the performance of our Common Stock for the periods indicated with the performance of the NASDAQ U.S. Stock Market Total Return Index (the “TRI”) and the NASDAQ Pharmaceutical Index (the “NPI”). The comparison assumes $100 was invested on December 31, 2006 in our Common Stock and in each of the foregoing indices and assumes the reinvestment of dividends, if any.

The performance graph and related information shall not be deemed “soliciting material” or be “filed” with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under the Securities Act or the Exchange Act, except to the extent that the Company specifically incorporates it by reference into such filing.

- 39 -

ITEM 6. SELECTED CONSOLIDATED FINANCIAL DATA

We present below our selected consolidated financial data for the years ended December 31, 2011, 2010 and 2009, and as of December 31, 2011 and 2010, which have been derived from the audited consolidated financial statements included elsewhere herein and should be read in conjunction with such consolidated financial statements and the accompanying notes. We present below our selected financial data for the years ended December 31, 2008 and 2007, and as of December 31, 2009, 2008 and 2007, which have been derived from audited financial statements not included herein. The results of operations of prior periods are not necessarily indicative of results that may be expected for any other period. See “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and “Business.”

	Year Ended December 31,
	2011			2010			2009			2008			2007
	(in thousands, except per share and ratio data)
Statement of Operations Data:
Revenue:
Product sales	$	104,863		$	47,159		$	154,074		$	—		$	—
Manufacturing and development services		24,840			22,695			50,653			—			—
Research and development collaborative agreements		1,272			87,497			71,022			48,422			41,851
Total revenue		130,975			157,351			275,749			48,422			41,851
Costs and expenses:
Cost of product sales		47,061			29,941			15,805			—			—
Cost of manufacturing and development services		28,999			15,016			18,215			—			—
Research and development expenses		196,182			196,370			173,709			243,257			246,293
Selling, general and administrative expenses		158,779			106,797			61,073			60,865			55,874
Commercial collaboration expenses		31,222			—			—			—			—
Facility-related exit (credits) charges		(1,717	)		—			759			—			(3,673	)
Total costs and expenses		460,526			348,124			269,561			304,122			298,494
Income (loss) from operations		(329,551	)		(190,773	)		6,188			(255,700	)		(256,643	)
Investment income		12,175			16,966			12,727			23,487			32,988
Interest expense		(62,056	)		(59,500	)		(58,424	)		(62,912	)		(60,716	)
Gain on extinguishment of debt		—			—			38,873			—			—
Gain on sale of long-term equity investment		—			—			5,259			32,518			—
Other income (expense)		(1,674	)		76			(238	)		(6,284	)		—
Income (loss) before taxes		(381,106	)		(233,231	)		4,385			(268,891	)		(284,371	)
Income tax benefit		—			—			1,274			—			—
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659		$	(268,891	)	$	(284,371	)
Net income (loss) per share, basic and diluted	$	(1.97	)	$	(1.24	)	$	0.04		$	(1.99	)	$	(2.12	)
Other Data:
Ratio of earnings to fixed charges		—			—			1.06			—			—
Coverage deficiency	$	(381,106	)	$	(233,231	)	$	—		$	(268,891	)	$	(284,371	)

- 40 -

ITEM 6. SELECTED CONSOLIDATED FINANCIAL DATA, CONTINUED

	As of December 31,
	2011			2010			2009			2008			2007
	(in thousands)
Balance Sheet Data:
Cash, cash equivalents, marketable securities, and restricted investments (1)	$	881,434		$	933,382		$	1,191,660		$	372,939		$	603,840
Total assets (1)		1,407,576			1,315,029			1,530,630			686,832			961,566
Total debt and lease financing (2)		813,840			623,367			598,435			664,074			637,513
Accumulated deficit		(2,801,003	)		(2,419,897	)		(2,186,666	)		(2,192,325	)		(1,923,434	)
Total stockholders’ equity (deficit)		456,419			585,763			755,415			(136,304	)		117,145

(1) “Cash, cash equivalents, marketable securities and restricted investments” and “Total assets” for 2011, 2010, 2009, 2008 and 2007 include $80,193, $79,510, $88,437, $69,360 and $70,931 respectively, of restricted investments relating to certain leases.

(2) “Total debt and lease financing” for 2011, 2010, 2009, 2008 and 2007 does not include any operating lease obligations under various facility and equipment lease arrangements. See “Management’s Discussion and Analysis of Financial Condition and Results of Operations – Liquidity and Capital Resources” for additional discussion.

- 41 -

ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Overview

Human Genome Sciences, Inc. (“HGS”) is a biopharmaceutical company that exists to place new therapies into the hands of those battling serious disease. Our lead products are BENLYSTA^® (belimumab) for systemic lupus erythematosus (“SLE”) and raxibacumab for inhalation anthrax.

BENLYSTA was approved in March 2011 by the U.S. Food and Drug Administration (“FDA”) for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. We launched BENLYSTA shortly thereafter and recognized revenue from our first BENLYSTA sales in March 2011. In July 2011, the European Commission granted marketing authorization for BENLYSTA as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy. BENLYSTA is currently available in the United States, Canada and an increasing number of European countries, including Germany, Spain, Austria, Denmark, Finland, Hungary, Norway and Sweden. In addition, regulatory submissions are pending in other countries.

We are developing BENLYSTA with our partner, GlaxoSmithKline (“GSK”), under a 2006 co-development and co-commercialization agreement. In the United States, we and GSK both have sales teams that are working together to commercialize BENLYSTA. In Germany, France and Spain, our team will work alongside GSK to commercialize BENLYSTA, and in the rest of the world GSK will lead local implementation of the commercialization of BENLYSTA. We recognize product sales revenue from BENLYSTA sales in the U.S., and GSK recognizes product sales revenue from sales in the rest of the world. We share profits and certain expenses with GSK on a worldwide basis. Under the agreement, we are responsible for the global supply of BENLYSTA.

We continue to deliver raxibacumab to the U.S. Strategic National Stockpile (“SNS”) for emergency use in treating inhalation anthrax. In 2009, we completed the delivery of 20,001 doses of raxibacumab to the SNS under an initial order and as a result recognized $162.5 million in product sales and manufacturing and development services revenue. In July 2009, the U.S. Government (“USG”) exercised its option under our contract to purchase 45,000 additional doses of raxibacumab, with delivery to be completed over a three-year period. HGS expects to receive approximately $142.0 million from this second order as deliveries are completed, $117.4 million of which has been recognized as revenue through December 31, 2011. In May 2009, we submitted a Biologics License Application (“BLA”) to the FDA for raxibacumab for the treatment of inhalation anthrax. We received a Complete Response Letter in November 2009, and we continue to work closely with the FDA to obtain approval. HGS will receive approximately $20.0 million from the USG if raxibacumab is licensed by the FDA.

In addition to our internal pipeline, we have substantial financial rights to two novel drugs that GSK has advanced to late-stage development. The first of these is darapladib, which was discovered by GSK based on HGS technology. In two Phase 3 trials, GSK is currently evaluating whether darapladib can reduce the risk of adverse cardiovascular events such as heart attack or stroke in patients with chronic coronary heart disease and acute coronary syndrome, respectively. The combined darapladib Phase 3 program spans 42 countries and has enrolled more than 28,500 patients. The second is albiglutide, for which GSK currently has eight Phase 3 trials in progress to evaluate the long-term efficacy, safety and tolerability of albiglutide as monotherapy and add-on therapy for patients with type 2 diabetes mellitus. Albiglutide was created by HGS using its proprietary albumin-fusion technology, and the product was licensed to GSK in 2004.

We are working on potential additional indications for BENLYSTA as well as additional methods of delivery. Currently, BENLYSTA is delivered by infusion at two-week intervals for the first three doses and every four weeks thereafter. In December 2011, we initiated dosing of patients in BLISS-SC, a Phase 3 trial of the subcutaneous formulation of BENLYSTA. If this trial is successful and regulatory authorities agree, the subcutaneous formulation will make it possible for patients to self-administer BENLYSTA by injection once a week. In 2012, we plan to initiate Phase 3 trials of BENLYSTA in vasculitis and active lupus nephritis.

- 42 -

Overview (continued)

We are also working to expand and advance our mid- and early-stage pipeline beyond BENLYSTA. A randomized Phase 2 trial is currently evaluating mapatumumab in combination with Nexavar^® (sorafenib) for the treatment of advanced hepatocellular cancer. Mapatumumab is a human monoclonal antibody to TRAIL receptor 1. In March 2011, we entered into an agreement with FivePrime Therapeutics, Inc. (“FivePrime”) to develop and commercialize HGS1036 (formerly FP-1039) for multiple cancers.

We and Novartis were developing ZALBIN^TM for the treatment of patients with chronic hepatitis C. In 2010, the FDA expressed concerns regarding the risk-benefit assessment of ZALBIN dosed at 900-mcg every two weeks. Based on the FDA and similar European Medicines Agency feedback, we and Novartis decided to end further development of ZALBIN in 2010.

Strategic partnerships are an important driver of our commercial success. We have a co-development and co-commercialization agreement with GSK for BENLYSTA, and raxibacumab is being developed under a contract with the Biomedical Advanced Research and Development Authority (“BARDA”) of the Office of the Assistant Secretary for Preparedness and Response (“ASPR”), U.S. Department of Health and Human Services (“HHS”). Our strategic partnerships with leading pharmaceutical and biotechnology companies allow us to leverage our strengths and gain access to sales and marketing infrastructure, as well as complementary technologies. Some of these partnerships provide us with licensing or other fees, clinical development cost-sharing, milestone payments and rights to royalty payments as products are developed and commercialized. In some cases, we are entitled to certain commercialization, co-promotion, revenue-sharing and other product rights.

Critical Accounting Policies and the Use of Estimates

A “critical accounting policy” is one that is both important to the portrayal of our financial condition and results of operations and that requires management’s most difficult, subjective or complex judgments. Such judgments are often the result of a need to make estimates about the effect of matters that are inherently uncertain. The preparation of our financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ materially from those estimates. See Note B, Summary of Significant Accounting Policies, of the Notes to the Consolidated Financial Statements for further discussion.

We currently believe the following accounting policies to be critical:

Investments. We account for investments in accordance with the Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“FASB ASC”) Topic 320, Investments – Debt and Equity Securities. We carry our investments at their respective fair values. We periodically evaluate the fair values of our investments to determine whether any declines in the fair value of investments represent an other-than-temporary impairment. This evaluation consists of a review of several factors, including but not limited to the length of time and extent that a security has been in an unrealized loss position, the existence of an event that would impair the issuer’s future repayment potential, the near term prospects for recovery of the market value of a security and our intent to hold the security until the market value recovers, which may be maturity. We also evaluate whether it is more likely than not that we will be required to sell the security before its anticipated recovery. If management determines that such an impairment exists we would recognize an impairment charge. Because we may determine that market or business conditions may lead us to sell a marketable security prior to maturity, we classify our marketable securities as “available-for-sale.” Investments in securities that are classified as available-for-sale and have readily determinable fair values are measured at fair market value in the balance sheets, and unrealized holding gains and losses for these investments are reported as a separate component of stockholders’ equity until realized, or an other-than-temporary impairment is recorded. We classify those marketable securities that may be used in

- 43 -

Critical Accounting Policies and the Use of Estimates (continued)

operations within one year as marketable securities. Those marketable securities in which we have both the ability to hold until maturity and have a maturity date beyond one year from our most recent consolidated balance sheet date are classified as non-current marketable securities.

For investments carried at fair value, we disclose the level within the fair value hierarchy as prescribed by FASB ASC Topic 820, Fair Value Measurements and Disclosures. We evaluate the types of securities in our investment portfolio to determine the proper classification in the fair value hierarchy based on trading activity and the observability of market inputs. We generally obtain a single quote or price per instrument from independent third parties to help us determine the fair value of securities in Level 1 and Level 2 of the fair value hierarchy.

Accounts receivable. Trade accounts receivable are recorded net of allowances for prompt payment discounts and doubtful accounts.

Inventories. Inventories, which are recorded at the lower of cost or market, include materials, labor and other direct and indirect costs and are valued using the first-in, first-out method. We capitalize inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. Inventory is evaluated for impairment by consideration of factors such as lower of cost or market, net realizable value, obsolescence or expiry. Our inventories have carrying values that do not exceed cost nor do they exceed net realizable value. We believe BENLYSTA has limited risk of obsolescence at this time based on our market research, which is used to estimate future demand.

Inventory that is not expected to be utilized until more than 12 months from the balance sheet date is classified as non-current. Estimating the level of inventory utilization for the upcoming 12 months requires management to exercise significant judgment. We maintain inventory levels in excess of 12 months to mitigate risks such as product shortage due to higher than anticipated product demand, long lead times for manufacturing finished goods, supply interruptions for raw materials and risks of production disruptions at our sole U.S. FDA-approved manufacturing site due to contamination, equipment failure or other facility-related issues. Carrying such levels of inventory impacts our liquidity and cash flows since the inventory will not be converted to cash for more than one year from the balance sheet date.

We evaluate our expiry risk by evaluating current and future product demand relative to product shelf life. We build demand forecasts by considering factors such as, but not limited to, overall market potential, market share, market acceptance and patient usage. Currently, the shelf life of our raw materials and work in process is approximately one to five years and three years, respectively. The shelf life for finished goods is three years. The product shelf life resets as inventory moves through each stage of completion.

We do not expect changes to current BENLYSTA demand estimates that would result in any material excess or obsolete inventory.

Deferred revenue. Deferred revenue consists primarily of amounts related to raxibacumab and certain BENLYSTA shipments. We recognize raxibacumab revenue based on the average contracted price as shipments occur and record the difference between the invoiced price and the average contracted price in deferred revenue. Revenue relating to BENLYSTA shipments to specialty distributors is deferred and recognized as revenue once product has been sold-through to healthcare providers.

Leases. We lease various real properties under operating leases that generally require us to pay taxes, insurance and maintenance. During 2006, we entered into a 20-year lease agreement with BioMed Realty Trust, Inc. (“BioMed”) for our Traville facility. We account for the Traville lease with BioMed as an operating lease.

- 44 -

Critical Accounting Policies and the Use of Estimates (continued)

In 2006 and as described further in Note F, Long-Term Debt, of the Notes to the Consolidated Financial Statements, we sold our large-scale manufacturing facility (“LSM”) and headquarters land to BioMed, and simultaneously agreed to lease such assets back over 20 years. We recorded the sale and leaseback of these assets as a financing transaction and accordingly recorded the allocated sale proceeds as outstanding debt on our balance sheet. We account for lease payments under the related lease agreements as principal and interest payments on this debt.

Impairments of long-lived assets. Long-lived assets to be held and used are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets might not be recoverable. Conditions that would necessitate an impairment assessment include a significant decline in the observable market value of an asset, a significant change in the extent or manner in which an asset is used, or a significant adverse change that would indicate that the carrying amount of an asset or group of assets is not recoverable. Determination of recoverability is based on an estimate of undiscounted cash flows resulting from the use of the asset and its eventual disposition. In the event that such cash flows are not expected to be sufficient to recover the carrying amount the assets, the assets are written down to their estimated fair values. Long-lived assets to be sold are carried at fair value less costs to sell.

Product sales. Product sales consist of U.S. sales of BENLYSTA and raxibacumab. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, delivery has occurred and title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, all performance obligations have been met and returns can be reasonably estimated. Product sales are recorded net of accruals for estimated rebates, chargebacks, discounts and other deductions (collectively, “sales deductions”) and returns. Amounts accrued for sales deductions and returns are adjusted when trends, significant events, or actual results indicate that adjustment is appropriate. With the exception of allowances for prompt payment, allowances for sales deductions and returns are included in accounts payable and accrued expenses in the accompanying consolidated balance sheet as of December 31, 2011.

We do not record sales deductions and returns for sales of raxibacumab due to the absence of discounts and rebates and no right of return under our contract with the USG. Aside from product recall, once delivery has occurred, product may not be returned for any reason, including failure to obtain FDA approval. Furthermore, we have no obligation to replace existing SNS doses if the formulation changes during the FDA approval process.

We estimate BENLYSTA sales deductions and returns utilizing actual sales data, contracts with distributors and wholesalers and third-party market research. Our estimates and assumptions are subject to inherent limitations and may need to be adjusted accordingly on a prospective basis. Specific considerations for BENLYSTA sold in the U.S. are as follows:

• With respect to BENLYSTA, we have determined that we qualify as the principal based on various elements of our agreement with GSK, including responsibility for manufacturing product for sale in the U.S., inventory risk and primary responsibility for changes to the product, including product specifications. We have an agreement with GSK whereby GSK provides distribution services.

• BENLYSTA is distributed in the U.S. using specialty distributors and wholesalers. Under this model, exclusive distributors purchase and take physical delivery and title of product, and then sell to physicians or their clinics. Because we received FDA approval in the first quarter of 2011, we currently cannot make a reasonable estimate of future product returns when product is delivered to distributors. Therefore, we currently do not recognize revenue upon product shipment to specialty distributors, even though the distributor is invoiced upon product shipment. Instead, we recognize revenue through the specialty distributor channel at the time of shipment to the physicians or their clinics. As of December 31, 2011, we have deferred

- 45 -

Critical Accounting Policies and the Use of Estimates (continued)

revenue of approximately $1.8 million with respect to BENLYSTA, which represents product shipped to specialty distributors but not yet sold through to physicians or clinics. The product at the specialty distributors is subject to return under the conditions described below. As of December 31, 2011, the manufacturing cost of product at the specialty distributors is negligible, as it was manufactured prior to our capitalization date in 2010. Royalties or other cost of sales will be recorded upon revenue recognition. Wholesalers supply product to all other healthcare providers (e.g. hospitals, pharmacies), however they do not take physical delivery of product. All wholesaler orders are drop-shipped directly to the healthcare providers. For wholesaler purchases, we currently recognize revenue upon shipment to the healthcare provider.

• Product returns. BENLYSTA customers are not offered a general right of return. However, we will accept product that is damaged or defective when shipped directly from GSK or for expired product up to 12 months subsequent to its expiration date. Due to the price of BENLYSTA and limited contractual rights of return, healthcare providers generally only carry inventory quantities estimated to meet projected short-term demand. Once product has been delivered to healthcare providers, the risk of material returns is significantly mitigated, and we are able to make a reasonable estimate of future returns at that point. In developing estimates for sales returns, we consider shelf life of the product, expected demand based on market data and publicly available return rates used for other biologic drugs. In addition, we consider the price of the product, the nature of healthcare providers, the ability of healthcare providers to obtain product on a just-in-time basis, the predictability of patient infusion and dosing and the absence of financial incentives that would promote bulk or advance purchasing. For reference, a 10% change to the returns allowance percentage for 2011 would result in a $0.1 million impact to net product sales for 2011.

• Rebates. Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or legal requirements with public sector (e.g. Medicaid) benefit providers. The allowance for rebates is based on statutory discount rates and expected utilization. Our estimates for expected utilization of rebates are based in part on third party market research data. Rebates are generally invoiced and paid quarterly in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity, plus an accrual balance for known prior quarters’ unpaid rebates. If actual future rebates vary from estimates, we may need to adjust prior period accruals, which would affect revenue in the period of adjustment. For reference, a 10% change to the rebate allowance percentage for 2011 would result in a $0.2 million impact to net product sales for 2011.

• Chargebacks. Chargebacks are discounts that occur when contracted customers purchase directly from an intermediary distributor or wholesaler. Contracted customers, which currently consist primarily of Public Health Service institutions and Federal government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The distributor or wholesaler, in turn, charges back the difference between the price initially paid by the distributor or wholesaler and the discounted price paid to the distributor or wholesaler by the customer. The allowance for distributor/wholesaler chargebacks is based on known sales to contracted customers.

• Distributor / Wholesaler deductions. U.S. specialty distributors and wholesalers are offered various forms of consideration including allowances, service fees and prompt payment discounts. Distributor allowances and service fees arise from contractual agreements with distributors and are generally a fixed rate per vial purchased. Wholesale customers are offered a prompt pay discount for payment within a specified period. Distributor allowances and service fees and wholesaler prompt payment discounts recorded in our 2011 statement of operations are based on actual product sales and are not estimates.

- 46 -

Critical Accounting Policies and the Use of Estimates (continued)

• Co-pay assistance. Patients who have commercial insurance and meet certain eligibility requirements may receive co-pay assistance. We accrue a liability for co-pay assistance based on actual program participation and estimates of program redemption using data provided by third-party administrators. For reference, a 10% change to the co-pay allowance percentage for 2011 would result in a negligible impact to net product sales for 2011.

The following table summarizes the activity of BENLYSTA sales deductions and return amounts recorded in Accrued expenses in our consolidated balance sheet for 2011 (dollars in millions):

	Rebates & Chargebacks			Wholesaler/Distributor Deductions, Co-pay Assistance & Prompt  Pay			Returns		Total
Balance as of January 1, 2011	$	—		$	—		$	—	$	—
Reserve for current period sales		0.5			0.2			0.1		0.8
Adjustment for prior period sales		—			—			—		—
Credits/payments for prior period sales		—			—			—		—
Credits/payments for current period sales		—			—			—		—
Balance as of June 30, 2011		0.5			0.2			0.1		0.8
Reserve for current period sales		1.6			0.6			0.3		2.5
Adjustment for prior period sales		0.1			—			—		0.1
Credits/payments for prior period sales		(0.2	)		(0.2	)		—		(0.4	)
Credits/payments for current period sales		(0.1	)		(0.1	)		—		(0.2	)
Balance as of September 30, 2011		1.9			0.5			0.4		2.8
Reserve for current period sales		2.3			0.9			0.3		3.5
Adjustment for prior period sales		—			(0.1	)		—		(0.1	)
Credits/payments for prior period sales		(0.6	)		(0.5	)		—		(1.1	)
Credits/payments for current period sales		(0.3	)		(0.1	)		—		(0.4	)
Balance as of December 31, 2011	$	3.3		$	0.7		$	0.7	$	4.7

Because our commercial launch of BENLYSTA began near the end of March 2011, we had no sales deductions and return activity for the three months ended March 31, 2011.

We are not the principal with respect to BENLYSTA sold outside the U.S., i.e. in the rest of world (“ROW”). Therefore, we do not record product sales with respect to this activity.

Manufacturing and development services. We have entered into agreements for manufacturing process development, clinical and commercial supply of certain biopharmaceutical products. Revenue under these agreements is recognized as services are performed or products delivered, depending on the nature of the work contracted, using a proportional performance method of accounting. Performance is assessed using output measures such as units-of-work performed to date as compared to total units-of-work contracted. Advance payments received in excess of amounts earned are classified as deferred revenue until earned.

Research and development collaborative agreements. Our revenue recognition policies for all non-refundable up-front license fees and milestone arrangements are in accordance with the guidance provided in FASB ASC Topic 605, Revenue Recognition. FASB ASC Topic 605 provides guidance on when an arrangement that involves multiple revenue-generating activities or deliverables should be divided into separate units of accounting for revenue recognition purposes, and if this division is required, how the arrangement consideration should be allocated among the separate units of accounting. If the deliverables

- 47 -

Critical Accounting Policies and the Use of Estimates (continued)

in a revenue arrangement constitute separate units of accounting according to FASB ASC Topic 605’s separation criteria, the revenue recognition policy must be determined for each identified unit. If the arrangement is a single unit of accounting, the revenue recognition policy must be determined for the entire arrangement. Under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting, non-refundable up-front license fees are deferred and recognized as revenue on a straight-line basis over the expected term of our continued involvement in the research and development process. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved, and the milestone payments are due and collectible. If not deemed substantive, we would recognize such milestones as revenue on a straight-line basis over the remaining expected term of continued involvement in the research and development process. Milestones are considered substantive if all of the following conditions are met: (1) it is commensurate with either our performance to meet the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the our performance to achieve the milestone, (2) it relates solely to past performance, and (3) the value of the milestone is reasonable relative to all the deliverables and payment terms (including other potential milestone consideration) within the arrangement. Payments received in advance of work performed are recorded as deferred revenue.

The up-front license fee and expense reimbursement received in 2006 from Novartis in connection with ZALBIN along with subsequently received milestones were recognized ratably over the estimated four-year clinical development period ending in 2010. Our initial payment from GSK in connection with BENLYSTA was recognized ratably over the estimated four-year clinical development period ending in 2010. Our up-front license fee with GSK in connection with albiglutide is being recognized ratably over the estimated eight-year clinical development period ending in 2012. Our revenues from other research and development collaborative agreements in 2011, 2010 and 2009 have generally been recognized in full upon receipt, as we have met the criteria for recognition.

Cost of product sales. We capitalize inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. Prior to capitalization, the cost of manufacturing drug product is recognized as research and development expense in the period that the cost is incurred. Therefore, manufacturing costs incurred prior to capitalization are not included in cost of product sales when revenue is recognized from the sale of that drug product.

Prior to receiving a follow-on order for raxibacumab from the USG in July 2009, we did not capitalize inventory costs related to this product. Although authorization to ship to the SNS was received in January 2009, there continued to be uncertainty around future product orders. Beginning in July 2009, the cost of manufacturing raxibacumab is recognized as a cost of product sales (capitalized and then expensed when revenue is recognized), rather than research and development expenses in the period that the cost is incurred.

Prior to the BENLSYTA Advisory Committee meeting in November 2010, we did not capitalize inventory costs related to this product. Following the positive outcome of the Advisory Committee, the cost of manufacturing BENLYSTA is being capitalized and will be expensed as cost of product sales as revenue is recognized, rather than being recorded as research and development expenses in the period that the cost is incurred.

Cost of product sales also includes royalties paid or payable to third parties based on the sales levels of certain products, distribution services costs and any applicable unabsorbed costs as a result of not operating our manufacturing facilities at full capacity.

- 48 -

Critical Accounting Policies and the Use of Estimates (continued)

Research and development expenses. Research and development expenses primarily include related salaries, outside services, materials and supplies and allocated facility costs. Such costs are charged to research and development expense as incurred. Our drug development expenses include accruals for clinical site and clinical research organization (“CRO”) costs. Estimates of the incurred to date but not yet received invoices must be made for clinical site and CRO costs in determining the accrued balance in any accounting period. Reimbursement of research and development expenses received in connection with collaborative cost-sharing agreements is recorded as a reduction of such expenses.

Stock compensation. We have a stock incentive plan (the “Incentive Plan”) under which options to purchase shares of our common stock may be granted to employees, consultants and directors at a price no less than the quoted market value on the date of grant. The Incentive Plan also provides for awards in the form of stock appreciation rights, restricted (non-vested) or unrestricted stock awards, stock-equivalent units or performance-based stock awards.

We account for share-based awards to employees and non-employee directors pursuant to FASB ASC Topic 718, Compensation – Stock Compensation, which requires that compensation cost resulting from share-based payment transactions be recognized in the financial statements at fair value over the service period. The amount of compensation expense recognized using the fair value method requires us to exercise judgment and make assumptions relating to the factors that determine the fair value of our stock option grants. We use the Black-Scholes-Merton model to estimate the fair value of our option grants. The fair value calculated by this model is a function of several factors, including grant price, the risk-free interest rate, the estimated term of the option and the estimated future volatility of the option. The estimated term and estimated future volatility of the options require our judgment.

Commercial collaboration expenses. Commercial collaboration expenses include GSK’s share of the collaboration profit with respect to BENLYSTA sales in the United States. At this time, it also includes our share of the ROW collaboration expense incurred by GSK. In the period when ROW results become profitable, we will begin to reflect such results as commercial collaboration income. Commercial collaboration expenses/income does not include any research and development expenses shared with GSK.

Income taxes. Deferred tax assets and liabilities are determined based on temporary differences between the financial reporting basis and the tax basis of assets and liabilities. These deferred tax assets and liabilities are measured using the enacted tax rates and laws that will be in effect when such amounts are expected to reverse or be utilized. The realization of total deferred tax assets is contingent upon the generation of future taxable income. A valuation allowance is provided to reduce such deferred tax assets to amounts more likely than not to be ultimately realized.

In determining the effective income tax rate, we analyze various factors, including projections of our annual earnings and taxing jurisdictions in which the earnings will be generated, the impact of state and local and foreign income taxes and our ability to use tax incentives. We file income tax returns in U.S. federal, state and foreign jurisdictions. Our income taxes have not been subject to examination by any tax jurisdictions since our inception. Accordingly, all our filed income tax returns are subject to examination by the taxing jurisdictions.

- 49 -

Results of Operations

Years Ended December 31, 2011 and 2010

Revenues. We had revenues of $131.0 million and $157.4 million for 2011 and 2010, respectively. Revenues for 2011 primarily included $52.3 million in BENLYSTA product sales ($59.2 million in gross sales before sales deductions and returns), as well as $52.5 million in raxibacumab product sales and $24.8 million in manufacturing and development services revenue. Revenues for 2010 consisted primarily of $82.8 million recognized from Novartis with respect to ZALBIN, as well as $47.2 million in raxibacumab product sales and $22.7 million from manufacturing and development services revenue. No revenue with respect to ZALBIN has been recognized beyond September 2010 due to our decision to end further development of ZALBIN based on regulatory feedback. BENLYSTA revenue in future periods is expected to increase as BENLYSTA sales progress. In addition, product sales in 2012 are expected to include approximately $25.0 million of raxibacumab sales related to the second USG order.

Cost of product sales. Cost of product sales was $47.1 million and $29.9 million for 2011 and 2010, respectively. The increase in cost of product sales for 2011 is primarily related to BENLYSTA royalties, increased raxibacumab product cost and royalties and expenses related to rejected or terminated production batches. Cost of product sales and gross margins for 2011 benefited from BENLYSTA product sales with no related cost of sales, other than royalties and distribution costs, because such inventory was manufactured prior to our capitalization date and charged to research and development expenses in the period manufactured. As of December 31, 2011 and 2010, we had BENLYSTA inventory which cost approximately $92.8 million and $112.8 million, respectively, with no carrying value, and accordingly, we expect our future cost of product sales and our gross margins to benefit from utilization of this inventory, which is sold on a first-in-first-out basis, to the extent it is used commercially rather than clinically.

As of December 31, 2011, our current inventory includes an aggregate of $10.8 million of raw materials and work in process relating to anticipated future orders for raxibacumab beyond that which is required to fulfill the second order from the USG. We currently expect to recover the cost of this inventory through future sales of raxibacumab. If we do not receive additional orders for raxibacumab, we would need to record a charge to cost of product sales for this amount of inventory. In addition, we would need to expense 2012 costs attributable to raxibacumab.

Cost of manufacturing and development services. Cost of manufacturing and development services was $29.0 million and $15.0 million for 2011 and 2010, respectively. Our manufacturing and development services costs include costs associated with contract manufacturing services and raxibacumab development services costs. Our costs with respect to contract manufacturing services can represent a significant portion of revenues, depending upon production volumes, efficiencies and product mix. During 2011, we expensed certain quarantined or terminated production batches that were manufactured. After briefly suspending production, we resumed production in September 2011 and returned to a normal production level with respect to this contract in late 2011.

Manufacturing capacity. To the extent our commercial production levels are below normal capacity and we are not manufacturing commercial product during any portion of a year, the costs attributable to this excess capacity would be recorded as cost of sales in the period incurred. Based on our current plans, we anticipate that our large-scale manufacturing facility will be operating below normal capacity during portions of 2012 and that such excess capacity costs could range between $35.0 million and $40.0 million.

Expenses. Research and development net expenses were $196.2 million for 2011 compared to $196.4 million for 2010. Our research and development expenses for 2011 and 2010 are net of $27.9 million and $61.6 million, respectively, of costs reimbursed primarily by GSK and Morphotek in 2011 and primarily by GSK and Novartis in 2010.

- 50 -

Results of Operations (continued)

Years Ended December 31, 2011 and 2010 (continued)

We track our research and development expenditures by type of cost incurred – research, pharmaceutical sciences, manufacturing and clinical development.

Our research costs increased to $27.3 million for 2011 as compared to $23.2 million for 2010. This increase is primarily due to increased HGS1036 research and increased new target activity, partially offset by decreased BENLYSTA, ZALBIN and HGS1029 research activity. Our research costs for 2011 and 2010 are net of $3.3 million and $2.9 million, respectively, of cost reimbursement from GSK and Morphotek in 2011, and GSK and Novartis in 2010 under cost sharing provisions in our collaboration agreements.

Our pharmaceutical sciences costs, where we focus on improving formulation, process development and production methods, decreased to $20.9 million for 2011 from $27.8 million for 2010. This decrease is primarily due to the discontinuation of ZALBIN in 2010, partially offset by an increase in HGS1036 activity. Pharmaceutical sciences costs for 2011 are net of $4.8 million of cost reimbursement from GSK and Morphotek. Pharmaceutical sciences costs for 2010 include $0.6 million of net costs incurred by GSK and Novartis under cost sharing provisions in our collaboration agreements.

Our research-related manufacturing costs decreased to $31.1 million for 2011 from $80.2 million for 2010. This decrease is primarily due to the expensing of manufacturing costs incurred to produce BENLYSTA during 2010 before we started to capitalize such costs in November 2010. These manufacturing costs for 2011 and 2010 are net of $5.4 million and $43.4 million, respectively, of cost reimbursement from GSK and Morphotek in 2011 and GSK and Novartis in 2010 under the cost sharing provisions in our collaboration agreements.

Our clinical development costs increased to $116.9 million for 2011 from $65.2 million for 2010. This increase is primarily due to the payment of a $50.0 million upfront license fee to FivePrime in 2011. Our clinical development costs for 2011 and 2010 are net of $14.4 million and $15.9 million, respectively, of cost reimbursement primarily from GSK under cost sharing provisions in our collaboration agreements.

The research and development expenditures noted above are categorized by functional area. We evaluate and prioritize our activities according to functional area, rather than on a per-project basis. For this reason, we do not maintain a formal accounting system that captures or allocates all costs, both direct and indirect, on a per-project basis. Therefore, we do not believe that our available project-by-project information would form a reasonable basis for disclosure to investors.

Selling, general and administrative expenses increased to $158.8 million for 2011 from $106.8 million for 2010. This increase is primarily due to increased commercial readiness activities, such as market research and additional personnel including our sales force, which was hired in late 2010. Selling, general and administrative expenses in future periods are likely to increase as the level of commercial activities rises.

Commercial collaboration expenses of $31.2 million for 2011 include GSK’s share of the collaboration profit with respect to BENLYSTA sales in the United States. It also includes our share of the ROW collaboration expense incurred by GSK. In the period when ROW results become profitable, we will begin to reflect the ROW results as commercial collaboration income.

Facility-related exit credits of $1.7 million for 2011 relate to the reversal of our remaining exit reserve for certain exited space. During 2011, we decided to use this remaining exited space and therefore reversed the remaining reserve. See Note J, Facility-Related Exit Credits, of the Notes to the Consolidated Financial Statements for additional discussion.

- 51 -

Results of Operations (continued)

Years Ended December 31, 2011 and 2010 (continued)

Investment income decreased to $12.2 million for 2011 from $17.0 million for 2010. The decrease is primarily due to lower average investment balances. Investment income also includes realized net gains on our marketable securities and restricted investments of $0.2 million for 2011 as compared to net losses of $0.3 million for 2010. Our average investment balances are now higher due to proceeds received from our 2011 debt offering, which should have a positive impact on our investment income in 2012. A general decline in interest rates may adversely affect the interest earned from our portfolio as securities mature and may be replaced with securities having a lower interest rate.

Interest expense increased to $62.1 million for 2011 compared to $59.5 million for 2010. Interest expense increased during 2011 and is anticipated to increase in 2012 compared to 2011 due to the issuance of $494.5 million of convertible senior notes in November 2011. Interest expense includes non-cash interest expense related to amortization of debt discount of $23.5 million and $23.1 million for 2011 and 2010, respectively, as a result of the adoption of FASB ASC 470 which requires that the liability and equity components of convertible debt instruments that may be settled in cash upon conversion (including partial cash settlement) be separately accounted for in a manner that reflects an issuer’s non-convertible debt borrowing rate.

We recorded other expense of $1.7 million for 2011 compared to other income of $0.1 million for 2010. The change from other income to other expense is primarily due to a charge for an other-than-temporary impairment of our investment in Aegera Therapeutics, Inc. in March 2011. See Note D, Collaborations and Other Agreements, of the Notes to the Consolidated Financial Statements for additional discussion.

Net income (loss). We recorded a net loss of $381.1 million, or $1.97 per basic and diluted share, for 2011, compared to net loss of $233.2 million, or $1.24 per basic and diluted share, for 2010. The increased net loss is primarily due to lower revenue recognized in 2011 from research and development collaborative agreements, increased selling, general and administrative expenses and commercial collaboration expense as we launched BENLYSTA, along with higher cost of product sales and cost of manufacturing and development services, partially offset by BENLYSTA revenue in 2011.

- 52 -

Results of Operations

Years Ended December 31, 2010 and 2009

Revenues. We had revenues of $157.4 million and $275.7 million for 2010 and 2009, respectively. Revenues for 2010 consisted primarily of $82.8 million recognized from Novartis primarily relating to recognition of all remaining unrecognized up-front license fees and milestones due to the decision to end further development of ZALBIN, as well as $47.2 million in raxibacumab product sales and $21.3 million from contract manufacturing services. Revenues for 2009 consisted primarily of $154.1 million in raxibacumab product sales, $54.2 million recognized from Novartis related to straight-line recognition of up-front license fees and milestones reached for ZALBIN, $26.1 million related to raxibacumab development services and $24.4 million from contract manufacturing services.

Cost of product sales. Cost of product sales was $29.9 million and $15.8 million for 2010 and 2009, respectively. Cost of product sales for 2010 includes the cost of manufacturing raxibacumab and royalties whereas the cost of product sales for 2009 included only royalties, as the manufacturing costs had been previously expensed. Cost of product sales for 2010 also includes amounts expensed related to rejected or terminated raxibacumab production batches.

Cost of manufacturing and development services. Cost of manufacturing and development services was $15.0 million and $18.2 million for 2010 and 2009, respectively. Our manufacturing and development services costs include costs associated with contract manufacturing services and raxibacumab development services costs. The decrease in manufacturing and development services costs is primarily due to reduced contract manufacturing activities.

Expenses. Research and development expenses were $196.4 million for 2010 as compared to $173.7 million for 2009. Our research and development expenses for 2010 are net of $61.6 million of costs primarily reimbursed by GSK and Novartis. Our research and development expenses for 2009 are net of $44.0 million of costs reimbursed primarily by GSK and Novartis.

Our research costs amounted to $23.2 million for 2010 as compared to $19.0 million for 2009. This increase is primarily due to activity related to HGS1029 and new target development. Our research costs for 2010 and 2009 are net of $2.9 million and $3.2 million, respectively, of cost reimbursement primarily from GSK and Novartis under cost sharing provisions in our collaboration agreements.

Our pharmaceutical sciences costs decreased to $27.8 million for 2010 from $31.4 million for 2009. This decrease is primarily due to decreased activity related to contract manufacturing services and ZALBIN, partially offset by increased BENLYSTA activity. Pharmaceutical sciences costs for 2010 include $0.6 million of net costs incurred by GSK and Novartis. Pharmaceutical sciences costs for 2009 are net of $0.5 million of cost reimbursement from GSK and Novartis under cost sharing provisions in our collaboration agreements.

Our manufacturing costs increased to $80.2 million for 2010 from $49.0 million for 2009. This increase is primarily due to increased BENLYSTA production partially offset by decreased ZALBIN activity and capitalization of raxibacumab manufacturing costs in 2010. Our manufacturing costs for 2010 and 2009 are net of $43.4 million and $9.7 million, respectively, of cost reimbursement from GSK and Novartis under the cost sharing provisions in our collaboration agreements. Manufacturing costs incurred to produce BENLYSTA prior to the FDA Advisory Committee vote to recommend approval were expensed as incurred.

Our clinical development costs decreased to $65.2 million for 2010 from $74.3 million for 2009. The decrease is primarily due to the completion of our first BENLYSTA Phase 3 clinical trial in 2009, completion of our second Phase 3 BENLYSTA clinical trial in March 2010 and decreased raxibacumab development activities. Our clinical development costs for 2010 and 2009 are net of $15.9 million and $30.5 million, respectively, of cost reimbursement from GSK and Novartis under cost sharing provisions in our collaboration agreements.

- 53 -

Results of Operations (continued)

Years Ended December 31, 2010 and 2009 (continued)

Selling, general and administrative expenses increased to $106.8 million for 2010 from $61.1 million for 2009. This increase is primarily due to increased commercial readiness activities, such as market research and additional personnel including our sales force, which was hired in late 2010.

Facility-related exit charges of $0.8 million for 2009 relate to an adjustment to our exit reserve for Wing C. See Note J, Facility-Related Exit Credits, of the Notes to the Consolidated Financial Statements for additional discussion.

Investment income increased to $17.0 million for 2010 from $12.7 million for 2009. The increase is primarily due to higher average investment balances partially offset by lower yields on our portfolio. Investment income also includes realized net losses on our marketable securities and restricted investments of $0.3 million for 2010 as compared to net losses of $0.8 million for 2009. The yield on our investments was approximately 1.6% for 2010, as compared to approximately 2.5% for 2009. A general decline in interest rates may adversely affect the interest earned from our portfolio as securities mature and may be replaced with securities having a lower interest rate.

Interest expense increased to $59.5 million for 2010 compared to $58.4 million for 2009. Interest expense includes non-cash interest expense related to amortization of debt discount of $23.1 million and $21.9 million for 2010 and 2009, respectively, as a result of the adoption of FASB ASC 470 which requires that the liability and equity components of convertible debt instruments that may be settled in cash upon conversion (including partial cash settlement) be separately accounted for in a manner that reflects an issuer’s non-convertible debt borrowing rate.

The gain on extinguishment of debt of $38.9 million for 2009 relates to the repurchase of convertible subordinated debt due in 2011 and 2012 with a face value of approximately $106.2 million for an aggregate cost of approximately $50.0 million plus accrued interest. The gain on extinguishment of debt is net of write-offs of related debt discount of $16.4 million and deferred financing charges of $0.9 million.

The gain on sale of long-term equity investment for 2009 of $5.3 million relates to the 2008 sale of our investment in CoGenesys, Inc. (“CoGenesys”). The agreement between CoGenesys and Teva Pharmaceutical Industries Ltd. (“Teva”) provided for an escrow of a portion of the purchase price. We received the final payment for our equity investment during 2009 and recorded a gain of $5.3 million with respect to this escrow.

We recorded other income of $0.1 million for 2010, and other expense of $0.2 million for 2009.

Income tax benefit. Income tax benefit of $1.3 million for 2009 represents a credit received in 2009 of $0.5 million for 2008 and an accrued income tax benefit of $0.8 million for 2009. We elected to accelerate recognition of research and development tax credits by electing out of bonus depreciation pursuant to regulations passed in 2008.

Net income (loss). We recorded a net loss of $233.2 million, or $1.24 per basic and diluted share, for 2010, compared to net income of $5.7 million, or $0.04 per basic and diluted share, for 2009. The change from net income to net loss is primarily due to lower product sales and manufacturing and development services revenue in 2010 versus 2009 and the gain on extinguishment of debt in 2009, partially offset by increased revenue recognized from the Novartis agreement in 2010.

- 54 -

Liquidity and Capital Resources

We had working capital of $326.6 million as of December 31, 2011 compared to working capital of $250.2 million as of December 31, 2010. The increase in our working capital is primarily due to the net proceeds from our $494.5 million issuance of 3% Convertible Senior Notes due 2018 and the conversion of $116.6 million aggregate principal (net of an unamortized discount of $1.2 million) of our 2 ¹/4% Convertible Subordinated Notes due 2011 that had been outstanding as of December 31, 2010. Increases to working capital were partially offset by cash used to fund our operations, the classification of $198.0 million of our 2 ¹/4% Convertible Subordinated Notes due 2012 as a current liability as of December 31, 2011 compared to non-current as of December 31, 2010, the cash repayment of approximately $78.0 million remaining principal of our 2 ¹/4% Convertible Subordinated Notes due 2011 at maturity and the $50.0 million upfront license fee paid to FivePrime during 2011.

We received FDA approval for BENLYSTA and began recognizing revenue from U.S. commercial sales of the product in March 2011. In addition to our commercial sales of BENLYSTA, we are currently completing a 2009 follow-on order from the USG for raxibacumab. We expect to receive a total of approximately $142.0 million from this order as deliveries are completed, $117.4 million of which was recognized as revenue through December 31, 2011. Shipments are to be delivered over a three-year period ending in 2012. We may also receive payments under collaboration agreements, to the extent milestones are met, which would further improve our working capital position.

We plan to manage our expenses at a level appropriate for our current and expected available resources. However, the amounts of expenditures that will be needed to carry out our business plan are subject to numerous uncertainties, which may adversely affect our liquidity and capital resources.

We are incurring significant sales and marketing costs as we develop the market for BENLYSTA in the U.S. and Europe with our BENLYSTA partner, GSK. In addition, we expect to continue to incur substantial expenses related to our research and development efforts. We have ongoing Phase 1, Phase 2 and Phase 3 trials and expect to initiate additional trials in the future, including post-marketing trials required by the FDA in connection with the approval of BENLYSTA. The duration and cost of our clinical trials are a function of numerous factors such as the type, complexity, novelty and intended use of the drug candidate, the number of patients to be enrolled in the trial, the amount of time it takes to enroll them, the length of time they must be treated and observed, and the number of clinical sites and countries for the trial.

- 55 -

Liquidity and Capital Resources (continued)

Our clinical development expenses are dependent on the clinical phase of our drug candidates. Our expenses increase as our drug candidates move to later phases of clinical development. The status of those clinical projects for which we incur clinical development expenses on our consolidated statements of operations is as follows:

		Clinical Trial Status as of December 31, (2)
Product Candidate (1)	Indication	2011	2010	2009
BENLYSTA	Systemic Lupus Erythematosus	(3)	Phase 3	Phase 3
BENLYSTA	Rheumatoid Arthritis	(4)	(4)	Phase 2
Raxibacumab	Anthrax	(5)	(5)	(5)
HGS1036	Cancer	(6)	—	—
Mapatumumab (7)	Cancer	Phase 2	Phase 2	Phase 2
HGS1029	Cancer	(8)	Phase 1	Phase 1

(1) Includes only those candidates for which an Investigational New Drug Application (“IND”) has been filed with the FDA and for which initial dosing of patients has occurred.

(2) Clinical Trial Status defined as when patients are being dosed.

(3) Product approved in the U.S. and Europe; Phase 3 sub-cutaneous formulation study underway; Phase 4 studies in planning stage.

(4) Phase 2 trial completed; treatment IND ongoing.

(5) BLA filed in 2009; Complete Response Letter received from the FDA; additional work ongoing.

(6) Formerly FP-1039. Phase 1 trial initiated by FivePrime was completed in 2011. We are planning to initiate a Phase 1b trial in 2012.

(7) Formerly HGS-ETR1.

(8) Further development discontinued.

We identify our drug candidates by conducting numerous preclinical studies. We may conduct multiple clinical trials to cover a variety of indications for each drug candidate. Based upon the results from our trials, we may elect to discontinue clinical trials for certain indications or certain drugs in order to concentrate our resources on more promising drug candidates. We are advancing a number of drug candidates, including antibodies, proteins and small molecules, in part to diversify the risks associated with our research and development spending. In addition, our manufacturing plants have been designed to enable multi-product manufacturing capability.

We must receive regulatory clearance to advance each of our products into and through each phase of clinical testing. Moreover, we must receive regulatory approval to launch any of our products commercially. In order to receive such approval, the appropriate regulatory agency must conclude that our clinical data establish safety and efficacy and that our products and the manufacturing facilities meet all applicable regulatory requirements.

Because of the uncertainties discussed above, the costs to advance our research and development projects are difficult to estimate and may vary significantly.

Part of our business plan includes collaborating with others. For example, we entered into a collaboration agreement with GSK in 2006 with respect to BENLYSTA. We and GSK share Phase 3 and 4 development costs, and share sales and marketing expenses and profits of any product that is commercialized in accordance with the collaboration agreement. During 2011, we recorded approximately $25.1 million due from GSK with respect to our cost sharing agreements as a reduction of research and development expenses.

We have collaborators who have sole responsibility for product development. For example, GSK is developing other products under separate agreements as part of our overall relationship with them. We have no control over the progress of GSK’s development plans. We cannot forecast with any degree of certainty whether any of our current or future collaborations will affect our drug development. To the extent milestones are met under existing collaboration agreements or we enter into additional collaborations with respect to our product candidates, we may receive additional payments and/or upfront fees, which would improve our liquidity.

- 56 -

Liquidity and Capital Resources (continued)

Our future capital requirements and the adequacy of our available funds will depend on many factors, primarily including the level of BENLYSTA revenue, the scope and costs of our clinical development programs, the scope and costs of our manufacturing and process development activities, the magnitude of our discovery and preclinical development programs and the level of our commercial activities.

Our long-term strategy includes the acquisition of other biotechnology companies or in-license of additional product candidates to complement and supplement our existing product pipeline, and we may acquire such companies and in-license additional product candidates that have demonstrated positive pre-clinical and/or clinical data. Any such acquisition or in-license agreement could include consideration in the form of cash, which would have an adverse effect on our liquidity.

We believe that our existing cash and investments, cash generated from BENLYSTA sales, payments received under the raxibacumab contract and other agreements and investment income will be sufficient to fund our operations for at least the next 12 months. However, in the event our 2 ¹/4% Convertible Subordinated Notes due 2012 are repaid in cash rather than converted to common stock in August 2012, our existing funds and anticipated cash flows would be adversely affected. We continuously evaluate opportunities to refinance our existing debt or raise additional funds, and depending on market conditions we may choose to seek alternative sources of funding such as debt or equity offerings in order to strengthen our financial position. There can be no assurance that any such financing required in the future will be available on acceptable terms, if at all.

To minimize our exposure to credit risk, we invest in securities with strong credit ratings and have established guidelines relative to diversification and maturity with the objectives of maintaining safety of principal and liquidity. We do not invest in derivative financial instruments or auction rate securities, and we generally hold our investments in debt securities until maturity. However, all of our investments are classified as available-for-sale as we may determine that market or business conditions may lead us to sell a security prior to maturity.

Our unrestricted and restricted funds may be invested in U.S. Treasury securities, government agency obligations, high grade corporate debt securities and various money market instruments rated “A-” or better. Such investments reflect our policy regarding the investment of liquid assets, which is to seek a reasonable rate of return consistent with an emphasis on safety, liquidity and preservation of capital.

As of December 31, 2011, we had net operating loss carryforwards (“NOLs”) for federal income tax purposes of approximately $2.1 billion, excluding approximately $0.4 billion of stock-based compensation NOLs, which expire, if unused, through December 31, 2031. We also have available research and development tax credit and other tax credit carryforwards of approximately $40.5 million, the majority of which will expire, if unused, through December 31, 2031.

We have certain contractual obligations that may have a future effect on our financial condition, changes in financial condition, results of operations, liquidity, capital expenditures or capital resources. Our operating leases are not recorded on our balance sheets. Debt associated with the 2006 sale of our LSM to BioMed and accompanying leaseback is recorded on our balance sheet as of December 31, 2011 and 2010. We have an option to purchase the Traville facility in 2016 for $303.0 million. This is not reflected in the contractual obligations table below because we are not obligated to exercise this option.

- 57 -

Liquidity and Capital Resources (continued)

Our contractual obligations as of December 31, 2011 are summarized as follows:

	Payments Due by Period
	(dollars in millions)
	Total		One year or less		Two to three years		Four to five years		After five years
Long-term debt - convertible notes(1)	$	809.8	$	226.2	$	29.7	$	29.7	$	524.2
Long-term lease commitment - BioMed(2)		421.5		25.5		52.6		54.7		288.7
Operating leases(3)		324.5		21.3		43.8		44.5		214.9
Raxibacumab royalties(4)		1.6		1.6		—		—		—
Total contractual cash obligations(5)	$	1,557.4	$	274.6	$	126.1	$	128.9	$	1,027.8

(1) Contractual interest obligations related to our convertible senior and subordinated notes included above total $108.6 million as of December 31, 2011. Contractual interest obligations of $19.5 million are due in one year or less and $29.7 million are due each period in two to three years, four to five years and after five years, respectively.

(2) Contractual interest obligations related to BioMed are included above and aggregate $368.5 million as of December 31, 2011. Contractual interest obligations of $25.5 million, $52.6 million, $53.8 million and $236.6 million are due in one year or less, two to three years, four to five years and after five years, respectively.

(3) Includes Traville headquarters operating lease with BioMed with aggregate payments of $307.2 million. Lease payments of $18.6 million, $38.3 million, $39.9 million and $210.4 million are due in one year or less, two to three years, four to five years and after five years, respectively.

(4) Includes royalties associated with the delivery of raxibacumab to the SNS.

(5) In the event we reach certain development milestones for raxibacumab such as regulatory approval, we would be obligated to make payments of up to $3.0 million. Except for BENLYSTA, our other products are in either Phase 1 or Phase 2 and would also obligate us to make certain milestone payments should they reach Phase 3 or regulatory approval. Because we cannot forecast with any degree of certainty whether any of these products will reach these milestones, we have excluded these amounts and any royalty payments, except for those royalty payments related to raxibacumab sales under the current order from the USG, from the above table. Additionally, we have a supply commitment with respect to BENLYSTA, however the contract includes termination clauses and therefore these amounts have been excluded from the table above. For additional discussion of our debt obligations and lease commitments, see Note F, Long-Term Debt and Note G, Commitments and Other Matters, of the Notes to the Consolidated Financial Statements.

- 58 -

Off-Balance Sheet Arrangements

During 1997 and 1999, we entered into two long-term leases with the Maryland Economic Development Corporation (“MEDCO”) expiring January 1, 2019 for a small-scale manufacturing facility aggregating 127,000 square feet and built to our specifications. We have accounted for these leases as operating leases. The facility was financed primarily through a combination of bonds issued by MEDCO (“MEDCO Bonds”) and loans issued to MEDCO by certain State of Maryland agencies. We have no equity interest in MEDCO.

Rent is based upon MEDCO’s debt service obligations, which contain a variable rate component. Assuming no significant changes in the current interest rate environment, our rent for 2012 is estimated to be approximately $2.0 million. The MEDCO Bonds are secured by letters of credit issued for the account of MEDCO which expire in December 2012. We are currently required to have restricted investments of approximately $34.3 million which serve as security for the MEDCO letters of credit reimbursement obligation. Upon default or early lease termination, the MEDCO Bond indenture trustee can draw upon the letters of credit to pay the MEDCO Bonds as they are tendered. In such an event, we could lose part or all of our restricted investments and could record a charge to earnings for a corresponding amount. Alternatively, we have an option through the end of the lease term to purchase this facility for an aggregate amount that declines from approximately $34.0 million in 2012 to approximately $21.0 million in 2019.

- 59 -

Cautionary Statement Pursuant to Private Securities Litigation Reform Act of 1995 – “Safe Harbor” for Forward-looking Statements

The information in this report includes statements that are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words such as “believes,” “plans,” “expects,” “will,” “anticipates,” “estimates” and other words of similar meaning in conjunction with, among other things, discussions of financial performance or financial condition, product sales, growth strategy, product development, regulatory approvals or expenditures.

Forward-looking statements are based on our current intentions, beliefs and expectations regarding future events. The Company cannot guarantee that any forward-looking statement will be accurate. Investors should realize that if underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could differ materially from the Company’s expectations. Investors are, therefore, cautioned not to place undue reliance on any forward-looking statement. Any forward-looking statement speaks only as of the date on which such statement is made, and, except as required by law, the Company does not undertake to update any forward-looking statement to reflect new information, events or circumstances.

Some important factors that could cause the Company’s actual results to differ from the Company’s expectations in any forward-looking statement include:

• our lack of commercial experience and dependence on the sales growth of BENLYSTA;

• any failure to commercialize BENLYSTA successfully;

• the occurrence of adverse safety events with our products, resulting in product recalls, reduced sales, withdrawals, regulatory action on the part of the FDA or the termination of clinical trials for products in development;

• changes in the availability of reimbursement for BENLYSTA;

• the inherent uncertainty of the timing, success of, and expense associated with, research, development, regulatory approval and commercialization of our pipeline products and new indications for existing products;

• substantial competition in our industry, including from branded and generic products;

• the highly regulated nature of our business;

• uncertainty regarding our intellectual property rights and those of others;

• the ability to manufacture at appropriate scale, and in compliance with regulatory requirements, to meet market demand for our product;

• our substantial indebtedness and lease obligations;

• our dependence on collaborations over which we may not always have full control;

• foreign exchange rate valuations and fluctuations;

• the impact of our acquisitions and strategic transactions;

- 60 -

Cautionary Statement Pursuant to Private Securities Litigation Reform Act of 1995 – “Safe Harbor” for Forward-looking Statements (continued)

• changes in the health care industry in the U.S. and other countries, including government laws and regulations relating to sales and promotion, reimbursement and pricing generally;

• significant litigation adverse to the Company, including product liability and patent infringement claims;

• our ability to attract and retain key personnel; and

• increased scrutiny of the health care industry by government agencies and state attorneys general resulting in investigations and prosecutions.

The foregoing list sets forth many, but not all, of the factors that could cause actual results to differ from the Company’s expectations in any forward-looking statement. New factors emerge from time to time and it is not possible for management to predict all such factors, nor can it assess the impact of any such factor on the business or the extent to which any factor, or combination of factors, may cause results to differ materially from those contained in any forward-looking statement. Investors should consider this cautionary statement, as well as the factors discussed in Part I, Item 1A, “Risk Factors,” when evaluating our forward-looking statements.

- 61 -

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We do not currently have operations of a material nature that are subject to risks of foreign currency fluctuations. We do not use derivative financial instruments in our operations or investment portfolio. Our investment portfolio may be comprised of low-risk U.S. Treasuries, government-sponsored enterprise securities, high-grade debt having at least an “A-” rating at time of purchase and various money market instruments. The short-term nature of these securities, which currently have an average term of approximately nine months, decreases the risk of a material loss caused by a market change related to interest rates.

We believe that a hypothetical 100 basis point adverse move (increase) in interest rates along the entire interest rate yield curve would adversely affect the fair value of our cash, cash equivalents, marketable securities and restricted investments by approximately $6.9 million, or approximately 0.8% of the aggregate fair value of $881.4 million, as of December 31, 2011. For these reasons, and because these securities are generally held to maturity, we believe we do not have significant exposure to market risks associated with changes in interest rates related to our debt securities held as of December 31, 2011. We believe that any interest rate change related to our debt securities held as of December 31, 2011 is not material to our consolidated financial statements. As of December 31, 2011, the yield on comparable nine-month investments was approximately 0.1%, as compared to our current portfolio yield of approximately 1.0%. However, given the short-term nature of these securities, a general decline in interest rates may adversely affect the interest earned from our portfolio as securities mature and may be replaced with securities having a lower interest rate.

To minimize our exposure to credit risk, we invest in securities with strong credit ratings and have established guidelines relative to diversification and maturity with the objectives of maintaining safety of principal and liquidity. We do not invest in derivative financial instruments, auction rate securities, loans held for sale or mortgage-backed securities backed by sub-prime or Alt-A collateral, and we generally hold our investments in debt securities until maturity. However, adverse changes in the credit markets relating to credit risks would adversely affect the fair value of our cash, cash equivalents, marketable securities and restricted investments.

Our facility leases for our Traville headquarters and large-scale manufacturing require us to maintain minimum levels of restricted investments of approximately $39.8 million, or $39.5 million if in the form of cash, as collateral for these facilities. Together with the requirement to maintain approximately $34.3 million in restricted investments with respect to our small-scale manufacturing facility leases, our overall level of restricted investments is currently required to be approximately $74.1 million. Although the market value for these investments may rise or fall as a result of changes in interest rates, we will be required to maintain this level of restricted investments in either a rising or declining interest rate environment.

Our convertible notes bear interest at fixed rates. As a result, our interest expense on these notes is not affected by changes in interest rates.

During 2010 we formed several wholly-owned European subsidiaries in preparation for commercial activity in that region. The activity in these subsidiaries is increasing; however we do not believe we have material exposure to foreign currency fluctuation risks at this time. Another wholly-owned subsidiary, Human Genome Sciences Pacific Pty Ltd. (“HGS Pacific”) sponsors some of our clinical trials in the Asia/Pacific region. We currently do not anticipate HGS Pacific to have any operational activity and therefore we do not believe we will have any foreign currency fluctuation risks with respect to HGS Pacific.

- 62 -

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The information required by this item is set forth on pages F-1 - F-41.

ITEM 9. CHANGES AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

None.

ITEM 9A. CONTROLS AND PROCEDURES

Disclosure Controls and Procedures

Our management, including our principal executive and principal financial officers, has evaluated the effectiveness of our disclosure controls and procedures as of December 31, 2011. Our disclosure controls and procedures are designed to provide reasonable assurance that the information required to be disclosed in this annual report on Form 10-K has been appropriately recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive and principal financial officers, to allow timely decisions regarding required disclosure. Based on that evaluation, our principal executive and principal financial officers have concluded that our disclosure controls and procedures are effective at the reasonable assurance level.

Changes in Internal Control

Our management, including our principal executive and principal financial officers, has evaluated any changes in our internal control over financial reporting that occurred during the quarterly period ended December 31, 2011, and has concluded that there was no change that occurred during the quarterly period ended December 31, 2011 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

Management Report on Internal Control over Financial Reporting

The management of the Company is responsible for establishing and maintaining adequate internal control over financial reporting. Internal control over financial reporting is defined in Rule 13a-15(f) or 15d-15(f) promulgated under the Securities Exchange Act of 1934, as amended, as a process designed by, or under the supervision of, the Company’s principal executive and principal financial officers and effected by the Company’s board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles and includes those policies and procedures that:

• pertain to the management of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Company;

• provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only in accordance with authorizations of management and directors of the Company; and

• provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on the financial statements.

- 63 -

ITEM 9A. CONTROLS AND PROCEDURES (continued)

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. All internal control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement preparation and presentation.

The Company’s management assessed the effectiveness of the Company’s internal control over financial reporting as of December 31, 2011. In making this assessment, the Company’s management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated Framework.

Based on our assessment, management believes that, as of December 31, 2011, the Company’s internal control over financial reporting is effective based on those criteria.

The Company’s independent registered public accounting firm has issued an audit report on internal control over financial reporting which follows herein.

ITEM 9B. OTHER INFORMATION

None.

- 64 -

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

ON INTERNAL CONTROL OVER FINANCIAL REPORTING

Board of Directors and Stockholders of

Human Genome Sciences, Inc.

Rockville, Maryland

We have audited Human Genome Sciences Inc.’s internal control over financial reporting as of December 31, 2011, based on criteria established in Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). Human Genome Sciences, Inc.’s management is responsible for maintaining effective internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying “Management Report on Internal Control over Financial Reporting.” Our responsibility is to express an opinion on the company’s internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, Human Genome Sciences, Inc. maintained, in all material respects, effective internal control over financial reporting as of December 31, 2011, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of Human Genome Sciences, Inc. as of December 31, 2011 and 2010, and the related consolidated statements of operations, stockholders’ equity (deficit), and cash flows for each of the three years in the period ended December 31, 2011 and our report dated February 28, 2012 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Baltimore, Maryland

February 28, 2012

- 65 -

PART III

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

We incorporate herein by reference the relevant information concerning directors, executive officers and corporate governance to be included in our definitive proxy statement for the 2012 annual meeting of stockholders (the “2012 Proxy Statement”).

ITEM 11. EXECUTIVE COMPENSATION

We incorporate herein by reference the relevant information concerning executive compensation to be included in the 2012 Proxy Statement.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

We incorporate herein by reference the relevant information concerning security ownership of certain beneficial owners and management to be included in the 2012 Proxy Statement.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

We incorporate herein by reference the relevant information concerning certain other relationships and related transactions to be included in the 2012 Proxy Statement.

ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICES

We incorporate herein by reference the relevant information concerning principal accounting fees and services to be included in the 2012 Proxy Statement.

- 66 -

PART IV

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

(a) The following documents are filed as part of this Annual Report:

(1) Index to Consolidated Financial Statements

	Page Number
Report of Ernst & Young LLP, Independent Registered Public Accounting Firm		F-2
Consolidated Balance Sheets at December 31, 2011 and 2010		F-3
Consolidated Statements of Operations for the years ended December 31, 2011, 2010 and 2009		F-4
Consolidated Statements of Stockholders’ Equity (Deficit) for the years ended December  31, 2011, 2010 and 2009		F-5
Consolidated Statements of Cash Flows for the years ended December 31, 2011, 2010 and 2009		F-6
Notes to Consolidated Financial Statements		F-8

(2) Financial Statement Schedules

Financial statement schedules are omitted because they are not applicable.

(3) Exhibits

Exhibit No.	Description
3.1	Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company’s Annual Report on Form 10-K, filed on March 31, 1994; Exhibit 3.3 to the Company’s Annual Report on Form 10-K/A, filed on April 3, 1998; Exhibit 3.1 to the Company’s Current Report on Form 8-K, filed on December 16, 1999; Exhibit 3.1 to the Company’s Quarterly Report on Form 10-Q, filed on July 31, 2001; Exhibit 3.1 to the Company’s Current Report on Form 8-K, filed on May 8, 2008; and Exhibit 3.2 to the Company’s Current Report on Form 8-K, filed on May 24, 2010).
3.2	Amended and Restated By-laws (incorporated by reference to Exhibit 3 to the Company’s Current Report on Form 8-K, filed on October 6, 2010).
4.1	Form of Common Stock Certificate (incorporated by reference to Exhibit 4.2 to the Company’s Registration Statement on Form S-3 (Registration No. 333-45272), filed on September 6, 2000).
4.2	Indenture, dated as of August 9, 2005, between the Company and The Bank of New York, as trustee, including the form of 2 1/4% Convertible Subordinated Notes due 2012 (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed on August 9, 2005).
4.3	Senior Indenture, dated as of November 7, 2011, between the Company and The Bank of New York, as trustee, (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed on November 7, 2011).
4.4	First Supplemental Indenture, dated as of November 7, 2011, between the Company and The Bank of New York, as trustee, including the form of 3% Convertible Senior Notes due 2018 (incorporated by reference to Exhibit 4.2 to the Company’s Current Report on Form 8-K, filed on November 7, 2011).
10.1†	Co-development and Commercialization Agreement, dated as of August 1, 2006, between Glaxo Group Limited and the Company (incorporated by reference to Exhibit 10.25 to the Company’s Annual Report on Form 10-K, filed on February 26, 2009).

- 67 -

10.2†	Amendment No. 1, dated as of November 25, 2009, to Co-development and Commercialization Agreement between Glaxo Group Limited and the Company.
10.3†	Amendment No. 2, dated as of October 5, 2010, to Co-development and Commercialization Agreement between Glaxo Group Limited and the Company.
10.4	Lease Agreement, dated as of December 1, 1997, between Maryland Economic Development Corporation and the Company (incorporated by reference to Exhibit 10.67 to the Company’s Annual Report on Form 10-K, filed on March 31, 1998).
10.5	Amendment No. 1, dated as of December 1, 2009, to Lease Agreement between Maryland Economic Development Corporation and the Company (incorporated by reference to Exhibit 10.10 to the Company’s Annual Report on Form 10-K, filed on March 2, 2010).
10.6	Amended and Restated Lease Agreement, dated as of December 1, 2009, between Maryland Economic Development Corporation and the Company (incorporated by reference to Exhibit 10.12 to the Company’s Annual Report on Form 10-K, filed on March 2, 2010).
10.7	Purchase and Sale Agreement, dated as of May 2, 2006, between BioMed Realty, L.P. and the Company (incorporated by reference to Exhibit 10.2 to the Company’s Quarterly Report on Form 10-Q, filed on August 9, 2006).
10.8	Lease Agreement, dated as of May 24, 2006, between BMR-Belward Campus Drive LSM LLC and the Company (incorporated by reference to Exhibit 10.3 to the Company’s Quarterly Report on Form 10-Q, filed on August 9, 2006).
10.9	Lease Agreement, dated as of May 24, 2006, between BMR-Shady Grove Road HQ LLC and the Company (incorporated by reference to Exhibit 10.4 to the Company’s Quarterly Report on Form 10-Q, filed on August 9, 2006).
10.10	Collateral Pledge Agreement, dated as of December 1, 2009, among the Company, as Pledgor, Manufacturers and Traders Trust Company, as Pledgee, and Manufacturers and Traders Trust Company, as the Collateral Agent (incorporated by reference to Exhibit 10.14 to the Company’s Annual Report on Form 10-K, filed on March 2, 2010).
10.11	Reimbursement Agreement, dated as of December 1, 2009, between the Company and Manufacturers and Traders Trust Company, relating to 1997 Series Revenue Bonds (incorporated by reference to Exhibit 10.11 to the Company’s Annual Report on Form 10-K, filed on March 2, 2010).
10.12	Reimbursement Agreement, dated as of December 1, 2009, between the Company and Manufacturers and Traders Trust Company, relating to Series 1999 A and B Revenue Bonds (incorporated by reference to Exhibit 10.13 to the Company’s Annual Report on Form 10-K, filed on March 2, 2010).
10.13†	Solicitation (as amended) and Modification of Contract, dated June 24, 2006, awarded by the U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority to the Company (incorporated by reference to Exhibit 10.5 to the Company’s Quarterly Report on Form 10-Q/A, filed on September 27, 2007).
10.14†	Amendment of Solicitation/Modification of Contract, dated July 17, 2009, awarded by the U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority to the Company (incorporated by reference to Exhibit 10.1 to the Company’s Form 10-Q, filed on October 29, 2009).
10.15*	Capped Call Transaction Confirmation, dated as of November 2, 2011, betweeen Barclays Bank PLC and the Company.
10.16*	Capped Call Transaction Confirmation, dated as of November 2, 2011, betweeen Goldman, Sachs & Co. and the Company.
10.17*	Additional Capped Call Transaction Confirmation, dated November 2, 2011, between Barclays Bank PLC and the Company.
10.18*	Additional Capped Call Transaction Confirmation, dated November 2, 2011, between Goldman, Sachs & Co. and the Company.
C 10.19	Form of Indemnification Agreement entered into with directors and officers (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, filed on July 22, 2010).

- 68 -

C 10.20	Employment Agreement, dated as of November 21, 2004, between the Company and H. Thomas Watkins (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed on November 23, 2004).
C 10.21	First Amendment, dated as of January 1, 2008, to Employment Agreement between the Company and H. Thomas Watkins (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed on December 20, 2007).
C 10.22	Second Amendment, dated as of January 1, 2009, to Employment Agreement between the Company and H. Thomas Watkins (incorporated by reference to Exhibit 10.26 to the Company’s Annual Report on Form 10-K, filed on February 26, 2009).
C 10.23	Third Amendment, dated as of July 18, 2011, to Employment Agreement between the Company and H. Thomas Watkins (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, filed on July 28, 2011).
C 10.24	Form of Executive Agreement (incorporated by reference to Exhibit 10.2 to the Company’s Quarterly Report on Form 10-Q, filed on July 28, 2011).
C 10.25	Second Amended and Restated Key Executive Severance Plan (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, filed on December 20, 2007).
C 10.26	Form of First Amendment to Second Amended and Restated Key Executive Severance Plan (incorporated by reference to Exhibit 10.28 to the Company’s Annual Report on Form 10-K, filed on February 26, 2009).
C 10.27	Form of Second Amendment to Second Amended and Restated Key Executive Severance Plan (incorporated by reference to Exhibit 10.3 to the Company’s Quarterly Report on Form 10-Q, filed on July 28, 2011).
C 10.28	Human Genome Sciences, Inc. Discretionary Bonus Policy (incorporated by reference to Exhibit 10.4 to the Company’s Current Report on Form 8-K, filed on December 20, 2007).
C 10.29	Human Genome Sciences, Inc. Amended and Restated Stock Incentive Plan (incorporated by reference to Annex A to the Company’s Definitive Proxy Statement on Schedule 14A, filed on March 24, 2009).
C 10.30	Human Genome Sciences, Inc. Second Amended and Restated Stock Incentive Plan (incorporated by reference to the Company’s Registration Statement on Form S-8, filed on July 28, 2011).
C 10.31	Form of Restricted Stock Agreement (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, filed on August 1, 2005).
C 10.32	Form of Stock Option Agreement (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, filed on September 20, 2004).
C 10.33	Form of Stock Unit Grant Agreement under the Non-Employee Director Equity Compensation Plan (incorporated by reference to Exhibit 10.5 to the Company’s Current Report on Form 8-K, filed on December 20, 2007).
12.1*	Ratio of Earnings to Fixed Charges.
21.1*	Subsidiaries.
23.1*	Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.

- 69 -

31.1*	Rule 13a-14(a) Certification of Principal Executive Officer.
31.2*	Rule 13a-14(a) Certification of Principal Financial Officer.
32.1*	Section 1350 Certification of Chief Executive Officer.
32.2*	Section 1350 Certification of Chief Financial Officer.
101.INS**	XBRL Instance Document.
101.SCH**	XBRL Schema Document.
101.CAL**	XBRL Calculation Linkbase Document.
101.DEF**	XBRL Definition Linkbase Document.
101.LAB**	XBRL Labels Linkbase Document.
101.PRE**	XBRL Presentation Linkbase Document.

* Filed herewith.

** In accordance with Regulation S-T, the XBRL - related information in Exhibit 101 to this Annual Report on Form 10-K shall be deemed “furnished herewith” and not “filed”.

† Confidential treatment requested for certain portions of this Exhibit pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended, which portions are omitted and filed separately with the Securities and Exchange Commission.

C Management contract or compensatory plan or arrangement.

- 70 -

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

HUMAN GENOME SCIENCES, INC.
BY:	/s/ H. Thomas Watkins
	H. Thomas Watkins
	President and Chief Executive Officer

Dated: February 28, 2012

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and the dates indicated:

Signature	Title	Date
/s/ H. Thomas Watkins H. Thomas Watkins	President, Chief Executive Officer and Director (Principal Executive Officer)	February 28, 2012
/s/ David P. Southwell David P. Southwell	Executive Vice President and Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer)	February 28, 2012
/s/ Argeris N. Karabelas, Ph.D. Argeris N. Karabelas, Ph.D.	Chairman of the Board	February 28, 2012
/s/ Allan Baxter, Ph.D Allan Baxter, Ph.D.	Director	February 28, 2012
/s/ Richard J. Danzig Richard J. Danzig	Director	February 28, 2012
/s/ Colin Goddard, Ph.D. Colin Goddard, Ph.D.	Director	February 28, 2012
/s/ Maxine Gowen, Ph.D. Maxine Gowen, Ph.D.	Director	February 28, 2012
/s/ Tuan Ha-Ngoc Tuan Ha-Ngoc	Director	February 28, 2012
/s/ John LaMattina, Ph.D. John LaMattina, Ph.D.	Director	February 28, 2012
/s/ Augustine Lawlor Augustine Lawlor	Director	February 28, 2012
/s/ George J. Morrow George J. Morrow	Director	February 28, 2012
/s/ Gregory Norden Gregory Norden	Director	February 28, 2012
/s/ Robert C. Young, M.D. Robert C. Young, M.D.	Director	February 28, 2012

- 71 -

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

	Page Number
Report of Ernst & Young LLP, Independent Registered Public Accounting Firm		F-2
Consolidated Balance Sheets at December 31, 2011 and 2010		F-3
Consolidated Statements of Operations for the years ended December 31, 2011, 2010 and 2009		F-4
Consolidated Statements of Stockholders’ Equity (Deficit) for the years ended December  31, 2011, 2010 and 2009		F-5
Consolidated Statements of Cash Flows for the years ended December 31, 2011, 2010 and 2009		F-6
Notes to Consolidated Financial Statements		F-8

F-1

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Board of Directors and Stockholders of

Human Genome Sciences, Inc.

Rockville, Maryland

We have audited the accompanying consolidated balance sheets of Human Genome Sciences, Inc. as of December 31, 2011 and 2010, and the related consolidated statements of operations, stockholders’ equity (deficit) and cash flows for each of the three years in the period ended December 31, 2011. These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Human Genome Sciences, Inc. at December 31, 2011 and 2010, and the consolidated results of its operations and its cash flows for each of the three years in the period ended December 31, 2011, in conformity with U.S. generally accepted accounting principles.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), Human Genome Sciences, Inc.’s internal control over financial reporting as of December 31, 2011, based on criteria established in Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 28, 2012 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Baltimore, Maryland

February 28, 2012

F-2

HUMAN GENOME SCIENCES, INC.

CONSOLIDATED BALANCE SHEETS

	December 31,
	2011			2010
	(in thousands)
Assets
Current assets:
Cash and cash equivalents	$	402,049		$	155,691
Marketable securities		119,234			282,016
Accounts receivable		54,758			25,958
Collaboration receivables		23,013			18,856
Inventory		41,659			43,091
Prepaid expenses and other current assets		9,388			5,569
Total current assets		650,101			531,181
Marketable securities, non-current		279,958			416,165
Property, plant and equipment (net of accumulated depreciation)		251,026			253,122
Restricted investments		80,193			79,510
Inventory, non-current		111,822			—
Collaboration receivables, non-current		22,630			29,225
Other assets		11,846			5,826
TOTAL ASSETS	$	1,407,576		$	1,315,029
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable and accrued expenses	$	47,453		$	41,798
Accrued payroll and related taxes		34,339			30,157
Convertible subordinated debt		198,037			188,620
Collaboration payable		33,230			12,984
Deferred revenues		9,452			5,134
Accrued exit expenses		—			1,238
Other current liabilities		1,038			1,013
Total current liabilities		323,549			280,944
Convertible senior debt, non-current		363,698			—
Convertible subordinated debt, non-current		—			184,231
Lease financing		252,105			250,516
Other liabilities		11,805			13,575
Total liabilities		951,157			729,266
Stockholders’ equity:
Preferred stock - $0.01 par value; 20,000,000 shares authorized; none outstanding		—			—
Common stock - $0.01 par value; 400,000,000 shares authorized; 198,750,531 and 188,980,748 shares issued and outstanding at December 31, 2011 and 2010, respectively		1,988			1,890
Additional paid-in capital		3,250,878			2,996,645
Accumulated other comprehensive income		4,556			7,125
Accumulated deficit		(2,801,003	)		(2,419,897	)
Total stockholders’ equity		456,419			585,763
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY	$	1,407,576		$	1,315,029

The accompanying Notes to Consolidated Financial Statements are an integral part hereof.

F-3

HUMAN GENOME SCIENCES, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

	Year Ended December 31,
	2011			2010			2009
	(in thousands, except share and per share amounts)
Revenue:
Product sales	$	104,863		$	47,159		$	154,074
Manufacturing and development services		24,840			22,695			50,653
Research and development collaborative agreements		1,272			87,497			71,022
Total revenue		130,975			157,351			275,749
Costs and expenses:
Cost of product sales		47,061			29,941			15,805
Cost of manufacturing and development services		28,999			15,016			18,215
Research and development expenses		196,182			196,370			173,709
Selling, general and administrative expenses		158,779			106,797			61,073
Commercial collaboration expenses		31,222			—			—
Facility-related exit (credits) charges		(1,717	)		—			759
Total costs and expenses		460,526			348,124			269,561
Income (loss) from operations		(329,551	)		(190,773	)		6,188
Investment income		12,175			16,966			12,727
Interest expense		(62,056	)		(59,500	)		(58,424	)
Gain on extinguishment of debt		—			—			38,873
Gain on sale of long-term equity investment		—			—			5,259
Other income (expense)		(1,674	)		76			(238	)
Income (loss) before taxes		(381,106	)		(233,231	)		4,385
Income tax benefit		—			—			1,274
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659
Basic and diluted net income (loss) per share	$	(1.97	)	$	(1.24	)	$	0.04
Weighted average shares outstanding, basic		193,667,672			187,791,437			149,334,426
Weighted average shares outstanding, diluted		193,667,672			187,791,437			155,053,473

The accompanying Notes to Consolidated Financial Statements are an integral part hereof.

F-4

HUMAN GENOME SCIENCES, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY (DEFICIT)

					Additional			Accumulated Other
	Common Stock				Paid-In			Comprehensive			Accumulated
	Shares		Amount		Capital			Income (Loss)			Deficit			Total
	(in thousands, except share amounts)
Balance - December 31, 2008		135,739,978	$	1,357	$	2,059,154		$	(4,490	)	$	(2,192,325	)	$	(136,304	)
Comprehensive income (loss):
Net income		—		—		—			—			5,659			5,659
Unrealized gain on investments		—		—		—			11,264			—			11,264
Cumulative translation adjustment		—		—		—			591			—			591
Comprehensive income															17,514
Issuance of common stock pursuant to public offerings		44,522,250		446		812,423			—			—			812,869
Shares of common stock issued pursuant to stock-based compensation plans		4,992,432		50		48,762			—			—			48,812
Stock-based compensation		—		—		12,524			—			—			12,524
Balance - December 31, 2009		185,254,660		1,853		2,932,863			7,365			(2,186,666	)		755,415
Comprehensive income (loss):
Net loss		—		—		—			—			(233,231	)		(233,231	)
Unrealized loss on investments		—		—		—			(212	)		—			(212	)
Cumulative translation adjustment		—		—		—			(28	)		—			(28	)
Comprehensive loss															(233,471	)
Issuance of common stock pursuant to bond redemption		562		—		8			—			—			8
Shares of common stock issued pursuant to stock-based compensation plans		3,725,526		37		38,344			—			—			38,381
Stock-based compensation		—		—		25,430			—			—			25,430
Balance - December 31, 2010		188,980,748		1,890		2,996,645			7,125			(2,419,897	)		585,763
Comprehensive income (loss):
Net loss		—		—		—			—			(381,106	)		(381,106	)
Unrealized loss on investments		—		—		—			(2,580	)		—			(2,580	)
Cumulative translation adjustment		—		—		—			11			—			11
Comprehensive loss		—		—		—			—			—			(383,675	)
Issuance of common stock pursuant to 2011 note conversion		7,678,426		77		119,098			—			—			119,175
Issuance of convertible senior notes due 2018		—		—		129,317			—			—			129,317
Purchase of capped call contracts		—		—		(50,933	)		—			—			(50,933	)
Shares of common stock issued pursuant to stock-based compensation plans		2,091,357		21		17,463			—			—			17,484
Stock-based compensation		—		—		39,288			—			—			39,288
Balance - December 31, 2011		198,750,531	$	1,988	$	3,250,878		$	4,556		$	(2,801,003	)	$	456,419

The accompanying Notes to Consolidated Financial Statements are an integral part hereof.

F-5

HUMAN GENOME SCIENCES, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

	Year Ended December 31,
	2011			2010			2009
	(in thousands)
Cash flows from operating activities:
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Stock-based compensation expense		35,915			25,430			12,524
Depreciation and amortization		21,686			21,305			21,255
Amortization of debt discount		23,485			23,052			21,936
Charge for impaired investment		3,008			—			—
Facility-related exit (credits) charges		(1,717	)		—			759
Accrued interest on marketable securities and restricted investments		1,309			5,552			(493	)
Gain on extinguishment of long-term debt		—			—			(38,873	)
Gain on sale of long-term equity investment		—			—			(5,259	)
Other		3,132			2,177			3,759
Changes in operating assets and liabilities:
Accounts receivable		(28,800	)		(2,066	)		(21,021	)
Collaboration receivables		2,438			(30,805	)		4,800
Inventory		(107,017	)		(22,942	)		(20,149	)
Prepaid expenses and other assets		(4,011	)		2,110			(1,640	)
Accounts payable and accrued expenses		6,315			3,444			(9,152	)
Accrued payroll and related taxes		4,182			(840	)		12,423
Collaboration payable		20,246			8,984			(4,000	)
Deferred revenues		4,318			(82,892	)		17,234
Accrued exit expenses		4			(1,533	)		(1,953	)
Other liabilities		(1,306	)		1,566			1,859
Net cash used in operating activities		(397,919	)		(280,689	)		(332	)
Cash flows from investing activities:
Purchase of marketable securities		(334,476	)		(840,145	)		(625,041	)
Proceeds from sale and maturities of marketable securities		630,485			681,687			388,277
Capital expenditures - property, plant, and equipment		(18,989	)		(9,782	)		(10,019	)
Proceeds from sale of long-term equity investment		319			—			5,259
Release of restricted investments		—			300			3,291
Net cash provided by (used in) investing activities		277,339			(167,940	)		(238,233	)
Cash flows from financing activities:
Purchase of restricted investments		(100,027	)		(31,672	)		(47,002	)
Proceeds from sale and maturities of restricted investments		98,675			30,081			26,426
Proceeds from issuance of common stock		18,382			39,269			861,573
Payments on maturity of convertible debt		(78,348	)		—			—
Proceeds from convertible senior note offering		494,500			—			—
Purchase of capped call contracts		(50,933	)		—			—
Debt issuance costs		(14,270	)		—			—
Purchase of treasury stock		(1,041	)		(1,025	)		(15	)
Extinguishment of long-term debt		—			—			(49,998	)
Net cash provided by financing activities		366,938			36,653			790,984
Net increase (decrease) in cash and cash equivalents		246,358			(411,976	)		552,419
Cash and cash equivalents - beginning of period		155,691			567,667			15,248
Cash and cash equivalents - end of period	$	402,049		$	155,691		$	567,667

F-6

HUMAN GENOME SCIENCES, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION, NON-CASH OPERATING, INVESTING AND FINANCING ACTIVITIES

	Year Ended December 31,
	2011		2010			2009
	(in thousands)
Cash paid (received) during the period for:
Interest	$	32,547	$	33,169		$	33,609
Income taxes	$	—	$	(1,948	)	$	809

During 2011, the Company recorded $808 of non-cash interest expense related to exchange offers accepted by certain note holders of the Company’s 2 ¹/4% Convertible Subordinated Notes due 2011. (See Note F – Long-term Debt, in the Notes to Consolidated Financial Statements).

During 2011, 2010 and 2009, the Company recorded non-cash accretion of $37, $277 and $1,384, respectively, related to certain headquarters space. (See Note J – Facility-Related Exit Credits, in the Notes to the Consolidated Financial Statements).

During 2011, 2010 and 2009, lease financing increased as a result of non-cash accretion with respect to the Company’s 2006 leases with BioMed Realty Trust, Inc. (“BioMed”) by $1,588, $1,889 and $2,151 respectively. Because the lease payments are less than the amount of calculated interest expense for the first nine years of the leases, the lease financing balance will increase through 2015.

During 2010, the Company was able to reduce certain of its lease-related collateral obligations and transferred restricted investments of $9,014 into marketable securities.

The accompanying Notes to Consolidated Financial Statements are an integral part hereof.

F-7

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE A) – The Company

Human Genome Sciences, Inc. (the “Company”) is a biopharmaceutical company that exists to place new therapies into the hands of those battling serious disease. Its lead products are BENLYSTA^® (belimumab) for systemic lupus erythematosus (“SLE”) and raxibacumab for inhalation anthrax.

BENLYSTA was approved in March 2011 by the U.S. Food and Drug Administration (“FDA”) for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. The Company launched BENLYSTA shortly thereafter and recognized revenue from its first BENLYSTA sales in March 2011. In July 2011, the European Commission granted marketing authorization for BENLYSTA in Europe as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy.

The Company, which is located primarily in the United States, operates in a single business segment.

(NOTE B) – Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in conformity with U.S. generally accepted accounting principles (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Such estimates are based on historical experience and on various assumptions that the Company believes to be reasonable under the circumstances. Actual results could differ from these estimates under different assumptions or conditions.

Principles of Consolidation

The consolidated financial statements include the accounts of Human Genome Sciences, Inc. and its subsidiaries, all of which are wholly-owned. All significant intercompany accounts and transactions have been eliminated.

Cash Equivalents, Marketable Securities and Restricted Investments

The Company considers all highly liquid investment instruments purchased with a maturity of three months or less to be cash equivalents.

The Company classifies its marketable securities with readily determinable fair values as “available-for-sale.” Investments in securities that are classified as available-for-sale are measured at fair market value in the balance sheets, and unrealized holding gains and losses on investments are reported as a separate component of stockholders’ equity until realized. Investments of less than 20% of privately-held companies are accounted for as cost-method investments. The Company reviews the carrying value of such investments on a periodic basis for indicators of impairment. Additionally, certain of the Company’s investments are held as restricted investments. Restricted investments with maturities less than three months are not classified as cash in the Company’s consolidated balance sheets. See Note C, Investments, for additional information.

F-8

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

Investment Risk

The Company has invested its cash in obligations of the U.S. Government (“USG”), government agencies and in high-grade debt securities and various money market instruments. The Company’s investment policy limits investments to certain types of instruments issued by institutions with credit ratings of “A-” or better, and places restrictions on maturities and concentrations in certain industries and by issuer. The Company does not hold auction rate securities, loans held for sale or mortgage-backed securities backed by sub-prime or Alt-A collateral.

Other-Than-Temporary Impairment of Investments

Periodically, the Company evaluates whether any investments have incurred an other-than-temporary impairment, based on the criteria under Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“FASB ASC”) Topic 320, Investments – Debt and Equity Securities. This evaluation consists of a review of several factors, including but not limited to the length of time and extent that a security has been in an unrealized loss position, the existence of an event that would impair the issuer’s future repayment potential, the near term prospects for recovery of the market value of a security and the intent of the Company to hold the security until the market value recovers and whether it is not more likely than not that the Company will be required to sell the security. If the Company determines that such impairment exists, the Company will recognize a charge in the consolidated statement of operations equal to the amount of such impairment. See Note D, Collaborations and Other Agreements – Aegera Agreement, for additional discussion.

Accounts Receivable

Trade accounts receivable are recorded net of allowances for prompt payment discounts and doubtful accounts.

Inventories

Inventories, which are recorded at the lower of cost or market, include materials, labor and other direct and indirect costs and are valued using the first-in, first-out method. The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. In the case of raxibacumab, manufacturing costs were capitalized after the Company received a follow-on order from the USG in July 2009. BENLYSTA manufacturing costs have been capitalized since the FDA Advisory Committee vote in November 2010 to recommend approval of the product.

Inventory that is not expected to be utilized until more than 12 months from the balance sheet date is classified as non-current. Estimating the level of inventory utilization for the upcoming 12 months requires management to exercise significant judgment. The Company maintains inventory levels in excess of 12 months to mitigate risks such as product shortage due to higher than anticipated product demand, long lead times for manufacturing finished goods, supply interruptions for raw materials and risks of production disruptions at its sole U.S. FDA-approved manufacturing site due to contamination, equipment failure or other facility-related issues. Carrying such levels of inventory impacts the Company’s liquidity and cash flows since the inventory will not be converted to cash for more than one year from the balance sheet date.

Inventory is evaluated for impairment by consideration of factors such as lower of cost or market, net realizable value, obsolescence or expiry. Inventories have carrying values that do not exceed cost nor do they exceed net realizable value. The Company believes BENLYSTA has limited risk of obsolescence at this time based on market research, which is used to estimate future demand.

F-9

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

The Company evaluates expiry risk by evaluating current and future product demand relative to product shelf life. The Company builds demand forecasts by considering factors such as, but not limited to, overall market potential, market share, market acceptance and patient usage. Currently, the shelf life of raw materials and work in process is approximately one to five years and three years, respectively. The shelf life for finished goods is three years. The product shelf life resets as inventory moves through each stage of completion.

Depreciation

Depreciation is computed using the straight-line method over the estimated useful lives of the assets as follows:

Buildings	30 years
Land improvements	lesser of the lease term or the useful life
Production equipment	5 - 10 years
Laboratory equipment	3 - 10 years
Computer equipment and software	3 - 5 years
Furniture and office equipment	3 - 5 years
Leasehold improvements	lesser of the lease term or the useful life

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable based on the criteria for accounting for the impairment or disposal of long-lived assets under FASB ASC Topic 360, Property, Plant and Equipment.

Deferred revenue

Deferred revenue consists primarily of amounts related to raxibacumab and certain BENLYSTA shipments. The Company recognizes raxibacumab revenue based on the average contracted price as shipments occur and records the difference between the invoiced price and the average contracted price in deferred revenue. Revenue generated from BENLYSTA shipments to specialty distributors is deferred and recognized once product has been sold-through to healthcare providers.

Product sales

Product sales consist of U.S. sales of BENLYSTA and raxibacumab. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, delivery has occurred and title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, all performance obligations have been met and returns can be reasonably estimated. Product sales are recorded net of accruals for estimated rebates, chargebacks, discounts and other deductions (collectively, “sales deductions”), and returns. Amounts accrued for sales deductions and returns are adjusted when trends, significant events, or actual results indicate that adjustment is appropriate. With the exception of allowances for prompt payment, allowances for sales deductions and returns are included in accounts payable and accrued expenses in the accompanying consolidated balance sheet as of December 31, 2011.

The Company does not record sales deductions and returns for sales of raxibacumab due to the absence of discounts and rebates and no right of return under the contract with the USG. Aside from product recall, once delivery has occurred, product may not be returned to the Company for any reason, including failure to obtain FDA approval. Furthermore, the Company has no obligation to replace existing Strategic National Stockpile (“SNS”) doses if the formulation changes during the FDA approval process.

F-10

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

The Company estimates BENLYSTA sales deductions and returns utilizing actual sales data, contracts with distributors and wholesalers and third-party market research. Company estimates and assumptions are subject to inherent limitations and may need to be adjusted accordingly on a prospective basis. Specific considerations for BENLYSTA sold in the U.S. are as follows:

• With respect to BENLYSTA, the Company has determined that it qualifies as the principal based on various elements of the Company’s agreement with GlaxoSmithKline (“GSK”), including responsibility for manufacturing product for sale in the U.S., inventory risk and primary responsibility for changes to the product, including product specifications. The Company has an agreement with GSK whereby GSK provides distribution services.

• BENLYSTA is distributed in the U.S. through specialty distributors and wholesalers. Under this model, exclusive distributors purchase and take physical delivery and title of product, and then sell to physicians or their clinics. Because the Company received FDA approval in the first quarter of 2011, the Company currently cannot make a reasonable estimate of future product returns when product is delivered to distributors. Therefore, the Company currently does not recognize revenue upon product shipment to specialty distributors, even though the distributor is invoiced upon product shipment. Instead, the Company recognizes revenue through the specialty distributor channel at the time of shipment to the physicians or their clinics. Wholesalers supply product to all other healthcare providers (e.g. hospitals, pharmacies), however they do not take physical delivery of product. All wholesaler orders are drop-shipped directly to the healthcare providers. For wholesaler purchases, the Company currently recognizes revenue upon shipment to the healthcare provider.

• Product returns. BENLYSTA customers are not offered a general right of return. However, the Company will accept product that is damaged or defective when shipped directly from GSK or for expired product up to 12 months subsequent to its expiration date. Due to the price of BENLYSTA and limited contractual rights of return, healthcare providers generally only carry inventory quantities estimated to meet projected short-term demand. Once product has been delivered to healthcare providers, the risk of material returns is significantly mitigated, and the Company is able to make a reasonable estimate of future returns at that point. In developing estimates for sales returns, the Company considers shelf life of the product, expected demand based on market data and publicly available return rates used for other biologic drugs. In addition, the Company considers the price of the product, the nature of healthcare providers, the ability of healthcare providers to obtain product on a just-in-time basis, the predictability of patient infusion and dosing and the absence of financial incentives that would promote bulk or advance purchasing.

• Rebates. Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or legal requirements with public sector (e.g. Medicaid) benefit providers. The allowance for rebates is based on statutory discount rates and expected utilization. The Company’s estimates for expected utilization of rebates are based in part on third party market research data. Rebates are generally invoiced and paid quarterly in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity, plus an accrual balance for known prior quarters’ unpaid rebates. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect revenue in the period of adjustment.

• Chargebacks. Chargebacks are discounts that occur when contracted customers purchase directly from an intermediary distributor or wholesaler. Contracted customers, which currently consist primarily of Public Health Service institutions and Federal government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The distributor or

F-11

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

wholesaler in turn, charges back the difference between the price initially paid by the distributor or wholesaler and the discounted price paid to the distributor or wholesaler by the customer. The allowance for distributor/wholesaler chargebacks is based on known sales to contracted customers.

• Distributor / Wholesaler deductions. U.S. specialty distributors and wholesalers are offered various forms of consideration including allowances, service fees and prompt payment discounts. Distributor allowances and service fees arise from contractual agreements with distributors and are generally a fixed rate per vial purchased. Wholesale customers are offered a prompt pay discount for payment within a specified period. Distributor allowances and service fees and wholesaler prompt payment discounts recorded in the Company’s 2011 statement of operations are based on actual product sales and are not estimates.

• Co-pay assistance. Patients who have commercial insurance and meet certain eligibility requirements may receive co-pay assistance. The Company accrues a liability for co-pay assistance based on actual program participation and estimates of program redemption using data provided by third-party administrators.

The Company is not the principal with respect to BENLYSTA sold outside of the U.S., i.e. in the rest of world (“ROW”). Therefore, the Company is not recording product sales with respect to this activity.

Manufacturing and development services

As part of its raxibacumab contract with the USG and the Biomedical Advanced Research and Development Authority (“BARDA”), the Company performed a variety of drug development services primarily relating to the conduct of animal and human studies. Upon BARDA’s acceptance of the initial raxibacumab delivery, the Company billed the USG for the drug development work previously performed, and recorded this as manufacturing and development services revenue during 2009. The Company has been recording additional development revenue as services are performed.

The Company has entered into agreements with certain commercial parties for manufacturing process development, clinical and commercial supply of certain biopharmaceutical products. Revenue under these agreements is recognized as services are performed or products delivered, depending on the nature of the work contracted, using the proportional performance method of accounting. Performance is assessed using output measures such as units-of-work performed to date as compared to total units-of-work contracted. Advance payments received in excess of amounts earned are classified as deferred revenue until earned.

Research and development collaborative agreements

Collaborative research and development agreements can provide for one or more of up-front license fees, research payments and milestone payments. In October 2009, the FASB issued new revenue recognition standards for arrangements with multiple deliverables, which were effective for the Company as of January 1, 2011. These standards address the determination of the unit(s) of accounting for multiple-element arrangements and how the arrangement’s consideration should be allocated to each unit of accounting. An item can generally be considered a separate unit of accounting if all of the following criteria are met: (1) the delivered item(s) has value to the customer on a stand-alone basis and (2) if the arrangement includes a general right of return relative to the delivered item(s), delivery or performance of the undelivered item(s) is considered probable and substantially in control of the Company. Items that cannot be divided into separate units are combined with other units of accounting, as appropriate. Consideration received is allocated among the separate units based on vendor-specific objective evidence (“VSOE”) if available; third-party evidence, if VSOE is unavailable; and estimated selling prices if neither VSOE nor third-party evidence is available. Revenue is recognized when the following criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the sales price is fixed or determinable; and (4) collectability is probable. The Company deems service to have been rendered if no continuing obligation exists on the part of the Company.

F-12

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

Revenue associated with non-refundable up-front license fees under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting are deferred and recognized as revenue on a straight-line basis over the expected term of the Company’s continued involvement in the research and development process. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved, and the milestone payments are due and collectible. If not deemed substantive, the Company would recognize such milestone as revenue on a straight-line basis over the remaining expected term of continued involvement in the research and development process. Milestones are considered substantive if all of the following conditions are met: (1) it is commensurate with either our performance to meet the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the our performance to achieve the milestone, (2) it relates solely to past performance, and (3) the value of the milestone is reasonable relative to all the deliverables and payment terms (including other potential milestone consideration) within the arrangement. Payments received in advance of work performed are recorded as deferred revenue.

The new accounting standards were adopted by the Company on a prospective basis on January 1, 2011. The Company did not enter into any new multiple-element arrangements or materially modify any existing arrangements during 2011. The adoption of these standards did not have a material effect on the Company’s consolidated results of operations, financial position or liquidity.

Cost of product sales

The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. Prior to capitalization, the cost of manufacturing drug product is recognized as research and development expense in the period that the cost is incurred. Therefore, manufacturing costs incurred prior to capitalization are not included in cost of product sales when revenue is recognized from the sale of that drug product.

Prior to receiving a follow-on order for raxibacumab from the USG in July 2009, the Company did not capitalize inventory costs related to this product. Although authorization to ship to the SNS was received in January 2009, there continued to be uncertainty around future product orders. Beginning in July 2009, the cost of manufacturing raxibacumab is recognized as a cost of product sales (capitalized and then expensed when revenue is recognized), rather than research and development expenses in the period that the cost is incurred.

Prior to the BENLSYTA Advisory Committee meeting in November 2010, the Company did not capitalize inventory costs related to this product. Following the positive outcome of the Advisory Committee, the cost of manufacturing BENLYSTA is being capitalized and will be expensed as cost of product sales as revenue is recognized, rather than being recorded as research and development expenses in the period that the cost is incurred.

Cost of product sales also includes royalties paid or payable to third parties based on the sales levels of certain products, distribution services costs, any applicable unabsorbed costs as a result of not operating the Company’s manufacturing facilities at full capacity and manufacturing-related period expenses.

Cost of manufacturing and development services

Cost of manufacturing and development services represents costs associated with the Company’s contract manufacturing arrangements and other development services. The costs associated with work previously performed to conduct animal and human studies for raxibacumab were recognized as research and development expenses in the period that the costs were incurred. Therefore, these pre-acceptance development costs are not included in cost of manufacturing and development services for 2009. The

F-13

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

Company is recording additional raxibacumab development services costs as incurred. Cost of manufacturing and development services also includes any applicable unabsorbed costs as a result of not operating the Company’s manufacturing facilities at full capacity and manufacturing-related period expenses.

Research and Development

Research and development costs are charged to expense as incurred, unless otherwise capitalized pursuant to FASB ASC Topic 730, Research and Development. Research and development costs include salaries and related benefits, outside services, licensing fees or milestones, materials and supplies, building costs and allocations of certain support costs. Research and development direct expenditures were $196,182, $196,370 and $173,709 for 2011, 2010 and 2009, respectively. Reimbursement of research and development expenses received in connection with collaborative cost-sharing agreements is recorded as a reduction of such expenses.

Leases

The Company accounts for its leases under FASB ASC Topic 840, Leases. The Company has a number of operating leases and has entered into sale-leaseback transactions for land and facilities. See Note G, Commitments and Other Matters, for additional discussion.

Stock-Based Compensation

The Company has a stock incentive plan (the “Incentive Plan”) under which options to purchase shares of the Company’s common stock may be granted to employees, consultants and directors with an exercise price no less than the quoted market value on the date of grant. The Incentive Plan also provides for the issuance of non-vested common stock (restricted stock) and other share-based compensation. The Company recognizes stock-based compensation expense related to employee stock options under FASB ASC Topic 718, Compensation – Stock Compensation. For income tax purposes, the Company follows the “with and without” method of accounting for the tax effect of excess tax benefits generated from stock-based compensation. See Note H, Stockholders’ Equity, for additional discussion.

Financing Costs Related to Long-term Debt

Costs associated with obtaining long-term debt are allocated between the debt and equity components as required by FASB ASC Topic 470, Debt. Costs allocated to the equity component are charged to Additional paid-in capital. Costs allocated to debt are deferred and amortized over the term of the related debt on a straight-line basis, which approximates the effective interest method.

Patent Application Costs

Patent application costs are charged to expense as incurred.

Commercial collaboration expenses

Commercial collaboration expenses include GSK’s share of the collaboration profit with respect to BENLYSTA sales in the United States. At this time, it also includes HGS’ share of the ROW collaboration expense incurred by GSK. In the period when ROW results become profitable, the Company will begin to reflect such results as commercial collaboration income. Commercial collaboration expenses/income does not include any research and development expenses shared with GSK.

F-14

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

Net Income (Loss) Per Share

The Company follows the provisions under FASB ASC Topic 260, Earnings Per Share, which requires the Company to present basic and diluted earnings per share. The Company’s basic and diluted income (loss) per share is calculated by dividing the net income (loss) by the weighted average number of shares of common stock outstanding during all periods presented. Shares issuable upon the conversion of the Company’s convertible debt and shares due to the Company upon settlement of the Company’s capped call contracts are excluded from diluted earnings per share calculations for 2011, 2010 and 2009 because the effects are anti-dilutive.

Major customers and concentration of credit risk

The Company sells BENLYSTA to a limited number of exclusive pharmaceutical specialty distributors and wholesalers in the U.S. and sells raxibacumab only to the USG. The Company periodically assesses the financial strength of its customers and establishes allowances for anticipated losses, if necessary. The following table includes those customers that represent more than 10% of total revenue of $130,975 for 2011:

Customer A	42	%
Customer B	14	%
Customer C	14	%

Two customers each having a balance of more than 10% of the Accounts receivable balance on the consolidated balance sheet as of December 31, 2011 represent an aggregate of 90% of Accounts receivable.

Foreign Currency

The functional currency of substantially all of the Company’s wholly-owned foreign subsidiaries is the U.S. dollar. For these foreign subsidiaries, monetary balance sheet and related income statement accounts are re-measured, with exchange gains and losses recorded in the consolidated statement of income. Non-monetary balance sheet items and related income statement accounts, which do not result in a fixed future cash inflow or outflow of foreign currency units, are re-measured at their historical exchange rates. In 2011, 2010 and 2009, the Company recorded negligible foreign currency re-measurement gains (losses), which are included in Other income (expense), net in the consolidated statements of income.

Comprehensive Income (Loss)

FASB ASC Topic 220, Comprehensive Income, requires unrealized gains and losses on the Company’s available-for-sale marketable securities and long-term equity investments and the activity for the cumulative translation adjustment to be included in other comprehensive income.

F-15

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

The components of accumulated other comprehensive income are as follows:

	December 31,
	2011		2010
Net unrealized gains on:
Marketable securities	$	4,352	$	6,317
Restricted investments		189		805
Foreign currency translation		15		3
Accumulated other comprehensive income	$	4,556	$	7,125

Accumulated other comprehensive income excludes net realized gains included in Net income (loss) of $236 and $4,504 for 2011 and 2009, respectively. Accumulated other comprehensive income excludes net realized losses included in Net income (loss) of $303 for 2010. The effect of income taxes on items in other comprehensive income is $0 for all periods presented.

Sources of Supply

The Company is currently able to obtain most of its raw materials, supplies and equipment from various sources, and generally has no dependence upon a single supplier. However, certain materials required for manufacturing are currently available only from single sources. The Company attempts to identify and qualify alternative sources of supply wherever possible.

Reclassifications

Within the December 31, 2010 consolidated balance sheet, long-term equity investments of $3,241 have been reclassified and are included in Other assets, and a lease termination liability that had been classified in Accrued exit expenses has been reclassified to Other current liabilities. Also within the December 31, 2010 consolidated balance sheet, deferred rent of $10,358, deferred revenue, non-current of $2,517 and accrued exit expenses, non-current of $700 have been reclassified and are included in Other liabilities. All of these reclassifications have been made to conform to current year presentation.

Recent Accounting Pronouncements

In January 2010, the FASB issued Accounting Standards Update (“ASU”) 2010-06, Improving Disclosures about Fair Value Measurements (“ASU 2010-06”). ASU 2010-06 requires disclosing the amounts of significant transfers in and out of Levels 1 and 2 fair value measurements and to describe the reasons for the transfers. The disclosures were effective for the Company beginning January 1, 2010, and had no material impact on the Company’s financial statements. Additionally, disclosures of the gross purchases, sales, issuances and settlements activity in Level 3 fair value measurements were required beginning January 1, 2011. The additional provisions of ASU 2010-06 did not have any effect on the Company’s consolidated results of operations, financial position or liquidity.

In April 2010, the FASB issued ASU 2010-17, Milestone Method of Revenue Recognition (“ASU 2010-17”), which provides guidance on defining a milestone and determining when it may be appropriate to apply the milestone method of revenue recognition for research or development transactions. Research or development arrangements frequently include payment provisions whereby a portion or all of the consideration is contingent upon milestone events such as successful completion of phases in a study or achieving a specific result from the research or development efforts. The amendments in this ASU provide guidance on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. ASU 2010-17 was effective for the Company on January 1, 2011. The adoption of ASU 2010-17 did not have a material effect on the Company’s consolidated results of operations, financial position or liquidity.

F-16

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE B) – Summary of Significant Accounting Policies (continued)

In December 2010, the FASB issued ASU 2010-27, Fees Paid to the Federal Government by Pharmaceutical Manufacturers (“ASU 2010-27”), which specifies that the liability for the new fee mandated by the Patient Protection and Affordable Care Act of 2010, as amended by the Health Care and Education Reconciliation Act, should be estimated and recorded in full upon the first qualifying sale with a corresponding deferred cost that is amortized to expense using a straight-line method of allocation unless another method better allocates the fee over the calendar year that it is payable. This ASU was effective for the Company beginning January 1, 2011. The adoption of ASU 2010-27 did not have a material effect on the Company’s consolidated results of operations, financial position or liquidity.

In May 2011, the FASB issued ASU 2011-04, Fair Value Measurement (Topic 820) (“ASU 2011-04”), which contains amendments to achieve common fair value measurement and disclosures in U.S. GAAP and International Financial Reporting Standards. ASU 2011-04 explains how to measure fair value for financial reporting. The guidance does not require fair value measurements in addition to those already required or permitted by other Topics. This ASU is effective for the Company beginning January 1, 2012. The adoption of ASU 2011-04 is not expected to have a material effect on the Company’s consolidated results of operation, financial position or liquidity.

In June 2011, the FASB issued ASU 2011-05, Comprehensive Income (Topic 220): Presentation of Comprehensive Income (“ASU 2011-05”). This guidance is intended to increase the prominence of other comprehensive income in financial statements by presenting it in either a single statement or two-statement approach. This ASU is effective for the Company beginning January 1, 2012. The adoption of ASU 2011-05 is not expected to have a material effect on the Company’s consolidated results of operations, financial position or liquidity.

(NOTE C) – Investments

Available for sale investments, including accrued interest, as of December 31, 2011 and 2010 were as follows:

	December 31, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	94,669	$	1,123	$	(63	)	$	95,729
Residential mortgage-backed securities		20,681		329		(2	)		21,008
Asset-backed securities		2,496		1		—			2,497
Subtotal - Marketable securities		117,846		1,453		(65	)		119,234
Corporate debt securities		177,725		2,866		(726	)		179,865
Residential mortgage-backed securities		47,158		737		(4	)		47,891
Government-sponsored enterprise securities		5,230		51		—			5,281
Asset-backed securities		46,881		49		(9	)		46,921
Subtotal - Marketable securities, non-current		276,994		3,703		(739	)		279,958
Cash and cash equivalents		11,649		1		—			11,650
U.S. Treasury and agencies		1,304		2		—			1,306
Corporate debt securities		51,773		316		(145	)		51,944
Residential mortgage-backed securities		5,977		30		(21	)		5,986
Government-sponsored enterprise securities		4,641		9		(1	)		4,649
Asset-backed securities		4,659		3		(4	)		4,658
Subtotal - Restricted investments		80,003		361		(171	)		80,193
Total	$	474,843	$	5,517	$	(975	)	$	479,385

F-17

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE C) – Investments (continued)

	December 31, 2010
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	125,708	$	1,655	$	(19	)	$	127,344
Residential mortgage-backed securities		53,944		787		(13	)		54,718
Government-sponsored enterprise securities		86,905		61		—			86,966
Asset-backed securities		12,983		5		—			12,988
Subtotal - Marketable securities		279,540		2,508		(32	)		282,016
Corporate debt securities		248,500		3,611		(881	)		251,230
Residential mortgage-backed securities		79,605		1,161		(20	)		80,746
Government-sponsored enterprise securities		25,402		3		(120	)		25,285
Asset-backed securities		58,822		84		(2	)		58,904
Subtotal - Marketable securities, non-current		412,329		4,859		(1,023	)		416,165
Cash and cash equivalents		7,455		—		—			7,455
U.S. Treasury and agencies		1,302		10		—			1,312
Corporate debt securities		45,931		620		(29	)		46,522
Residential mortgage-backed securities		6,368		128		—			6,496
Government-sponsored enterprise securities		13,237		72		(6	)		13,303
Asset-backed securities		4,412		10		—			4,422
Subtotal - Restricted investments		78,705		840		(35	)		79,510
Total	$	770,574	$	8,207	$	(1,090	)	$	777,691

The Company’s investments in mortgage-backed securities have no single maturity date and accordingly, have been allocated on a pro rata basis to each maturity range based on each maturity range’s percentage of the total value. See Note K, Fair Value Measurements, for the fair value of the Company’s financial assets and liabilities.

The Company’s restricted investments with respect to its headquarters (“Traville”) lease serve as collateral for a letter of credit which serves as the security deposit for the duration of the lease, although the Company has the ability to reduce the restricted investments that are in the form of securities by substituting a cash security deposit in the amount of $19,750 to be maintained with the landlord. Presently, to secure the security deposit letter of credit, the Company is required to maintain margin value of the collateral of at least $19,750.

The Company’s restricted investments with respect to its large-scale manufacturing facility (“LSM”) lease, as amended, will serve as collateral in favor of the landlord in lieu of providing the landlord with either a cash deposit or a standby letter of credit. Under the LSM lease, the Company is required to pledge to the landlord a minimum of $20,000 in marketable securities or provide the landlord with a $19,750 cash security deposit. As of December 31, 2011 and 2010, the Company has pledged marketable securities.

F-18

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE C) – Investments (continued)

In addition, the Company is also required to maintain $34,300 in restricted investments, with respect to two leases with the Maryland Economic Development Corporation (“MEDCO”) for its small-scale manufacturing facility. The facility was financed primarily through a combination of bonds issued by MEDCO (“MEDCO Bonds”) and loans issued to MEDCO by certain State of Maryland agencies. The MEDCO Bonds are secured by letters of credit issued for the account of MEDCO which expire in December 2012. The Company is required to maintain restricted investments which serve as security for the MEDCO letters of credit reimbursement obligation.

Marketable securities and Restricted investments – unrealized losses

The Company owned 343 available-for-sale securities as of December 31, 2011. Of these 343 securities, 77 had unrealized losses as of December 31, 2011. The Company did not have any investments in a loss position for greater than 12 months as of December 31, 2011. The Company has evaluated its marketable securities and restricted investments and has determined that none of these investments has an other-than-temporary impairment, as it has no intent to sell securities with unrealized losses and it is not more likely than not that the Company will be required to sell any securities with unrealized losses, given the Company’s current and anticipated financial position. The Company’s gross unrealized losses and fair value of investments with unrealized losses as of December 31, 2010 were as follows:

	December 31, 2010
	Loss Position for Less Than Twelve Months					Loss Position for Greater Than Twelve Months					Total
	Fair Value		Unrealized Losses			Fair Value		Unrealized Losses			Fair Value		Unrealized Losses
Corporate debt securities	$	35,432	$	(18	)	$	1,536	$	(1	)	$	36,968	$	(19	)
Residential mortgage-backed securities		54,718		(13	)		—		—			54,718		(13	)
Asset-backed securities		3,286		—			—		—			3,286		—
Subtotal - Marketable securities		93,436		(31	)		1,536		(1	)		94,972		(32	)
Corporate debt securities		56,992		(881	)		—		—			56,992		(881	)
Residential mortgage-backed securities		80,746		(20	)		—		—			80,746		(20	)
Government-sponsored enterprise securities		20,237		(120	)		—		—			20,237		(120	)
Asset-backed securities		8,400		(2	)		—		—			8,400		(2	)
Subtotal - Marketable securities, non-current		166,375		(1,023	)		—		—			166,375		(1,023	)
Corporate debt securities		7,110		(29	)		—		—			7,110		(29	)
Government-sponsored enterprise securities		1,502		(6	)		—		—			1,502		(6	)
Subtotal - Restricted investments		8,612		(35	)		—		—			8,612		(35	)
Total	$	268,423	$	(1,089	)	$	1,536	$	(1	)	$	269,959	$	(1,090	)

The Company’s equity investment of less than 20% in privately-held companies, which consists of its investment in Aegera Therapeutics, Inc. (“Aegera”), is carried at cost and included in Other assets on the consolidated balance sheet as of December 31, 2010. As of December 31, 2011, the Company no longer owns this investment. See Note D, Collaborations and Other Agreements – Aegera Agreement, for additional information.

F-19

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE C) – Investments (continued)

Other Information

The following table summarizes maturities of the Company’s marketable securities and restricted investment securities as of December 31, 2011:

	Marketable Securities				Marketable Securities, non-current				Restricted Investments
	Amortized Cost		Fair Value		Amortized Cost		Fair Value		Amortized Cost		Fair Value
Less than one year	$	117,846	$	119,234	$	—	$	—	$	34,914	$	35,003
Due in year two through year three		—		—		219,106		221,040		41,663		41,813
Due in year four through year five		—		—		41,695		42,473		3,295		3,245
Due after five years		—		—		16,193		16,445		131		132
Total	$	117,846	$	119,234	$	276,994	$	279,958	$	80,003	$	80,193

The Company’s net proceeds, realized gains and realized losses from its investments are as follows:

	Year Ended December 31,
	2011			2010			2009
Proceeds on sale and maturities of investments	$	728,185		$	708,896		$	368,560
Realized gains		1,652			1,673			7,026
Realized losses		(1,416	)		(1,976	)		(2,522	)

Realized gains and losses on securities are included in investment income in the consolidated statements of operations. The cost of the securities sold is based on the specific identification method. Realized gains shown above also include gains related to the sale of long-term equity investments, which are shown separately on the consolidated statements of operations.

During 2011, 2010 and 2009, the Company recognized interest income of $11,939, $17,269 and $13,506 respectively, in investment income.

(NOTE D) – Collaborations and Other Agreements

GlaxoSmithKline Agreement

During 2006, the Company entered into a license agreement with GSK for the co-development and co-commercialization of BENLYSTA arising from an option GSK exercised in 2005, relating to an earlier collaboration agreement. The agreement grants GSK a co-development and co-commercialization license, under which both companies will jointly conduct activities related to the development and sale of products in the United States and abroad. The Company and GSK share Phase 3 and 4 development costs, and share sales and marketing expenses and profits of any product commercialized under the agreement. The Company has primary responsibility for bulk manufacturing and for commercial manufacturing of the finished drug product. In partial consideration of the rights granted to GSK in this agreement, the Company received a non-refundable payment of $24,000 during 2006 and recognized this payment as revenue over the remaining clinical development period, which ended in 2010. The Company recognized revenue of $3,445 and $4,737 in 2010 and 2009, respectively, relating to this payment. In March 2011, the FDA approved BENLYSTA and in July 2011 the European Commission granted marketing authorization for BENLYSTA.

F-20

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE D) – Collaborations and Other Agreements (continued)

The BENLYSTA agreement arises from a 1993 agreement, as amended, in which the Company entered into a collaboration agreement providing GSK a first right to develop and market products in human and animal health care (“GSK Products”), based upon human genes identified by the Company. In June 1996, this agreement was substantially amended (the “1996 GSK Agreement”).

With respect to the Company’s rights under the 1996 GSK Agreement, the Company is entitled to (1) royalties on the net sales of certain GSK Products developed pursuant to the agreement, (2) product development milestones and (3) the option to co-promote up to 20% of any product developed by GSK under the collaboration agreement. If the Company were to exercise its option to co-promote any GSK Products, it would be entitled to receive additional amounts from GSK in proportion to its level of co-promotion. The Company has been informed that GSK is pursuing research programs involving specific genes for the creation or development of small molecule drugs. The Company cannot provide any assurance that any of these programs will be continued or result in any approved drugs.

In 2004, the Company entered into an agreement with GSK under which GSK acquired exclusive worldwide rights to develop and commercialize albiglutide, a drug that had been in late-stage preclinical development by the Company for potential use in the treatment of diabetes. In 2004, the Company received an up-front fee of $6,000 and is recognizing this revenue ratably over the clinical development period, which is estimated to be eight years. With respect to this fee, the Company recognized $434, $460 and $741 as revenue in 2011, 2010 and 2009, respectively. As of December 31, 2011, the Company has received and recognized development milestones aggregating $27,000 under the agreement, including $9,000 received and recognized in 2009.

GSK’s share of the collaboration profit with respect to BENLYSTA sales in the U.S. and HGS’ share of the ROW collaboration expense incurred by GSK are included in the Commercial collaboration expenses line in the consolidated statement of operations for 2011.

Research and development expenses are net of $25,060, $62,022 and $43,069 for 2011, 2010 and 2009, respectively, of costs reimbursed by GSK. The Company shares certain research and development costs including personnel costs, outside services, clinical manufacturing and overhead with GSK under cost sharing provisions in the GSK collaboration agreement.

U.S. Government Agreement

During 2006, the USG exercised its option under the second phase of a 2005 contract to purchase 20,001 doses of raxibacumab for the SNS. Under this two-phase contract, the Company has supplied raxibacumab, a human monoclonal antibody developed for use in the treatment of anthrax disease, to the USG. Along with the cost to manufacture the 20,001 doses, the Company has incurred the cost to conduct several animal and human studies as part of this contract. During 2009, the Company received authorization from BARDA to ship raxibacumab to the SNS and delivered all of the 20,001 doses. In July 2009, the USG agreed to purchase 45,000 additional doses of raxibacumab for the SNS, to be delivered over a three-year period beginning in 2009. The Company expects to receive a total of approximately $142,000 from this order as deliveries are completed. The Company recognized $52,529, $47,159 and $154,074 in product revenue related to raxibacumab in 2011, 2010 and 2009, respectively. The Company recognized $2,829, $1,438 and $26,146 in manufacturing and development services revenue related to the work to conduct the animal and human studies and other raxibacumab activities in 2011, 2010 and 2009, respectively. The Company is entitled to receive approximately $20,000 under the contract with the USG if raxibacumab is licensed by the FDA.

F-21

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE D) – Collaborations and Other Agreements (continued)

MedImmune LLC Agreement

In 1999, the Company entered into a collaborative agreement with Cambridge Antibody Technology Ltd. (assumed by MedImmune LLC (“MedImmune”) through acquisition) to jointly pursue the development of fully human monoclonal antibody therapeutics. MedImmune will receive milestone payments from the Company in connection with the development of any such antibodies as well as royalty payments on the Company’s net sales of such licensed product following regulatory approval. In the event of the achievement of certain other milestones or successful product launch of other products, the Company would be obligated to pay MedImmune additional compensation. Since 1999, the Company has exercised one option and made milestone payments to MedImmune totaling $8,000 pursuant to this agreement.

In 2000, the Company entered into a second agreement with Cambridge Antibody Technology Ltd. The 2000 agreement provides the Company with rights to use MedImmune technology to develop and sell an unlimited number of fully human antibodies for therapeutic and diagnostic purposes. The Company will pay MedImmune clinical development milestones and royalties based on product sales. Since 2000, the Company has exercised several options and made certain payments.

During 2011, 2010 and 2009, the Company incurred aggregate royalty expenses under these agreements of approximately $6,631, $2,389 and $8,600, respectively, associated with U.S. sales of BENLYSTA and raxibacumab. These royalty expenses are included in cost of product sales on the consolidated statements of operations. Royalty expenses to MedImmune related to ROW sales of BENLYSTA are included in commercial collaboration expense on the 2011 consolidated statement of operations.

FivePrime Therapeutics Agreement

In 2011, the Company entered into an agreement with FivePrime Therapeutics, Inc. (“FivePrime”) to develop and commercialize FivePrime’s FP-1039 product candidate for multiple cancers. The Company paid FivePrime an upfront license fee of $50,000, which is reflected in research and development expenses in the consolidated statement of operations for 2011. The Company’s policy is that upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified are expensed as incurred. The Company may be required to pay up to $445,000 in future development, regulatory and commercial milestone payments, as well as royalty payments on net sales if the product is commercialized. HGS has exclusive rights to develop and commercialize FP-1039, now known as HGS1036, for all indications in the United States, Canada and the European Union (“EU”). FivePrime has an option to co-promote HGS1036 and any next-generation products in the United States, and retains full development and commercialization rights in all other regions of the world outside the U.S., Canada and the EU. The Company incurred and expensed additional research and development costs of $2,218 related to HGS1036 development during 2011.

Morphotek Agreement

During 2009, the Company entered into an agreement with Morphotek, Inc. to discover, develop and commercialize therapeutic monoclonal antibodies in the fields of oncology and immunology that specifically target antigens discovered by the Company. With respect to each antibody candidate, the Company and Morphotek have the right to opt in to participate in development and commercialization. The Company and Morphotek currently share research and development costs with respect to one collaboration product and the Company has primary responsibility for manufacturing clinical supplies of that product. Research and development expenses for 2011 are net of $3,983 of costs reimbursed by Morphotek. No research and development expenses were shared during 2010 and 2009.

F-22

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE D) – Collaborations and Other Agreements (continued)

Novartis Agreement

During 2006, the Company entered into an agreement with Novartis International Pharmaceutical Ltd. (“Novartis”) for the co-development and commercialization of ZALBIN^TM. In 2010, the Company and Novartis ended development of ZALBIN based upon the feedback contained in a Complete Response Letter received from the FDA.

Under the agreement, Novartis had paid the Company $207,500 through the end of 2009. The Company was recognizing these payments as revenue ratably over the estimated remaining development period. Based on the decision to end further development of ZALBIN, the Company recognized all remaining deferred revenue related to these payments in September 2010. The Company recognized revenue of $82,806 and $54,158 in 2010 and 2009, respectively, under this agreement. The Company’s share of Novartis-incurred research and development expenses was $663 in 2010. Research and development expenses in 2009 are net of $851 of costs reimbursed by Novartis.

Aegera Agreement

During 2007, the Company entered into a collaboration and license agreement with Aegera of Montreal, Canada under which the Company acquired exclusive worldwide rights (excluding Japan) to develop and commercialize certain oncology molecules and related backup compounds to be chosen during a research period extended through 2011.

During March 2011, the Company determined that its investment in Aegera had incurred an other-than-temporary impairment based on changes in Aegera’s business activities and wrote down its investment of approximately $3,150 to approximately $240. The impairment loss is included in Other income (expense) on the consolidated statement of operations for 2011. In May 2011, Aegera was acquired by Pharmascience, Inc. and the Company received proceeds of approximately $320 resulting in a gain on the sale of the investment of approximately $80, which is included in Other income (expense) on the consolidated statement of operations for 2011. The Company incurred and expensed research costs of $2,453, $2,364 and $2,321 related to the Aegera agreement during 2011, 2010 and 2009, respectively. In December 2011, the Company made the decision to discontinue further development of the early-stage product being developed under the Aegera collaboration.

Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys) License Agreement and Manufacturing Services Agreement

The Company sold its CoGenesys division in 2006 and entered into a license agreement, as amended, that is now with Teva Biopharmaceuticals USA, Inc. (“Teva Bio”). Under the license agreement, as amended, the Company is entitled to various milestone and royalty rights on certain products, if they are developed and commercialized. Teva Bio can obtain additional product rights by extending the initial seven-year research term upon the payment of additional consideration. In addition, the Company entered into a three-year manufacturing services agreement, as amended, which ended during 2009. The Company allocated the consideration received to both the product license and manufacturing services agreement, which was recognized ratably over the term of the manufacturing services agreement, as amended. The Company recognized approximately $2,100 of revenue during 2009 relating to these agreements. See Note L, Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys), for additional discussion.

F-23

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE E) – Other Financial Information

Collaboration Receivables

Collaboration receivables of $23,013 as of December 31, 2011 include $12,436 due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which is expected to be sold within the next year. Collaboration receivables also include $9,833 in unbilled receivables from GSK in connection with Company’s cost-sharing agreements and other unbilled receivables. Collaboration receivables of $18,856 as of December 31, 2010 include $13,165 due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which will be sold within the next year, $5,166 in unbilled receivables from GSK in connection with the Company’s cost-sharing agreements and other unbilled receivables.

Collaboration receivables, non-current of $22,630 and $29,225 as of December 31, 2011 and 2010, respectively, relate to the amounts due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which is not expected to be sold within the next year.

Inventory

Inventories consist of the following:

	December 31, 2011				December 31, 2010
	Current		Non-current		Current		Non-current
Raw materials	$	12,183	$	4,852	$	12,641	$	—
Work-in-process		22,567		102,887		23,426		—
Finished goods		6,909		4,083		7,024		—
Total	$	41,659	$	111,822	$	43,091	$	—

Inventory that is not expected to be sold until more than 12 months from the balance sheet date is classified as non-current.

BENLYSTA-related inventories that were either purchased or manufactured prior to the date the Company began capitalizing BENLYSTA inventory (November 2010) were $92,824 and $112,822 as of December 31, 2011 and 2010, respectively. These inventories have a carrying value of zero, as the costs to purchase or produce this inventory were expensed as research and development expense in the period manufactured, and accordingly are not reflected in the inventory balances shown above. These inventories could be used in clinical trials, sold in the U.S. as commercial product or sold to GSK at cost for the ROW sale of BENLYSTA.

As of December 31, 2011, the Company has current raw material and work in process inventory relating to raxibacumab beyond that which is required to fulfill the second order from the USG. See Note G, Commitments and Other Matters, for additional discussion.

Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets of $9,388 and $5,569 as of December 31, 2011 and 2010, respectively, consisted primarily of deposits, deferred financing fees and insurance payments made in advance.

F-24

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE E) – Other Financial Information (continued)

Property, Plant and Equipment

Property, plant and equipment are stated at cost and are summarized as follows:

	December 31,
	2011			2010
Building (LSM)	$	204,151		$	204,151
Laboratory and production equipment		100,400			96,462
Computer equipment and software		42,033			39,296
Land and improvements		30,521			30,521
Leasehold improvements		32,414			26,678
Furniture and office equipment		8,427			7,274
Construction-in-progress		8,246			5,364
		426,192			409,746
Less: accumulated depreciation		(175,166	)		(156,624	)
	$	251,026		$	253,122

Depreciation expense was $20,337, $20,055 and $19,960 for 2011, 2010 and 2009, respectively.

Accounts Payable and Accrued Expenses

Accounts payable and accrued expenses are comprised of the following:

	December 31,
	2011		2010
Accounts payable	$	4,442	$	6,364
Accrued clinical trial costs		9,302		13,665
Sales deductions and returns allowance		4,345		—
Other accrued expenses		29,364		21,769
	$	47,453	$	41,798

Accrued clinical trial costs consist primarily of investigator fees, contract research organization services and laboratory costs. Other accrued expenses consist primarily of interest payable, accrued royalties and miscellaneous accrued expenses.

Collaboration Payable

Collaboration payable of $33,230 as of December 31, 2011, represents cost reimbursements due to GSK in connection with BENLYSTA. Collaboration payable of $12,984 as of December 31, 2010 represents cost reimbursements due to GSK and Novartis in connection with the Company’s cost sharing agreements.

F-25

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE F) – Long-term Debt

The components of short-term and long-term debt are as follows:

			December 31,
Debt	Interest Rate	Maturities	2011			2010
3% Convertible Senior Notes due 2018	3.0%	November 2018	$	363,698		$	—
2 1/4% Convertible Subordinated Notes due 2011	2.25%	October 2011		—			188,620
2 1/4% Convertible Subordinated Notes due 2012	2.25%	August 2012		198,037			184,231
				561,735			372,851
BioMed lease financing	11.0%	May 2026		252,105			250,516
				813,840			623,367
Less current portion				(198,037	)		(188,620	)
			$	615,803		$	434,747

Annual maturities of all long-term debt (representing cash to be paid) are as follows:

2012	$	206,736
2013		—
2014		—
2015		187
2016		671
2017 and thereafter		546,603
	$	754,197

The difference between total debt of $813,840 and annual maturities of $754,197 is due to the accounting for the sale-leaseback of the Company’s headquarters land and LSM as a financing transaction and the debt discount relating to the convertible senior and subordinated notes. During 2006, the Company entered into a purchase and sale agreement with BioMed in connection with the Company’s Traville headquarters land and LSM. The Company is accounting for the sale-leaseback as a financing transaction. Payments due for the BioMed debt resulting from this financing are based upon an allocation of fair value of the properties included in the transaction. Aggregate lease financing payments, including interest, over the remaining fourteen year period are approximately $421,504 including an annual lease escalation of 2%. Interest expense associated with this debt is being calculated at approximately 11%, which approximated the Company’s incremental borrowing rate at the time of the agreement. For the first nine years of the leases, the payments are less than the amount of calculated interest expense, which results in an increase in the debt balance during this period, reaching $254,699 in 2015. Accordingly, the Company has classified the full amount of the debt outstanding as of December 31, 2011 as long-term. Beginning in 2015, the payments begin to reduce the debt balance and are reflected in the annual maturities shown herein. At the end of the twenty-year leases, the remaining debt will be approximately $201,738.

In November 2011, the Company completed the private placement of $494,500 of 3% Convertible Senior Notes due 2018 (“3% Notes due 2018”), convertible into common stock at approximately $13.33 per share. Under FASB ASC Topic 470, Debt (“ASC 470”), $361,340 of the proceeds from the 3% Notes due 2018 was allocated to long-term debt and $133,160 was allocated to equity based on the Company’s non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $361,340 of 3% Notes due 2018 amounted to approximately $10,428, which are being amortized on a straight-line basis, which approximates the effective interest method, over the life of the 3% Notes due 2018. The 3% Notes due 2018 also contain a provision for a “make-whole” premium to be paid by the Company to holders of the 3% Notes due 2018 in the event of certain changes in control that could occur

F-26

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE F) – Long-term Debt (continued)

during the life of the 3% Notes due 2018. The premium is payable in the form of the Company’s common stock by increasing the conversion rate to the holders of the notes who convert their notes. The premium, which is expressed as additional shares of common stock per one thousand dollars principal amount of notes, is based upon the price of the Company’s stock as of the effective date of the change in control. The maximum premium possible is approximately $114,116, or approximately 23% of the aggregate face value of 3% Notes due 2018 outstanding, in the event a qualified change in control occurs with a stock price of at least $10.25 per share at such date. If the stock price on the effective date of a change in control is less than $10.25 per share or greater than $75.00 per share, no premium will be paid.

In connection with the issuance of the 3% Notes due 2018, the Company entered into capped call contracts with certain counterparties covering approximately 37,110,692 shares of the Company’s common stock issuable upon the conversion of the 3% Notes due 2018. The capped call contracts have a strike price of $13.33 per share and a cap price of $18.45 per share, and are settled upon maturity of the capped call contracts (“Settlement Date”). If the price of the Company’s common stock at the Settlement Date is above the strike price of the capped calls, the counterparties will deliver shares of the Company’s common stock and/or cash, at the Company’s option. In the event the Company elects to receive shares, the counterparties will deliver shares based on computing the aggregate value of the capped call contracts (number of underlying shares of the convertibles notes multiplied by the difference between the price of the Company’s common stock at the Settlement Date, up to the capped price per share, and the strike price) and then dividing such aggregate value by the price of the Company’s common stock as of the Settlement Date. In the event the Company elects to receive cash, the counterparties will deliver cash equal to the aggregate value of the capped call contracts. If the price of the Company’s common stock at the Settlement Date is below the strike price of the capped call contracts, the capped call contracts will expire with no shares and/or cash being delivered to the Company. The Company paid approximately $50,933 for these capped calls in 2011 and recorded this cost in Additional paid-in capital.

During 2004, the Company completed the private placement of $280,000 of 2 ¹/4% Convertible Subordinated Notes due 2011 (“2 ¹/4% Notes due 2011”), convertible into common stock at approximately $15.55 per share. Under ASC 470, $191,804 of the proceeds from the 2 ¹/4% Notes due 2011 was allocated to long-term debt and $88,196 was allocated to equity based on the Company’s non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $191,804 of 2 ¹/4% Notes due 2011 amounted to approximately $5,924, which were being amortized on a straight-line basis, which approximated the effective interest method, over the life of the 2 ¹/4% Notes due 2011. During 2009, the Company repurchased 2 ¹/4% Notes due 2011 with a face value of $82,900 (as discussed below), and wrote off the related unamortized debt issuance costs and debt discount. During the third quarter of 2011, the Company issued an aggregate of 7,614,000 shares of common stock in several separate transactions in exchange for $116,600 aggregate principal amount (net of an unamortized discount of $1,200) of the 2 ¹/4% Notes due 2011. The Company also recorded approximately $808 of interest expense in 2011 related to exchange offers accepted by certain note holders. The remaining approximately $78,000 principal amount of these notes was repaid in October 2011 in cash.

During 2005, the Company completed an offering of $230,000 of 2 ¹/4% Convertible Subordinated Notes due 2012 (“2 ¹/4% Notes due 2012”), convertible into common stock at approximately $17.78 per share. Under ASC 470, $143,266 of the proceeds from the 2 ¹/4% Notes due 2012 was allocated to long-term debt and $86,734 was allocated to equity based on the Company’s non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $143,266 of 2 ¹/4% Notes due 2012 amounted to approximately $4,220, which are being amortized on a straight-line basis, which approximates the effective interest method, over the life of the 2 ¹/4% Notes due 2012. During 2009, the Company repurchased 2 ¹/4% Notes due 2012 with a face value of $23,250 (as discussed below), and wrote off the related unamortized debt issuance costs and debt discount. The 2 ¹/4% Notes due 2012 also contain a provision for a “make-whole” premium to be paid by the Company to holders of the 2 ¹/4% Notes due 2012 in the event of certain changes in control that could occur during the life of the 2 ¹/4% Notes due 2012. The premium is payable in the form of the Company’s common stock by increasing the conversion rate to the

F-27

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE F) – Long-term Debt (continued)

holders of the notes who convert their notes. The premium, which is expressed as additional shares of common stock per one thousand dollars principal amount of notes, is based upon the price of the Company’s stock as of the effective date of the change in control. As of December 31, 2011, the maximum premium possible is approximately $21,334, or approximately 10% of the aggregate face value of 2 ¹/4% Notes due 2012 outstanding, in the event a qualified change in control occurs with a stock price of at least $14.82 per share at such date. If the stock price on the effective date of a change in control is less than $14.82 per share or greater than $100.00 per share, no premium will be paid.

During 2009, the Company repurchased 2 ¹/4% Notes due 2011 with a face value of $82,900 and 2 ¹/4% Notes due 2012 with a face value of $23,250 for an aggregate cost of approximately $50,000 plus accrued interest. The repurchase resulted in a gain on extinguishment of debt of $38,873, net of the related debt discount of $16,424 and debt issuance costs of $855.

The carrying amount and fair value of the Company’s short-term and long-term debt are as follows:

	December 31,
	2011				2010
	Carrying Amount		Fair Value		Carrying Amount		Fair Value
3% Convertible Senior Notes due 2018	$	363,698	$	433,924	$	—	$	—
2 1/4% Convertible Subordinated Notes due 2011		—		—		188,620		320,311
2 1/4% Convertible Subordinated Notes due 2012		198,037		200,534		184,231		314,245
BioMed lease financing		252,105		263,688		250,516		266,016
	$	813,840	$	898,146	$	623,367	$	900,572

The fair value of the BioMed lease financing is determined using a discounted cash flow analysis and current rates for corporate debt having similar characteristics and companies with similar credit worthiness.

The components of the convertible debt are as follows:

	December 31, 2011
	Face Value		Unamortized Debt Discount			Carrying Amount
3% Convertible Senior Notes due 2018	$	494,500	$	(130,802	)	$	363,698
2 1/4% Convertible Subordinated Notes due 2012		206,736		(8,699	)		198,037
	$	701,236	$	(139,501	)	$	561,735

	December 31, 2010
	Face Value		Unamortized Debt Discount			Carrying Amount
2 1/4% Convertible Subordinated Notes due 2011	$	197,100	$	(8,480	)	$	188,620
2 1/4% Convertible Subordinated Notes due 2012		206,740		(22,509	)		184,231
	$	403,840	$	(30,989	)	$	372,851

The Company’s 3% Notes due 2018 are unsecured obligations of the Company and rank equal in right of payment with all other senior indebtedness, if any, and senior in right of payment to the Company’s existing and future subordinated indebtedness. The 3% Notes due 2018 are not redeemable prior to maturity, but

F-28

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE F) – Long-term Debt (continued)

can be repurchased by the Company on the open market. The indentures under which the 3% Notes due 2018 have been issued contain no financial covenants or any restriction on the payments of dividends, the incurrence of additional senior indebtedness, or other indebtedness, or the Company’s issuance or repurchase of securities. There are no sinking fund requirements with respect to the 3% Notes due 2018.

The Company’s 2 ¹/4% Notes due 2012 are unsecured obligations of the Company and rank junior in right of payment to the Company’s existing and future senior indebtedness. The 2 ¹/4% Notes due 2012 are not redeemable prior to maturity, but can be repurchased by the Company on the open market. The indentures under which the 2 ¹/4% Notes due 2012 have been issued contain no financial covenants or any restriction on the payments of dividends, the incurrence of senior indebtedness, or other indebtedness, or the Company’s issuance or repurchase of securities. There are no sinking fund requirements with respect to the 2 ¹/4% Notes due 2012.

(NOTE G) – Commitments and Other Matters

Leases

The Company leases office and laboratory premises pursuant to operating leases expiring at various dates through 2026. Minimum annual rentals are as follows:

Year Ending December 31,
2012	$	21,305
2013		21,843
2014		21,973
2015		22,113
2016		22,431
2017 and thereafter		214,881
	$	324,546

The operating lease commitment of $324,546 includes lease payments associated with the Company’s lease with BioMed for its Traville headquarters. During 2006 the Company entered into a lease with BioMed for its Traville headquarters following the termination of the Company’s Traville lease with its former lessor. Based upon an allocation of fair value, the initial annual rent for Traville was approximately $16,653. The aggregate rental payments over the remaining lease term are approximately $307,243, including an annual escalation of 2% which is accounted for on a straight-line basis over the lease term. The Company has an option to purchase the Traville facility in 2016 for $303,000. There are no financial covenants with respect to the BioMed lease.

As part of its agreement with BioMed, the Company committed to exercise purchase options with respect to certain equipment currently used at the Traville facility at the end of the applicable equipment lease terms. The equipment was subject to several operating leases with an unrelated party. The Company exercised the purchase option related to the remaining leases in 2009 at a cost of approximately $5,300. The Company will transfer ownership of this facility-related equipment to BioMed at the earlier of the end of the Traville lease term or at certain other pre-specified events.

The Company has entered into two long-term leases, as amended, with MEDCO expiring January 1, 2019 for a small-scale manufacturing facility built to the Company’s specifications. The Company has accounted for these leases as operating leases. The facility was financed primarily through a combination of MEDCO Bonds and loans issued to MEDCO by certain State of Maryland agencies. The Company has no equity interest in MEDCO.

F-29

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE G) – Commitments and Other Matters (continued)

Rent is based upon MEDCO’s debt service obligations. Annual base rent under the leases during 2011 was approximately $1,108. Annual base rent under the leases in 2012 is expected to increase to approximately $2,036. The MEDCO Bonds are secured by letters of credit issued for the account of MEDCO which expire in December 2012. The Company has restricted investments of approximately $35,900 and $35,400 as of December 31, 2011 and 2010, respectively, associated with these leases which serve as security for the MEDCO letters of credit reimbursement obligation. Upon default or early lease termination, the MEDCO Bond indenture trustee can draw upon the letters of credit to pay the MEDCO Bonds as they are tendered. In such an event, the Company could lose part or all of its restricted investments and could record a charge to earnings for a corresponding amount. Alternatively, the Company has an option during or at the end of the lease term to purchase this facility for an aggregate amount that declines from approximately $34,000 in 2012 to approximately $21,000 in 2019. The amended leases contain no debt covenants with respect to the Company’s financial condition. See Note C, Investments, for additional discussion of the Company’s restricted investments.

The Company’s leases for office and laboratory space provide for certain rent escalations on each anniversary of the lease commencement date. For financial reporting purposes, rent expense is charged to operations on a straight-line basis over the term of the lease, resulting in a liability for deferred rent of $11,795 and $10,358 as of December 31, 2011 and 2010, respectively.

Rent expense aggregated $19,976, $20,949 and $22,357 for 2011, 2010 and 2009, respectively. The decrease in rent expense each year is due to the expiration of certain equipment leases.

401(k) Plan

The Company has a 401(k) pension plan available to eligible full-time employees. Participating employees may contribute up to 100% of their total eligible compensation to the plan, subject to Internal Revenue Service limitations. The Company currently matches a portion of the employee contributions. The Company’s contribution was $5,257, $2,592 and $1,645 for 2011, 2010 and 2009, respectively.

Contingent Liabilities

In the ordinary course of business, the Company is involved in various legal proceedings, including, among others, patent oppositions, patent revocations, patent infringement litigation, securities class actions, shareholder derivative litigation and other matters incidental to its business. While it is not possible to accurately predict or determine the eventual outcome of these matters or estimate a range of loss, one or more of these matters currently pending could have a material adverse effect on the Company’s financial condition, results of operations or cash flows.

In November 2011, two securities class actions were filed in the U.S. District Court for the District of Maryland against the Company and a number of its current and former executive officers and directors, alleging violations of securities laws during 2010 and 2009. In addition, three shareholder derivative actions have been filed during December 2011 and January 2012 in the United States District Court for the District of Maryland that are related to essentially the same allegations made in the securities class actions. The Company believes these suits are without merit and plans to vigorously defend these claims. Currently, the Company cannot estimate any potential loss related to these claims. No reserve has been established for any potential liability relating to these suits.

Loss Contingencies

As of December 31, 2011, current inventory includes an aggregate of $10,785 of raw materials and work in process relating to anticipated future orders for raxibacumab beyond that which is required to fulfill the second order from the USG. The Company currently expects to recover the cost of this inventory through future sales of raxibacumab. If the Company does not receive additional orders for raxibacumab, it would need to record a charge to cost of product sales for this amount of inventory.

F-30

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE H) – Stockholders’ Equity

Public Offerings of Common Stock

During 2009, the Company completed two public offerings of its common stock. The Company issued 26,697,250 shares in August 2009 at a price of $14.00 per share, resulting in net proceeds of approximately $356,500. The Company also issued 17,825,000 shares in December 2009 at a price of $26.75 per share, resulting in net proceeds of approximately $456,400.

Stock-based Compensation Plans

The Company has two stock-based compensation plans as described below. The following is a summary of the stock-based compensation expense that has been recorded in the consolidated statements of operations for the years indicated:

	Year Ended December 31,
	2011		2010		2009
Employee stock option and employee stock purchase plan	$	33,920	$	24,277	$	11,935
Restricted stock units		1,903		1,068		589
Restricted stock awards		92		85		—
Total	$	35,915	$	25,430	$	12,524

Stock-based compensation expense for 2011 is net of $3,373 capitalized as part of inventory production. No income tax benefit was recognized in the consolidated statements of operations for stock-based compensation for the years presented due to the Company’s net loss position.

Stock Incentive Plan

The Company has a stock incentive plan (the “Incentive Plan”) under which options to purchase new shares of the Company’s common stock may be granted to employees, consultants and directors at an exercise price no less than the quoted market value on the date of grant. The Incentive Plan also provides for awards in the form of stock appreciation rights, restricted (non-vested) or unrestricted stock awards, stock-equivalent units or performance-based stock awards. The Company issues both qualified and non-qualified options under the Incentive Plan. The vesting period of the options is determined by the Board of Directors and is generally four years. Upon acquisition by a person, or group of persons, of more than 50% of the Company’s outstanding common stock, outstanding options shall immediately vest in full and be exercisable. The Company recognizes compensation expense for an award with only service conditions that has a graded vesting schedule on a straight-line basis over the requisite service period for the entire award. All options expire after ten years or earlier from the date of grant.

As of December 31, 2011, the total authorized number of shares under the Incentive Plan, including prior plans, was 59,845,420. Options available for future grant were 6,478,055 as of December 31, 2011.

F-31

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE H) – Stockholders’ Equity (continued)

Stock Options

A summary of stock option activity for 2011 is as follows:

	Shares			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (years)	Aggregate Intrinsic Value (1)
Outstanding at January 1, 2011		24,028,688		$	14.55	6.32	$	275,278
Granted		4,404,965			25.57
Exercised		(1,954,840	)		8.69			32,946
Forfeited		(429,950	)		22.40
Expired		(980,051	)		39.28
Outstanding at December 31, 2011		25,068,812			15.84	6.24		25,815
Vested and expected to vest at December 31, 2011		24,331,795			15.66	6.17		24,941
Exercisable at December 31, 2011		17,017,555			12.40	5.14		18,023

(1) Aggregate intrinsic value includes only options in which the exercise price of the option is less than the market value of the Company’s stock on December 31, 2011, or for exercised options, the intrinsic value on the exercise date.

The following table summarizes information about stock options outstanding as of December 31, 2011:

	Options Outstanding					Options Exercisable
Range of Exercise Price	Number Outstanding		Weighted- Average Remaining Contractual Life (In Years)	Weighted- Average Exercise Price		Number Exercisable		Weighted- Average Exercise Price
$  0.52 to $10.00		6,545,064	6.34	$	3.68		5,160,920	$	4.19
$10.01 to $12.50		6,617,214	3.96		10.96		6,526,235		10.96
$12.51 to $15.00		2,320,924	3.82		13.03		2,055,903		12.87
$15.01 to $33.00		9,585,610	8.32		28.18		3,274,497		27.92
		25,068,812					17,017,555

During 2011, 2010 and 2009, the Company issued 1,954,840, 3,600,641 and 4,584,767 shares of common stock, respectively, in conjunction with stock option exercises. The Company received cash proceeds from the exercise of these stock options of approximately $16,982, $37,841 and $48,147, for 2011, 2010 and 2009, respectively.

As of December 31, 2011, total unrecognized compensation cost related to stock options amounted to $104,153, which is expected to be recognized over a weighted-average period of 2.5 years as the options vest. There were non-vested stock options outstanding for 8,064,257 shares as of December 31, 2011.

F-32

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE H) – Stockholders’ Equity (continued)

The total intrinsic value of stock options exercised during 2011, 2010 and 2009 was approximately $32,946, $66,779 and $51,205, respectively. The total fair value of stock options which vested during 2011, 2010 and 2009 was approximately $38,830, $20,286 and $12,353, respectively. The weighted-average grant-date fair value of stock options granted during 2011, 2010 and 2009 was $14.26, $17.31 and $0.91 per share, respectively.

The fair values of employee stock options granted during 2011, 2010 and 2009 were determined based on the Black-Scholes-Merton option-pricing model using the following range of assumptions:

	Year Ended December 31,
	2011	2010	2009
Expected life:
Stock options	5.5 years	5.5 years	5.5 years
Employee stock purchase plan rights	1.0 years	1.0 years	1.0 years
Interest rate	1.1% - 2.4%	1.3% - 2.7%	1.4% - 2.8%
Volatility	52.6% - 66.2%	55.0% - 65.4%	53.0% - 83.5%
Dividend yield	0%	0%	0%

An explanation of the above assumptions is as follows:

Expected Life of Stock-based Awards – The expected life of stock-based awards is the period of time for which the stock-based award is expected to be outstanding. This estimate is based on historical exercise data.

Interest Rate – The risk-free rate over the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of grant.

Volatility – Volatility is a measure of the amount by which a financial variable such as a share price has fluctuated (historical volatility) or is expected to fluctuate (implied volatility) during a period. The Company uses a combination of historical volatility and the implied volatility of its traded convertible notes as the basis for its expected volatility. In 2010, because the Company’s then outstanding traded convertible notes were nearing maturity, the Company added historical volatility to its overall volatility calculation. The weighted average volatility used was 61.7%, 63.5% and 55.9% for 2011, 2010 and 2009, respectively.

Dividend Yield – The Company has never declared or paid dividends and has no plans to do so in the foreseeable future.

Restricted Stock

Under the Incentive Plan, the Company has granted both restricted stock awards and restricted stock units (“RSUs”). RSUs have service conditions and vest ratably on an annual basis over a four-year period. During 2011, the Company awarded 280,906 RSUs at a weighted-average grant date fair value of $26.59 per share. The Company incurred $1,995, $1,153 and $589 of compensation expense for 2011, 2010 and 2009, respectively, related to both RSUs and restricted stock awards.

F-33

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE H) – Stockholders’ Equity (continued)

A summary of the status of the Company’s restricted stock as of December 31, 2011 and changes during 2011 is presented below:

	Shares			Weighted-Average Grant-Date Fair Value
Restricted stock at January 1, 2011		203,782		$	16.01
Granted		280,906			26.59
Vested		(97,421	)		12.81
Forfeited		(11,454	)		16.96
Restricted stock at December 31, 2011		375,813			24.72
Expected to vest at December 31, 2011		333,521			24.94

Stock-based compensation expense under FASB ASC Topic 718, Compensation – Stock Compensation, for 2011, 2010 and 2009 is not necessarily representative of the level of stock-based compensation expense in future years due to, among other things, (1) the vesting period of the stock-based compensation and (2) the number and fair value of additional stock-based grants in future years.

Employee Stock Purchase Plan

The Company has an Employee Stock Purchase Plan (the “Purchase Plan”), as amended, registering 2,000,000 shares of $0.01 par value common stock for issuance under this plan. Under the Purchase Plan, eligible employees may purchase shares of common stock on certain dates and at certain prices as set forth in the plan. The common stock is purchased under the Purchase Plan at a discounted rate, currently at 15%, which results in this plan qualifying as compensatory. During 2011, the Company issued 68,025 shares of common stock pursuant to the Purchase Plan and recorded compensation cost of approximately $758. The weighted-average fair value of the employee stock purchase plan rights granted during 2011, 2010 and 2009 was $5.81, $6.65 and $0.53 per share, respectively. Common stock reserved for future employee purchase under the Purchase Plan aggregated 596,625 shares as of December 31, 2011. There are no other investment options for participants.

F-34

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE I) – Income Taxes

The Company provides for income taxes using the liability method. The difference between the tax provision and the amount that would be computed by applying the statutory Federal income tax rate to income before taxes is attributable to the following:

	Year Ended December 31,
	2011			2010			2009
Federal income tax provision at 35%	$	(133,331	)	$	(77,112	)	$	1,491
State taxes, net of federal tax benefit		(7,342	)		(7,324	)		185
Foreign income tax rate differential		5,436			—			—
Permanent differences, net		8,749			3,247			(336	)
Tax credits, principally for research and development		(5,917	)		428			(1,813	)
State net operating loss carryforward adjustments		60,010			—			—
Research and development credit refunds		—			—			(1,274	)
Other		3,130			(183	)		(2,967	)
Change in valuation allowance on deferred tax asset		69,265			80,944			3,440
	$	—		$	—		$	(1,274	)

The change in valuation allowance as reported above excludes the change in valuation allowance associated with the net deferred tax asset recorded in connection with the net unrealized gains on investments, as such amounts are recorded as a component of other comprehensive income. In 2011, the Company recorded a charge of $60,010, fully offset by valuation allowance release, to adjust the Company’s deferred tax assets related to state net operating loss carryforwards. The charge was necessary to account for the adoption of a more favorable state income apportionment methodology provided to Maryland manufacturers and the impact of the Company’s commercialization activities. The effective rate reconciliation now includes a foreign income tax rate differential to account for the Company’s international operations and a line for net permanent differences.

Temporary differences and carryforwards that give rise to a significant portion of deferred tax assets and liabilities are as follows:

	Current Asset			Long-Term Asset  (Liability)
December 31, 2011
Net operating loss carryforward	$	—		$	824,005
Research and development and other tax credit carryforwards		—			40,791
Capital loss carryforwards		—			315
Deferred revenue		2,910			—
Lease termination charges		—			2,644
Net unrealized gains on investments		—			(1,690	)
Intangible assets		1,613			20,037
Equity-based compensation		—			19,729
Depreciation		—			23,523
Unamortized debt discount		—			(51,924	)
Reserves and accruals		7,453			8,763
Other		—			1,626
		11,976			887,819
Less valuation allowance		(11,976	)		(887,819	)
	$	—		$	—

F-35

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE I) – Income Taxes (continued)

	Current Asset			Long-Term Asset  (Liability)
December 31, 2010
Net operating loss carryforward	$	—		$	796,645
Research and development and other tax credit carryforwards		—			34,854
Deferred revenue		2,182			761
Lease termination charges		—			3,302
Net unrealized gains on investments		—			(2,806	)
Intangible assets		385			4,104
Equity-based compensation		—			13,664
Depreciation		—			18,633
Unamortized debt discount		—			(11,922	)
Reserves and accruals		7,453			10,968
Other		—			1,436
		10,020			869,639
Less valuation allowance		(10,020	)		(869,639	)
	$	—		$	—

The Company recognized a valuation allowance to the full extent of its deferred tax assets since the likelihood of realization of the benefit is not more likely than not. The valuation allowance increased by $20,136 during 2011 to $899,795 as of December 31, 2011. The increase is primarily related to the net operating loss carryforward generated in the current year, partially offset by valuation allowance release related to state net operating losses and $49,129 related to non-deductible debt discount on the Company’s 2011 convertible debt offering that was allocated to equity.

Provision for income taxes is comprised of the following:

	Year Ended December 31,
	2011		2010		2009
Current:
Federal	$	—	$	—	$	(1,274	)
State		—		—		—
Foreign taxes		—		—		—
Deferred		—		—		—
	$	—	$	—	$	(1,274	)

The Company has available tax credit carryforwards of approximately $40,533 which expire, if unused, from the year 2012 through the year 2031. The Company has net operating loss (“NOL”) carryforwards for federal income tax purposes of approximately $2,051,487, excluding stock-based compensation NOLs, which expire, if unused, from the year 2012 through the year 2031. In connection with the adoption of stock-based compensation guidance in 2006, the Company elected to follow the with-and-without approach to determine the sequence in which deductions and NOL carryforwards are utilized. As of December 31, 2011, the Company has approximately $366,185 of NOL carryforwards that relate to stock-based compensation for which future tax benefits, if any, will be credited to equity.

F-36

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE I) – Income Taxes (continued)

Internal Revenue Code Section 382 (“Section 382”) imposes annual limitations on the utilization of NOL carryforwards and other tax attributes upon an ownership change. In general terms, an ownership change may result from transactions that increase the aggregate ownership of certain stockholders in the Company’s stock by more than 50 percentage points over a testing period (generally three years). The Company updated a Section 382 analysis originally completed during 2010. Based on this analysis and other reviews of relevant shareholder activity, the Company’s NOLs and other tax attributes are not limited under Section 382. The Company’s future utilization of all of the Company’s NOLs and other tax attributes is dependent upon the Company’s ability to generate sufficient income during the carryforward periods and no further significant changes in ownership.

The Company accounts for uncertain tax positions pursuant to the guidance of FASB ASC Topic 740, Income Taxes. The Company recognizes interest and penalties related to uncertain tax positions, if any, in income tax expense. As of December 31, 2011 and 2010, the Company did not accrue any interest related to uncertain tax positions. The Company’s income taxes have not been subject to examination by any tax jurisdictions since the Company’s inception. Accordingly, all income tax returns filed by the Company are subject to examination by the taxing jurisdictions.

A reconciliation of the beginning and ending amount of gross unrecognized tax benefits is as follows:

	2011			2010			2009
Balance as of January 1	$	29,523		$	30,022		$	30,282
Gross increases related to prior year tax positions		910			—			—
Gross decreases related to prior year tax positions		(635	)		(803	)		(1,108	)
Gross increases related to current year tax positions		1,133			304			848
Balance as of December 31	$	30,931		$	29,523		$	30,022

The Company believes that any of its uncertain tax positions would not result in adjustments to its effective tax rate because likely corresponding adjustments to deferred tax assets would be offset by adjustments to recorded valuation allowances. It is reasonably possible that the balance of uncertain tax positions will decrease by up to $1,284 within the next 12 months due to the statutory expiration of certain tax carryforwards.

(NOTE J) – Facility-Related Exit Credits

During 2011, the Company decided to utilize certain headquarters space (“Wing C”) which it had previously not used and was not expecting to use. In conjunction with this decision, the Company reversed the remaining reserve related to this space, recording a facility-related exit credit of $1,717 in the consolidated statement of operations during 2011.

The following table summarizes the activity related to the liability for exit charges for 2011, all of which is facilities-related:

Balance as of January 1, 2011	$	1,938
Accretion recorded		37
Cash items		(258	)
Reserve adjustment		(1,717	)
Balance as of December 31, 2011	$	—

F-37

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE K) – Fair Value Measurements

The FASB guidance regarding the fair value of all assets and liabilities defines fair value, provides guidance for measuring fair value and requires certain disclosures. This guidance does not require any new fair value measurements, but rather applies to all other accounting pronouncements that require or permit fair value measurements. This guidance does not apply to measurements related to share-based payments.

The FASB Codification discusses valuation techniques, such as the market approach (comparable market prices), the income approach (present value of future income or cash flow), and the cost approach (cost to replace the service capacity of an asset or replacement cost). The guidance utilizes a fair value hierarchy that prioritizes the inputs to valuation techniques used to measure fair value into three broad levels. The following is a brief description of those three levels:

Level 1:	Observable inputs such as quoted prices (unadjusted) in active markets for identical assets or liabilities.
Level 2:	Inputs other than quoted prices that are observable for the asset or liability, either directly or indirectly. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.
Level 3:	Unobservable inputs that reflect the reporting entity’s own assumptions.

Active markets are those in which transactions occur with sufficient frequency and volume to provide pricing information on an ongoing basis. Inactive markets are those in which there are few transactions for the asset, prices are not current, or price quotations vary substantially either over time or among market makers, or in which little information is released publicly. With regard to the Company’s financial assets subject to fair value measurements, the Company believes that all of the assets it holds are actively traded because there is sufficient frequency and volume to obtain pricing information on an ongoing basis.

F-38

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE K) – Fair Value Measurements (continued)

The Company’s assets and liabilities subject to fair value measurements on a recurring basis and the related fair value hierarchy are as follows:

	Fair Value as of December 31, 2011
	Level 1		Level 2		Level 3		Total
Cash and cash equivalents	$	402,049	$	—	$	—	$	402,049
Corporate debt securities	$	—	$	95,729	$	—	$	95,729
Residential mortgage-backed securities		—		21,008		—		21,008
Asset-backed securities		—		2,497		—		2,497
Marketable securities	$	—	$	119,234	$	—	$	119,234
Corporate debt securities	$	—	$	179,865	$	—	$	179,865
Residential mortgage-backed securities		—		47,891		—		47,891
Government-sponsored enterprise securities		—		5,281		—		5,281
Asset-backed securities		—		46,921		—		46,921
Marketable securities, non-current	$	—	$	279,958	$	—	$	279,958
Money market funds	$	11,650	$	—	$	—	$	11,650
U.S. Treasury securities		1,306		—		—		1,306
Corporate debt securities		—		51,944		—		51,944
Residential mortgage-backed securities		—		5,986		—		5,986
Government-sponsored enterprise securities		—		4,649		—		4,649
Asset-backed securities		—		4,658		—		4,658
Restricted investments	$	12,956	$	67,237	$	—	$	80,193

The Company evaluates the types of securities in its investment portfolios to determine the proper classification in the fair value hierarchy based on trading activity and the observability of market inputs.

The Company generally obtains a single quote or price per instrument from independent third parties to help it determine the fair value of securities in Level 1 and Level 2 of the fair value hierarchy. The Company’s Level 1 cash and money market instruments are valued based on quoted prices from third parties, and the Company’s Level 1 U.S. Treasury securities are valued based on broker quotes. The Company’s Level 2 assets are valued using a multi-dimensional pricing model that includes a variety of inputs including actual trade data, benchmark yield data, non-binding broker/dealer quotes, issuer spread data, monthly payment information, collateral performance and other reference information. These are all observable inputs. The Company reviews the values generated by the multi-dimensional pricing model for reasonableness, which could include reviewing other publicly available information.

The Company does not hold auction rate securities, loans held for sale, mortgage-backed securities backed by sub-prime or Alt-A collateral or any other investments which require the Company to determine fair value using a discounted cash flow approach. Therefore, the Company does not need to adjust its analysis or change its assumptions specifically to factor illiquidity in the markets into its fair values.

The fair value of the Company’s accounts receivable, collaboration receivables, other assets, accounts payable, accrued expenses and collaboration payable approximate their carrying amount due to the relatively short maturity of these items. The fair value of the Company’s convertible senior and subordinated debt is based on quoted market prices. The quoted market price of the Company’s convertible senior and subordinated debt was

F-39

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE K) – Fair Value Measurements (continued)

approximately $634,458 (book value of $561,735) as of December 31, 2011. With respect to its lease financing, the Company evaluated its incremental borrowing rate as of December 31, 2011, based on the current interest rate environment and the Company’s credit risk. The fair value of the BioMed lease financing was approximately $263,688 (book value of $252,105) as of December 31, 2011 based on a discounted cash flow analysis, and current rates for corporate debt having similar characteristics and companies with similar creditworthiness.

(NOTE L) – Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys)

In 2008, Teva Pharmaceuticals Industries, Ltd. (“Teva”) acquired all of the outstanding stock of CoGenesys and CoGenesys became a wholly-owned subsidiary of Teva called Teva Bio. CoGenesys had been a division of the Company until 2006, when the Company completed the sale of assets and concurrently entered into a license agreement and manufacturing services agreement.

As consideration for the assets conveyed, liabilities assumed and intellectual property licensed, the Company obtained an equity interest in CoGenesys. The Company allocated the consideration received to both the product license and manufacturing services agreement, which was recognized ratably over the term of the manufacturing services agreement, as amended, which ended in 2009.

Under the license agreement, as amended, the Company is entitled to various milestone and royalty rights on certain products, if they are developed and commercialized. Teva Bio can obtain additional product rights by extending the initial seven-year research term upon the payment of additional consideration.

As a result of Teva’s acquisition of CoGenesys in 2008, the Company received $47,336 as partial payment for its equity investment in CoGenesys. The terms of the agreement between Teva and CoGenesys required an escrow account be established for 10% of the purchase price as security for CoGenesys’ representations, warranties, and covenants. During 2009, the Company received the final payment for its equity investment in CoGenesys and recorded a gain of $5,259.

(NOTE M) – Earnings Per Share

Diluted net income (loss) per share was determined as follows:

	Year Ended December 31,
	2011			2010			2009
Numerator:
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659
Denominator:
Weighted average shares outstanding		193,667,672			187,791,437			149,334,426
Effect of dilutive securities:
Employee stock options and restricted stock units		—			—			5,719,047
Weighted average shares used for diluted net income (loss) per share		193,667,672			187,791,437			155,053,473
Diluted net income (loss) per share	$	(1.97	)	$	(1.24	)	$	0.04

Common stock issued in connection with the Company’s Employee Stock Purchase Plan and through exercised options granted pursuant to the Incentive Plan are included in the Company’s weighted average share balance based upon the issuance date of the related shares. As of December 31, 2011, 2010 and 2009, the Company had 25,068,812, 24,028,688 and 24,601,174, respectively, stock options outstanding. The Company had 48,735,519, 24,302,742 and 24,303,304 shares issuable upon the conversion of the

F-40

HUMAN GENOME SCIENCES, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(dollars in thousands, except per share data)

(NOTE M) – Earnings Per Share (continued)

Company’s convertible debt as of December 31, 2011, 2010 and 2009, respectively. The shares issuable upon the conversion of the Company’s convertible debt and shares due to the Company upon settlement of the Company’s capped call option contracts are excluded from the weighted average shares as they are anti-dilutive.

(NOTE N) – Quarterly Financial Information (unaudited)

Quarterly financial information for 2011 and 2010 is presented in the following table:

	1st Quarter			2nd Quarter			3rd Quarter			4th Quarter
2011
Revenue	$	26,573		$	24,858		$	34,022		$	45,522
Loss from operations		(115,999	)		(68,494	)		(75,995	)		(69,063	)
Net loss		(130,995	)		(80,660	)		(88,429	)		(81,022	)
Net loss per share, basic and diluted		(0.69	)		(0.42	)		(0.45	)		(0.41	)
2010
Revenue	$	46,514		$	38,792		$	50,782		$	21,263
Loss from operations		(37,773	)		(46,992	)		(29,826	)		(76,182	)
Net loss		(47,877	)		(56,863	)		(40,859	)		(87,632	)
Net loss per share, basic and diluted		(0.26	)		(0.30	)		(0.22	)		(0.46	)

The Company’s results for the first quarter of 2011 include an upfront license fee paid to FivePrime of $50,000, or $0.26 per basic and diluted share. See Note D, Collaborations and Other Agreements, for additional information.

The Company’s results for the third quarter of 2010 include additional revenue recognized based on the decision to end future development of ZALBIN of $34,126, or $0.18 per basic and diluted share.

F-41

EX-10.15

Exhibit 10.15

EXECUTION VERSION

To:	Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville, Maryland 20850-7464 Attn: James H. Davis Telephone: 301-309-8504 Email: Jim_Davis@hgsi.com
From:	Barclays Bank PLC 5 The North Colonnade Canary Wharf, London E14 4BB Facsimile: +44(20)77736461 Telephone: +44 (20) 777 36810 c/o Barclays Capital Inc. as Agent for Barclays Bank PLC 745 Seventh Avenue New York, NY 10019 Telephone: +1 212 412 4000
Re:	Capped Call Transaction
Date:	November 2, 2011

Dear Sir(s):

The purpose of this communication (this “Confirmation”) is to set forth the terms and conditions of the above-referenced transaction entered into on the Trade Date specified below (the “Transaction”) between Barclays Bank PLC (“Dealer”), through its agent Barclays Capital Inc. (the “Agent”), and Human Genome Sciences, Inc. (“Counterparty”). This communication constitutes a “Confirmation” as referred to in the ISDA Master Agreement specified below. This Confirmation shall replace any previous agreements and serve as the final documentation for the Transaction. Dealer is not a member of the Securities Investor Protection Corporation. Dealer is regulated by the Financial Services Authority.

1. This Confirmation is subject to, and incorporates, the definitions and provisions of the 2006 ISDA Definitions (including the Annex thereto) (the “2006 Definitions”) and the definitions and provisions of the 2002 ISDA Equity Derivatives Definitions (the “Equity Definitions”, and together with the 2006 Definitions, the “Definitions”), in each case as published by the International Swaps and Derivatives Association, Inc. (“ISDA”). In the event of any inconsistency between the 2006 Definitions and the Equity Definitions, the Equity Definitions will govern.

Each party is hereby advised, and each such party acknowledges, that the other party has engaged in, or refrained from engaging in, substantial financial transactions and has taken other material actions in reliance upon, and in consideration for, the parties’ entry into the Transaction to which this Confirmation relates on the terms and conditions set forth below.

This Confirmation evidences a complete and binding agreement between Dealer and Counterparty as to the terms of the Transaction to which this Confirmation relates. This Confirmation shall be subject to an agreement (the “Agreement”) in the form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) as if Dealer and Counterparty had executed an agreement in such form (without any Schedule except for (i) the election of Loss and Second Method and US Dollars (“USD”) as the Termination Currency, (ii) the replacement of the word “third” in the last line of Section 5(a)(i) of the Agreement with the word “second,” and (iii) such other elections as set forth in this Confirmation).

All provisions contained in, or incorporated by reference to, the Agreement will govern this Confirmation except as expressly modified herein. In the event of any inconsistency between this Confirmation and either the Definitions or the Agreement, this Confirmation shall govern.

The Transaction hereunder, and any additional capped call Share Option Transactions with respect to the Shares between Dealer and Counterparty in which the confirmation for any such transaction specifically references the Agreement, shall be the sole Transaction(s) under the Agreement. If, at any time, there exists any other agreement in the form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) or 2002 ISDA Master Agreement (each, an “ISDA Master Agreement”) between Dealer and Counterparty or any confirmation or other agreement between Dealer and Counterparty pursuant to which an ISDA Master Agreement is deemed to exist between Dealer and Counterparty, then unless such ISDA Master Agreement, such confirmation or agreement or any other agreement to which Dealer and Counterparty are parties specifically references the Agreement, the Transaction shall not be considered a Transaction under, or otherwise governed by, such existing or deemed ISDA Master Agreement.

2. The Transaction constitutes a Share Option Transaction for purposes of the Equity Definitions. The terms of the particular Transaction to which this Confirmation relates are as follows:

General Terms:
Trade Date:	November 2, 2011
Components:	The Transaction will be divided into individual Components, each with the terms set forth in this Confirmation, and, in particular, with the Number of Options and Expiration Date set forth in Annex A to this Confirmation. The exercise, valuation and settlement of the Transaction will be effected separately for each Component as if each Component were a separate Transaction under the Agreement.
Option Style:	European
Option Type:	Call
Seller:	Dealer
Buyer:	Counterparty
Shares:	The common stock of Counterparty, par value USD0.01 per share (Ticker Symbol: “HGSI”).
Number of Options:	For each Component, as provided in Annex A to this Confirmation.
Option Entitlement:	One Share per Option.
Strike Price:	USD13.33
Cap Price:	USD18.45
Premium:	The aggregate Premium for the Transaction is USD26,238,600.
Premium Payment Date:	The Effective Date
Effective Date:	November 7, 2011 or such other date as agreed by the parties.
Exchange:	The NASDAQ Global Select Market
Related Exchange:	All Exchanges
Procedures for Exercise:
Expiration Time:	Valuation Time

2

Expiration Date:	As provided in Annex A to this Confirmation (or, if such date is not a Scheduled Trading Day, the next following Scheduled Trading Day that is not already an Expiration Date for another Component); provided that, notwithstanding anything to the contrary in the Equity Definitions, if that date is a Disrupted Day, the Calculation Agent may determine that the Expiration Date for such Component is a Disrupted Day in whole or in part, in which case the Calculation Agent shall, in its reasonable discretion, determine the number of Options for which such day shall be the Expiration Date and (i) allocate the remaining Options for such Expiration Date to one or more of the remaining Expiration Dates, (ii) designate the first succeeding Scheduled Trading Day that is not a Disrupted Day and is not or is not deemed to be an Expiration Date in respect of any other Component of the Transaction hereunder as the Expiration Date for such remaining Options, or (iii) a combination thereof, in each case the Calculation Agent shall provide email notice to Counterparty of such determination as soon as reasonably practicable; provided further that if the Expiration Date for a Component (including any portion of a Component whose Expiration Date was postponed as a result of clause (ii) or (iii) above) has not occurred as of the Final Disruption Date, (a) such Final Disruption Date shall be deemed to be the Expiration Date and Valuation Date for such Component, and (b) the Calculation Agent shall determine the Settlement Price for such Component on the basis of its good faith estimate of the trading value for the relevant Shares. Section 6.6 of the Equity Definitions shall not apply to any Disrupted Day occurring on an Expiration Date.
Final Disruption Date:	November 28, 2018
VWAP Price:	For any Expiration Date or other Exchange Business Day, the volume weighted average price of the Shares as displayed on Bloomberg Page “HGSI<equity>AQR” (or any successor page thereto) for the Counterparty with respect to the period between 9:30 a.m. to 4:00 p.m. (New York City time) on such day, as determined by Calculation Agent. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the VWAP Price in a commercially reasonable manner.
10b-18 VWAP Price:	For any Expiration Date or other Exchange Business Day, the Rule 10b-18 dollar volume weighted average price of the Shares based on transactions executed during such Expiration Date, as reported on Bloomberg Page “HGSI<equity>AQR SEC” (or any successor page thereto) on such day. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the 10b-18 VWAP Price in a commercially reasonable manner.
Market Disruption Event:	Section 6.3(a) of the Equity Definitions is hereby amended by (A) replacing clause (ii) thereof in its entirety with the following: “(ii) an Exchange Disruption, ” and (B) by replacing the words “or (iii) an Early Closure.” therein with “(iii) an Early Closure, or (iv) a Regulatory Disruption.”
	Section 6.3(d) of the Equity Definitions is hereby amended by deleting the remainder of the provision following the term “Scheduled Closing Time” in the fourth line thereof.

3

Regulatory Disruption:	Any event that Dealer, in its reasonable discretion, determines that it is prudent, with regard to any legal, regulatory or self-regulatory requirements or related policies and procedures (whether or not such requirements, policies or procedures are imposed by law or have been voluntarily adopted by Dealer, and including without limitation Sections 9 or 10 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), Rule 10b-18, Rule 10b-5 and Regulation 14E under the Exchange Act, and Regulation M), for Dealer to refrain from or decrease any market activity in connection with the Transaction.
Exchange Business Day; Disrupted Day:	Sections 1.29 and 6.4 of the Equity Definitions are hereby amended by adding “, unless the Calculation Agent reasonably determines that any failure of such Exchange or Related Exchange to open, or to remain open, does not have a material effect on the trading market for the Shares” following the words “regular trading sessions” in the third line thereof and the words “regular trading session” in the second line thereof, respectively.
Automatic Exercise:	Applicable; and means that the Number of Options for the relevant Component will be deemed to be automatically exercised at the Expiration Time on the Expiration Date for such Component if at such time such Component is In-the-Money, as determined by the Calculation Agent, unless Buyer notifies Seller (by telephone or in writing) prior to the Expiration Time on such Expiration Date that it does not wish Automatic Exercise to occur with respect to such Component, in which case Automatic Exercise will not apply with respect to such Component. “In-the-Money” means, in respect of any Component, that the Settlement Price on the Expiration Date for such Component is greater than the Strike Price for such Component.
Dealer’s Telephone Number and Telex and/or Facsimile Number and Contact Details for purpose of Giving Notice:	As specified in Section 6 below.
Settlement Terms:
Settlement Method Election:	Applicable; provided that (a) Section 7.1 of the Equity Definitions is hereby amended by replacing the term “Physical Settlement” with the term “Net Share Settlement or Combination Settlement”, (b) Counterparty must make a single irrevocable election for all Components, (c) such Settlement Method Election would be effective only if Counterparty represents and warrants to Dealer in writing on the date of such Settlement Method Election that none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares as of such date, (d) Counterparty’s Settlement Method Election shall correspond to the “settlement method” (as defined in the indenture for the 3.00% Convertible Senior Notes due November 15, 2018 (the “Convertible Notes” and such indenture, the “Indenture”)) elected by Counterparty with respect to the Convertible Notes such that (x) “physical settlement” or “combination settlement“ with a “specified dollar amount” (each, as defined in the Indenture) equal to or less than $1,000 with respect to the Convertible Notes shall mean that Net Share

4

	Settlement applies to the Transaction, (y) “cash settlement“ (as defined in the Indenture) shall mean that Cash Settlement applies to the Transaction, and (z) “combination settlement“ with a “specified dollar amount” greater than $1,000 with respect to the Convertible Notes shall mean that Combination Settlement applies to the Transaction, and (d) if the Settlement Method Election is “Combination Settlement”, Counterparty shall provide the Cash Percentage in the notice pursuant to Section 7.1 of the Equity Definitions; provided that if Counterparty fails to provide such Cash Percentage then the Default Settlement Method shall apply.
Electing Party:	Counterparty
Settlement Method Election Date:	The fifth Scheduled Trading Day prior to the scheduled Expiration Date for the first Component.
Default Settlement Method:	Net Share Settlement
Settlement Currency:	USD
Settlement Price:	For any Valuation Date, the VWAP Price for such Valuation Date, unless Net Share Settlement or Combination Settlement applies, in which case the Calculation Agent may decide in its sole discretion that the 10b-18 VWAP Price for such Valuation Date shall be the VWAP Price.
Strike Price Differential:	For any Component:
	(i) if the Settlement Price on the Expiration Date for such Component exceeds the Strike Price for such Component but is less than the Cap Price for such Component, an amount equal to the excess of such Settlement Price over such Strike Price.
	(ii) if the Settlement Price on the Expiration Date for such Component equals or exceeds the Cap Price for such Component, an amount equal to the excess of such Cap Price over the Strike Price for such Component; or
	(iii) if the Settlement Price on the Expiration Date for such Component is less than or equal to the Strike Price for such Component, zero.
Net Share Settlement:
Settlement Date:	The Settlement Date shall be one Settlement Cycle immediately following the Expiration Date for each Component (or, in respect of all or part of its obligation to deliver the Number of Shares to be Delivered, such other earlier date or dates Dealer shall determine in its sole reasonable discretion).
Net Share Settlement:	If Net Share Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty a number of Shares equal to the Number of Shares to be Delivered for such Component to the account specified by Counterparty and cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component.
Number of Shares to be Delivered:	For any Component, subject to the last sentence of Section 9.5 of the Equity Definitions, the product of (i) the product of the Number of Options for such Component and the Strike Price Differential divided by the Settlement Price on the Expiration Date for such Component and (ii) one minus the Cash Percentage.

5

Cash Settlement:
Cash Settlement Payment Date:	The Cash Settlement Payment Date shall be the third Scheduled Trading Day after the Expiration Date for each Component.
Cash Settlement:	If Cash Settlement applies, on the relevant Cash Settlement Payment Date for such Component, Dealer shall pay to Counterparty an amount equal to the Option Cash Settlement Amount for such Component to the account specified by Counterparty.
Combination Settlement:
Combination Settlement:	If Combination Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty: (i) an amount in cash equal to the product of the Option Cash Settlement Amount and the Cash Percentage (as defined below) and (ii) the Number of Shares to be Delivered, and (y) cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component, in each case, to the account(s) specified by Counterparty.
Cash Percentage:	The percentage to be specified by Counterparty in the notice delivered by Counterparty to Dealer pursuant to Section 7.1 of the Equity Definitions, which percentage shall equal (x) the amount of cash a holder of USD1,000 principal amount of Convertible Notes would receive upon conversion under the Indenture minus USD1,000 divided by (y) the cash value of the “settlement amount” (calculated using the “daily VWAP”) (each as defined in the Indenture) minus USD1,000. If Net Share Settlement applies, the Cash Percentage shall be deemed to be zero.
Other Applicable Provisions:	To the extent Dealer is obligated to deliver Shares hereunder, the provisions of Sections 9.1(c), 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the Issuer of the Shares) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction.
Restricted Certificated Shares:	Notwithstanding anything to the contrary in the Equity Definitions, Dealer may, in whole or in part, deliver Shares required to be delivered to Counterparty hereunder in certificated form in lieu of delivery through the Clearance System. With respect to such certificated Shares, the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by deleting the remainder of the provision after the word “encumbrance” in the fourth line thereof.
Share Adjustments:
Method of Adjustment:	Calculation Agent Adjustment; provided that the Equity Definitions shall be amended by adding the words “or the Transaction” after the words “theoretical value of the relevant Shares” in Section 11.2(a), 11.2(c) and 11.2(e)(vii); provided, further that adjustments may be made to account for changes in volatility, expected dividends, stock loan rate and liquidity relative to the relevant Shares.

6

Dividends:	If at any time prior to final settlement of the Transaction, (i) Counterparty alters the amount per Share or frequency of its Ordinary Dividend Amount on the Shares or (ii) Counterparty declares any dividend other than an Ordinary Dividend Amount on the Shares, then the Calculation Agent will make such adjustments as it in good faith determines appropriate to account for the economic effect on the Transaction thereof.
Ordinary Dividend Amount:	USD0.00
Extraordinary Events:
New Shares:	In the definition of “New Shares” in Section 12.1(i) of the Equity Definitions, the text in subsection (i) shall be deleted in its entirety and replaced with: “publicly quoted, traded or listed on any of the New York Stock Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or their respective successors)”.
Merger Events:	Applicable
Consequences of Merger Events:
(a)    Share-for-Share:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price; provided, further, that if, with respect to a Merger Event, the consideration for the Shares includes (or, at the option of a holder of Shares, may include) shares (or depositary receipts with respect to shares) of an entity or person not organized under the laws of the United States, any State thereof or the District of Columbia, Cancellation and Payment (Calculation Agent Determination) shall apply.
(b)    Share-for-Other:	Cancellation and Payment (Calculation Agent Determination)
(c)    Share-for-Combined:	Component Adjustment
Tender Offer:	Applicable
Consequences of all Tender Offers:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price.
Announcement Event:	If an Announcement Event has occurred, the Calculation Agent shall have the right to determine the economic effect of the Announcement Event on the theoretical value of the Transaction (including without limitation any change in volatility, stock loan rate or liquidity relevant to the Shares or to the Transaction) (i) at a time that it deems appropriate, from the Announcement Date to the date of such determination (a “Determination Date”), and (ii) on the earlier to occur of (x) the relevant Merger Date or Tender Offer Date, as the case may be, and (y) a date on which a payment amount is determined pursuant to Sections 12.7 or 12.8 of the Equity Definitions (such earlier date, a “Final Determination Date”), from the Announcement Date or the Determination Date, as applicable, to such Final Determination Date. If any such economic effect is deemed to be material in the Calculation Agent’s sole but commercially reasonable discretion, the Calculation Agent may adjust the terms of the Transaction to reflect such economic effect. “Announcement Event” shall mean the occurrence of an Announcement Date (as defined below).

7

Announcement Date:	The definition of “Announcement Date” in Section 12.1(l) of the Equity Definitions shall be amended by (i) replacing the word “leads to the” in the third and the fifth lines thereof with the words “, if completed, would lead to a”, (ii) replacing the words “voting shares” in the fifth line thereof with the word “Shares”, (iii) inserting the words “by an entity with direct knowledge” after the word “announcement” in the second and the fourth lines thereof, (iv) inserting the words “or to explore the possibility of engaging in” after the words “engage in” in the second line thereto, (v) inserting the words “or to explore the possibility of purchasing or otherwise obtaining” after the word “obtain” in the fourth line thereto, (vi) deleting the parenthetical in the third and the fifth line thereof, (vii) adding immediately after the words “Merger Event” in the third line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention)” and (viii) adding immediately after the words “Tender Offer” in the fifth line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention).”
Nationalization, Insolvency or Delisting:	Cancellation and Payment (Calculation Agent Determination); provided that, in addition to the provisions of Section 12.6(a)(iii) of the Equity Definitions, it shall also constitute a Delisting if the Exchange is located in the United States and the Shares are not immediately re-listed, re-traded or re-quoted on any of the New York Stock Exchange, The NASDAQ Global Select Market or The NASDAQ Global Market (or any of their respective successors); if the Shares are immediately re-listed, re-traded or re-quoted on any such exchange or quotation system, such exchange or quotation system shall thereafter be deemed to be the Exchange.
Additional Disruption Events:
(a)    Change in Law:	Applicable; provided that any determination as to whether (i) the adoption of or any change in any applicable law or regulation (including, without limitation, any tax law) or (ii) the promulgation of or any change in or public announcement of the formal or informal interpretation by any court, tribunal or regulatory authority with competent jurisdiction of any applicable law or regulation (including any action taken by a taxing authority), in each case, constitutes a “Change in Law” shall be made without regard to Section 739 of the Wall Street Transparency and Accountability Act of 2010 or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the Trade Date; provided, further, that Section 12.9(a)(ii)(B) of the Equity Definitions is hereby amended by (i) inserting the words “or Hedge Positions” after the word “Shares” in clause (X) thereof, (ii) replacing the phrase “the interpretation” in the third line thereof with the phrase “or announcement or statement of the formal or informal interpretation” and (iii) immediately following the word “Transaction” in clause (X) thereof, adding the phrase “in the manner contemplated in good faith by Hedging Party on the Trade Date”.

8

(b)    Failure to Deliver:	Applicable
(c)    Insolvency Filing:	Applicable
(d)    Hedging Disruption:	Applicable; provided that Section 12.9(a)(v) of the Equity Definitions is hereby modified by inserting the following two phrases at the end of such Section:
	“For the avoidance of doubt, the term “equity price risk” shall be deemed to include, but shall not be limited to, stock price and volatility risk. And, for the further avoidance of doubt, any such transactions or assets referred to in phrases (A) or (B) above must be available on commercially reasonable pricing terms.”
(e)    Increased Cost of Hedging:	Applicable
(f)     Loss of Stock Borrow:	Not Applicable
(g)    Increased Cost of Stock Borrow:	Not Applicable
Hedging Party:	For all applicable Additional Disruption Events, Dealer
Determining Party:	For all applicable Extraordinary Events, Dealer
Non-Reliance:	Applicable
Agreements and Acknowledgments
Regarding Hedging Activities:	Applicable
Additional Acknowledgments:	Applicable
3.      Calculation Agent:	Dealer
4.      Account Details:
Dealer Payment Instructions:	To be provided by Dealer.

Counterparty Payment / Share Delivery Instructions: To be provided by Counterparty.

5.      Offices:

The Office of Dealer for the Transaction is: Not applicable. Dealer is not a Multibranch Party.

The Office of Counterparty for the Transaction is: Not applicable. Counterparty is not a Multibranch Party.

6.      Notices: For purposes of this Confirmation:

Address for notices or communications to Counterparty:

To:	Human Genome Sciences, Inc.
	14200 Shady Grove Road
	Rockville, Maryland 20850-7464
Attn:	James H. Davis
Telephone:	301-309-8504
Email:	Jim_Davis@hgsi.com

9

Address for notices or communications to Dealer:

To:	Barclays Bank PLC
	c/o Barclays Capital Inc.
	745 Seventh Avenue
	New York, NY 10019
Attn:	Paul Robinson
Telephone:	(+1) 212-526-0111
Facsimile:	917-522-0458

7. Representations, Warranties and Agreements:

(a) In addition to the representations, warranties and agreements in the Agreement and those contained elsewhere herein, Counterparty represents and warrants to and for the benefit of, and agrees with, Dealer as follows:

(i) On the Trade Date, on any Settlement Method Election Date and as of the date of any election by Counterparty of the Share Termination Alternative under (and as defined in) Section 8(a) below, (A) none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares and (B) all reports and other documents filed by Counterparty with the Securities and Exchange Commission pursuant to the Exchange Act when considered as a whole (with the more recent such reports and documents deemed to amend inconsistent statements contained in any earlier such reports and documents), do not contain any untrue statement of a material fact or any omission of a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances in which they were made, not misleading.

(ii) During the period starting on the first Expiration Date and ending on the last Expiration Date (the “Settlement Period”), the Shares or any securities that are convertible into, or exchangeable or exercisable for Shares shall not be subject to a “restricted period,” as such term is defined in Regulation M under the Exchange Act (“Regulation M”) and (B) Counterparty shall not engage in any “distribution,” as such term is defined in Regulation M, other than a distribution meeting the requirements of the exceptions set forth in sections 101(b)(10) and 102(b)(7) of Regulation M, until the second Exchange Business Day immediately following the relevant Settlement Period.

(iii) On the Trade Date and during the Settlement Period, neither Counterparty nor any “affiliate” or “affiliated purchaser” (each as defined in Rule 10b-18 under the Exchange Act (“Rule 10b-18”)) shall directly or indirectly (including, without limitation, by means of any cash-settled or other derivative instrument) purchase, offer to purchase, place any bid or limit order that would effect a purchase of, or commence any tender offer relating to, any Shares (or an equivalent interest, including a unit of beneficial interest in a trust or limited partnership or a depository share) or any security convertible into or exchangeable or exercisable for Shares.

(iv) Without limiting the generality of Section 13.1 of the Equity Definitions, Counterparty acknowledges that neither Dealer nor any of its affiliates is making any representations or warranties or taking any position or expressing any view with respect to the treatment of the Transaction under any accounting standards including ASC Topic 260, Earnings Per Share, ASC Topic 815, Derivatives and Hedging, ASC Topic 480, Distinguishing Liabilities from Equity and ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (or any successor issue statements) or under FASB’s Liabilities & Equity Project.

(v) Without limiting the generality of Section 3(a)(iii) of the Agreement, the Transaction will not violate Rule 13e-1 or Rule 13e-4 under the Exchange Act.

(vi) Prior to the Trade Date, Counterparty shall deliver to Dealer a resolution of Counterparty’s board of directors or a duly authorized committee thereof authorizing the Transaction and such other certificate or certificates as Dealer shall reasonably request.

10

(vii) Counterparty represents (A) on the Trade Date and (B) on the date of any election by Counterparty of the Share Termination Alternative under Section 8(a) below, that it is not entering into this Transaction or making such election to create actual or apparent trading activity in the Shares (or any security convertible into or exchangeable for Shares) or to raise or depress or otherwise manipulate the price of the Shares (or any security convertible into or exchangeable for Shares) or otherwise in violation of the Exchange Act.

(viii) Counterparty is not, and after giving effect to the transactions contemplated hereby will not be, required to register as an “investment company” as such term is defined in the Investment Company Act of 1940, as amended.

(ix) On each of the Trade Date and the Premium Payment Date, Counterparty is not, or will not be, “insolvent” (as such term is defined under Section 101(32) of the U.S. Bankruptcy Code (Title 11 of the United States Code) (the “Bankruptcy Code”)) and Counterparty would be able to purchase a number of Shares equal to the Number of Shares hereunder in compliance with the laws of the jurisdiction of its incorporation.

(x) No state or local (including non-U.S. jurisdictions) law, rule, regulation or regulatory order (other than state insurance holding company laws) applicable to the Shares would give rise to any reporting, consent, registration or other requirement (including without limitation a requirement to obtain prior approval from any person or entity) as a result of Dealer or its affiliates owning or holding (however defined) Shares.

(xi) The representations and warranties of Counterparty set forth in Section 3 of the Agreement and Section 1 of the Underwriting Agreement dated November 2, 2011 between Counterparty and Morgan Stanley & Co. LLC and Credit Suisse Securities (USA) LLC (the “Underwriting Agreement”) are true and correct and are hereby deemed to be repeated to Dealer as if set forth herein.

(xii) Counterparty understands no obligations of Dealer to it hereunder will be entitled to the benefit of deposit insurance and that such obligations will not be guaranteed by any affiliate of Dealer or any governmental agency.

(b) During the Settlement Period, Counterparty shall (i) notify Dealer prior to the opening of trading in the Shares on any day on which Counterparty makes, or expects to be made, any public announcement (as defined in Rule 165(f) under the Securities Act of 1933, as amended (the “Securities Act”)) of any merger, acquisition, or similar transaction involving a recapitalization relating to Counterparty (other than any such transaction in which the consideration consists solely of cash and there is no valuation period), (ii) promptly notify Dealer following any such announcement that such announcement has been made, and (iii) promptly deliver to Dealer following the making of any such announcement a certificate indicating (A) Counterparty’s average daily Rule 10b-18 purchases (as defined in Rule 10b-18) during the three full calendar months preceding the date of the announcement of such transaction and (B) Counterparty’s block purchases (as defined in Rule 10b-18) effected pursuant to paragraph (b)(4) of Rule 10b-18 during the three full calendar months preceding the date of the announcement of such transaction. In addition, Counterparty shall promptly notify Dealer of the earlier to occur of the completion of such transaction and the completion of the vote by target stockholders. Counterparty acknowledges that any such public announcement may cause Dealer to elect to treat one or more Scheduled Trading Days as Disrupted Days pursuant to the provisions of “Regulatory Disruption” above. Accordingly, Counterparty acknowledges that its actions in relation to any such announcement or transaction must comply with the standards set forth in subclause (c) immediately below.

(c) Counterparty shall not enter into or alter any hedging transaction relating to the Shares corresponding to or offsetting the Transaction. Counterparty also acknowledges and agrees that any amendment, modification, waiver or termination of this Confirmation or the Agreement must be effected in accordance with the requirements for the amendment or termination of a “plan” as defined in Rule 10b5-1(c) under the Exchange Act. Without limiting the generality of the foregoing, any such amendment, modification, waiver or termination shall be made in good faith and not as part of a plan or scheme to evade the prohibitions of Rule 10b-5 under the Exchange Act.

11

(d) Each of Dealer and Counterparty agrees and represents that it is an “eligible contract participant” as defined in Section 1a(12) of the U.S. Commodity Exchange Act, as amended, and is entering into the Transaction as principal (and not as agent or in any other capacity, fiduciary or otherwise) and not for the benefit of any third party.

(e) Each of Dealer and Counterparty acknowledges that the offer and sale of the Transaction to it is intended to be exempt from registration under the Securities Act by virtue of Section 4(2) thereof. Accordingly, Counterparty represents and warrants to Dealer and Dealer represents to Counterparty that (i) it has the financial ability to bear the economic risk of its investment in the Transaction and is able to bear a total loss of its investment and its investments in and liabilities in respect of the Transaction, which it understands are not readily marketable, are not disproportionate to its net worth, (ii) it is an “accredited investor” as that term is defined in Regulation D as promulgated under the Securities Act, (iii) it is entering into the Transaction for its own account and without a view to the distribution or resale thereof, (iv) the assignment, transfer or other disposition of the Transaction has not been and will not be registered under the Securities Act and is restricted under this Confirmation, the Securities Act and state securities laws and (v) its financial condition is such that it has no need for liquidity with respect to its investment in the Transaction and no need to dispose of any portion thereof to satisfy any existing or contemplated undertaking or indebtedness and is capable of assessing the merits of and understanding (on its own behalf or through independent professional advice), and understands and accepts, the terms, conditions and risks of the Transaction.

(f) Each of Dealer and Counterparty agrees and acknowledges that Dealer is a “financial institution,” “swap participant” or “financial participant” within the meaning of Sections 101(22), 101(53C) and 101(22A) of the Bankruptcy Code. The parties hereto further agree and acknowledge that it is the intent of the parties (A) that this Confirmation is (i) a “securities contract,” as such term is defined in Section 741(7) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “settlement payment,” within the meaning of Section 546 of the Bankruptcy Code, and (ii) a “swap agreement,” as such term is defined in Section 101(53B) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “transfer,” as such term is defined in Section 101(54) of the Bankruptcy Code and a “payment or other transfer of property” within the meaning of Sections 362 and 546 of the Bankruptcy Code, and (B) that Dealer is entitled to the protections afforded by, among other sections, Sections 362(b)(6), 362(b)(17), 362(o),546(e), 546(g), 548(d)(2), 555, 560 and 561 of the Bankruptcy Code.

(g) Counterparty shall deliver to Dealer an opinion of counsel, dated as of the Effective Date and reasonably acceptable to Dealer in form and substance, with respect to the matters set forth in Section 3(a) of the Agreement.

(h) Counterparty hereby agrees and acknowledges that the Transaction has not been registered with the Securities and Exchange Commission or any state securities commission and that the Options are being written by Dealer to Counterparty in reliance upon exemptions from any such registration requirements. Counterparty acknowledges that all Options acquired from Dealer will be acquired for investment purposes only and not for the purpose of resale or other transfer except in compliance with the requirements of the Securities Act. Counterparty will not sell or otherwise transfer any Option or any interest therein except in compliance with the requirements of the Securities Act and any subsequent offer or sale of the Options will be solely for Counterparty’s account and not as part of a distribution that would be in violation of the Securities Act.

(i) Each party acknowledges and agrees to be bound by the Conduct Rules of the Financial Industry Regulatory Authority, Inc. applicable to transactions in options, and further agrees not to violate the position and exercise limits set forth therein.

12

8. Other Provisions:

(a) Alternative Calculations and Payment on Early Termination and on Certain Extraordinary Events. If (i) Dealer shall owe Counterparty, or (ii) Counterparty shall owe Dealer, any amount pursuant to Section 12.2 of the Equity Definitions and “Consequences of Merger Events” above, or Sections 12.3, 12.6, 12.7 or 12.9 of the Equity Definitions (except in the event of a Tender Offer or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash) or pursuant to Section 6(d)(ii) of the Agreement (except in the event of an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, that resulted from an event or events within Counterparty’s control) (in the case of (i) or (ii), a “Payment Obligation”), Counterparty shall have the right, in its sole discretion, to (i) require Dealer to satisfy any such Payment Obligation by the Share Termination Alternative (as defined below), or (ii) elect to settle any Payment Obligation owed by Counterparty by the Share Termination Alternative (as defined below), by giving irrevocable telephonic notice to Dealer, confirmed in writing within one Scheduled Trading Day, no later than 9:30 A.M. New York City time on the Merger Date, Tender Offer Date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable (“Notice of Share Termination”); provided that if Counterparty does not elect to require Dealer to satisfy its Payment Obligation by the Share Termination Alternative, Dealer shall have the right, in its good faith and reasonable discretion, to elect to satisfy its Payment Obligation by the Share Termination Alternative, notwithstanding Counterparty’s failure to elect or election to the contrary; and provided further that Counterparty shall not have the right to so elect (but, for the avoidance of doubt, Dealer shall have the right to so elect) in the event of (i) an Insolvency, a Nationalization or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash or (ii) an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, which Event of Default or Termination Event resulted from an event or events within Counterparty’s control. Upon such Notice of Share Termination, the following provisions shall apply on the Scheduled Trading Day immediately following the relevant merger date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable:

Share Termination Alternative:	Applicable and means that Dealer shall deliver to Counterparty the Share Termination Delivery Property on the date on which the Payment Obligation would otherwise be due pursuant to “Consequences of Merger Events” above, Section 12.7 or 12.9 of the Equity Definitions or Section 6(d)(ii) of the Agreement, as applicable, or such later date as the Calculation Agent may reasonably determine (the “Share Termination Payment Date”), in satisfaction of the Payment Obligation.
Share Termination Delivery
Property:	A number of Share Termination Delivery Units, as calculated by the Calculation Agent, equal to the Payment Obligation divided by the Share Termination Unit Price. The Calculation Agent shall adjust the Share Termination Delivery Property by replacing any fractional portion of the aggregate amount of a security therein with an amount of cash equal to the value of such fractional security based on the values used to calculate the Share Termination Unit Price.
Share Termination Unit Price:	The value of property contained in one Share Termination Delivery Unit on the date such Share Termination Delivery Units are to be delivered as Share Termination Delivery Property, as determined by the Calculation Agent in its good faith discretion by commercially reasonable means and notified by the Calculation Agent to Dealer at the time of notification of the Payment Obligation.
Share Termination Delivery Unit:	In the case of a Termination Event, Event of Default, Delisting or Additional Disruption Event, one Share or, in the case of an Insolvency,

13

	Nationalization, Merger Event or Tender Offer, one Share or a unit consisting of the number or amount of each type of property received by a holder of one Share (without consideration of any requirement to pay cash or other consideration in lieu of fractional amounts of any securities) in such Insolvency, Nationalization, Merger Event or Tender Offer, as applicable. If such Insolvency, Nationalization, Merger Event or Tender Offer involves a choice of consideration to be received by holders, such holder shall be deemed to have elected to receive the maximum possible amount of cash.
Failure to Deliver:	Applicable
Other applicable provisions:	If Share Termination Alternative is applicable, the provisions of Sections 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the issuer of the Shares or any portion of the Share Termination Delivery Units) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction, except that all references to “Shares” shall be read as references to “Share Termination Delivery Units.”

(b) Disposition of Hedge Shares. Counterparty hereby agrees that if, in the reasonable judgment of Dealer, any Shares (the “Hedge Shares”) acquired by Dealer for the purpose of hedging its obligations pursuant to the Transaction cannot be sold in the public market by Dealer without registration under the Securities Act, Counterparty shall, at its election: (i) in order to allow Dealer to sell the Hedge Shares in a registered offering, make available to Dealer an effective registration statement under the Securities Act to cover the resale of such Hedge Shares and (A) enter into an agreement, in form and substance reasonably satisfactory to Dealer and the Counterparty, substantially in the form of an underwriting agreement for a registered offering, (B) provide accountant’s “comfort” letters in customary form for registered offerings of equity securities, (C) provide disclosure opinions of nationally recognized outside counsel to Counterparty reasonably acceptable to Dealer, (D) provide other customary opinions, certificates and closing documents customary in form for registered offerings of equity securities and (E) afford Dealer a reasonable opportunity to conduct a “due diligence” investigation with respect to Counterparty customary in scope for underwritten offerings of equity securities; provided, however, that if Dealer, in its good faith reasonable discretion, is not satisfied with access to due diligence materials, the results of its due diligence investigation, or the procedures and documentation for the registered offering referred to above, then clause (ii) or clause (iii) of this Section 8(b) shall apply at the election of Counterparty; (ii) in order to allow Dealer to sell the Hedge Shares in a private placement, enter into a private placement agreement substantially similar to private placement purchase agreements customary for private placements of equity offerings of similar size, securities, in form and substance reasonably satisfactory to Dealer and Counterparty, including customary representations, covenants, blue sky and other governmental filings and/or registrations, indemnities to Dealer, due diligence rights (for Dealer or any designated buyer of the Hedge Shares from Dealer), opinions and certificates and such other documentation as is customary for private placements agreements, equity offerings of similar size all reasonably acceptable to Dealer (in which case, the Calculation Agent shall make any adjustments to the terms of the Transaction that are necessary, in its reasonable judgment, to compensate Dealer for any discount from the public market price of the Shares incurred on the sale of Hedge Shares in a private placement); or (iii) purchase the Hedge Shares from Dealer at the VWAP Price on such Exchange Business Days, and in the amounts, requested by Dealer. “VWAP Price” means, on any Exchange Business Day, the per Share volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page HGSI <equity> VAP (or any successor thereto) in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such Exchange Business Day (or if such volume-weighted average price is unavailable or is manifestly incorrect, the market value of one Share on such Exchange Business Day, as determined by the Calculation Agent using a volume-weighted method). This Section 8(b) shall survive the termination, expiration or early unwind of the Transaction. For the avoidance of doubt, unless Counterparty elects to purchase the Hedge Shares pursuant to clause (iii) of this paragraph (c),

14

nothing in this Confirmation shall be interpreted as requiring Counterparty to repurchase Hedge Shares or otherwise to pay any amount of cash to Dealer pursuant to this paragraph (c) and under no circumstances shall Counterparty be required to repurchase Hedge Shares or otherwise to pay any cash to Dealer pursuant to this paragraph (c), other than any cash payment required by an underwriting agreement entered into pursuant to clause (i)(A) or a private placement agreement entered into pursuant to clause (ii).

(c) Amendment to Equity Definitions. (i) The following amendment shall be made to the Equity Definitions:

Section 12.6(a)(ii) of the Equity Definitions is hereby amended by (1) deleting from the fourth line thereof the word “or” after the word “official” and inserting a comma therefor, and (2) deleting the semi-colon at the end of subsection (B) thereof and inserting the following words therefor “or (C) at Dealer’s option, the occurrence of any of the events specified in Section 5(a)(vii) (1) through (9) of the ISDA Master Agreement with respect to that Issuer, provided however that any reference to 15 days in Section 5(a)(vii), shall instead be a reference to 60 days.

(ii) Solely for purposes of applying the Equity Definitions and for purposes of this Confirmation, any reference in the Equity Definitions to a Strike Price shall be deemed to be a reference to either of the Strike Price or the Cap Price, or both, as appropriate.

(d) Repurchase Notices. Counterparty shall, at least five Scheduled Trading Days prior to effecting any repurchase of Shares or consummating or otherwise executing or engaging in any transaction or event that would lead to an increase in the Conversion Rate (as such term is defined in the Indenture) (a “Conversion Rate Adjustment Event”), give Dealer a written notice of such repurchase or Conversion Rate Adjustment Event (a “Repurchase Notice”) if, following such repurchase or Conversion Rate Adjustment Event, the Notice Percentage as determined on the date of such Repurchase Notice is (i) greater than 4.5% and (ii) greater by 0.5% than the Notice Percentage included in the immediately preceding Repurchase Notice (or, in the case of the first such Repurchase Notice, greater than 4.5%). The “Notice Percentage” as of any day is the fraction (A) the numerator of which is the aggregate of the Number of Shares for all Components under the Transaction and the number of Shares underlying any other capped call transactions between Counterparty and Dealer and (B) the denominator of which is the number of Shares outstanding on such day. In the event that Counterparty fails to provide Dealer with a Repurchase Notice on the day and in the manner specified in this Section 8(d) then Counterparty agrees to indemnify and hold harmless Dealer, its affiliates and their respective directors, officers, employees, agents and controlling persons (Dealer and each such person being an “Indemnified Party”) from and against any and all losses (including losses relating to Dealer’s hedging activities as a consequence of becoming, or of the risk of becoming, a Section 16 “insider,” including without limitation any forbearance from hedging activities or cessation of hedging activities and any losses in connection therewith with respect to the Transaction), claims, damages and liabilities (or actions in respect thereof), joint or several, to which such Indemnified Party may become subject under applicable securities laws, including without limitation, Section 16 of the Exchange Act relating to or arising out of such failure. If for any reason the foregoing indemnification is unavailable to any Indemnified Party or insufficient to hold harmless any Indemnified Party, then Counterparty shall contribute, to the maximum extent permitted by law, to the amount paid or payable by the Indemnified Party as a result of such loss, claim, damage or liability. In addition, Counterparty will reimburse any Indemnified Party for all expenses (including reasonable counsel fees and expenses) as they are incurred (after notice to Counterparty) in connection with the investigation of, preparation for or defense or settlement of any pending or threatened claim or any action, suit or proceeding arising therefrom, whether or not such Indemnified Party is a party thereto and whether or not such claim, action, suit or proceeding is initiated or brought by or on behalf of Counterparty. This indemnity shall survive the completion of the Transaction contemplated by this Confirmation and any assignment and delegation of the Transaction made pursuant to this Confirmation or the Agreement shall inure to the benefit of any permitted assignee of Dealer.

(e) Transfer and Assignment. Either party may transfer any of its rights or obligations under the Transaction with the prior written consent of the non-transferring party, such consent not to be unreasonably withheld or delayed; provided that notwithstanding any provision of the Agreement to the contrary, Dealer may, subject to applicable law, freely transfer and assign all of its rights and obligations under the Transaction without the consent of Counterparty to any affiliate of Dealer of equal or better credit rating than Dealer or affiliate of Dealer whose obligations are guaranteed by Dealer, provided further that (I) if (x) Counterparty has

15

not consented to a transfer proposed by Dealer that requires Counterparty’s consent as determined by Dealer, and (y) Dealer determines, in its commercially reasonable discretion, that such transfer would be reasonably necessary or prudent to (i) preserve Dealer’s hedging or hedge unwind activity (or anticipated hedging or hedge unwind activity) hereunder in light of existing liquidity conditions in the cash market or any other relevant market, (ii) to enable Dealer to effect transactions in Shares or cash-settled swaps in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is in compliance with applicable laws, regulations, policies and procedures applicable to Dealer or (iii) to avoid an Excess Ownership Position, or (II) if (x) any Excess Ownership Position exists and (y) Dealer, in its discretion, is unable to effect a transfer or assignment to a third party in accordance with the requirements set forth above after using its commercially reasonable efforts on pricing terms and within a time period reasonably acceptable to Dealer such that an Excess Ownership Position no longer exists, then in each case Dealer may designate a Scheduled Trading Day as an Early Termination Date with respect to all or a portion (the “Terminated Portion”) of the Transaction. In the event that Dealer so designates an Early Termination Date, a payment or delivery shall be made pursuant to Section 6 of the Agreement and/or Section 8(b) of this Confirmation as if (i) an Early Termination Date had been designated in respect of a Transaction having terms identical to the Terminated Portion of the Transaction, (ii) Counterparty shall be the sole Affected Party with respect to such partial termination and (iii) such portion of the Transaction shall be the only Terminated Transaction. “Excess Ownership Position” means any of the following: (i) the Equity Percentage exceeds 4.0%, (ii) Dealer or any “affiliate” or “associate” of Dealer would own in excess of 8.0% of the outstanding Shares for purposes of Section 203 of the Delaware General Corporation Law, (iii) Dealer or any affiliate thereof owns, directly or indirectly, in excess of 4.0% of the outstanding Shares for purposes of Section 382 of the Internal Revenue Code of 1986, as determined in accordance with Treasury Regulation Section 1.382-2T(g), (h), (j) and (k) (or any successor provisions), including any ownership by application of constructive ownership rules, or (iv) Dealer, Dealer Group (as defined below) or any person whose ownership position would be aggregated with that of Dealer or Dealer Group (Dealer, Dealer Group or any such person, a “Dealer Person”) under any federal, state or local laws, regulations or regulatory orders applicable to ownership of Shares (“Applicable Laws”), owns, beneficially owns, constructively owns, controls, holds the power to vote or otherwise meets a relevant definition of ownership in excess of a number of Shares equal to (x) the number of Shares that would give rise to reporting or registration obligations or other requirements (including obtaining prior approval by a state or federal regulator) of a Dealer Person under Applicable Laws and with respect to which such requirements have not been met or the relevant approval has not been received or that would give rise to any consequences adverse to Dealer (including that any transfer of Shares or any distribution of dividends to Dealer or any of its affiliates would be prohibited or void) under the constitutive documents of Counterparty or any contract or agreement to which Counterparty is a party, in each case minus (y) 1% of the number of Shares outstanding on the date of determination. The “Equity Percentage” as of any day is the fraction, expressed as a percentage, (A) the numerator of which is the number of Shares that Dealer and any of its affiliates or any other person subject to aggregation with Dealer, for purposes of the “beneficial ownership” test under Section 13 of the Exchange Act, or of any “group” (within the meaning of Section 13) of which Dealer is or may be deemed to be a part (Dealer and any such affiliates, persons and groups, collectively, “Dealer Group”), beneficially owns (within the meaning of Section 13 of the Exchange Act), without duplication, on such day and (B) the denominator of which is the number of Shares outstanding on such day. In the case of a transfer or assignment by Counterparty of its rights and obligations hereunder and under the Agreement, in whole or in part (any such Options so transferred or assigned, the “Transfer Options”), to any party, withholding of such consent by Dealer shall not be considered unreasonable if such transfer or assignment does not meet the reasonable conditions that Dealer may impose including, but not limited to, the following conditions:

(A) With respect to any Transfer Options, Counterparty shall not be released from its notice and indemnification obligations pursuant to Section 8(d) of this Confirmation or any obligations under Section 2 (regarding Extraordinary Events) or 8(b) of this Confirmation;

(B) Any Transfer Options shall only be transferred or assigned to a third party that is a U.S. person (as defined in the Internal Revenue Code of 1986, as amended);

(C) Such transfer or assignment shall be effected on terms, including any reasonable undertakings by such third party (including, but not limited to, undertakings with respect to compliance with applicable securities laws in a manner that, in the reasonable judgment of Dealer, will not expose Dealer to material risks under applicable securities laws) and execution of any documentation and delivery of legal opinions with respect to securities laws and other matters by such third party and Counterparty as are requested and reasonably satisfactory to Dealer;

16

(D) Neither Dealer nor Counterparty will, as a result of such transfer and assignment, be required to pay the transferee an amount under Section 2(d)(i)(4) of the Agreement greater than an amount that such party would have been required to pay in the absence of such transfer and assignment;

(E) An Event of Default, Potential Event of Default or Termination Event shall not occur as a result of such transfer and assignment; and

(F) Without limiting the generality of clause (B), Counterparty shall have caused the transferee to make such Payee Tax Representations and to provide such tax documentation as may be reasonably requested by Dealer to permit Dealer to determine that results described in clauses (D) and (E) will not occur upon or after such transfer and assignment.

(f) Staggered Settlement. (A) Upon a Settlement Method Election, if Dealer is required to deliver any Shares upon settlement, or (B) if Dealer is required, or elects, to satisfy any Payment Obligation by the Share Termination Alternative, then, in either case, Dealer may elect, on one or more occasions, to deliver to Counterparty all or any portion of the Shares or Share Termination Delivery Units, as the case may be, that Dealer would otherwise be required to deliver on the relevant Settlement Date or Share Termination Payment Date (each, a “Nominal Settlement Date”) on a date (an “Early Settlement Date”) prior to such Nominal Settlement Date, provided that:

(i) Dealer must deliver written notice to Counterparty at least three Business Days prior to such Early Settlement Date, specifying (x) such Early Settlement Date, and (y) the number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty on such Early Settlement Date; and

(ii) the aggregate number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty hereunder on all such Early Settlement Dates and the Nominal Settlement Date shall not be less than the number of Shares or Share Termination Delivery Units that Dealer would otherwise have been required to deliver on such Nominal Settlement Date.

For the avoidance of doubt, any such delivery by Dealer of Shares or Share Termination Delivery Units will satisfy Dealer’s obligation to deliver the number of Shares or Share Termination Delivery Units so delivered on the relevant Nominal Settlement Date. If the number of Shares, or Share Termination Delivery Units, so delivered exceeds the number of Shares required to be delivered under the Transaction, Counterparty shall promptly return the excess number of Shares, or Share Termination Delivery Units to Dealer; provided that Dealer may by notice to Counterparty elect to receive such excess number of Shares or Share Termination Delivery Units on two or more dates over a commercially reasonable period of time; provided further that Counterparty may elect in its sole discretion, in lieu of returning such excess number of Shares or Share Termination Delivery Units, to pay to Dealer an amount of cash equal to the value of such Shares or Share Termination Delivery Units, as reasonably determined by the Calculation Agent based on the Settlement Price on the Expiration Date for the relevant Component.

(g) Right to Extend. Dealer, acting in good faith and in a commercially reasonable manner, may postpone any Exercise Date, Settlement Date or Cash Settlement Payment Date or any other date of valuation or delivery by Dealer, with respect to some or all of the relevant Options, if Dealer determines, in its reasonable discretion, that such extension is reasonably necessary or appropriate to (i) preserve Dealer’s or its affiliate’s hedging or hedge unwind activity hereunder in light of existing liquidity conditions in the cash market, the stock loan market or any other relevant market or (ii) to enable Dealer or its affiliate to effect purchases of Shares in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is or would, if Dealer or such affiliate were Counterparty or an affiliated purchaser of Counterparty, be in compliance with applicable legal, regulatory or self-regulatory requirements, or with related policies and procedures applicable to Dealer and/or such affiliate; provided, however, that Counterparty shall not be required to make any payment to Dealer on account of such extension.

17

(h) Cross-Default. It shall be an Event of Default under the Agreement with Counterparty as the Defaulting Party if Counterparty defaults (i) in any scheduled payment of principal of any indebtedness of Counterparty or of any of its subsidiaries, aggregating more than $25.0 million in principal amount, when due and payable after giving effect to any applicable grace period or (ii) in the performance of any other term or provision of any indebtedness of Counterparty or of any of its subsidiaries in excess of $25.0 million principal amount that results in such indebtedness becoming or being declared due and payable before the date on which it would otherwise become due and payable, and such acceleration is not rescinded or annulled, or such indebtedness is not discharged, within a period of five days after there has been given, by registered or certified mail, to Counterparty by Dealer, a written notice specifying such default or defaults and stating that such notice is a “Notice of Default” and referencing this Confirmation.

(i) Notice of Event of Default. Promptly upon becoming aware of any Event of Default or Potential Event of Default where Counterparty is or would be the Defaulting Party, Counterparty will notify Dealer, specifying the nature of such Event of Default or Potential Event of Default, and will give to Dealer such other information about such Event of Default or Potential Event of Default as Dealer may reasonably require.

(j) Adjustments. For the avoidance of doubt, whenever the Calculation Agent is called upon to make an adjustment pursuant to the terms of this Confirmation or the Definitions to take into account the effect of an event, the Calculation Agent shall make such adjustment by reference to the effect of such event on the Hedging Party, assuming that the Hedging Party maintains a commercially reasonable hedge position.

(k) Disclosure. Effective from the date of commencement of discussions concerning the Transaction, Counterparty and each of its employees, representatives, or other agents may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of the Transaction and all materials of any kind (including opinions or other tax analyses) that are provided to Counterparty relating to such tax treatment and tax structure.

(l) Designation by Dealer. Notwithstanding any other provision in this Confirmation to the contrary requiring or allowing Dealer to purchase, sell, receive or deliver any Shares or other securities to or from Counterparty, Dealer may designate any of its affiliates to purchase, sell, receive or deliver such Shares or other securities and otherwise to perform Dealer’s obligations in respect of the Transaction and any such designee may assume such obligations. Dealer shall not be discharged of any of its obligations to Counterparty except to the extent of actual full and final performance of its obligations to Counterparty by the designee.

(m) Set-off. The parties agree to amend Section 6 of the Agreement by replacing Section 6(f) in its entirety with the following:

“(f) Upon the occurrence of an Event of Default or Termination Event with respect to a party who is the Defaulting Party or the Affected Party (“X”), the other party (“Y”) will have the right (but not be obliged) without prior notice to X or any other person to set-off or apply any obligation of X under an Equity Contract owed to Y (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation) against any obligation of Y under an Equity Contract owed to X (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation). Y will give notice to the other party of any set-off effected under this Section 6(f).

“Equity Contract” shall mean for purposes of this Section 6(f) any transaction relating to Shares between X and Y that qualifies as ‘equity’ under applicable accounting rules.

Amounts (or the relevant portion of such amounts) subject to set-off may be converted by Y into the Termination Currency at the rate of exchange at which such party would be able, acting in a reasonable manner and in good faith, to purchase the relevant amount of such currency.

If any obligation is unascertained, Y may in good faith estimate that obligation and set-off in respect of the estimate, subject to the relevant party accounting to the other when the obligation is ascertained.

18

Nothing in this Section 6(f) shall be effective to create a charge or other security interest. This Section 6(f) shall be without prejudice and in addition to any right of set-off, combination of accounts, lien or other right to which any party is at any time otherwise entitled (whether by operation of law, contract or otherwise).”

(n) Equity Rights. Dealer acknowledges and agrees that this Confirmation is not intended to convey to it rights with respect to the Transaction that are senior to the claims of common stockholders in the event of Counterparty’s bankruptcy. For the avoidance of doubt, the parties agree that the preceding sentence shall not apply at any time other than during Counterparty’s bankruptcy to any claim arising as a result of a breach by Counterparty of any of its obligations under this Confirmation or the Agreement. For the avoidance of doubt, the parties acknowledge that this Confirmation is not secured by any collateral that would otherwise secure the obligations of Counterparty herein under or pursuant to any other agreement.

(o) Early Unwind. In the event the sale by Counterparty of the Convertible Notes is not consummated with the underwriters pursuant to the Underwriting Agreement for any reason by the close of business in New York on the Effective Date (or such later date as agreed upon by the parties, which in no event shall be later than November 17, 2011) (the Effective Date or such later date being the “Early Unwind Date”), the Transaction shall automatically terminate, on the Early Unwind Date and (i) the Transaction and all of the respective rights and obligations of Dealer and Counterparty thereunder shall be cancelled and terminated and (ii) each party shall be released and discharged by the other party from and agrees not to make any claim against the other party with respect to any obligations or liabilities of either party arising out of and to be performed in connection with the Transaction either prior to or after the Early Unwind Date.

(p) No Waiver of Rights. (i) Without limiting Section 9(d) or (f) of the Agreement, the parties hereby agree that no payment or delivery by a party made pursuant to this Confirmation shall be presumed to preclude such party’s right under this Confirmation or the Agreement to challenge the determination of the amount of such payment or delivery obligation at a later date or be deemed to be a waiver of any Event of Default or Termination Event that exists as of the date of any such payment or delivery.

(ii) Section 9(f) of the Agreement shall be amended by the addition of the following at the end of the provision: “(1) Failure by a party to expressly reserve any right, power or privilege it has under the Agreement, and/or (2) continued performance by a party of its obligations or enjoyment of any rights under the Agreement shall not in any way undermine or prejudice the effectiveness of this Section.”

(q) The Agreement is further supplemented by the following provisions:

1. The “Automatic Early Termination” provisions of Section 6(a) will not apply to Dealer or Counterparty.

2. Netting. The provisions of Section 2(c) of the Agreement will apply, provided that each occurrence of the word “Transaction” shall be replaced with “Equity Contract” and each occurrence of the word “Transactions” shall be replaced with “Equity Contracts”, and clause (ii) of Section 2(c) shall be replaced in its entirety with “(ii) in respect of Equity Contracts”.

(r) Tax Representations and Forms.

(i) Part 2(b) of the ISDA Schedule – Payee Representation:

For the purpose of Section 3(f) of this Agreement, Counterparty makes the following representation to Dealer:

Counterparty is a corporation established under the laws of the State of Delaware and is a U.S. person (as that term is defined in Section 7701(a)(30) of the United States Internal Revenue Code of 1986, as amended).

19

For the purpose of Section 3(f) of this Agreement, Dealer makes the following representation to Counterparty:

(A) Each payment received or to be received by it in connection with this Agreement is effectively connected with its conduct of a trade or business within the United States; and

(B) It is a “foreign person” (as that term is used in Section 1.6041-4(a)(4) of the United States Treasury Regulations) for United States federal income tax purposes.

(ii) Part 3(a) of the ISDA Schedule – Tax Forms:

Party Required to Deliver Document

	Form/Document/Certificate	Date by which to be Delivered
Counterparty	A complete and duly executed United States Internal Revenue Service Form W-9 (or successor thereto.)	(i) Upon execution and delivery of this Agreement; (ii) promptly upon reasonable demand by Dealer; and (iii) promptly upon learning that any such Form previously provided by Counterparty has become obsolete or incorrect.
Dealer	A complete and duly executed United States Internal Revenue Service Form W-8ECI (or successor thereto.)	(i) Upon execution and delivery of this Agreement; and (ii) promptly upon learning that any such Form previously provided by Dealer has become obsolete or incorrect.

(s) Illegality. The parties agree that for the avoidance of doubt, for purposes of Section 5(b)(i) of the Agreement, “any applicable law” shall include the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (“Dodd-Frank”), without regard to Section 739 of Dodd-Frank or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the date on which a Transaction is entered into, and the consequences specified in the Agreement, including without limitation, the consequences specified in Section 6 of the Agreement, shall apply to any Illegality arising from any such act, rule or regulation.

(t) Waiver of Trial by Jury. EACH OF COUNTERPARTY AND DEALER HEREBY IRREVOCABLY WAIVES (ON ITS OWN BEHALF AND, TO THE EXTENT PERMITTED BY APPLICABLE LAW, ON BEHALF OF ITS STOCKHOLDERS) ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THE TRANSACTION OR THE ACTIONS OF DEALER OR ITS AFFILIATES IN THE NEGOTIATION, PERFORMANCE OR ENFORCEMENT HEREOF.

(u) Governing Law; Jurisdiction. THIS CONFIRMATION AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS CONFIRMATION SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REFERENCE TO CONFLICT OF LAW PRINCIPLES. THE PARTIES HERETO IRREVOCABLY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK AND THE

20

UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK IN CONNECTION WITH ALL MATTERS RELATING HERETO AND WAIVE ANY OBJECTION TO THE LAYING OF VENUE IN, AND ANY CLAIM OF INCONVENIENT FORUM WITH RESPECT TO, THESE COURTS.

(v) Amendment. This Confirmation and the Agreement may not be modified, amended or supplemented, except in a written instrument signed by Counterparty and Dealer.

(w) Counterparts. This Confirmation may be executed in several counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument.

(x) Credit Support Provider and Credit Support Document. Credit Support Provider and Credit Support Document means, in relation to either Dealer or Counterparty: None.

(y) Role of Agent. Each of Dealer and Counterparty acknowledges to and agrees with the other party hereto and to and with the Agent that (i) the Agent is acting as agent for Dealer under the Transaction pursuant to instructions from such party, (ii) the Agent is not a principal or party to the Transaction, and may transfer its rights and obligations with respect to the Transaction, (iii) the Agent shall have no responsibility, obligation or liability, by way of issuance, guaranty, endorsement or otherwise in any manner with respect to the performance of either party under the Transaction, (iv) Dealer and the Agent have not given, and Counterparty is not relying (for purposes of making any investment decision or otherwise) upon, any statements, opinions or representations (whether written or oral) of Dealer or the Agent, other than the representations expressly set forth in this Confirmation or the Agreement, and (v) each party agrees to proceed solely against the other party, and not the Agent, to collect or recover any money or securities owed to it in connection with the Transaction. Each party hereto acknowledges and agrees that the Agent is an intended third party beneficiary hereunder. Counterparty acknowledges that the Agent is an affiliate of Dealer.

(z) Regulatory Provisions. The time of dealing for the Transaction will be confirmed by Dealer upon written request by Counterparty. The Agent will furnish to Counterparty upon written request a statement as to the source and amount of any remuneration received or to be received by the Agent in connection with a Transaction.

(aa) Method of Delivery. Whenever delivery of funds or other assets is required hereunder by or to Counterparty, such delivery shall be effected through Agent. In addition, all notices, demands and communications of any kind relating to the Transaction between Dealer and Counterparty shall be transmitted exclusively through Agent.

21

Yours faithfully,
BARCLAYS CAPITAL INC., acting solely as Agent in connection with this Transaction
By:	/s/ Paul Robinson
	Name: Paul Robinson
	Title: Managing Director

Agreed and Accepted By:
HUMAN GENOME SCIENCES, INC.
By:	/s/ David P. Southwell
	Name: David P. Southwell
	Title: Executive Vice President and Chief           Financial Officer

EX-10.16

Exhibit 10.16

EXECUTION VERSION

To:	Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville, Maryland 20850-7464 Attn: James H. Davis Telephone: 301-309-8504 Email: Jim_Davis@hgsi.com
From:	Goldman, Sachs & Co. 200 West Street New York, NY 10282-2198
Re:	Capped Call Transaction
Ref. No:	SDB4165352420
Date:	November 2, 2011

Dear Sir(s):

The purpose of this communication (this “Confirmation”) is to set forth the terms and conditions of the above-referenced transaction entered into on the Trade Date specified below (the “Transaction”) between Goldman, Sachs & Co. (“Dealer”) and Human Genome Sciences, Inc. (“Counterparty”). This communication constitutes a “Confirmation” as referred to in the ISDA Master Agreement specified below. This Confirmation shall replace any previous agreements and serve as the final documentation for the Transaction.

1. This Confirmation is subject to, and incorporates, the definitions and provisions of the 2006 ISDA Definitions (including the Annex thereto) (the “2006 Definitions”) and the definitions and provisions of the 2002 ISDA Equity Derivatives Definitions (the “Equity Definitions”, and together with the 2006 Definitions, the “Definitions”), in each case as published by the International Swaps and Derivatives Association, Inc. (“ISDA”). In the event of any inconsistency between the 2006 Definitions and the Equity Definitions, the Equity Definitions will govern.

Each party is hereby advised, and each such party acknowledges, that the other party has engaged in, or refrained from engaging in, substantial financial transactions and has taken other material actions in reliance upon, and in consideration for, the parties’ entry into the Transaction to which this Confirmation relates on the terms and conditions set forth below.

This Confirmation evidences a complete and binding agreement between Dealer and Counterparty as to the terms of the Transaction to which this Confirmation relates. This Confirmation shall be subject to an agreement (the “Agreement”) in the form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) as if Dealer and Counterparty had executed an agreement in such form (without any Schedule except for (i) the election of Loss and Second Method and US Dollars (“USD”) as the Termination Currency, (ii) the replacement of the word “third” in the last line of Section 5(a)(i) of the Agreement with the word “second,” and (iii) such other elections as set forth in this Confirmation).

All provisions contained in, or incorporated by reference to, the Agreement will govern this Confirmation except as expressly modified herein. In the event of any inconsistency between this Confirmation and either the Definitions or the Agreement, this Confirmation shall govern.

The Transaction hereunder, and any additional capped call Share Option Transactions with respect to the Shares between Dealer and Counterparty in which the confirmation for any such transaction specifically references the Agreement, shall be the sole Transaction(s) under the Agreement. If, at any time, there exists any other agreement in the

form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) or 2002 ISDA Master Agreement (each, an “ISDA Master Agreement”) between Dealer and Counterparty or any confirmation or other agreement between Dealer and Counterparty pursuant to which an ISDA Master Agreement is deemed to exist between Dealer and Counterparty, then unless such ISDA Master Agreement, such confirmation or agreement or any other agreement to which Dealer and Counterparty are parties specifically references the Agreement, the Transaction shall not be considered a Transaction under, or otherwise governed by, such existing or deemed ISDA Master Agreement.

2. The Transaction constitutes a Share Option Transaction for purposes of the Equity Definitions. The terms of the particular Transaction to which this Confirmation relates are as follows:

General Terms:
Trade Date:	November 2, 2011
Components:	The Transaction will be divided into individual Components, each with the terms set forth in this Confirmation, and, in particular, with the Number of Options and Expiration Date set forth in Annex A to this Confirmation. The exercise, valuation and settlement of the Transaction will be effected separately for each Component as if each Component were a separate Transaction under the Agreement.
Option Style:	European
Option Type:	Call
Seller:	Dealer
Buyer:	Counterparty
Shares:	The common stock of Counterparty, par value USD0.01 per share (Ticker Symbol: “HGSI”).
Number of Options:	For each Component, as provided in Annex A to this Confirmation.
Option Entitlement:	One Share per Option.
Strike Price:	USD13.33
Cap Price:	USD18.45
Premium:	The aggregate Premium for the Transaction is USD17,492,400.
Premium Payment Date:	The Effective Date
Effective Date:	November 7, 2011 or such other date as agreed by the parties.
Exchange:	The NASDAQ Global Select Market
Related Exchange:	All Exchanges
Procedures for Exercise:
Expiration Time:	Valuation Time
Expiration Date:	As provided in Annex A to this Confirmation (or, if such date is not a Scheduled Trading Day, the next following Scheduled Trading Day that is not already an Expiration Date for another Component); provided that, notwithstanding anything to the contrary in the Equity Definitions, if that date is a Disrupted Day, the Calculation Agent may determine that the Expiration Date for such Component is a Disrupted Day in whole or in part, in which case the Calculation Agent shall, in its reasonable discretion,

2

	determine the number of Options for which such day shall be the Expiration Date and (i) allocate the remaining Options for such Expiration Date to one or more of the remaining Expiration Dates, (ii) designate the first succeeding Scheduled Trading Day that is not a Disrupted Day and is not or is not deemed to be an Expiration Date in respect of any other Component of the Transaction hereunder as the Expiration Date for such remaining Options, or (iii) a combination thereof, in each case the Calculation Agent shall provide email notice to Counterparty of such determination as soon as reasonably practicable; provided further that if the Expiration Date for a Component (including any portion of a Component whose Expiration Date was postponed as a result of clause (ii) or (iii) above) has not occurred as of the Final Disruption Date, (a) such Final Disruption Date shall be deemed to be the Expiration Date and Valuation Date for such Component, and (b) the Calculation Agent shall determine the Settlement Price for such Component on the basis of its good faith estimate of the trading value for the relevant Shares. Section 6.6 of the Equity Definitions shall not apply to any Disrupted Day occurring on an Expiration Date.
Final Disruption Date:	November 28, 2018
VWAP Price:	For any Expiration Date or other Exchange Business Day, the volume weighted average price of the Shares as displayed on Bloomberg Page “HGSI<equity>AQR” (or any successor page thereto) for the Counterparty with respect to the period between 9:30 a.m. to 4:00 p.m. (New York City time) on such day, as determined by Calculation Agent. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the VWAP Price in a commercially reasonable manner.
10b-18 VWAP Price:	For any Expiration Date or other Exchange Business Day, the Rule 10b-18 dollar volume weighted average price of the Shares based on transactions executed during such Expiration Date, as reported on Bloomberg Page “HGSI<equity>AQR SEC” (or any successor page thereto) on such day. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the 10b-18 VWAP Price in a commercially reasonable manner.
Market Disruption Event:	Section 6.3(a) of the Equity Definitions is hereby amended by (A) replacing clause (ii) thereof in its entirety with the following: “(ii) an Exchange Disruption, ” and (B) by replacing the words “or (iii) an Early Closure.” therein with “(iii) an Early Closure, or (iv) a Regulatory Disruption.”
	Section 6.3(d) of the Equity Definitions is hereby amended by deleting the remainder of the provision following the term “Scheduled Closing Time” in the fourth line thereof.
Regulatory Disruption:	Any event that Dealer, in its reasonable discretion, determines that it is prudent, with regard to any legal, regulatory or self-regulatory requirements or related policies and procedures (whether or not such requirements, policies or procedures are imposed by law or have been voluntarily adopted by Dealer, and including without limitation Sections 9 or 10 of the Securities Exchange Act of 1934,

3

	as amended (the “Exchange Act”), Rule 10b-18, Rule 10b-5 and Regulation 14E under the Exchange Act, and Regulation M), for Dealer to refrain from or decrease any market activity in connection with the Transaction.
Exchange Business Day; Disrupted Day:	Sections 1.29 and 6.4 of the Equity Definitions are hereby amended by adding “, unless the Calculation Agent reasonably determines that any failure of such Exchange or Related Exchange to open, or to remain open, does not have a material effect on the trading market for the Shares” following the words “regular trading sessions” in the third line thereof and the words “regular trading session” in the second line thereof, respectively.
Automatic Exercise:	Applicable; and means that the Number of Options for the relevant Component will be deemed to be automatically exercised at the Expiration Time on the Expiration Date for such Component if at such time such Component is In-the-Money, as determined by the Calculation Agent, unless Buyer notifies Seller (by telephone or in writing) prior to the Expiration Time on such Expiration Date that it does not wish Automatic Exercise to occur with respect to such Component, in which case Automatic Exercise will not apply with respect to such Component. “In-the-Money” means, in respect of any Component, that the Settlement Price on the Expiration Date for such Component is greater than the Strike Price for such Component.
Dealer’s Telephone Number and Telex and/or Facsimile Number and Contact Details for purpose of Giving Notice:
	As specified in Section 6 below.
Settlement Terms:
Settlement Method Election:	Applicable; provided that (a) Section 7.1 of the Equity Definitions is hereby amended by replacing the term “Physical Settlement” with the term “Net Share Settlement or Combination Settlement”, (b) Counterparty must make a single irrevocable election for all Components, (c) such Settlement Method Election would be effective only if Counterparty represents and warrants to Dealer in writing on the date of such Settlement Method Election that none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares as of such date, (d) Counterparty’s Settlement Method Election shall correspond to the “settlement method” (as defined in the indenture for the 3.00% Convertible Senior Notes due November 15, 2018 (the “Convertible Notes” and such indenture, the “Indenture”)) elected by Counterparty with respect to the Convertible Notes such that (x) “physical settlement” or “combination settlement“ with a “specified dollar amount” (each, as defined in the Indenture) equal to or less than $1,000 with respect to the Convertible Notes shall mean that Net Share Settlement applies to the Transaction, (y) “cash settlement“ (as defined in the Indenture) shall mean that Cash Settlement applies to the Transaction, and (z) “combination settlement“ with a “specified dollar amount” greater than $1,000 with respect to the Convertible Notes shall mean that Combination Settlement applies to the Transaction, and (d) if the Settlement Method Election is “Combination Settlement”, Counterparty shall provide the Cash

4

	Percentage in the notice pursuant to Section 7.1 of the Equity Definitions; provided that if Counterparty fails to provide such Cash Percentage then the Default Settlement Method shall apply.
Electing Party:	Counterparty
Settlement Method Election Date:	The fifth Scheduled Trading Day prior to the scheduled Expiration Date for the first Component.
Default Settlement Method:	Net Share Settlement
Settlement Currency:	USD
Settlement Price:	For any Valuation Date, the VWAP Price for such Valuation Date, unless Net Share Settlement or Combination Settlement applies, in which case the Calculation Agent may decide in its sole discretion that the 10b-18 VWAP Price for such Valuation Date shall be the VWAP Price.
Strike Price Differential:	For any Component:
	(i) if the Settlement Price on the Expiration Date for such Component exceeds the Strike Price for such Component but is less than the Cap Price for such Component, an amount equal to the excess of such Settlement Price over such Strike Price.
	(ii) if the Settlement Price on the Expiration Date for such Component equals or exceeds the Cap Price for such Component, an amount equal to the excess of such Cap Price over the Strike Price for such Component; or
	(iii) if the Settlement Price on the Expiration Date for such Component is less than or equal to the Strike Price for such Component, zero.
Net Share Settlement:
Settlement Date:	The Settlement Date shall be one Settlement Cycle immediately following the Expiration Date for each Component (or, in respect of all or part of its obligation to deliver the Number of Shares to be Delivered, such other earlier date or dates Dealer shall determine in its sole reasonable discretion).
Net Share Settlement:	If Net Share Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty a number of Shares equal to the Number of Shares to be Delivered for such Component to the account specified by Counterparty and cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component.
Number of Shares to be Delivered:	For any Component, subject to the last sentence of Section 9.5 of the Equity Definitions, the product of (i) the product of the Number of Options for such Component and the Strike Price Differential divided by the Settlement Price on the Expiration Date for such Component and (ii) one minus the Cash Percentage.
Cash Settlement:
Cash Settlement Payment Date:	The Cash Settlement Payment Date shall be the third Scheduled Trading Day after the Expiration Date for each Component.

5

Cash Settlement:	If Cash Settlement applies, on the relevant Cash Settlement Payment Date for such Component, Dealer shall pay to Counterparty an amount equal to the Option Cash Settlement Amount for such Component to the account specified by Counterparty.
Combination Settlement:
Combination Settlement:	If Combination Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty: (i) an amount in cash equal to the product of the Option Cash Settlement Amount and the Cash Percentage (as defined below) and (ii) the Number of Shares to be Delivered, and (y) cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component, in each case, to the account(s) specified by Counterparty.
Cash Percentage:	The percentage to be specified by Counterparty in the notice delivered by Counterparty to Dealer pursuant to Section 7.1 of the Equity Definitions, which percentage shall equal (x) the amount of cash a holder of USD1,000 principal amount of Convertible Notes would receive upon conversion under the Indenture minus USD1,000 divided by (y) the cash value of the “settlement amount” (calculated using the “daily VWAP”) (each as defined in the Indenture) minus USD1,000. If Net Share Settlement applies, the Cash Percentage shall be deemed to be zero.
Other Applicable Provisions:	To the extent Dealer is obligated to deliver Shares hereunder, the provisions of Sections 9.1(c), 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the Issuer of the Shares) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction.
Restricted Certificated Shares:	Notwithstanding anything to the contrary in the Equity Definitions, Dealer may, in whole or in part, deliver Shares required to be delivered to Counterparty hereunder in certificated form in lieu of delivery through the Clearance System. With respect to such certificated Shares, the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by deleting the remainder of the provision after the word “encumbrance” in the fourth line thereof.
Share Adjustments:
Method of Adjustment:	Calculation Agent Adjustment; provided that the Equity Definitions shall be amended by adding the words “or the Transaction” after the words “theoretical value of the relevant Shares” in Section 11.2(a), 11.2(c) and 11.2(e)(vii); provided, further that adjustments may be made to account for changes in volatility, expected dividends, stock loan rate and liquidity relative to the relevant Shares.
Dividends:	If at any time prior to final settlement of the Transaction, (i) Counterparty alters the amount per Share or frequency of its Ordinary Dividend Amount on the Shares or (ii) Counterparty declares any dividend other than an Ordinary Dividend Amount on

6

	the Shares, then the Calculation Agent will make such adjustments as it in good faith determines appropriate to account for the economic effect on the Transaction thereof.
Ordinary Dividend Amount:	USD0.00
Extraordinary Events:
New Shares:	In the definition of “New Shares” in Section 12.1(i) of the Equity Definitions, the text in subsection (i) shall be deleted in its entirety and replaced with: “publicly quoted, traded or listed on any of the New York Stock Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or their respective successors)”.
Merger Events:	Applicable
Consequences of Merger Events:
(a)    Share-for-Share:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price; provided, further, that if, with respect to a Merger Event, the consideration for the Shares includes (or, at the option of a holder of Shares, may include) shares (or depositary receipts with respect to shares) of an entity or person not organized under the laws of the United States, any State thereof or the District of Columbia, Cancellation and Payment (Calculation Agent Determination) shall apply.
(b)    Share-for-Other:	Cancellation and Payment (Calculation Agent Determination)
(c)    Share-for-Combined:	Component Adjustment
Tender Offer:	Applicable
Consequences of all Tender Offers:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price.
Announcement Event:	If an Announcement Event has occurred, the Calculation Agent shall have the right to determine the economic effect of the Announcement Event on the theoretical value of the Transaction (including without limitation any change in volatility, stock loan rate or liquidity relevant to the Shares or to the Transaction) (i) at a time that it deems appropriate, from the Announcement Date to the date of such determination (a “Determination Date”), and (ii) on the earlier to occur of (x) the relevant Merger Date or Tender Offer Date, as the case may be, and (y) a date on which a payment amount is determined pursuant to Sections 12.7 or 12.8 of the Equity Definitions (such earlier date, a “Final Determination Date”), from the Announcement Date or the Determination Date, as applicable, to such Final Determination Date. If any such economic effect is deemed to be material in the Calculation Agent’s sole but commercially reasonable discretion, the Calculation Agent may adjust the terms of the Transaction to reflect such economic effect. “Announcement Event” shall mean the occurrence of an Announcement Date (as defined below).
Announcement Date:	The definition of “Announcement Date” in Section 12.1(l) of the Equity Definitions shall be amended by (i) replacing the word “leads to the” in the third and the fifth lines thereof with the words

7

	“, if completed, would lead to a”, (ii) replacing the words “voting shares” in the fifth line thereof with the word “Shares”, (iii) inserting the words “by an entity with direct knowledge” after the word “announcement” in the second and the fourth lines thereof, (iv) inserting the words “or to explore the possibility of engaging in” after the words “engage in” in the second line thereto, (v) inserting the words “or to explore the possibility of purchasing or otherwise obtaining” after the word “obtain” in the fourth line thereto, (vi) deleting the parenthetical in the third and the fifth line thereof, (vii) adding immediately after the words “Merger Event” in the third line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention)” and (viii) adding immediately after the words “Tender Offer” in the fifth line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention).”
Nationalization, Insolvency
or Delisting:	Cancellation and Payment (Calculation Agent Determination); provided that, in addition to the provisions of Section 12.6(a)(iii) of the Equity Definitions, it shall also constitute a Delisting if the Exchange is located in the United States and the Shares are not immediately re-listed, re-traded or re-quoted on any of the New York Stock Exchange, The NASDAQ Global Select Market or The NASDAQ Global Market (or any of their respective successors); if the Shares are immediately re-listed, re-traded or re-quoted on any such exchange or quotation system, such exchange or quotation system shall thereafter be deemed to be the Exchange.
Additional Disruption Events:
(a)    Change in Law:	Applicable; provided that any determination as to whether (i) the adoption of or any change in any applicable law or regulation (including, without limitation, any tax law) or (ii) the promulgation of or any change in or public announcement of the formal or informal interpretation by any court, tribunal or regulatory authority with competent jurisdiction of any applicable law or regulation (including any action taken by a taxing authority), in each case, constitutes a “Change in Law” shall be made without regard to Section 739 of the Wall Street Transparency and Accountability Act of 2010 or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the Trade Date; provided, further, that Section 12.9(a)(ii)(B) of the Equity Definitions is hereby amended by (i) inserting the words “or Hedge Positions” after the word “Shares” in clause (X) thereof, (ii) replacing the phrase “the interpretation” in the third line thereof with the phrase “or announcement or statement of the formal or informal interpretation” and (iii) immediately following the word “Transaction” in clause (X) thereof, adding the phrase “in the manner contemplated in good faith by Hedging Party on the Trade Date”.
(b)    Failure to Deliver:	Applicable
(c)    Insolvency Filing:	Applicable

8

(d)    Hedging Disruption:	Applicable; provided that Section 12.9(a)(v) of the Equity Definitions is hereby modified by inserting the following two phrases at the end of such Section:
	“For the avoidance of doubt, the term “equity price risk” shall be deemed to include, but shall not be limited to, stock price and volatility risk. And, for the further avoidance of doubt, any such transactions or assets referred to in phrases (A) or (B) above must be available on commercially reasonable pricing terms.”
(e)    Increased Cost of Hedging:	Applicable
(f)     Loss of Stock Borrow:	Not Applicable
(g)    Increased Cost of Stock Borrow:	Not Applicable
Hedging Party:	For all applicable Additional Disruption Events, Dealer
Determining Party:	For all applicable Extraordinary Events, Dealer
Non-Reliance:	Applicable
Agreements and Acknowledgments
Regarding Hedging Activities:	Applicable
Additional Acknowledgments:	Applicable
3.      Calculation Agent:	Dealer
4.      Account Details:
Dealer Payment Instructions:
Chase Manhattan Bank New York
For A/C Goldman, Sachs & Co.
A/C #930-1-011483
ABA: 021-000021

Counterparty Payment / Share Delivery Instructions: To be provided by Counterparty.

5.      Offices:

The Office of Dealer for the Transaction is: 200 West Street, New York, NY 10282-2198

The Office of Counterparty for the Transaction is: Not applicable. Counterparty is not a Multibranch Party.

6.      Notices: For purposes of this Confirmation:

Address for notices or communications to Counterparty:

To:	Human Genome Sciences, Inc.
	14200 Shady Grove Road
	Rockville, Maryland 20850-7464
Attn:	James H. Davis
Telephone:	301-309-8504
Email:	Jim_Davis@hgsi.com

Address for notices or communications to Dealer:

To:	Goldman, Sachs & Co.
	200 West Street
	New York, NY 10282-2198
Attn:	Serge Marquié,
	Equity Capital Markets
Telephone:	212-902-9779
Facsimile:	917-977-4253
Email:	marqse@am.ibd.gs.com

9

With a copy to:
Attn:	Michael Voris
	Equity Capital Markets
Telephone:	212-902-4895
Facsimile:	212- 291 5027
Email:	michael.voris@gs.com
And email notification to the following address:
Eq-derivs-notifications@am.ibd.gs.com

7. Representations, Warranties and Agreements:

(a) In addition to the representations, warranties and agreements in the Agreement and those contained elsewhere herein, Counterparty represents and warrants to and for the benefit of, and agrees with, Dealer as follows:

(i) On the Trade Date, on any Settlement Method Election Date and as of the date of any election by Counterparty of the Share Termination Alternative under (and as defined in) Section 8(a) below, (A) none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares and (B) all reports and other documents filed by Counterparty with the Securities and Exchange Commission pursuant to the Exchange Act when considered as a whole (with the more recent such reports and documents deemed to amend inconsistent statements contained in any earlier such reports and documents), do not contain any untrue statement of a material fact or any omission of a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances in which they were made, not misleading.

(ii) During the period starting on the first Expiration Date and ending on the last Expiration Date (the “Settlement Period”), the Shares or any securities that are convertible into, or exchangeable or exercisable for Shares shall not be subject to a “restricted period,” as such term is defined in Regulation M under the Exchange Act (“Regulation M”) and (B) Counterparty shall not engage in any “distribution,” as such term is defined in Regulation M, other than a distribution meeting the requirements of the exceptions set forth in sections 101(b)(10) and 102(b)(7) of Regulation M, until the second Exchange Business Day immediately following the relevant Settlement Period.

(iii) On the Trade Date and during the Settlement Period, neither Counterparty nor any “affiliate” or “affiliated purchaser” (each as defined in Rule 10b-18 under the Exchange Act (“Rule 10b-18”)) shall directly or indirectly (including, without limitation, by means of any cash-settled or other derivative instrument) purchase, offer to purchase, place any bid or limit order that would effect a purchase of, or commence any tender offer relating to, any Shares (or an equivalent interest, including a unit of beneficial interest in a trust or limited partnership or a depository share) or any security convertible into or exchangeable or exercisable for Shares.

(iv) Without limiting the generality of Section 13.1 of the Equity Definitions, Counterparty acknowledges that neither Dealer nor any of its affiliates is making any representations or warranties or taking any position or expressing any view with respect to the treatment of the Transaction under any accounting standards including ASC Topic 260, Earnings Per Share, ASC Topic 815, Derivatives and Hedging, ASC Topic 480, Distinguishing Liabilities from Equity and ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (or any successor issue statements) or under FASB’s Liabilities & Equity Project.

10

(v) Without limiting the generality of Section 3(a)(iii) of the Agreement, the Transaction will not violate Rule 13e-1 or Rule 13e-4 under the Exchange Act.

(vi) Prior to the Trade Date, Counterparty shall deliver to Dealer a resolution of Counterparty’s board of directors or a duly authorized committee thereof authorizing the Transaction and such other certificate or certificates as Dealer shall reasonably request.

(vii) Counterparty represents (A) on the Trade Date and (B) on the date of any election by Counterparty of the Share Termination Alternative under Section 8(a) below, that it is not entering into this Transaction or making such election to create actual or apparent trading activity in the Shares (or any security convertible into or exchangeable for Shares) or to raise or depress or otherwise manipulate the price of the Shares (or any security convertible into or exchangeable for Shares) or otherwise in violation of the Exchange Act.

(viii) Counterparty is not, and after giving effect to the transactions contemplated hereby will not be, required to register as an “investment company” as such term is defined in the Investment Company Act of 1940, as amended.

(ix) On each of the Trade Date and the Premium Payment Date, Counterparty is not, or will not be, “insolvent” (as such term is defined under Section 101(32) of the U.S. Bankruptcy Code (Title 11 of the United States Code) (the “Bankruptcy Code”)) and Counterparty would be able to purchase a number of Shares equal to the Number of Shares hereunder in compliance with the laws of the jurisdiction of its incorporation.

(x) No state or local (including non-U.S. jurisdictions) law, rule, regulation or regulatory order (other than state insurance holding company laws) applicable to the Shares would give rise to any reporting, consent, registration or other requirement (including without limitation a requirement to obtain prior approval from any person or entity) as a result of Dealer or its affiliates owning or holding (however defined) Shares.

(xi) The representations and warranties of Counterparty set forth in Section 3 of the Agreement and Section 1 of the Underwriting Agreement dated November 2, 2011 between Counterparty and Morgan Stanley & Co. LLC and Credit Suisse Securities (USA) LLC (the “Underwriting Agreement”) are true and correct and are hereby deemed to be repeated to Dealer as if set forth herein.

(xii) Counterparty understands no obligations of Dealer to it hereunder will be entitled to the benefit of deposit insurance and that such obligations will not be guaranteed by any affiliate of Dealer or any governmental agency.

(b) During the Settlement Period, Counterparty shall (i) notify Dealer prior to the opening of trading in the Shares on any day on which Counterparty makes, or expects to be made, any public announcement (as defined in Rule 165(f) under the Securities Act of 1933, as amended (the “Securities Act”)) of any merger, acquisition, or similar transaction involving a recapitalization relating to Counterparty (other than any such transaction in which the consideration consists solely of cash and there is no valuation period), (ii) promptly notify Dealer following any such announcement that such announcement has been made, and (iii) promptly deliver to Dealer following the making of any such announcement a certificate indicating (A) Counterparty’s average daily Rule 10b-18 purchases (as defined in Rule 10b-18) during the three full calendar months preceding the date of the announcement of such transaction and (B) Counterparty’s block purchases (as defined in Rule 10b-18) effected pursuant to paragraph (b)(4) of Rule 10b-18 during the three full calendar months preceding the date of the announcement of such transaction. In addition, Counterparty shall promptly notify Dealer of the earlier to occur of the completion of such transaction and the completion of the vote by target stockholders. Counterparty acknowledges that any such public announcement may cause Dealer to elect to treat one or more Scheduled Trading Days as Disrupted Days pursuant to the provisions of “Regulatory Disruption” above. Accordingly, Counterparty acknowledges that its actions in relation to any such announcement or transaction must comply with the standards set forth in subclause (c) immediately below.

11

(c) Counterparty shall not enter into or alter any hedging transaction relating to the Shares corresponding to or offsetting the Transaction. Counterparty also acknowledges and agrees that any amendment, modification, waiver or termination of this Confirmation or the Agreement must be effected in accordance with the requirements for the amendment or termination of a “plan” as defined in Rule 10b5-1(c) under the Exchange Act. Without limiting the generality of the foregoing, any such amendment, modification, waiver or termination shall be made in good faith and not as part of a plan or scheme to evade the prohibitions of Rule 10b-5 under the Exchange Act.

(d) Each of Dealer and Counterparty agrees and represents that it is an “eligible contract participant” as defined in Section 1a(12) of the U.S. Commodity Exchange Act, as amended, and is entering into the Transaction as principal (and not as agent or in any other capacity, fiduciary or otherwise) and not for the benefit of any third party.

(e) Each of Dealer and Counterparty acknowledges that the offer and sale of the Transaction to it is intended to be exempt from registration under the Securities Act by virtue of Section 4(2) thereof. Accordingly, Counterparty represents and warrants to Dealer and Dealer represents to Counterparty that (i) it has the financial ability to bear the economic risk of its investment in the Transaction and is able to bear a total loss of its investment and its investments in and liabilities in respect of the Transaction, which it understands are not readily marketable, are not disproportionate to its net worth, (ii) it is an “accredited investor” as that term is defined in Regulation D as promulgated under the Securities Act, (iii) it is entering into the Transaction for its own account and without a view to the distribution or resale thereof, (iv) the assignment, transfer or other disposition of the Transaction has not been and will not be registered under the Securities Act and is restricted under this Confirmation, the Securities Act and state securities laws and (v) its financial condition is such that it has no need for liquidity with respect to its investment in the Transaction and no need to dispose of any portion thereof to satisfy any existing or contemplated undertaking or indebtedness and is capable of assessing the merits of and understanding (on its own behalf or through independent professional advice), and understands and accepts, the terms, conditions and risks of the Transaction.

(f) Each of Dealer and Counterparty agrees and acknowledges that Dealer is a “financial institution,” “swap participant” and “financial participant” within the meaning of Sections 101(22), 101(53C) and 101(22A) of the Bankruptcy Code. The parties hereto further agree and acknowledge that it is the intent of the parties (A) that this Confirmation is (i) a “securities contract,” as such term is defined in Section 741(7) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “settlement payment,” within the meaning of Section 546 of the Bankruptcy Code, and (ii) a “swap agreement,” as such term is defined in Section 101(53B) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “transfer,” as such term is defined in Section 101(54) of the Bankruptcy Code and a “payment or other transfer of property” within the meaning of Sections 362 and 546 of the Bankruptcy Code, and (B) that Dealer is entitled to the protections afforded by, among other sections, Sections 362(b)(6), 362(b)(17), 362(o),546(e), 546(g), 548(d)(2), 555, 560 and 561 of the Bankruptcy Code.

(g) Counterparty shall deliver to Dealer an opinion of counsel, dated as of the Effective Date and reasonably acceptable to Dealer in form and substance, with respect to the matters set forth in Section 3(a) of the Agreement.

(h) Counterparty hereby agrees and acknowledges that the Transaction has not been registered with the Securities and Exchange Commission or any state securities commission and that the Options are being written by Dealer to Counterparty in reliance upon exemptions from any such registration requirements. Counterparty acknowledges that all Options acquired from Dealer will be acquired for investment purposes only and not for the purpose of resale or other transfer except in compliance with the requirements of the Securities Act. Counterparty will not sell or otherwise transfer any Option or any interest therein except in compliance with the requirements of the Securities Act and any subsequent offer or sale of the Options will be solely for Counterparty’s account and not as part of a distribution that would be in violation of the Securities Act.

12

(i) Each party acknowledges and agrees to be bound by the Conduct Rules of the Financial Industry Regulatory Authority, Inc. applicable to transactions in options, and further agrees not to violate the position and exercise limits set forth therein.

8. Other Provisions:

(a) Alternative Calculations and Payment on Early Termination and on Certain Extraordinary Events. If (i) Dealer shall owe Counterparty, or (ii) Counterparty shall owe Dealer, any amount pursuant to Section 12.2 of the Equity Definitions and “Consequences of Merger Events” above, or Sections 12.3, 12.6, 12.7 or 12.9 of the Equity Definitions (except in the event of a Tender Offer or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash) or pursuant to Section 6(d)(ii) of the Agreement (except in the event of an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, that resulted from an event or events within Counterparty’s control) (in the case of (i) or (ii), a “Payment Obligation”), Counterparty shall have the right, in its sole discretion, to (i) require Dealer to satisfy any such Payment Obligation by the Share Termination Alternative (as defined below), or (ii) elect to settle any Payment Obligation owed by Counterparty by the Share Termination Alternative (as defined below), by giving irrevocable telephonic notice to Dealer, confirmed in writing within one Scheduled Trading Day, no later than 9:30 A.M. New York City time on the Merger Date, Tender Offer Date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable (“Notice of Share Termination”); provided that if Counterparty does not elect to require Dealer to satisfy its Payment Obligation by the Share Termination Alternative, Dealer shall have the right, in its good faith and reasonable discretion, to elect to satisfy its Payment Obligation by the Share Termination Alternative, notwithstanding Counterparty’s failure to elect or election to the contrary; and provided further that Counterparty shall not have the right to so elect (but, for the avoidance of doubt, Dealer shall have the right to so elect) in the event of (i) an Insolvency, a Nationalization or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash or (ii) an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, which Event of Default or Termination Event resulted from an event or events within Counterparty’s control. Upon such Notice of Share Termination, the following provisions shall apply on the Scheduled Trading Day immediately following the relevant merger date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable:

Share Termination Alternative:	Applicable and means that Dealer shall deliver to Counterparty the Share Termination Delivery Property on the date on which the Payment Obligation would otherwise be due pursuant to “Consequences of Merger Events” above, Section 12.7 or 12.9 of the Equity Definitions or Section 6(d)(ii) of the Agreement, as applicable, or such later date as the Calculation Agent may reasonably determine (the “Share Termination Payment Date”), in satisfaction of the Payment Obligation.
Share Termination Delivery
Property:	A number of Share Termination Delivery Units, as calculated by the Calculation Agent, equal to the Payment Obligation divided by the Share Termination Unit Price. The Calculation Agent shall adjust the Share Termination Delivery Property by replacing any fractional portion of the aggregate amount of a security therein with an amount of cash equal to the value of such fractional security based on the values used to calculate the Share Termination Unit Price.
Share Termination Unit Price:	The value of property contained in one Share Termination Delivery Unit on the date such Share Termination Delivery Units are to be delivered as Share Termination Delivery Property, as determined by the Calculation Agent in its good faith discretion by commercially reasonable means and notified by the Calculation Agent to Dealer at the time of notification of the Payment Obligation.

13

Share Termination Delivery Unit:	In the case of a Termination Event, Event of Default, Delisting or Additional Disruption Event, one Share or, in the case of an Insolvency, Nationalization, Merger Event or Tender Offer, one Share or a unit consisting of the number or amount of each type of property received by a holder of one Share (without consideration of any requirement to pay cash or other consideration in lieu of fractional amounts of any securities) in such Insolvency, Nationalization, Merger Event or Tender Offer, as applicable. If such Insolvency, Nationalization, Merger Event or Tender Offer involves a choice of consideration to be received by holders, such holder shall be deemed to have elected to receive the maximum possible amount of cash.
Failure to Deliver:	Applicable
Other applicable provisions:	If Share Termination Alternative is applicable, the provisions of Sections 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the issuer of the Shares or any portion of the Share Termination Delivery Units) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction, except that all references to “Shares” shall be read as references to “Share Termination Delivery Units.”

(b) Disposition of Hedge Shares. Counterparty hereby agrees that if, in the reasonable judgment of Dealer, any Shares (the “Hedge Shares”) acquired by Dealer for the purpose of hedging its obligations pursuant to the Transaction cannot be sold in the public market by Dealer without registration under the Securities Act, Counterparty shall, at its election: (i) in order to allow Dealer to sell the Hedge Shares in a registered offering, make available to Dealer an effective registration statement under the Securities Act to cover the resale of such Hedge Shares and (A) enter into an agreement, in form and substance reasonably satisfactory to Dealer and the Counterparty, substantially in the form of an underwriting agreement for a registered offering, (B) provide accountant’s “comfort” letters in customary form for registered offerings of equity securities, (C) provide disclosure opinions of nationally recognized outside counsel to Counterparty reasonably acceptable to Dealer, (D) provide other customary opinions, certificates and closing documents customary in form for registered offerings of equity securities and (E) afford Dealer a reasonable opportunity to conduct a “due diligence” investigation with respect to Counterparty customary in scope for underwritten offerings of equity securities; provided, however, that if Dealer, in its good faith reasonable discretion, is not satisfied with access to due diligence materials, the results of its due diligence investigation, or the procedures and documentation for the registered offering referred to above, then clause (ii) or clause (iii) of this Section 8(b) shall apply at the election of Counterparty; (ii) in order to allow Dealer to sell the Hedge Shares in a private placement, enter into a private placement agreement substantially similar to private placement purchase agreements customary for private placements of equity offerings of similar size, securities, in form and substance reasonably satisfactory to Dealer and Counterparty, including customary representations, covenants, blue sky and other governmental filings and/or registrations, indemnities to Dealer, due diligence rights (for Dealer or any designated buyer of the Hedge Shares from Dealer), opinions and certificates and such other documentation as is customary for private placements agreements, equity offerings of similar size all reasonably acceptable to Dealer (in which case, the Calculation Agent shall make any adjustments to the terms of the Transaction that are necessary, in its reasonable judgment, to compensate Dealer for any discount from the public market price of the Shares incurred on the sale of Hedge Shares in a private placement); or (iii) purchase the Hedge Shares from Dealer at the VWAP Price on such Exchange Business Days, and in the amounts, requested by Dealer. “VWAP Price” means, on any Exchange Business Day, the per Share volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page HGSI <equity> VAP (or any successor thereto) in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such Exchange Business Day (or if such volume-weighted average price is unavailable or is manifestly incorrect, the market value of one Share on such Exchange Business Day, as determined by the Calculation Agent using a volume-weighted method). This

14

Section 8(b) shall survive the termination, expiration or early unwind of the Transaction. For the avoidance of doubt, unless Counterparty elects to purchase the Hedge Shares pursuant to clause (iii) of this paragraph (c), nothing in this Confirmation shall be interpreted as requiring Counterparty to repurchase Hedge Shares or otherwise to pay any amount of cash to Dealer pursuant to this paragraph (c) and under no circumstances shall Counterparty be required to repurchase Hedge Shares or otherwise to pay any cash to Dealer pursuant to this paragraph (c), other than any cash payment required by an underwriting agreement entered into pursuant to clause (i)(A) or a private placement agreement entered into pursuant to clause (ii).

(c) Amendment to Equity Definitions. (i) The following amendment shall be made to the Equity Definitions:

Section 12.6(a)(ii) of the Equity Definitions is hereby amended by (1) deleting from the fourth line thereof the word “or” after the word “official” and inserting a comma therefor, and (2) deleting the semi-colon at the end of subsection (B) thereof and inserting the following words therefor “or (C) at Dealer’s option, the occurrence of any of the events specified in Section 5(a)(vii) (1) through (9) of the ISDA Master Agreement with respect to that Issuer, provided however that any reference to 15 days in Section 5(a)(vii), shall instead be a reference to 60 days.

(ii) Solely for purposes of applying the Equity Definitions and for purposes of this Confirmation, any reference in the Equity Definitions to a Strike Price shall be deemed to be a reference to either of the Strike Price or the Cap Price, or both, as appropriate.

(d) Repurchase Notices. Counterparty shall, at least five Scheduled Trading Days prior to effecting any repurchase of Shares or consummating or otherwise executing or engaging in any transaction or event that would lead to an increase in the Conversion Rate (as such term is defined in the Indenture) (a “Conversion Rate Adjustment Event”), give Dealer a written notice of such repurchase or Conversion Rate Adjustment Event (a “Repurchase Notice”) if, following such repurchase or Conversion Rate Adjustment Event, the Notice Percentage as determined on the date of such Repurchase Notice is (i) greater than 8.0% and (ii) greater by 0.5% than the Notice Percentage included in the immediately preceding Repurchase Notice (or, in the case of the first such Repurchase Notice, greater than 8.0%). The “Notice Percentage” as of any day is the fraction (A) the numerator of which is the aggregate of the Number of Shares for all Components under the Transaction and the number of Shares underlying any other capped call transactions between Counterparty and Dealer and (B) the denominator of which is the number of Shares outstanding on such day. In the event that Counterparty fails to provide Dealer with a Repurchase Notice on the day and in the manner specified in this Section 8(d) then Counterparty agrees to indemnify and hold harmless Dealer, its affiliates and their respective directors, officers, employees, agents and controlling persons (Dealer and each such person being an “Indemnified Party”) from and against any and all losses (including losses relating to Dealer’s hedging activities as a consequence of becoming, or of the risk of becoming, a Section 16 “insider,” including without limitation any forbearance from hedging activities or cessation of hedging activities and any losses in connection therewith with respect to the Transaction), claims, damages and liabilities (or actions in respect thereof), joint or several, to which such Indemnified Party may become subject under applicable securities laws, including without limitation, Section 16 of the Exchange Act relating to or arising out of such failure. If for any reason the foregoing indemnification is unavailable to any Indemnified Party or insufficient to hold harmless any Indemnified Party, then Counterparty shall contribute, to the maximum extent permitted by law, to the amount paid or payable by the Indemnified Party as a result of such loss, claim, damage or liability. In addition, Counterparty will reimburse any Indemnified Party for all expenses (including reasonable counsel fees and expenses) as they are incurred (after notice to Counterparty) in connection with the investigation of, preparation for or defense or settlement of any pending or threatened claim or any action, suit or proceeding arising therefrom, whether or not such Indemnified Party is a party thereto and whether or not such claim, action, suit or proceeding is initiated or brought by or on behalf of Counterparty. This indemnity shall survive the completion of the Transaction contemplated by this Confirmation and any assignment and delegation of the Transaction made pursuant to this Confirmation or the Agreement shall inure to the benefit of any permitted assignee of Dealer.

(e) Transfer and Assignment. Either party may transfer any of its rights or obligations under the Transaction with the prior written consent of the non-transferring party, such consent not to be unreasonably withheld or delayed; provided that notwithstanding any provision of the Agreement to the contrary, Dealer may, subject to applicable law, freely transfer and assign all of its rights and obligations under the Transaction

15

without the consent of Counterparty to any affiliate of Dealer of equal or better credit rating than Dealer or affiliate of Dealer whose obligations are guaranteed by the parent or holding company of Dealer, provided further that (I) if (x) Counterparty has not consented to a transfer proposed by Dealer that requires Counterparty’s consent as determined by Dealer, and (y) Dealer determines, in its commercially reasonable discretion, that such transfer would be reasonably necessary or prudent to (i) preserve Dealer’s hedging or hedge unwind activity (or anticipated hedging or hedge unwind activity) hereunder in light of existing liquidity conditions in the cash market or any other relevant market, (ii) to enable Dealer to effect transactions in Shares or cash-settled swaps in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is in compliance with applicable laws, regulations, policies and procedures applicable to Dealer or (iii) to avoid an Excess Ownership Position, or (II) if (x) any Excess Ownership Position exists and (y) Dealer, in its discretion, is unable to effect a transfer or assignment to a third party in accordance with the requirements set forth above after using its commercially reasonable efforts on pricing terms and within a time period reasonably acceptable to Dealer such that an Excess Ownership Position no longer exists, then in each case Dealer may designate a Scheduled Trading Day as an Early Termination Date with respect to all or a portion (the “Terminated Portion”) of the Transaction. In the event that Dealer so designates an Early Termination Date, a payment or delivery shall be made pursuant to Section 6 of the Agreement and/or Section 8(b) of this Confirmation as if (i) an Early Termination Date had been designated in respect of a Transaction having terms identical to the Terminated Portion of the Transaction, (ii) Counterparty shall be the sole Affected Party with respect to such partial termination and (iii) such portion of the Transaction shall be the only Terminated Transaction. “Excess Ownership Position” means any of the following: (i) the Equity Percentage exceeds 4.0%, (ii) Dealer or any “affiliate” or “associate” of Dealer would own in excess of 8.0% of the outstanding Shares for purposes of Section 203 of the Delaware General Corporation Law, (iii) Dealer or any affiliate thereof owns, directly or indirectly, in excess of 4.0% of the outstanding Shares for purposes of Section 382 of the Internal Revenue Code of 1986, as determined in accordance with Treasury Regulation Section 1.382-2T(g), (h), (j) and (k) (or any successor provisions), including any ownership by application of constructive ownership rules, or (iv) Dealer, Dealer Group (as defined below) or any person whose ownership position would be aggregated with that of Dealer or Dealer Group (Dealer, Dealer Group or any such person, a “Dealer Person”) under any federal, state or local laws, regulations or regulatory orders applicable to ownership of Shares (“Applicable Laws”), owns, beneficially owns, constructively owns, controls, holds the power to vote or otherwise meets a relevant definition of ownership in excess of a number of Shares equal to (x) the number of Shares that would give rise to reporting or registration obligations or other requirements (including obtaining prior approval by a state or federal regulator) of a Dealer Person under Applicable Laws and with respect to which such requirements have not been met or the relevant approval has not been received or that would give rise to any consequences adverse to Dealer (including that any transfer of Shares or any distribution of dividends to Dealer or any of its affiliates would be prohibited or void) under the constitutive documents of Counterparty or any contract or agreement to which Counterparty is a party, in each case minus (y) 1% of the number of Shares outstanding on the date of determination. The “Equity Percentage” as of any day is the fraction, expressed as a percentage, (A) the numerator of which is the number of Shares that Dealer and any of its affiliates or any other person subject to aggregation with Dealer, for purposes of the “beneficial ownership” test under Section 13 of the Exchange Act, or of any “group” (within the meaning of Section 13) of which Dealer is or may be deemed to be a part (Dealer and any such affiliates, persons and groups, collectively, “Dealer Group”), beneficially owns (within the meaning of Section 13 of the Exchange Act), without duplication, on such day and (B) the denominator of which is the number of Shares outstanding on such day. In the case of a transfer or assignment by Counterparty of its rights and obligations hereunder and under the Agreement, in whole or in part (any such Options so transferred or assigned, the “Transfer Options”), to any party, withholding of such consent by Dealer shall not be considered unreasonable if such transfer or assignment does not meet the reasonable conditions that Dealer may impose including, but not limited to, the following conditions:

(A) With respect to any Transfer Options, Counterparty shall not be released from its notice and indemnification obligations pursuant to Section 8(d) of this Confirmation or any obligations under Section 2 (regarding Extraordinary Events) or 8(b) of this Confirmation;

(B) Any Transfer Options shall only be transferred or assigned to a third party that is a U.S. person (as defined in the Internal Revenue Code of 1986, as amended);

16

(C) Such transfer or assignment shall be effected on terms, including any reasonable undertakings by such third party (including, but not limited to, undertakings with respect to compliance with applicable securities laws in a manner that, in the reasonable judgment of Dealer, will not expose Dealer to material risks under applicable securities laws) and execution of any documentation and delivery of legal opinions with respect to securities laws and other matters by such third party and Counterparty as are requested and reasonably satisfactory to Dealer;

(D) Neither Dealer nor Counterparty will, as a result of such transfer and assignment, be required to pay the transferee an amount under Section 2(d)(i)(4) of the Agreement greater than an amount that such party would have been required to pay in the absence of such transfer and assignment;

(E) An Event of Default, Potential Event of Default or Termination Event shall not occur as a result of such transfer and assignment; and

(F) Without limiting the generality of clause (B), Counterparty shall have caused the transferee to make such Payee Tax Representations and to provide such tax documentation as may be reasonably requested by Dealer to permit Dealer to determine that results described in clauses (D) and (E) will not occur upon or after such transfer and assignment.

(f) Staggered Settlement. (A) Upon a Settlement Method Election, if Dealer is required to deliver any Shares upon settlement, or (B) if Dealer is required, or elects, to satisfy any Payment Obligation by the Share Termination Alternative, then, in either case, Dealer may elect, on one or more occasions, to deliver to Counterparty all or any portion of the Shares or Share Termination Delivery Units, as the case may be, that Dealer would otherwise be required to deliver on the relevant Settlement Date or Share Termination Payment Date (each, a “Nominal Settlement Date”) on a date (an “Early Settlement Date”) prior to such Nominal Settlement Date, provided that:

(i) Dealer must deliver written notice to Counterparty at least three Business Days prior to such Early Settlement Date, specifying (x) such Early Settlement Date, and (y) the number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty on such Early Settlement Date; and

(ii) the aggregate number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty hereunder on all such Early Settlement Dates and the Nominal Settlement Date shall not be less than the number of Shares or Share Termination Delivery Units that Dealer would otherwise have been required to deliver on such Nominal Settlement Date.

For the avoidance of doubt, any such delivery by Dealer of Shares or Share Termination Delivery Units will satisfy Dealer’s obligation to deliver the number of Shares or Share Termination Delivery Units so delivered on the relevant Nominal Settlement Date. If the number of Shares, or Share Termination Delivery Units, so delivered exceeds the number of Shares required to be delivered under the Transaction, Counterparty shall promptly return the excess number of Shares, or Share Termination Delivery Units to Dealer; provided that Dealer may by notice to Counterparty elect to receive such excess number of Shares or Share Termination Delivery Units on two or more dates over a commercially reasonable period of time; provided further that Counterparty may elect in its sole discretion, in lieu of returning such excess number of Shares or Share Termination Delivery Units, to pay to Dealer an amount of cash equal to the value of such Shares or Share Termination Delivery Units, as reasonably determined by the Calculation Agent based on the Settlement Price on the Expiration Date for the relevant Component.

(g) Right to Extend. Dealer, acting in good faith and in a commercially reasonable manner, may postpone any Exercise Date, Settlement Date or Cash Settlement Payment Date or any other date of valuation or delivery by Dealer, with respect to some or all of the relevant Options, if Dealer determines, in its reasonable discretion, that such extension is reasonably necessary or appropriate to (i) preserve Dealer’s or its affiliate’s hedging or hedge unwind activity hereunder in light of existing liquidity conditions in the cash market, the stock loan market or any other relevant market or (ii) to enable Dealer or its affiliate to effect purchases of Shares in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is or would, if Dealer or such affiliate were Counterparty or an affiliated purchaser of Counterparty, be in compliance with applicable legal, regulatory or self-regulatory requirements, or with related policies and procedures applicable to Dealer and/or such affiliate; provided, however, that Counterparty shall not be required to make any payment to Dealer on account of such extension.

17

(h) Cross-Default. It shall be an Event of Default under the Agreement with Counterparty as the Defaulting Party if Counterparty defaults (i) in any scheduled payment of principal of any indebtedness of Counterparty or of any of its subsidiaries, aggregating more than $25.0 million in principal amount, when due and payable after giving effect to any applicable grace period or (ii) in the performance of any other term or provision of any indebtedness of Counterparty or of any of its subsidiaries in excess of $25.0 million principal amount that results in such indebtedness becoming or being declared due and payable before the date on which it would otherwise become due and payable, and such acceleration is not rescinded or annulled, or such indebtedness is not discharged, within a period of five days after there has been given, by registered or certified mail, to Counterparty by Dealer, a written notice specifying such default or defaults and stating that such notice is a “Notice of Default” and referencing this Confirmation.

(i) Notice of Event of Default. Promptly upon becoming aware of any Event of Default or Potential Event of Default where Counterparty is or would be the Defaulting Party, Counterparty will notify Dealer, specifying the nature of such Event of Default or Potential Event of Default, and will give to Dealer such other information about such Event of Default or Potential Event of Default as Dealer may reasonably require.

(j) Adjustments. For the avoidance of doubt, whenever the Calculation Agent is called upon to make an adjustment pursuant to the terms of this Confirmation or the Definitions to take into account the effect of an event, the Calculation Agent shall make such adjustment by reference to the effect of such event on the Hedging Party, assuming that the Hedging Party maintains a commercially reasonable hedge position.

(k) Disclosure. Effective from the date of commencement of discussions concerning the Transaction, Counterparty and each of its employees, representatives, or other agents may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of the Transaction and all materials of any kind (including opinions or other tax analyses) that are provided to Counterparty relating to such tax treatment and tax structure.

(l) Designation by Dealer. Notwithstanding any other provision in this Confirmation to the contrary requiring or allowing Dealer to purchase, sell, receive or deliver any Shares or other securities to or from Counterparty, Dealer may designate any of its affiliates to purchase, sell, receive or deliver such Shares or other securities and otherwise to perform Dealer’s obligations in respect of the Transaction and any such designee may assume such obligations. Dealer shall not be discharged of any of its obligations to Counterparty except to the extent of actual full and final performance of its obligations to Counterparty by the designee.

(m) Set-off. The parties agree to amend Section 6 of the Agreement by replacing Section 6(f) in its entirety with the following:

“(f) Upon the occurrence of an Event of Default or Termination Event with respect to a party who is the Defaulting Party or the Affected Party (“X”), the other party (“Y”) will have the right (but not be obliged) without prior notice to X or any other person to set-off or apply any obligation of X under an Equity Contract owed to Y (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation) against any obligation of Y under an Equity Contract owed to X (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation). Y will give notice to the other party of any set-off effected under this Section 6(f).

“Equity Contract” shall mean for purposes of this Section 6(f) any transaction relating to Shares between X and Y that qualifies as ‘equity’ under applicable accounting rules.

Amounts (or the relevant portion of such amounts) subject to set-off may be converted by Y into the Termination Currency at the rate of exchange at which such party would be able, acting in a reasonable manner and in good faith, to purchase the relevant amount of such currency.

18

If any obligation is unascertained, Y may in good faith estimate that obligation and set-off in respect of the estimate, subject to the relevant party accounting to the other when the obligation is ascertained.

Nothing in this Section 6(f) shall be effective to create a charge or other security interest. This Section 6(f) shall be without prejudice and in addition to any right of set-off, combination of accounts, lien or other right to which any party is at any time otherwise entitled (whether by operation of law, contract or otherwise).”

(n) Equity Rights. Dealer acknowledges and agrees that this Confirmation is not intended to convey to it rights with respect to the Transaction that are senior to the claims of common stockholders in the event of Counterparty’s bankruptcy. For the avoidance of doubt, the parties agree that the preceding sentence shall not apply at any time other than during Counterparty’s bankruptcy to any claim arising as a result of a breach by Counterparty of any of its obligations under this Confirmation or the Agreement. For the avoidance of doubt, the parties acknowledge that this Confirmation is not secured by any collateral that would otherwise secure the obligations of Counterparty herein under or pursuant to any other agreement.

(o) Early Unwind. In the event the sale by Counterparty of the Convertible Notes is not consummated with the underwriters pursuant to the Underwriting Agreement for any reason by the close of business in New York on the Effective Date (or such later date as agreed upon by the parties, which in no event shall be later than November 17, 2011) (the Effective Date or such later date being the “Early Unwind Date”), the Transaction shall automatically terminate, on the Early Unwind Date and (i) the Transaction and all of the respective rights and obligations of Dealer and Counterparty thereunder shall be cancelled and terminated and (ii) each party shall be released and discharged by the other party from and agrees not to make any claim against the other party with respect to any obligations or liabilities of either party arising out of and to be performed in connection with the Transaction either prior to or after the Early Unwind Date.

(p) No Waiver of Rights. (i) Without limiting Section 9(d) or (f) of the Agreement, the parties hereby agree that no payment or delivery by a party made pursuant to this Confirmation shall be presumed to preclude such party’s right under this Confirmation or the Agreement to challenge the determination of the amount of such payment or delivery obligation at a later date or be deemed to be a waiver of any Event of Default or Termination Event that exists as of the date of any such payment or delivery.

(ii) Section 9(f) of the Agreement shall be amended by the addition of the following at the end of the provision: “(1) Failure by a party to expressly reserve any right, power or privilege it has under the Agreement, and/or (2) continued performance by a party of its obligations or enjoyment of any rights under the Agreement shall not in any way undermine or prejudice the effectiveness of this Section.”

(q) The Agreement is further supplemented by the following provisions:

1. The “Automatic Early Termination” provisions of Section 6(a) will not apply to Dealer or Counterparty.

2. Netting. The provisions of Section 2(c) of the Agreement will apply, provided that each occurrence of the word “Transaction” shall be replaced with “Equity Contract” and each occurrence of the word “Transactions” shall be replaced with “Equity Contracts”, and clause (ii) of Section 2(c) shall be replaced in its entirety with “(ii) in respect of Equity Contracts”.

(r) Tax Representations and Forms. Each of Dealer and Counterparty (x) represents that for the purpose of Section 3(f) of the Agreement, it is a “U.S. Person” (as that term is used in Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended), and (y) for purposes of Sections 4(a)(i) and 4(a)(iii) of the Agreement, agrees to deliver U.S. Internal Revenue Service Form W-9 (A) prior to execution of the Agreement,

19

promptly upon reasonable demand by the other party and promptly upon learning that any form or other document previously provided by either Dealer or Counterparty, as applicable, has become obsolete or incorrect.

(s) Illegality. The parties agree that for the avoidance of doubt, for purposes of Section 5(b)(i) of the Agreement, “any applicable law” shall include the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (“Dodd-Frank”), without regard to Section 739 of Dodd-Frank or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the date on which a Transaction is entered into, and the consequences specified in the Agreement, including without limitation, the consequences specified in Section 6 of the Agreement, shall apply to any Illegality arising from any such act, rule or regulation.

(t) Waiver of Trial by Jury. EACH OF COUNTERPARTY AND DEALER HEREBY IRREVOCABLY WAIVES (ON ITS OWN BEHALF AND, TO THE EXTENT PERMITTED BY APPLICABLE LAW, ON BEHALF OF ITS STOCKHOLDERS) ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THE TRANSACTION OR THE ACTIONS OF DEALER OR ITS AFFILIATES IN THE NEGOTIATION, PERFORMANCE OR ENFORCEMENT HEREOF.

(u) Governing Law; Jurisdiction. THIS CONFIRMATION AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS CONFIRMATION SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REFERENCE TO CONFLICT OF LAW PRINCIPLES. THE PARTIES HERETO IRREVOCABLY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK AND THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK IN CONNECTION WITH ALL MATTERS RELATING HERETO AND WAIVE ANY OBJECTION TO THE LAYING OF VENUE IN, AND ANY CLAIM OF INCONVENIENT FORUM WITH RESPECT TO, THESE COURTS.

(v) Amendment. This Confirmation and the Agreement may not be modified, amended or supplemented, except in a written instrument signed by Counterparty and Dealer.

(w) Counterparts. This Confirmation may be executed in several counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument.

(x) Credit Support Provider and Credit Support Document. Credit Support Provider and Credit Support Document means, in relation to either Dealer or Counterparty: None.

20

Yours faithfully,
GOLDMAN, SACHS & CO.
By:	/s/ Daniel Kopper
	Name: Daniel Kopper
	Title: Vice President

Agreed and Accepted By:
HUMAN GENOME SCIENCES, INC.
By:	/s/ David P. Southwell
	Name: David P. Southwell
	Title: Executive Vice President and
	Chief Financial Officer

EX-10.17

Exhibit 10.17

EXECUTION VERSION

To:	Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville, Maryland 20850-7464 Attn: James H. Davis Telephone: 301-309-8504 Email: Jim_Davis@hgsi.com
From:	Barclays Bank PLC 5 The North Colonnade Canary Wharf, London E14 4BB Facsimile: +44(20)77736461 Telephone: +44 (20) 777 36810 c/o Barclays Capital Inc. as Agent for Barclays Bank PLC 745 Seventh Avenue New York, NY 10019 Telephone: +1 212 412 4000
Re:	Additional Capped Call Transaction
Date:	November 2, 2011

Dear Sir(s):

The purpose of this communication (this “Confirmation”) is to set forth the terms and conditions of the above-referenced transaction entered into on the Trade Date specified below (the “Transaction”) between Barclays Bank PLC (“Dealer”), through its agent Barclays Capital Inc. (the “Agent”), and Human Genome Sciences, Inc. (“Counterparty”). This communication constitutes a “Confirmation” as referred to in the Agreement (as defined in the confirmation for the capped call Share Option Transaction with respect to 19,362,100 Shares between Dealer and Counterparty entered into on November 2, 2011 (the “Base Capped Call Transaction”)). This Confirmation shall replace any previous agreements and serve as the final documentation for the Transaction. Dealer is not a member of the Securities Investor Protection Corporation. Dealer is regulated by the Financial Services Authority.

1. This Confirmation is subject to, and incorporates, the definitions and provisions of the 2006 ISDA Definitions (including the Annex thereto) (the “2006 Definitions”) and the definitions and provisions of the 2002 ISDA Equity Derivatives Definitions (the “Equity Definitions”, and together with the 2006 Definitions, the “Definitions”), in each case as published by the International Swaps and Derivatives Association, Inc. (“ISDA”). In the event of any inconsistency between the 2006 Definitions and the Equity Definitions, the Equity Definitions will govern.

Each party is hereby advised, and each such party acknowledges, that the other party has engaged in, or refrained from engaging in, substantial financial transactions and has taken other material actions in reliance upon, and in consideration for, the parties’ entry into the Transaction to which this Confirmation relates on the terms and conditions set forth below.

This Confirmation evidences a complete and binding agreement between Dealer and Counterparty as to the terms of the Transaction to which this Confirmation relates. This Confirmation shall be subject to the Agreement. All provisions contained in, or incorporated by reference to, the Agreement will govern this Confirmation except as expressly modified herein. In the event of any inconsistency between this Confirmation and either the Definitions or the Agreement, this Confirmation shall govern.

The Transaction hereunder and the Base Capped Call Transaction shall be the sole Transaction(s) under the Agreement. If, at any time, there exists any agreement (other than the Agreement) in the form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) or 2002 ISDA Master Agreement (each, an “ISDA Master Agreement”) between Dealer and Counterparty or any confirmation or other agreement between Dealer and Counterparty pursuant to which an ISDA Master Agreement is deemed to exist between Dealer and Counterparty, then notwithstanding anything to the contrary in such ISDA Master Agreement, such confirmation or agreement or any other agreement to which Dealer and Counterparty are parties, the Transaction shall not be considered a Transaction under, or otherwise governed by, such existing or deemed ISDA Master Agreement.

2. The Transaction constitutes a Share Option Transaction for purposes of the Equity Definitions. The terms of the particular Transaction to which this Confirmation relates are as follows:

General Terms:
Trade Date:	November 2, 2011
Components:	The Transaction will be divided into individual Components, each with the terms set forth in this Confirmation, and, in particular, with the Number of Options and Expiration Date set forth in Annex A to this Confirmation. The exercise, valuation and settlement of the Transaction will be effected separately for each Component as if each Component were a separate Transaction under the Agreement.
Option Style:	European
Option Type:	Call
Seller:	Dealer
Buyer:	Counterparty
Shares:	The common stock of Counterparty, par value USD0.01 per share (Ticker Symbol: “HGSI”).
Number of Options:	For each Component, as provided in Annex A to this Confirmation.
Option Entitlement:	One Share per Option.
Strike Price:	USD13.33
Cap Price:	USD18.45
Premium:	The aggregate Premium for the Transaction is USD4,321,242.
Premium Payment Date:	The Effective Date
Effective Date:	November 7, 2011 or such other date as agreed by the parties.
Exchange:	The NASDAQ Global Select Market
Related Exchange:	All Exchanges
Procedures for Exercise:
Expiration Time:	Valuation Time
Expiration Date:	As provided in Annex A to this Confirmation (or, if such date is not a Scheduled Trading Day, the next following Scheduled Trading Day that is not already an Expiration Date for another Component); provided that, notwithstanding anything to the contrary in the Equity Definitions, if that date is a Disrupted Day, the Calculation Agent may determine that the Expiration Date for

2

	such Component is a Disrupted Day in whole or in part, in which case the Calculation Agent shall, in its reasonable discretion, determine the number of Options for which such day shall be the Expiration Date and (i) allocate the remaining Options for such Expiration Date to one or more of the remaining Expiration Dates, (ii) designate the first succeeding Scheduled Trading Day that is not a Disrupted Day and is not or is not deemed to be an Expiration Date in respect of any other Component of the Transaction hereunder as the Expiration Date for such remaining Options, or (iii) a combination thereof, in each case the Calculation Agent shall provide email notice to Counterparty of such determination as soon as reasonably practicable; provided further that if the Expiration Date for a Component (including any portion of a Component whose Expiration Date was postponed as a result of clause (ii) or (iii) above) has not occurred as of the Final Disruption Date, (a) such Final Disruption Date shall be deemed to be the Expiration Date and Valuation Date for such Component, and (b) the Calculation Agent shall determine the Settlement Price for such Component on the basis of its good faith estimate of the trading value for the relevant Shares. Section 6.6 of the Equity Definitions shall not apply to any Disrupted Day occurring on an Expiration Date.
Final Disruption Date:	November 28, 2018
VWAP Price:	For any Expiration Date or other Exchange Business Day, the volume weighted average price of the Shares as displayed on Bloomberg Page “HGSI<equity>AQR” (or any successor page thereto) for the Counterparty with respect to the period between 9:30 a.m. to 4:00 p.m. (New York City time) on such day, as determined by Calculation Agent. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the VWAP Price in a commercially reasonable manner.
10b-18 VWAP Price:	For any Expiration Date or other Exchange Business Day, the Rule 10b-18 dollar volume weighted average price of the Shares based on transactions executed during such Expiration Date, as reported on Bloomberg Page “HGSI<equity>AQR SEC” (or any successor page thereto) on such day. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the 10b-18 VWAP Price in a commercially reasonable manner.
Market Disruption Event:	Section 6.3(a) of the Equity Definitions is hereby amended by (A) replacing clause (ii) thereof in its entirety with the following: “(ii) an Exchange Disruption, ” and (B) by replacing the words “or (iii) an Early Closure.” therein with “(iii) an Early Closure, or (iv) a Regulatory Disruption.”
	Section 6.3(d) of the Equity Definitions is hereby amended by deleting the remainder of the provision following the term “Scheduled Closing Time” in the fourth line thereof.
Regulatory Disruption:	Any event that Dealer, in its reasonable discretion, determines that it is prudent, with regard to any legal, regulatory or self-regulatory requirements or related policies and procedures (whether or not such requirements, policies or procedures are imposed by law or

3

	have been voluntarily adopted by Dealer, and including without limitation Sections 9 or 10 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), Rule 10b-18, Rule 10b-5 and Regulation 14E under the Exchange Act, and Regulation M), for Dealer to refrain from or decrease any market activity in connection with the Transaction.
Exchange Business Day; Disrupted Day:	Sections 1.29 and 6.4 of the Equity Definitions are hereby amended by adding “, unless the Calculation Agent reasonably determines that any failure of such Exchange or Related Exchange to open, or to remain open, does not have a material effect on the trading market for the Shares” following the words “regular trading sessions” in the third line thereof and the words “regular trading session” in the second line thereof, respectively.
Automatic Exercise:	Applicable; and means that the Number of Options for the relevant Component will be deemed to be automatically exercised at the Expiration Time on the Expiration Date for such Component if at such time such Component is In-the-Money, as determined by the Calculation Agent, unless Buyer notifies Seller (by telephone or in writing) prior to the Expiration Time on such Expiration Date that it does not wish Automatic Exercise to occur with respect to such Component, in which case Automatic Exercise will not apply with respect to such Component. “In-the-Money” means, in respect of any Component, that the Settlement Price on the Expiration Date for such Component is greater than the Strike Price for such Component.
Dealer’s Telephone Number and Telex and/or Facsimile Number and Contact Details for purpose of Giving Notice:	As specified in Section 6 below.
Settlement Terms:
Settlement Method Election:	Applicable; provided that (a) Section 7.1 of the Equity Definitions is hereby amended by replacing the term “Physical Settlement” with the term “Net Share Settlement or Combination Settlement”, (b) Counterparty must make a single irrevocable election for all Components, (c) such Settlement Method Election would be effective only if Counterparty represents and warrants to Dealer in writing on the date of such Settlement Method Election that none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares as of such date, (d) Counterparty’s Settlement Method Election shall correspond to the “settlement method” (as defined in the indenture for the 3.00% Convertible Senior Notes due November 15, 2018 (the “Convertible Notes” and such indenture, the ”Indenture”)) elected by Counterparty with respect to the Convertible Notes such that (x) “physical settlement” or “combination settlement“ with a “specified dollar amount” (each, as defined in the Indenture) equal to or less than $1,000 with respect to the Convertible Notes shall mean that Net Share Settlement applies to the Transaction, (y) “cash settlement“ (as defined in the Indenture) shall mean that Cash Settlement applies to the Transaction, and (z) “combination settlement“ with a “specified dollar amount” greater than $1,000 with respect to the Convertible Notes shall mean that Combination Settlement applies

4

	to the Transaction, and (d) if the Settlement Method Election is “Combination Settlement”, Counterparty shall provide the Cash Percentage in the notice pursuant to Section 7.1 of the Equity Definitions; provided that if Counterparty fails to provide such Cash Percentage then the Default Settlement Method shall apply.
Electing Party:	Counterparty
Settlement Method Election Date:	The fifth Scheduled Trading Day prior to the scheduled Expiration Date for the first Component.
Default Settlement Method:	Net Share Settlement
Settlement Currency:	USD
Settlement Price:	For any Valuation Date, the VWAP Price for such Valuation Date, unless Net Share Settlement or Combination Settlement applies, in which case the Calculation Agent may decide in its sole discretion that the 10b-18 VWAP Price for such Valuation Date shall be the VWAP Price.
Strike Price Differential:	For any Component:
	(i) if the Settlement Price on the Expiration Date for such Component exceeds the Strike Price for such Component but is less than the Cap Price for such Component, an amount equal to the excess of such Settlement Price over such Strike Price.
	(ii) if the Settlement Price on the Expiration Date for such Component equals or exceeds the Cap Price for such Component, an amount equal to the excess of such Cap Price over the Strike Price for such Component; or
	(iii) if the Settlement Price on the Expiration Date for such Component is less than or equal to the Strike Price for such Component, zero.
Net Share Settlement:
Settlement Date:	The Settlement Date shall be one Settlement Cycle immediately following the Expiration Date for each Component (or, in respect of all or part of its obligation to deliver the Number of Shares to be Delivered, such other earlier date or dates Dealer shall determine in its sole reasonable discretion).
Net Share Settlement:
	If Net Share Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty a number of Shares equal to the Number of Shares to be Delivered for such Component to the account specified by Counterparty and cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component.
Number of Shares to be Delivered:	For any Component, subject to the last sentence of Section 9.5 of the Equity Definitions, the product of (i) the product of the Number of Options for such Component and the Strike Price Differential divided by the Settlement Price on the Expiration Date for such Component and (ii) one minus the Cash Percentage.
Cash Settlement:
Cash Settlement Payment Date:	The Cash Settlement Payment Date shall be the third Scheduled Trading Day after the Expiration Date for each Component.

5

Cash Settlement:	If Cash Settlement applies, on the relevant Cash Settlement Payment Date for such Component, Dealer shall pay to Counterparty an amount equal to the Option Cash Settlement Amount for such Component to the account specified by Counterparty.
Combination Settlement:
Combination Settlement:	If Combination Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty: (i) an amount in cash equal to the product of the Option Cash Settlement Amount and the Cash Percentage (as defined below) and (ii) the Number of Shares to be Delivered, and (y) cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component, in each case, to the account(s) specified by Counterparty.
Cash Percentage:	The percentage to be specified by Counterparty in the notice delivered by Counterparty to Dealer pursuant to Section 7.1 of the Equity Definitions, which percentage shall equal (x) the amount of cash a holder of USD1,000 principal amount of Convertible Notes would receive upon conversion under the Indenture minus USD1,000 divided by (y) the cash value of the “settlement amount” (calculated using the “daily VWAP”) (each as defined in the Indenture) minus USD1,000. If Net Share Settlement applies, the Cash Percentage shall be deemed to be zero.
Other Applicable Provisions:	To the extent Dealer is obligated to deliver Shares hereunder, the provisions of Sections 9.1(c), 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the Issuer of the Shares) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction.
Restricted Certificated Shares:	Notwithstanding anything to the contrary in the Equity Definitions, Dealer may, in whole or in part, deliver Shares required to be delivered to Counterparty hereunder in certificated form in lieu of delivery through the Clearance System. With respect to such certificated Shares, the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by deleting the remainder of the provision after the word “encumbrance” in the fourth line thereof.
Share Adjustments:
Method of Adjustment:	Calculation Agent Adjustment; provided that the Equity Definitions shall be amended by adding the words “or the Transaction” after the words “theoretical value of the relevant Shares” in Section 11.2(a), 11.2(c) and 11.2(e)(vii); provided, further that adjustments may be made to account for changes in volatility, expected dividends, stock loan rate and liquidity relative to the relevant Shares.
Dividends:	If at any time prior to final settlement of the Transaction, (i) Counterparty alters the amount per Share or frequency of its Ordinary Dividend Amount on the Shares or (ii) Counterparty declares any dividend other than an Ordinary Dividend Amount on

6

	the Shares, then the Calculation Agent will make such adjustments as it in good faith determines appropriate to account for the economic effect on the Transaction thereof.
Ordinary Dividend Amount:	USD0.00
Extraordinary Events:
New Shares:	In the definition of “New Shares” in Section 12.1(i) of the Equity Definitions, the text in subsection (i) shall be deleted in its entirety and replaced with: “publicly quoted, traded or listed on any of the New York Stock Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or their respective successors)”.
Merger Events:	Applicable
Consequences of Merger Events:
(a) Share-for-Share:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price; provided, further, that if, with respect to a Merger Event, the consideration for the Shares includes (or, at the option of a holder of Shares, may include) shares (or depositary receipts with respect to shares) of an entity or person not organized under the laws of the United States, any State thereof or the District of Columbia, Cancellation and Payment (Calculation Agent Determination) shall apply.
(b) Share-for-Other:	Cancellation and Payment (Calculation Agent Determination)
(c) Share-for-Combined:	Component Adjustment
Tender Offer:	Applicable
Consequences of all Tender Offers:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price.
Announcement Event:	If an Announcement Event has occurred, the Calculation Agent shall have the right to determine the economic effect of the Announcement Event on the theoretical value of the Transaction (including without limitation any change in volatility, stock loan rate or liquidity relevant to the Shares or to the Transaction) (i) at a time that it deems appropriate, from the Announcement Date to the date of such determination (a “Determination Date”), and (ii) on the earlier to occur of (x) the relevant Merger Date or Tender Offer Date, as the case may be, and (y) a date on which a payment amount is determined pursuant to Sections 12.7 or 12.8 of the Equity Definitions (such earlier date, a “Final Determination Date”), from the Announcement Date or the Determination Date, as applicable, to such Final Determination Date. If any such economic effect is deemed to be material in the Calculation Agent’s sole but commercially reasonable discretion, the Calculation Agent may adjust the terms of the Transaction to reflect such economic effect. “Announcement Event” shall mean the occurrence of an Announcement Date (as defined below).
Announcement Date:	The definition of “Announcement Date” in Section 12.1(l) of the Equity Definitions shall be amended by (i) replacing the word “leads to the” in the third and the fifth lines thereof with the words

7

	“, if completed, would lead to a”, (ii) replacing the words “voting shares” in the fifth line thereof with the word “Shares”, (iii) inserting the words “by an entity with direct knowledge” after the word “announcement” in the second and the fourth lines thereof, (iv) inserting the words “or to explore the possibility of engaging in” after the words “engage in” in the second line thereto, (v) inserting the words “or to explore the possibility of purchasing or otherwise obtaining” after the word “obtain” in the fourth line thereto, (vi) deleting the parenthetical in the third and the fifth line thereof, (vii) adding immediately after the words “Merger Event” in the third line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention)” and (viii) adding immediately after the words “Tender Offer” in the fifth line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention).”
Nationalization, Insolvency or Delisting:	Cancellation and Payment (Calculation Agent Determination); provided that, in addition to the provisions of Section 12.6(a)(iii) of the Equity Definitions, it shall also constitute a Delisting if the Exchange is located in the United States and the Shares are not immediately re-listed, re-traded or re-quoted on any of the New York Stock Exchange, The NASDAQ Global Select Market or The NASDAQ Global Market (or any of their respective successors); if the Shares are immediately re-listed, re-traded or re-quoted on any such exchange or quotation system, such exchange or quotation system shall thereafter be deemed to be the Exchange.
Additional Disruption Events:
(a) Change in Law:	Applicable; provided that any determination as to whether (i) the adoption of or any change in any applicable law or regulation (including, without limitation, any tax law) or (ii) the promulgation of or any change in or public announcement of the formal or informal interpretation by any court, tribunal or regulatory authority with competent jurisdiction of any applicable law or regulation (including any action taken by a taxing authority), in each case, constitutes a “Change in Law” shall be made without regard to Section 739 of the Wall Street Transparency and Accountability Act of 2010 or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the Trade Date; provided, further, that Section 12.9(a)(ii)(B) of the Equity Definitions is hereby amended by (i) inserting the words “or Hedge Positions” after the word “Shares” in clause (X) thereof, (ii) replacing the phrase “the interpretation” in the third line thereof with the phrase “or announcement or statement of the formal or informal interpretation” and (iii) immediately following the word “Transaction” in clause (X) thereof, adding the phrase “in the manner contemplated in good faith by Hedging Party on the Trade Date”.
(b) Failure to Deliver:	Applicable
(c) Insolvency Filing:	Applicable

8

(d)    Hedging Disruption:	Applicable; provided that Section 12.9(a)(v) of the Equity Definitions is hereby modified by inserting the following two phrases at the end of such Section:
	“For the avoidance of doubt, the term “equity price risk” shall be deemed to include, but shall not be limited to, stock price and volatility risk. And, for the further avoidance of doubt, any such transactions or assets referred to in phrases (A) or (B) above must be available on commercially reasonable pricing terms.”
(e)    Increased Cost of Hedging:	Applicable
(f)     Loss of Stock Borrow:	Not Applicable
(g)    Increased Cost of Stock Borrow:	Not Applicable
Hedging Party:	For all applicable Additional Disruption Events, Dealer
Determining Party:	For all applicable Extraordinary Events, Dealer
Non-Reliance:	Applicable
Agreements and Acknowledgments
Regarding Hedging Activities:	Applicable
Additional Acknowledgments:	Applicable
3.      Calculation Agent:	Dealer
4.      Account Details:
Dealer Payment Instructions:	To be provided by Dealer.

Counterparty Payment / Share Delivery Instructions: To be provided by Counterparty.

5.      Offices:

The Office of Dealer for the Transaction is: Not applicable. Dealer is not a Multibranch Party.

The Office of Counterparty for the Transaction is: Not applicable. Counterparty is not a Multibranch Party.

6.      Notices: For purposes of this Confirmation:

Address for notices or communications to Counterparty:

To:	Human Genome Sciences, Inc.
	14200 Shady Grove Road
	Rockville, Maryland 20850-7464
Attn:	James H. Davis
Telephone:	301-309-8504
Email:	Jim_Davis@hgsi.com
Address for notices or communications to Dealer:
To:	Barclays Bank PLC c/o Barclays Capital Inc.
	745 Seventh Avenue
	New York, NY 10019
Attn:	Paul Robinson
Telephone:	(+1) 212-526-0111
Facsimile:	917-522-0458

9

7. Representations, Warranties and Agreements:

(a) In addition to the representations, warranties and agreements in the Agreement and those contained elsewhere herein, Counterparty represents and warrants to and for the benefit of, and agrees with, Dealer as follows:

(i) On the Trade Date, on any Settlement Method Election Date and as of the date of any election by Counterparty of the Share Termination Alternative under (and as defined in) Section 8(a) below, (A) none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares and (B) all reports and other documents filed by Counterparty with the Securities and Exchange Commission pursuant to the Exchange Act when considered as a whole (with the more recent such reports and documents deemed to amend inconsistent statements contained in any earlier such reports and documents), do not contain any untrue statement of a material fact or any omission of a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances in which they were made, not misleading.

(ii) During the period starting on the Trade Date and ending on the day Dealer fully establishes its initial Hedge Positions with respect to the Transactions (the “Initial Hedge Period”), and during the period starting on the first Expiration Date and ending on the last Expiration Date (the “Settlement Period”) the Shares or any securities that are convertible into, or exchangeable or exercisable for Shares shall not be subject to a “restricted period,” as such term is defined in Regulation M under the Exchange Act (“Regulation M”) and (B) Counterparty shall not engage in any “distribution,” as such term is defined in Regulation M, other than the distribution of the Convertible Notes or a distribution meeting the requirements of the exceptions set forth in sections 101(b)(10) and 102(b)(7) of Regulation M, until the second Exchange Business Day immediately following the Initial Hedge Period or the relevant Settlement Period, as applicable.

(iii) On the Trade Date and during the Initial Hedge Period and during the Settlement Period, neither Counterparty nor any “affiliate” or “affiliated purchaser” (each as defined in Rule 10b-18 under the Exchange Act (“Rule 10b-18”)) shall directly or indirectly (including, without limitation, by means of any cash-settled or other derivative instrument) purchase, offer to purchase, place any bid or limit order that would effect a purchase of, or commence any tender offer relating to, any Shares (or an equivalent interest, including a unit of beneficial interest in a trust or limited partnership or a depository share) or any security convertible into or exchangeable or exercisable for Shares (including, without limitation, any Rule 10b-18 purchases of blocks (as defined in Rule 10b-18)). Counterparty represents and warrants that neither it nor any affiliated purchaser has made any purchases of blocks pursuant to the proviso in Rule 10b-18(b)(4) during the four full calendar weeks immediately preceding the start of the Initial Hedge Period.

(iv) Without limiting the generality of Section 13.1 of the Equity Definitions, Counterparty acknowledges that neither Dealer nor any of its affiliates is making any representations or warranties or taking any position or expressing any view with respect to the treatment of the Transaction under any accounting standards including ASC Topic 260, Earnings Per Share, ASC Topic 815, Derivatives and Hedging, ASC Topic 480, Distinguishing Liabilities from Equity and ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (or any successor issue statements) or under FASB’s Liabilities & Equity Project.

(v) Without limiting the generality of Section 3(a)(iii) of the Agreement, the Transaction will not violate Rule 13e-1 or Rule 13e-4 under the Exchange Act.

(vi) Prior to the Trade Date, Counterparty shall deliver to Dealer a resolution of Counterparty’s board of directors or a duly authorized committee thereof authorizing the Transaction and such other certificate or certificates as Dealer shall reasonably request.

(vii) Counterparty represents (A) on the Trade Date and (B) on the date of any election by Counterparty of the Share Termination Alternative under Section 8(a) below, that it is not entering into

10

this Transaction or making such election to create actual or apparent trading activity in the Shares (or any security convertible into or exchangeable for Shares) or to raise or depress or otherwise manipulate the price of the Shares (or any security convertible into or exchangeable for Shares) or otherwise in violation of the Exchange Act.

(viii) Counterparty is not, and after giving effect to the transactions contemplated hereby will not be, required to register as an “investment company” as such term is defined in the Investment Company Act of 1940, as amended.

(ix) On each of the Trade Date and the Premium Payment Date, Counterparty is not, or will not be, “insolvent” (as such term is defined under Section 101(32) of the U.S. Bankruptcy Code (Title 11 of the United States Code) (the “Bankruptcy Code”)) and Counterparty would be able to purchase a number of Shares equal to the Number of Shares hereunder in compliance with the laws of the jurisdiction of its incorporation.

(x) No state or local (including non-U.S. jurisdictions) law, rule, regulation or regulatory order (other than state insurance holding company laws) applicable to the Shares would give rise to any reporting, consent, registration or other requirement (including without limitation a requirement to obtain prior approval from any person or entity) as a result of Dealer or its affiliates owning or holding (however defined) Shares.

(xi) The representations and warranties of Counterparty set forth in Section 3 of the Agreement and Section 1 of the Underwriting Agreement dated November 2, 2011 between Counterparty and Morgan Stanley & Co. LLC and Credit Suisse Securities (USA) LLC (the “Underwriting Agreement”) are true and correct and are hereby deemed to be repeated to Dealer as if set forth herein.

(xii) Counterparty understands no obligations of Dealer to it hereunder will be entitled to the benefit of deposit insurance and that such obligations will not be guaranteed by any affiliate of Dealer or any governmental agency.

(b) During the Settlement Period, Counterparty shall (i) notify Dealer prior to the opening of trading in the Shares on any day on which Counterparty makes, or expects to be made, any public announcement (as defined in Rule 165(f) under the Securities Act of 1933, as amended (the “Securities Act”)) of any merger, acquisition, or similar transaction involving a recapitalization relating to Counterparty (other than any such transaction in which the consideration consists solely of cash and there is no valuation period), (ii) promptly notify Dealer following any such announcement that such announcement has been made, and (iii) promptly deliver to Dealer following the making of any such announcement a certificate indicating (A) Counterparty’s average daily Rule 10b-18 purchases (as defined in Rule 10b-18) during the three full calendar months preceding the date of the announcement of such transaction and (B) Counterparty’s block purchases (as defined in Rule 10b-18) effected pursuant to paragraph (b)(4) of Rule 10b-18 during the three full calendar months preceding the date of the announcement of such transaction. In addition, Counterparty shall promptly notify Dealer of the earlier to occur of the completion of such transaction and the completion of the vote by target stockholders. Counterparty acknowledges that any such public announcement may cause Dealer to elect to treat one or more Scheduled Trading Days as Disrupted Days pursuant to the provisions of “Regulatory Disruption” above. Accordingly, Counterparty acknowledges that its actions in relation to any such announcement or transaction must comply with the standards set forth in subclause (c) immediately below.

(c) Counterparty shall not enter into or alter any hedging transaction relating to the Shares corresponding to or offsetting the Transaction. Counterparty also acknowledges and agrees that any amendment, modification, waiver or termination of this Confirmation or the Agreement must be effected in accordance with the requirements for the amendment or termination of a “plan” as defined in Rule 10b5-1(c) under the Exchange Act. Without limiting the generality of the foregoing, any such amendment, modification, waiver or termination shall be made in good faith and not as part of a plan or scheme to evade the prohibitions of Rule 10b-5 under the Exchange Act.

11

(d) Each of Dealer and Counterparty agrees and represents that it is an “eligible contract participant” as defined in Section 1a(12) of the U.S. Commodity Exchange Act, as amended, and is entering into the Transaction as principal (and not as agent or in any other capacity, fiduciary or otherwise) and not for the benefit of any third party.

(e) Each of Dealer and Counterparty acknowledges that the offer and sale of the Transaction to it is intended to be exempt from registration under the Securities Act by virtue of Section 4(2) thereof. Accordingly, Counterparty represents and warrants to Dealer and Dealer represents to Counterparty that (i) it has the financial ability to bear the economic risk of its investment in the Transaction and is able to bear a total loss of its investment and its investments in and liabilities in respect of the Transaction, which it understands are not readily marketable, are not disproportionate to its net worth, (ii) it is an “accredited investor” as that term is defined in Regulation D as promulgated under the Securities Act, (iii) it is entering into the Transaction for its own account and without a view to the distribution or resale thereof, (iv) the assignment, transfer or other disposition of the Transaction has not been and will not be registered under the Securities Act and is restricted under this Confirmation, the Securities Act and state securities laws and (v) its financial condition is such that it has no need for liquidity with respect to its investment in the Transaction and no need to dispose of any portion thereof to satisfy any existing or contemplated undertaking or indebtedness and is capable of assessing the merits of and understanding (on its own behalf or through independent professional advice), and understands and accepts, the terms, conditions and risks of the Transaction.

(f) Each of Dealer and Counterparty agrees and acknowledges that Dealer is a “financial institution,” “swap participant” or “financial participant” within the meaning of Sections 101(22), 101(53C) and 101(22A) of the Bankruptcy Code. The parties hereto further agree and acknowledge that it is the intent of the parties (A) that this Confirmation is (i) a “securities contract,” as such term is defined in Section 741(7) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “settlement payment,” within the meaning of Section 546 of the Bankruptcy Code, and (ii) a “swap agreement,” as such term is defined in Section 101(53B) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “transfer,” as such term is defined in Section 101(54) of the Bankruptcy Code and a “payment or other transfer of property” within the meaning of Sections 362 and 546 of the Bankruptcy Code, and (B) that Dealer is entitled to the protections afforded by, among other sections, Sections 362(b)(6), 362(b)(17), 362(o),546(e), 546(g), 548(d)(2), 555, 560 and 561 of the Bankruptcy Code.

(g) Counterparty shall deliver to Dealer an opinion of counsel, dated as of the Effective Date and reasonably acceptable to Dealer in form and substance, with respect to the matters set forth in Section 3(a) of the Agreement.

(h) Counterparty hereby agrees and acknowledges that the Transaction has not been registered with the Securities and Exchange Commission or any state securities commission and that the Options are being written by Dealer to Counterparty in reliance upon exemptions from any such registration requirements. Counterparty acknowledges that all Options acquired from Dealer will be acquired for investment purposes only and not for the purpose of resale or other transfer except in compliance with the requirements of the Securities Act. Counterparty will not sell or otherwise transfer any Option or any interest therein except in compliance with the requirements of the Securities Act and any subsequent offer or sale of the Options will be solely for Counterparty’s account and not as part of a distribution that would be in violation of the Securities Act.

(i) Each party acknowledges and agrees to be bound by the Conduct Rules of the Financial Industry Regulatory Authority, Inc. applicable to transactions in options, and further agrees not to violate the position and exercise limits set forth therein.

8. Other Provisions:

(a) Alternative Calculations and Payment on Early Termination and on Certain Extraordinary Events. If (i) Dealer shall owe Counterparty, or (ii) Counterparty shall owe Dealer, any amount pursuant to

12

Section 12.2 of the Equity Definitions and “Consequences of Merger Events” above, or Sections 12.3, 12.6, 12.7 or 12.9 of the Equity Definitions (except in the event of a Tender Offer or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash) or pursuant to Section 6(d)(ii) of the Agreement (except in the event of an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, that resulted from an event or events within Counterparty’s control) (in the case of (i) or (ii), a “Payment Obligation”), Counterparty shall have the right, in its sole discretion, to (i) require Dealer to satisfy any such Payment Obligation by the Share Termination Alternative (as defined below), or (ii) elect to settle any Payment Obligation owed by Counterparty by the Share Termination Alternative (as defined below), by giving irrevocable telephonic notice to Dealer, confirmed in writing within one Scheduled Trading Day, no later than 9:30 A.M. New York City time on the Merger Date, Tender Offer Date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable (“Notice of Share Termination”); provided that if Counterparty does not elect to require Dealer to satisfy its Payment Obligation by the Share Termination Alternative, Dealer shall have the right, in its good faith and reasonable discretion, to elect to satisfy its Payment Obligation by the Share Termination Alternative, notwithstanding Counterparty’s failure to elect or election to the contrary; and provided further that Counterparty shall not have the right to so elect (but, for the avoidance of doubt, Dealer shall have the right to so elect) in the event of (i) an Insolvency, a Nationalization or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash or (ii) an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, which Event of Default or Termination Event resulted from an event or events within Counterparty’s control. Upon such Notice of Share Termination, the following provisions shall apply on the Scheduled Trading Day immediately following the relevant merger date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable:

Share Termination Alternative:	Applicable and means that Dealer shall deliver to Counterparty the Share Termination Delivery Property on the date on which the Payment Obligation would otherwise be due pursuant to “Consequences of Merger Events” above, Section 12.7 or 12.9 of the Equity Definitions or Section 6(d)(ii) of the Agreement, as applicable, or such later date as the Calculation Agent may reasonably determine (the “Share Termination Payment Date”), in satisfaction of the Payment Obligation.
Share Termination Delivery
Property:	A number of Share Termination Delivery Units, as calculated by the Calculation Agent, equal to the Payment Obligation divided by the Share Termination Unit Price. The Calculation Agent shall adjust the Share Termination Delivery Property by replacing any fractional portion of the aggregate amount of a security therein with an amount of cash equal to the value of such fractional security based on the values used to calculate the Share Termination Unit Price.
Share Termination Unit Price:	The value of property contained in one Share Termination Delivery Unit on the date such Share Termination Delivery Units are to be delivered as Share Termination Delivery Property, as determined by the Calculation Agent in its good faith discretion by commercially reasonable means and notified by the Calculation Agent to Dealer at the time of notification of the Payment Obligation.
Share Termination Delivery Unit:	In the case of a Termination Event, Event of Default, Delisting or Additional Disruption Event, one Share or, in the case of an Insolvency, Nationalization, Merger Event or Tender Offer, one Share or a unit consisting of the number or amount of each type of property received by a holder of one Share (without consideration of any requirement to pay cash or other consideration in lieu of fractional amounts of any securities) in

13

	such Insolvency, Nationalization, Merger Event or Tender Offer, as applicable. If such Insolvency, Nationalization, Merger Event or Tender Offer involves a choice of consideration to be received by holders, such holder shall be deemed to have elected to receive the maximum possible amount of cash.
Failure to Deliver:	Applicable
Other applicable provisions:	If Share Termination Alternative is applicable, the provisions of Sections 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the issuer of the Shares or any portion of the Share Termination Delivery Units) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction, except that all references to “Shares” shall be read as references to “Share Termination Delivery Units.”

(b) Disposition of Hedge Shares. Counterparty hereby agrees that if, in the reasonable judgment of Dealer, any Shares (the “Hedge Shares”) acquired by Dealer for the purpose of hedging its obligations pursuant to the Transaction cannot be sold in the public market by Dealer without registration under the Securities Act, Counterparty shall, at its election: (i) in order to allow Dealer to sell the Hedge Shares in a registered offering, make available to Dealer an effective registration statement under the Securities Act to cover the resale of such Hedge Shares and (A) enter into an agreement, in form and substance reasonably satisfactory to Dealer and the Counterparty, substantially in the form of an underwriting agreement for a registered offering, (B) provide accountant’s “comfort” letters in customary form for registered offerings of equity securities, (C) provide disclosure opinions of nationally recognized outside counsel to Counterparty reasonably acceptable to Dealer, (D) provide other customary opinions, certificates and closing documents customary in form for registered offerings of equity securities and (E) afford Dealer a reasonable opportunity to conduct a “due diligence” investigation with respect to Counterparty customary in scope for underwritten offerings of equity securities; provided, however, that if Dealer, in its good faith reasonable discretion, is not satisfied with access to due diligence materials, the results of its due diligence investigation, or the procedures and documentation for the registered offering referred to above, then clause (ii) or clause (iii) of this Section 8(b) shall apply at the election of Counterparty; (ii) in order to allow Dealer to sell the Hedge Shares in a private placement, enter into a private placement agreement substantially similar to private placement purchase agreements customary for private placements of equity offerings of similar size, securities, in form and substance reasonably satisfactory to Dealer and Counterparty, including customary representations, covenants, blue sky and other governmental filings and/or registrations, indemnities to Dealer, due diligence rights (for Dealer or any designated buyer of the Hedge Shares from Dealer), opinions and certificates and such other documentation as is customary for private placements agreements, equity offerings of similar size all reasonably acceptable to Dealer (in which case, the Calculation Agent shall make any adjustments to the terms of the Transaction that are necessary, in its reasonable judgment, to compensate Dealer for any discount from the public market price of the Shares incurred on the sale of Hedge Shares in a private placement); or (iii) purchase the Hedge Shares from Dealer at the VWAP Price on such Exchange Business Days, and in the amounts, requested by Dealer. “VWAP Price” means, on any Exchange Business Day, the per Share volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page HGSI <equity> VAP (or any successor thereto) in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such Exchange Business Day (or if such volume-weighted average price is unavailable or is manifestly incorrect, the market value of one Share on such Exchange Business Day, as determined by the Calculation Agent using a volume-weighted method). This Section 8(b) shall survive the termination, expiration or early unwind of the Transaction. For the avoidance of doubt, unless Counterparty elects to purchase the Hedge Shares pursuant to clause (iii) of this paragraph (c), nothing in this Confirmation shall be interpreted as requiring Counterparty to repurchase Hedge Shares or otherwise to pay any amount of cash to Dealer pursuant to this paragraph (c) and under no circumstances shall Counterparty be required to repurchase Hedge Shares or otherwise to pay any cash to Dealer pursuant to this paragraph (c), other than any cash payment required by an underwriting agreement entered into pursuant to clause (i)(A) or a private placement agreement entered into pursuant to clause (ii).

14

(c) Amendment to Equity Definitions. (i) The following amendment shall be made to the Equity Definitions:

Section 12.6(a)(ii) of the Equity Definitions is hereby amended by (1) deleting from the fourth line thereof the word “or” after the word “official” and inserting a comma therefor, and (2) deleting the semi-colon at the end of subsection (B) thereof and inserting the following words therefor “or (C) at Dealer’s option, the occurrence of any of the events specified in Section 5(a)(vii) (1) through (9) of the ISDA Master Agreement with respect to that Issuer, provided however that any reference to 15 days in Section 5(a)(vii), shall instead be a reference to 60 days.

(ii) Solely for purposes of applying the Equity Definitions and for purposes of this Confirmation, any reference in the Equity Definitions to a Strike Price shall be deemed to be a reference to either of the Strike Price or the Cap Price, or both, as appropriate.

(d) Repurchase Notices. Counterparty shall, at least five Scheduled Trading Days prior to effecting any repurchase of Shares or consummating or otherwise executing or engaging in any transaction or event that would lead to an increase in the Conversion Rate (as such term is defined in the Indenture) (a “Conversion Rate Adjustment Event”), give Dealer a written notice of such repurchase or Conversion Rate Adjustment Event (a “Repurchase Notice”) if, following such repurchase or Conversion Rate Adjustment Event, the Notice Percentage as determined on the date of such Repurchase Notice is (i) greater than 4.5% and (ii) greater by 0.5% than the Notice Percentage included in the immediately preceding Repurchase Notice (or, in the case of the first such Repurchase Notice, greater than 4.5%). The “Notice Percentage” as of any day is the fraction (A) the numerator of which is the aggregate of the Number of Shares for all Components under the Transaction and the number of Shares underlying any other capped call transactions between Counterparty and Dealer and (B) the denominator of which is the number of Shares outstanding on such day. In the event that Counterparty fails to provide Dealer with a Repurchase Notice on the day and in the manner specified in this Section 8(d) then Counterparty agrees to indemnify and hold harmless Dealer, its affiliates and their respective directors, officers, employees, agents and controlling persons (Dealer and each such person being an “Indemnified Party”) from and against any and all losses (including losses relating to Dealer’s hedging activities as a consequence of becoming, or of the risk of becoming, a Section 16 “insider,” including without limitation any forbearance from hedging activities or cessation of hedging activities and any losses in connection therewith with respect to the Transaction), claims, damages and liabilities (or actions in respect thereof), joint or several, to which such Indemnified Party may become subject under applicable securities laws, including without limitation, Section 16 of the Exchange Act relating to or arising out of such failure. If for any reason the foregoing indemnification is unavailable to any Indemnified Party or insufficient to hold harmless any Indemnified Party, then Counterparty shall contribute, to the maximum extent permitted by law, to the amount paid or payable by the Indemnified Party as a result of such loss, claim, damage or liability. In addition, Counterparty will reimburse any Indemnified Party for all expenses (including reasonable counsel fees and expenses) as they are incurred (after notice to Counterparty) in connection with the investigation of, preparation for or defense or settlement of any pending or threatened claim or any action, suit or proceeding arising therefrom, whether or not such Indemnified Party is a party thereto and whether or not such claim, action, suit or proceeding is initiated or brought by or on behalf of Counterparty. This indemnity shall survive the completion of the Transaction contemplated by this Confirmation and any assignment and delegation of the Transaction made pursuant to this Confirmation or the Agreement shall inure to the benefit of any permitted assignee of Dealer.

(e) Transfer and Assignment. Either party may transfer any of its rights or obligations under the Transaction with the prior written consent of the non-transferring party, such consent not to be unreasonably withheld or delayed; provided that notwithstanding any provision of the Agreement to the contrary, Dealer may, subject to applicable law, freely transfer and assign all of its rights and obligations under the Transaction without the consent of Counterparty to any affiliate of Dealer of equal or better credit rating than Dealer or affiliate of Dealer whose obligations are guaranteed by Dealer, provided further that (I) if (x) Counterparty has not consented to a transfer proposed by Dealer that requires Counterparty’s consent as determined by Dealer, and (y) Dealer determines, in its commercially reasonable discretion, that such transfer would be reasonably necessary or prudent to (i) preserve Dealer’s hedging or hedge unwind activity (or anticipated hedging or hedge

15

unwind activity) hereunder in light of existing liquidity conditions in the cash market or any other relevant market, (ii) to enable Dealer to effect transactions in Shares or cash-settled swaps in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is in compliance with applicable laws, regulations, policies and procedures applicable to Dealer or (iii) to avoid an Excess Ownership Position, or (II) if (x) any Excess Ownership Position exists and (y) Dealer, in its discretion, is unable to effect a transfer or assignment to a third party in accordance with the requirements set forth above after using its commercially reasonable efforts on pricing terms and within a time period reasonably acceptable to Dealer such that an Excess Ownership Position no longer exists, then in each case Dealer may designate a Scheduled Trading Day as an Early Termination Date with respect to all or a portion (the “Terminated Portion”) of the Transaction. In the event that Dealer so designates an Early Termination Date, a payment or delivery shall be made pursuant to Section 6 of the Agreement and/or Section 8(b) of this Confirmation as if (i) an Early Termination Date had been designated in respect of a Transaction having terms identical to the Terminated Portion of the Transaction, (ii) Counterparty shall be the sole Affected Party with respect to such partial termination and (iii) such portion of the Transaction shall be the only Terminated Transaction. “Excess Ownership Position” means any of the following: (i) the Equity Percentage exceeds 4.0%, (ii) Dealer or any “affiliate” or “associate” of Dealer would own in excess of 8.0% of the outstanding Shares for purposes of Section 203 of the Delaware General Corporation Law, (iii) Dealer or any affiliate thereof owns, directly or indirectly, in excess of 4.0% of the outstanding Shares for purposes of Section 382 of the Internal Revenue Code of 1986, as determined in accordance with Treasury Regulation Section 1.382-2T(g), (h), (j) and (k) (or any successor provisions), including any ownership by application of constructive ownership rules, or (iv) Dealer, Dealer Group (as defined below) or any person whose ownership position would be aggregated with that of Dealer or Dealer Group (Dealer, Dealer Group or any such person, a “Dealer Person”) under any federal, state or local laws, regulations or regulatory orders applicable to ownership of Shares (“Applicable Laws”), owns, beneficially owns, constructively owns, controls, holds the power to vote or otherwise meets a relevant definition of ownership in excess of a number of Shares equal to (x) the number of Shares that would give rise to reporting or registration obligations or other requirements (including obtaining prior approval by a state or federal regulator) of a Dealer Person under Applicable Laws and with respect to which such requirements have not been met or the relevant approval has not been received or that would give rise to any consequences adverse to Dealer (including that any transfer of Shares or any distribution of dividends to Dealer or any of its affiliates would be prohibited or void) under the constitutive documents of Counterparty or any contract or agreement to which Counterparty is a party, in each case minus (y) 1% of the number of Shares outstanding on the date of determination. The “Equity Percentage” as of any day is the fraction, expressed as a percentage, (A) the numerator of which is the number of Shares that Dealer and any of its affiliates or any other person subject to aggregation with Dealer, for purposes of the “beneficial ownership” test under Section 13 of the Exchange Act, or of any “group” (within the meaning of Section 13) of which Dealer is or may be deemed to be a part (Dealer and any such affiliates, persons and groups, collectively, “Dealer Group”), beneficially owns (within the meaning of Section 13 of the Exchange Act), without duplication, on such day and (B) the denominator of which is the number of Shares outstanding on such day. In the case of a transfer or assignment by Counterparty of its rights and obligations hereunder and under the Agreement, in whole or in part (any such Options so transferred or assigned, the “Transfer Options”), to any party, withholding of such consent by Dealer shall not be considered unreasonable if such transfer or assignment does not meet the reasonable conditions that Dealer may impose including, but not limited to, the following conditions:

(A) With respect to any Transfer Options, Counterparty shall not be released from its notice and indemnification obligations pursuant to Section 8(d) of this Confirmation or any obligations under Section 2 (regarding Extraordinary Events) or 8(b) of this Confirmation;

(B) Any Transfer Options shall only be transferred or assigned to a third party that is a U.S. person (as defined in the Internal Revenue Code of 1986, as amended);

(C) Such transfer or assignment shall be effected on terms, including any reasonable undertakings by such third party (including, but not limited to, undertakings with respect to compliance with applicable securities laws in a manner that, in the reasonable judgment of Dealer, will not expose Dealer to material risks under applicable securities laws) and execution of any documentation and delivery of legal opinions with respect to securities laws and other matters by such third party and Counterparty as are requested and reasonably satisfactory to Dealer;

16

(D) Neither Dealer nor Counterparty will, as a result of such transfer and assignment, be required to pay the transferee an amount under Section 2(d)(i)(4) of the Agreement greater than an amount that such party would have been required to pay in the absence of such transfer and assignment;

(E) An Event of Default, Potential Event of Default or Termination Event shall not occur as a result of such transfer and assignment; and

(F) Without limiting the generality of clause (B), Counterparty shall have caused the transferee to make such Payee Tax Representations and to provide such tax documentation as may be reasonably requested by Dealer to permit Dealer to determine that results described in clauses (D) and (E) will not occur upon or after such transfer and assignment.

(f) Staggered Settlement. (A) Upon a Settlement Method Election, if Dealer is required to deliver any Shares upon settlement, or (B) if Dealer is required, or elects, to satisfy any Payment Obligation by the Share Termination Alternative, then, in either case, Dealer may elect, on one or more occasions, to deliver to Counterparty all or any portion of the Shares or Share Termination Delivery Units, as the case may be, that Dealer would otherwise be required to deliver on the relevant Settlement Date or Share Termination Payment Date (each, a “Nominal Settlement Date”) on a date (an “Early Settlement Date”) prior to such Nominal Settlement Date, provided that:

(i) Dealer must deliver written notice to Counterparty at least three Business Days prior to such Early Settlement Date, specifying (x) such Early Settlement Date, and (y) the number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty on such Early Settlement Date; and

(ii) the aggregate number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty hereunder on all such Early Settlement Dates and the Nominal Settlement Date shall not be less than the number of Shares or Share Termination Delivery Units that Dealer would otherwise have been required to deliver on such Nominal Settlement Date.

For the avoidance of doubt, any such delivery by Dealer of Shares or Share Termination Delivery Units will satisfy Dealer’s obligation to deliver the number of Shares or Share Termination Delivery Units so delivered on the relevant Nominal Settlement Date. If the number of Shares, or Share Termination Delivery Units, so delivered exceeds the number of Shares required to be delivered under the Transaction, Counterparty shall promptly return the excess number of Shares, or Share Termination Delivery Units to Dealer; provided that Dealer may by notice to Counterparty elect to receive such excess number of Shares or Share Termination Delivery Units on two or more dates over a commercially reasonable period of time; provided further that Counterparty may elect in its sole discretion, in lieu of returning such excess number of Shares or Share Termination Delivery Units, to pay to Dealer an amount of cash equal to the value of such Shares or Share Termination Delivery Units, as reasonably determined by the Calculation Agent based on the Settlement Price on the Expiration Date for the relevant Component.

(g) Right to Extend. Dealer, acting in good faith and in a commercially reasonable manner, may postpone any Exercise Date, Settlement Date or Cash Settlement Payment Date or any other date of valuation or delivery by Dealer, with respect to some or all of the relevant Options, if Dealer determines, in its reasonable discretion, that such extension is reasonably necessary or appropriate to (i) preserve Dealer’s or its affiliate’s hedging or hedge unwind activity hereunder in light of existing liquidity conditions in the cash market, the stock loan market or any other relevant market or (ii) to enable Dealer or its affiliate to effect purchases of Shares in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is or would, if Dealer or such affiliate were Counterparty or an affiliated purchaser of Counterparty, be in compliance with applicable legal, regulatory or self-regulatory requirements, or with related policies and procedures applicable to Dealer and/or such affiliate; provided, however, that Counterparty shall not be required to make any payment to Dealer on account of such extension.

(h) Cross-Default. It shall be an Event of Default under the Agreement with Counterparty as the Defaulting Party if Counterparty defaults (i) in any scheduled payment of principal of any indebtedness of Counterparty or of any of its subsidiaries, aggregating more than $25.0 million in principal amount, when due

17

and payable after giving effect to any applicable grace period or (ii) in the performance of any other term or provision of any indebtedness of Counterparty or of any of its subsidiaries in excess of $25.0 million principal amount that results in such indebtedness becoming or being declared due and payable before the date on which it would otherwise become due and payable, and such acceleration is not rescinded or annulled, or such indebtedness is not discharged, within a period of five days after there has been given, by registered or certified mail, to Counterparty by Dealer, a written notice specifying such default or defaults and stating that such notice is a “Notice of Default” and referencing this Confirmation.

(i) Notice of Event of Default. Promptly upon becoming aware of any Event of Default or Potential Event of Default where Counterparty is or would be the Defaulting Party, Counterparty will notify Dealer, specifying the nature of such Event of Default or Potential Event of Default, and will give to Dealer such other information about such Event of Default or Potential Event of Default as Dealer may reasonably require.

(j) Adjustments. For the avoidance of doubt, whenever the Calculation Agent is called upon to make an adjustment pursuant to the terms of this Confirmation or the Definitions to take into account the effect of an event, the Calculation Agent shall make such adjustment by reference to the effect of such event on the Hedging Party, assuming that the Hedging Party maintains a commercially reasonable hedge position.

(k) Disclosure. Effective from the date of commencement of discussions concerning the Transaction, Counterparty and each of its employees, representatives, or other agents may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of the Transaction and all materials of any kind (including opinions or other tax analyses) that are provided to Counterparty relating to such tax treatment and tax structure.

(l) Designation by Dealer. Notwithstanding any other provision in this Confirmation to the contrary requiring or allowing Dealer to purchase, sell, receive or deliver any Shares or other securities to or from Counterparty, Dealer may designate any of its affiliates to purchase, sell, receive or deliver such Shares or other securities and otherwise to perform Dealer’s obligations in respect of the Transaction and any such designee may assume such obligations. Dealer shall not be discharged of any of its obligations to Counterparty except to the extent of actual full and final performance of its obligations to Counterparty by the designee.

(m) Set-off. The parties agree to amend Section 6 of the Agreement by replacing Section 6(f) in its entirety with the following:

“(f) Upon the occurrence of an Event of Default or Termination Event with respect to a party who is the Defaulting Party or the Affected Party (“X”), the other party (“Y”) will have the right (but not be obliged) without prior notice to X or any other person to set-off or apply any obligation of X under an Equity Contract owed to Y (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation) against any obligation of Y under an Equity Contract owed to X (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation). Y will give notice to the other party of any set-off effected under this Section 6(f).

“Equity Contract” shall mean for purposes of this Section 6(f) any transaction relating to Shares between X and Y that qualifies as ‘equity’ under applicable accounting rules.

Amounts (or the relevant portion of such amounts) subject to set-off may be converted by Y into the Termination Currency at the rate of exchange at which such party would be able, acting in a reasonable manner and in good faith, to purchase the relevant amount of such currency.

If any obligation is unascertained, Y may in good faith estimate that obligation and set-off in respect of the estimate, subject to the relevant party accounting to the other when the obligation is ascertained.

18

Nothing in this Section 6(f) shall be effective to create a charge or other security interest. This Section 6(f) shall be without prejudice and in addition to any right of set-off, combination of accounts, lien or other right to which any party is at any time otherwise entitled (whether by operation of law, contract or otherwise).”

(n) Equity Rights. Dealer acknowledges and agrees that this Confirmation is not intended to convey to it rights with respect to the Transaction that are senior to the claims of common stockholders in the event of Counterparty’s bankruptcy. For the avoidance of doubt, the parties agree that the preceding sentence shall not apply at any time other than during Counterparty’s bankruptcy to any claim arising as a result of a breach by Counterparty of any of its obligations under this Confirmation or the Agreement. For the avoidance of doubt, the parties acknowledge that this Confirmation is not secured by any collateral that would otherwise secure the obligations of Counterparty herein under or pursuant to any other agreement.

(o) Early Unwind. In the event the sale by Counterparty of the Convertible Notes is not consummated with the underwriters pursuant to the Underwriting Agreement for any reason by the close of business in New York on the Effective Date (or such later date as agreed upon by the parties, which in no event shall be later than November 17, 2011) (the Effective Date or such later date being the “Early Unwind Date”), the Transaction shall automatically terminate, on the Early Unwind Date and (i) the Transaction and all of the respective rights and obligations of Dealer and Counterparty thereunder shall be cancelled and terminated and (ii) each party shall be released and discharged by the other party from and agrees not to make any claim against the other party with respect to any obligations or liabilities of either party arising out of and to be performed in connection with the Transaction either prior to or after the Early Unwind Date.

(p) No Waiver of Rights. (i) Without limiting Section 9(d) or (f) of the Agreement, the parties hereby agree that no payment or delivery by a party made pursuant to this Confirmation shall be presumed to preclude such party’s right under this Confirmation or the Agreement to challenge the determination of the amount of such payment or delivery obligation at a later date or be deemed to be a waiver of any Event of Default or Termination Event that exists as of the date of any such payment or delivery.

(ii) Section 9(f) of the Agreement shall be amended by the addition of the following at the end of the provision: “(1) Failure by a party to expressly reserve any right, power or privilege it has under the Agreement, and/or (2) continued performance by a party of its obligations or enjoyment of any rights under the Agreement shall not in any way undermine or prejudice the effectiveness of this Section.”

(q) The Agreement is further supplemented by the following provisions:

1. The “Automatic Early Termination” provisions of Section 6(a) will not apply to Dealer or Counterparty.

2. Netting. The provisions of Section 2(c) of the Agreement will apply, provided that each occurrence of the word “Transaction” shall be replaced with “Equity Contract” and each occurrence of the word “Transactions” shall be replaced with “Equity Contracts”, and clause (ii) of Section 2(c) shall be replaced in its entirety with “(ii) in respect of Equity Contracts”.

(r) Tax Representations and Forms.

(i) Part 2(b) of the ISDA Schedule – Payee Representation:

For the purpose of Section 3(f) of this Agreement, Counterparty makes the following representation to Dealer:

Counterparty is a corporation established under the laws of the State of Delaware and is a U.S. person (as that term is defined in Section 7701(a)(30) of the United States Internal Revenue Code of 1986, as amended).

19

For the purpose of Section 3(f) of this Agreement, Dealer makes the following representation to Counterparty:

(A) Each payment received or to be received by it in connection with this Agreement is effectively connected with its conduct of a trade or business within the United States; and

(B) It is a “foreign person” (as that term is used in Section 1.6041-4(a)(4) of the United States Treasury Regulations) for United States federal income tax purposes.

(ii) Part 3(a) of the ISDA Schedule – Tax Forms:

Party Required to Deliver Document

	Form/Document/Certificate	Date by which to be Delivered
Counterparty	A complete and duly executed United States Internal Revenue Service Form W-9 (or successor thereto.)	(i) Upon execution and delivery of this Agreement; (ii) promptly upon reasonable demand by Dealer; and (iii) promptly upon learning that any such Form previously provided by Counterparty has become obsolete or incorrect.
Dealer	A complete and duly executed United States Internal Revenue Service Form W-8ECI (or successor thereto.)	(i) Upon execution and delivery of this Agreement; and (ii) promptly upon learning that any such Form previously provided by Dealer has become obsolete or incorrect.

(s) Illegality. The parties agree that for the avoidance of doubt, for purposes of Section 5(b)(i) of the Agreement, “any applicable law” shall include the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (“Dodd-Frank”), without regard to Section 739 of Dodd-Frank or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the date on which a Transaction is entered into, and the consequences specified in the Agreement, including without limitation, the consequences specified in Section 6 of the Agreement, shall apply to any Illegality arising from any such act, rule or regulation.

(t) Waiver of Trial by Jury. EACH OF COUNTERPARTY AND DEALER HEREBY IRREVOCABLY WAIVES (ON ITS OWN BEHALF AND, TO THE EXTENT PERMITTED BY APPLICABLE LAW, ON BEHALF OF ITS STOCKHOLDERS) ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THE TRANSACTION OR THE ACTIONS OF DEALER OR ITS AFFILIATES IN THE NEGOTIATION, PERFORMANCE OR ENFORCEMENT HEREOF.

(u) Governing Law; Jurisdiction. THIS CONFIRMATION AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS CONFIRMATION SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REFERENCE TO CONFLICT OF LAW PRINCIPLES. THE PARTIES HERETO IRREVOCABLY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK AND THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK IN CONNECTION WITH ALL MATTERS RELATING HERETO AND WAIVE ANY OBJECTION TO THE LAYING OF VENUE IN, AND ANY CLAIM OF INCONVENIENT FORUM WITH RESPECT TO, THESE COURTS.

20

(v) Amendment. This Confirmation and the Agreement may not be modified, amended or supplemented, except in a written instrument signed by Counterparty and Dealer.

(w) Counterparts. This Confirmation may be executed in several counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument.

(x) Credit Support Provider and Credit Support Document. Credit Support Provider and Credit Support Document means, in relation to either Dealer or Counterparty: None.

(y) Role of Agent. Each of Dealer and Counterparty acknowledges to and agrees with the other party hereto and to and with the Agent that (i) the Agent is acting as agent for Dealer under the Transaction pursuant to instructions from such party, (ii) the Agent is not a principal or party to the Transaction, and may transfer its rights and obligations with respect to the Transaction, (iii) the Agent shall have no responsibility, obligation or liability, by way of issuance, guaranty, endorsement or otherwise in any manner with respect to the performance of either party under the Transaction, (iv) Dealer and the Agent have not given, and Counterparty is not relying (for purposes of making any investment decision or otherwise) upon, any statements, opinions or representations (whether written or oral) of Dealer or the Agent, other than the representations expressly set forth in this Confirmation or the Agreement, and (v) each party agrees to proceed solely against the other party, and not the Agent, to collect or recover any money or securities owed to it in connection with the Transaction. Each party hereto acknowledges and agrees that the Agent is an intended third party beneficiary hereunder. Counterparty acknowledges that the Agent is an affiliate of Dealer.

(z) Regulatory Provisions. The time of dealing for the Transaction will be confirmed by Dealer upon written request by Counterparty. The Agent will furnish to Counterparty upon written request a statement as to the source and amount of any remuneration received or to be received by the Agent in connection with a Transaction.

(aa) Method of Delivery. Whenever delivery of funds or other assets is required hereunder by or to Counterparty, such delivery shall be effected through Agent. In addition, all notices, demands and communications of any kind relating to the Transaction between Dealer and Counterparty shall be transmitted exclusively through Agent.

21

Yours faithfully,
BARCLAYS CAPITAL INC.,
acting solely as Agent in connection with this Transaction
By:	/s/ Adam Lawlor
	Name: Adam Lawlor
	Title: Authorised Signatory

Agreed and Accepted By:
HUMAN GENOME SCIENCES, INC.
By:	/s/ David P. Southwell
	Name: David P. Southwell
	Title: Executive Vice President and
	Chief Financial Officer

EX-10.18

Exhibit 10.18

EXECUTION VERSION

To:	Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville, Maryland 20850-7464 Attn: James H. Davis Telephone: 301-309-8504 Email: Jim_Davis@hgsi.com
From:	Goldman, Sachs & Co. 200 West Street New York, NY 10282-2198
Re:	Additional Capped Call Transaction
Ref. No:	SDB4165352416
Date:	November 2, 2011

Dear Sir(s):

The purpose of this communication (this “Confirmation”) is to set forth the terms and conditions of the above-referenced transaction entered into on the Trade Date specified below (the “Transaction”) between Goldman, Sachs & Co. (“Dealer”) and Human Genome Sciences, Inc. (“Counterparty”). This communication constitutes a “Confirmation” as referred to in the Agreement (as defined in the confirmation for the capped call Share Option Transaction with respect to the Shares between Dealer and Counterparty entered into on November 2, 2011, reference number SDB4165352420 (the “Base Capped Call Transaction”)). This Confirmation shall replace any previous agreements and serve as the final documentation for the Transaction.

1. This Confirmation is subject to, and incorporates, the definitions and provisions of the 2006 ISDA Definitions (including the Annex thereto) (the “2006 Definitions”) and the definitions and provisions of the 2002 ISDA Equity Derivatives Definitions (the “Equity Definitions”, and together with the 2006 Definitions, the “Definitions”), in each case as published by the International Swaps and Derivatives Association, Inc. (“ISDA”). In the event of any inconsistency between the 2006 Definitions and the Equity Definitions, the Equity Definitions will govern.

Each party is hereby advised, and each such party acknowledges, that the other party has engaged in, or refrained from engaging in, substantial financial transactions and has taken other material actions in reliance upon, and in consideration for, the parties’ entry into the Transaction to which this Confirmation relates on the terms and conditions set forth below.

This Confirmation evidences a complete and binding agreement between Dealer and Counterparty as to the terms of the Transaction to which this Confirmation relates. This Confirmation shall be subject to the Agreement. All provisions contained in, or incorporated by reference to, the Agreement will govern this Confirmation except as expressly modified herein. In the event of any inconsistency between this Confirmation and either the Definitions or the Agreement, this Confirmation shall govern.

The Transaction hereunder and the Base Capped Call Transaction shall be the sole Transaction(s) under the Agreement. If, at any time, there exists any agreement (other than the Agreement) in the form of the 1992 ISDA Master Agreement (Multicurrency – Cross Border) or 2002 ISDA Master Agreement (each, an “ISDA Master Agreement”) between Dealer and Counterparty or any confirmation or other agreement between Dealer and Counterparty pursuant to which an ISDA Master Agreement is deemed to exist between Dealer and Counterparty, then notwithstanding anything to the contrary in such ISDA Master Agreement, such confirmation or agreement or any other agreement to which Dealer and Counterparty are parties, the Transaction shall not be considered a Transaction under, or otherwise governed by, such existing or deemed ISDA Master Agreement.

2. The Transaction constitutes a Share Option Transaction for purposes of the Equity Definitions. The terms of the particular Transaction to which this Confirmation relates are as follows:

General Terms:
Trade Date:	November 2, 2011
Components:	The Transaction will be divided into individual Components, each with the terms set forth in this Confirmation, and, in particular, with the Number of Options and Expiration Date set forth in Annex A to this Confirmation. The exercise, valuation and settlement of the Transaction will be effected separately for each Component as if each Component were a separate Transaction under the Agreement.
Option Style:	European
Option Type:	Call
Seller:	Dealer
Buyer:	Counterparty
Shares:	The common stock of Counterparty, par value USD0.01 per share (Ticker Symbol: “HGSI”).
Number of Options:	For each Component, as provided in Annex A to this Confirmation.
Option Entitlement:	One Share per Option.
Strike Price:	USD13.33
Cap Price:	USD18.45
Premium:	The aggregate Premium for the Transaction is USD2,880,828.
Premium Payment Date:	The Effective Date
Effective Date:	November 7, 2011 or such other date as agreed by the parties.
Exchange:	The NASDAQ Global Select Market
Related Exchange:	All Exchanges
Procedures for Exercise:
Expiration Time:	Valuation Time
Expiration Date:	As provided in Annex A to this Confirmation (or, if such date is not a Scheduled Trading Day, the next following Scheduled Trading Day that is not already an Expiration Date for another Component); provided that, notwithstanding anything to the contrary in the Equity Definitions, if that date is a Disrupted Day, the Calculation Agent may determine that the Expiration Date for such Component is a Disrupted Day in whole or in part, in which case the Calculation Agent shall, in its reasonable discretion, determine the number of Options for which such day shall be the Expiration Date and (i) allocate the remaining Options for such Expiration Date to one or more of the remaining Expiration Dates, (ii) designate the first succeeding Scheduled Trading Day that is not a Disrupted Day and is not or is not deemed to be an Expiration Date in respect of any other Component of the Transaction hereunder as the Expiration Date for such remaining Options, or

2

	(iii) a combination thereof, in each case the Calculation Agent shall provide email notice to Counterparty of such determination as soon as reasonably practicable; provided further that if the Expiration Date for a Component (including any portion of a Component whose Expiration Date was postponed as a result of clause (ii) or (iii) above) has not occurred as of the Final Disruption Date, (a) such Final Disruption Date shall be deemed to be the Expiration Date and Valuation Date for such Component, and (b) the Calculation Agent shall determine the Settlement Price for such Component on the basis of its good faith estimate of the trading value for the relevant Shares. Section 6.6 of the Equity Definitions shall not apply to any Disrupted Day occurring on an Expiration Date.
Final Disruption Date:	November 28, 2018
VWAP Price:	For any Expiration Date or other Exchange Business Day, the volume weighted average price of the Shares as displayed on Bloomberg Page “HGSI<equity>AQR” (or any successor page thereto) for the Counterparty with respect to the period between 9:30 a.m. to 4:00 p.m. (New York City time) on such day, as determined by Calculation Agent. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the VWAP Price in a commercially reasonable manner.
10b-18 VWAP Price:	For any Expiration Date or other Exchange Business Day, the Rule 10b-18 dollar volume weighted average price of the Shares based on transactions executed during such Expiration Date, as reported on Bloomberg Page “HGSI<equity>AQR SEC” (or any successor page thereto) on such day. If no such average price is available, or there is a Market Disruption Event on such Expiration Date or other Exchange Business Day, the Calculation Agent shall determine the 10b-18 VWAP Price in a commercially reasonable manner.
Market Disruption Event:	Section 6.3(a) of the Equity Definitions is hereby amended by (A) replacing clause (ii) thereof in its entirety with the following: “(ii) an Exchange Disruption, ” and (B) by replacing the words “or (iii) an Early Closure.” therein with “(iii) an Early Closure, or (iv) a Regulatory Disruption.”
	Section 6.3(d) of the Equity Definitions is hereby amended by deleting the remainder of the provision following the term “Scheduled Closing Time” in the fourth line thereof.
Regulatory Disruption:	Any event that Dealer, in its reasonable discretion, determines that it is prudent, with regard to any legal, regulatory or self-regulatory requirements or related policies and procedures (whether or not such requirements, policies or procedures are imposed by law or have been voluntarily adopted by Dealer, and including without limitation Sections 9 or 10 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), Rule 10b-18, Rule 10b-5 and Regulation 14E under the Exchange Act, and Regulation M), for Dealer to refrain from or decrease any market activity in connection with the Transaction.
Exchange Business Day; Disrupted Day:	Sections 1.29 and 6.4 of the Equity Definitions are hereby amended by adding “, unless the Calculation Agent reasonably

3

	determines that any failure of such Exchange or Related Exchange to open, or to remain open, does not have a material effect on the trading market for the Shares” following the words “regular trading sessions” in the third line thereof and the words “regular trading session” in the second line thereof, respectively.
Automatic Exercise:	Applicable; and means that the Number of Options for the relevant Component will be deemed to be automatically exercised at the Expiration Time on the Expiration Date for such Component if at such time such Component is In-the-Money, as determined by the Calculation Agent, unless Buyer notifies Seller (by telephone or in writing) prior to the Expiration Time on such Expiration Date that it does not wish Automatic Exercise to occur with respect to such Component, in which case Automatic Exercise will not apply with respect to such Component. “In-the-Money” means, in respect of any Component, that the Settlement Price on the Expiration Date for such Component is greater than the Strike Price for such Component.
Dealer’s Telephone Number and Telex and/or Facsimile Number and Contact Details for purpose of Giving Notice:	As specified in Section 6 below.
Settlement Terms:
Settlement Method Election:	Applicable; provided that (a) Section 7.1 of the Equity Definitions is hereby amended by replacing the term “Physical Settlement” with the term “Net Share Settlement or Combination Settlement”, (b) Counterparty must make a single irrevocable election for all Components, (c) such Settlement Method Election would be effective only if Counterparty represents and warrants to Dealer in writing on the date of such Settlement Method Election that none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares as of such date, (d) Counterparty’s Settlement Method Election shall correspond to the “settlement method” (as defined in the indenture for the 3.00% Convertible Senior Notes due November 15, 2018 (the “Convertible Notes” and such indenture, the ”Indenture”)) elected by Counterparty with respect to the Convertible Notes such that (x) “physical settlement” or “combination settlement“ with a “specified dollar amount” (each, as defined in the Indenture) equal to or less than $1,000 with respect to the Convertible Notes shall mean that Net Share Settlement applies to the Transaction, (y) “cash settlement“ (as defined in the Indenture) shall mean that Cash Settlement applies to the Transaction, and (z) “combination settlement“ with a “specified dollar amount” greater than $1,000 with respect to the Convertible Notes shall mean that Combination Settlement applies to the Transaction, and (d) if the Settlement Method Election is “Combination Settlement”, Counterparty shall provide the Cash Percentage in the notice pursuant to Section 7.1 of the Equity Definitions; provided that if Counterparty fails to provide such Cash Percentage then the Default Settlement Method shall apply.
Electing Party:	Counterparty
Settlement Method Election Date:	The fifth Scheduled Trading Day prior to the scheduled Expiration Date for the first Component.

4

Default Settlement Method:	Net Share Settlement
Settlement Currency:	USD
Settlement Price:	For any Valuation Date, the VWAP Price for such Valuation Date, unless Net Share Settlement or Combination Settlement applies, in which case the Calculation Agent may decide in its sole discretion that the 10b-18 VWAP Price for such Valuation Date shall be the VWAP Price.
Strike Price Differential:	For any Component:
	(i) if the Settlement Price on the Expiration Date for such Component exceeds the Strike Price for such Component but is less than the Cap Price for such Component, an amount equal to the excess of such Settlement Price over such Strike Price.
	(ii) if the Settlement Price on the Expiration Date for such Component equals or exceeds the Cap Price for such Component, an amount equal to the excess of such Cap Price over the Strike Price for such Component; or
	(iii) if the Settlement Price on the Expiration Date for such Component is less than or equal to the Strike Price for such Component, zero.
Net Share Settlement:
Settlement Date:	The Settlement Date shall be one Settlement Cycle immediately following the Expiration Date for each Component (or, in respect of all or part of its obligation to deliver the Number of Shares to be Delivered, such other earlier date or dates Dealer shall determine in its sole reasonable discretion).
Net Share Settlement:	If Net Share Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty a number of Shares equal to the Number of Shares to be Delivered for such Component to the account specified by Counterparty and cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component.
Number of Shares to be Delivered:	For any Component, subject to the last sentence of Section 9.5 of the Equity Definitions, the product of (i) the product of the Number of Options for such Component and the Strike Price Differential divided by the Settlement Price on the Expiration Date for such Component and (ii) one minus the Cash Percentage.
Cash Settlement:
Cash Settlement Payment Date:	The Cash Settlement Payment Date shall be the third Scheduled Trading Day after the Expiration Date for each Component.
Cash Settlement:	If Cash Settlement applies, on the relevant Cash Settlement Payment Date for such Component, Dealer shall pay to Counterparty an amount equal to the Option Cash Settlement Amount for such Component to the account specified by Counterparty.
Combination Settlement:
Combination Settlement:	If Combination Settlement applies, on the Settlement Date for each Component, Dealer shall deliver to Counterparty: (i) an amount in

5

	cash equal to the product of the Option Cash Settlement Amount and the Cash Percentage (as defined below) and (ii) the Number of Shares to be Delivered, and (y) cash in lieu of any fractional shares for such Component valued at the Settlement Price on the Expiration Date for such Component, in each case, to the account(s) specified by Counterparty.
Cash Percentage:	The percentage to be specified by Counterparty in the notice delivered by Counterparty to Dealer pursuant to Section 7.1 of the Equity Definitions, which percentage shall equal (x) the amount of cash a holder of USD1,000 principal amount of Convertible Notes would receive upon conversion under the Indenture minus USD1,000 divided by (y) the cash value of the “settlement amount” (calculated using the “daily VWAP”) (each as defined in the Indenture) minus USD1,000. If Net Share Settlement applies, the Cash Percentage shall be deemed to be zero.
Other Applicable Provisions:	To the extent Dealer is obligated to deliver Shares hereunder, the provisions of Sections 9.1(c), 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the Issuer of the Shares) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction.
Restricted Certificated Shares:	Notwithstanding anything to the contrary in the Equity Definitions, Dealer may, in whole or in part, deliver Shares required to be delivered to Counterparty hereunder in certificated form in lieu of delivery through the Clearance System. With respect to such certificated Shares, the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by deleting the remainder of the provision after the word “encumbrance” in the fourth line thereof.
Share Adjustments:
Method of Adjustment:	Calculation Agent Adjustment; provided that the Equity Definitions shall be amended by adding the words “or the Transaction” after the words “theoretical value of the relevant Shares” in Section 11.2(a), 11.2(c) and 11.2(e)(vii); provided, further that adjustments may be made to account for changes in volatility, expected dividends, stock loan rate and liquidity relative to the relevant Shares.
Dividends:	If at any time prior to final settlement of the Transaction, (i) Counterparty alters the amount per Share or frequency of its Ordinary Dividend Amount on the Shares or (ii) Counterparty declares any dividend other than an Ordinary Dividend Amount on the Shares, then the Calculation Agent will make such adjustments as it in good faith determines appropriate to account for the economic effect on the Transaction thereof.
Ordinary Dividend Amount:	USD0.00

6

Extraordinary Events:
New Shares:	In the definition of “New Shares” in Section 12.1(i) of the Equity Definitions, the text in subsection (i) shall be deleted in its entirety and replaced with: “publicly quoted, traded or listed on any of the New York Stock Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or their respective successors)”.
Merger Events:	Applicable
Consequences of Merger Events:
(a)    Share-for-Share:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price; provided, further, that if, with respect to a Merger Event, the consideration for the Shares includes (or, at the option of a holder of Shares, may include) shares (or depositary receipts with respect to shares) of an entity or person not organized under the laws of the United States, any State thereof or the District of Columbia, Cancellation and Payment (Calculation Agent Determination) shall apply.
(b)    Share-for-Other:	Cancellation and Payment (Calculation Agent Determination)
(c)    Share-for-Combined:	Component Adjustment
Tender Offer:	Applicable
Consequences of all Tender Offers:	Modified Calculation Agent Adjustment; provided however, the Cap Price shall not be adjusted so that it is less than the Strike Price.
Announcement Event:	If an Announcement Event has occurred, the Calculation Agent shall have the right to determine the economic effect of the Announcement Event on the theoretical value of the Transaction (including without limitation any change in volatility, stock loan rate or liquidity relevant to the Shares or to the Transaction) (i) at a time that it deems appropriate, from the Announcement Date to the date of such determination (a “Determination Date”), and (ii) on the earlier to occur of (x) the relevant Merger Date or Tender Offer Date, as the case may be, and (y) a date on which a payment amount is determined pursuant to Sections 12.7 or 12.8 of the Equity Definitions (such earlier date, a “Final Determination Date”), from the Announcement Date or the Determination Date, as applicable, to such Final Determination Date. If any such economic effect is deemed to be material in the Calculation Agent’s sole but commercially reasonable discretion, the Calculation Agent may adjust the terms of the Transaction to reflect such economic effect. “Announcement Event” shall mean the occurrence of an Announcement Date (as defined below).
Announcement Date:	The definition of “Announcement Date” in Section 12.1(l) of the Equity Definitions shall be amended by (i) replacing the word “leads to the” in the third and the fifth lines thereof with the words “, if completed, would lead to a”, (ii) replacing the words “voting shares” in the fifth line thereof with the word “Shares”, (iii) inserting the words “by an entity with direct knowledge” after the word “announcement” in the second and the fourth lines thereof, (iv) inserting the words “or to explore the possibility of engaging in” after the words “engage in” in the second line thereto, (v) inserting the words “or to explore the possibility of purchasing or otherwise obtaining” after the word “obtain” in the fourth line thereto, (vi) deleting the parenthetical in the third and the fifth line

7

	thereof, (vii) adding immediately after the words “Merger Event” in the third line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention)” and (viii) adding immediately after the words “Tender Offer” in the fifth line thereof “, and any publicly announced change or amendment to such an announcement (including the announcement of an abandonment of such intention).”
Nationalization, Insolvency or Delisting:	Cancellation and Payment (Calculation Agent Determination); provided that, in addition to the provisions of Section 12.6(a)(iii) of the Equity Definitions, it shall also constitute a Delisting if the Exchange is located in the United States and the Shares are not immediately re-listed, re-traded or re-quoted on any of the New York Stock Exchange, The NASDAQ Global Select Market or The NASDAQ Global Market (or any of their respective successors); if the Shares are immediately re-listed, re-traded or re-quoted on any such exchange or quotation system, such exchange or quotation system shall thereafter be deemed to be the Exchange.
Additional Disruption Events:
(a)    Change in Law:	Applicable; provided that any determination as to whether (i) the adoption of or any change in any applicable law or regulation (including, without limitation, any tax law) or (ii) the promulgation of or any change in or public announcement of the formal or informal interpretation by any court, tribunal or regulatory authority with competent jurisdiction of any applicable law or regulation (including any action taken by a taxing authority), in each case, constitutes a “Change in Law” shall be made without regard to Section 739 of the Wall Street Transparency and Accountability Act of 2010 or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the Trade Date; provided, further, that Section 12.9(a)(ii)(B) of the Equity Definitions is hereby amended by (i) inserting the words “or Hedge Positions” after the word “Shares” in clause (X) thereof, (ii) replacing the phrase “the interpretation” in the third line thereof with the phrase “or announcement or statement of the formal or informal interpretation” and (iii) immediately following the word “Transaction” in clause (X) thereof, adding the phrase “in the manner contemplated in good faith by Hedging Party on the Trade Date”.
(b)    Failure to Deliver:	Applicable
(c)    Insolvency Filing:	Applicable
(d)    Hedging Disruption:	Applicable; provided that Section 12.9(a)(v) of the Equity Definitions is hereby modified by inserting the following two phrases at the end of such Section:
	“For the avoidance of doubt, the term “equity price risk” shall be deemed to include, but shall not be limited to, stock price and volatility risk. And, for the further avoidance of doubt, any such transactions or assets referred to in phrases (A) or (B) above must be available on commercially reasonable pricing terms.”

8

(e)    Increased Cost of Hedging:	Applicable
(f)     Loss of Stock Borrow:	Not Applicable
(g)    Increased Cost of Stock Borrow:	Not Applicable
Hedging Party:	For all applicable Additional Disruption Events, Dealer
Determining Party:	For all applicable Extraordinary Events, Dealer
Non-Reliance:	Applicable
Agreements and Acknowledgments
Regarding Hedging Activities:	Applicable
Additional Acknowledgments:	Applicable
3.      Calculation Agent:	Dealer
4.      Account Details:
Dealer Payment Instructions:
Chase Manhattan Bank New York
For A/C Goldman, Sachs & Co.
A/C #930-1-011483
ABA: 021-000021

Counterparty Payment / Share Delivery Instructions: To be provided by Counterparty.

5.      Offices:

The Office of Dealer for the Transaction is: 200 West Street, New York, NY 10282-2198

The Office of Counterparty for the Transaction is: Not applicable. Counterparty is not a Multibranch Party.

6.      Notices: For purposes of this Confirmation:

Address for notices or communications to Counterparty:

To:	Human Genome Sciences, Inc.
	14200 Shady Grove Road
	Rockville, Maryland 20850-7464
Attn:	James H. Davis
Telephone:	301-309-8504
Email:	Jim_Davis@hgsi.com
Address for notices or communications to Dealer:
To:	Goldman, Sachs & Co.
	200 West Street
	New York, NY 10282-2198
Attn:	Serge Marquié,
	Equity Capital Markets
Telephone:	212-902-9779
Facsimile:	917-977-4253
Email:	marqse@am.ibd.gs.com

9

With a copy to:
Attn:	Michael Voris
	Equity Capital Markets
Telephone:	212-902-4895
Facsimile:	212- 291 5027
Email:	michael.voris@gs.com
And email notification to the following address:
Eq-derivs-notifications@am.ibd.gs.com

7. Representations, Warranties and Agreements:

(a) In addition to the representations, warranties and agreements in the Agreement and those contained elsewhere herein, Counterparty represents and warrants to and for the benefit of, and agrees with, Dealer as follows:

(i) On the Trade Date, on any Settlement Method Election Date and as of the date of any election by Counterparty of the Share Termination Alternative under (and as defined in) Section 8(a) below, (A) none of Counterparty and its officers and directors is aware of any material nonpublic information regarding Counterparty or the Shares and (B) all reports and other documents filed by Counterparty with the Securities and Exchange Commission pursuant to the Exchange Act when considered as a whole (with the more recent such reports and documents deemed to amend inconsistent statements contained in any earlier such reports and documents), do not contain any untrue statement of a material fact or any omission of a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances in which they were made, not misleading.

(ii) During the period starting on the Trade Date and ending on the day Dealer fully establishes its initial Hedge Positions with respect to the Transactions (the “Initial Hedge Period”), and during the period starting on the first Expiration Date and ending on the last Expiration Date (the “Settlement Period”) the Shares or any securities that are convertible into, or exchangeable or exercisable for Shares shall not be subject to a “restricted period,” as such term is defined in Regulation M under the Exchange Act (“Regulation M”) and (B) Counterparty shall not engage in any “distribution,” as such term is defined in Regulation M, other than the distribution of the Convertible Notes or a distribution meeting the requirements of the exceptions set forth in sections 101(b)(10) and 102(b)(7) of Regulation M, until the second Exchange Business Day immediately following the Initial Hedge Period or the relevant Settlement Period, as applicable.

(iii) On the Trade Date and during the Initial Hedge Period and during the Settlement Period, neither Counterparty nor any “affiliate” or “affiliated purchaser” (each as defined in Rule 10b-18 under the Exchange Act (“Rule 10b-18”)) shall directly or indirectly (including, without limitation, by means of any cash-settled or other derivative instrument) purchase, offer to purchase, place any bid or limit order that would effect a purchase of, or commence any tender offer relating to, any Shares (or an equivalent interest, including a unit of beneficial interest in a trust or limited partnership or a depository share) or any security convertible into or exchangeable or exercisable for Shares (including, without limitation, any Rule 10b-18 purchases of blocks (as defined in Rule 10b-18)). Counterparty represents and warrants that neither it nor any affiliated purchaser has made any purchases of blocks pursuant to the proviso in Rule 10b-18(b)(4) during the four full calendar weeks immediately preceding the start of the Initial Hedge Period.

(iv) Without limiting the generality of Section 13.1 of the Equity Definitions, Counterparty acknowledges that neither Dealer nor any of its affiliates is making any representations or warranties or taking any position or expressing any view with respect to the treatment of the Transaction under any accounting standards including ASC Topic 260, Earnings Per Share, ASC Topic 815, Derivatives and Hedging, ASC Topic 480, Distinguishing Liabilities from Equity and ASC 815-40, Derivatives and Hedging – Contracts in Entity’s Own Equity (or any successor issue statements) or under FASB’s Liabilities & Equity Project.

10

(v) Without limiting the generality of Section 3(a)(iii) of the Agreement, the Transaction will not violate Rule 13e-1 or Rule 13e-4 under the Exchange Act.

(vi) Prior to the Trade Date, Counterparty shall deliver to Dealer a resolution of Counterparty’s board of directors or a duly authorized committee thereof authorizing the Transaction and such other certificate or certificates as Dealer shall reasonably request.

(vii) Counterparty represents (A) on the Trade Date and (B) on the date of any election by Counterparty of the Share Termination Alternative under Section 8(a) below, that it is not entering into this Transaction or making such election to create actual or apparent trading activity in the Shares (or any security convertible into or exchangeable for Shares) or to raise or depress or otherwise manipulate the price of the Shares (or any security convertible into or exchangeable for Shares) or otherwise in violation of the Exchange Act.

(viii) Counterparty is not, and after giving effect to the transactions contemplated hereby will not be, required to register as an “investment company” as such term is defined in the Investment Company Act of 1940, as amended.

(ix) On each of the Trade Date and the Premium Payment Date, Counterparty is not, or will not be, “insolvent” (as such term is defined under Section 101(32) of the U.S. Bankruptcy Code (Title 11 of the United States Code) (the “Bankruptcy Code”)) and Counterparty would be able to purchase a number of Shares equal to the Number of Shares hereunder in compliance with the laws of the jurisdiction of its incorporation.

(x) No state or local (including non-U.S. jurisdictions) law, rule, regulation or regulatory order (other than state insurance holding company laws) applicable to the Shares would give rise to any reporting, consent, registration or other requirement (including without limitation a requirement to obtain prior approval from any person or entity) as a result of Dealer or its affiliates owning or holding (however defined) Shares.

(xi) The representations and warranties of Counterparty set forth in Section 3 of the Agreement and Section 1 of the Underwriting Agreement dated November 2, 2011 between Counterparty and Morgan Stanley & Co. LLC and Credit Suisse Securities (USA) LLC (the “Underwriting Agreement”) are true and correct and are hereby deemed to be repeated to Dealer as if set forth herein.

(xii) Counterparty understands no obligations of Dealer to it hereunder will be entitled to the benefit of deposit insurance and that such obligations will not be guaranteed by any affiliate of Dealer or any governmental agency.

(b) During the Settlement Period, Counterparty shall (i) notify Dealer prior to the opening of trading in the Shares on any day on which Counterparty makes, or expects to be made, any public announcement (as defined in Rule 165(f) under the Securities Act of 1933, as amended (the “Securities Act”)) of any merger, acquisition, or similar transaction involving a recapitalization relating to Counterparty (other than any such transaction in which the consideration consists solely of cash and there is no valuation period), (ii) promptly notify Dealer following any such announcement that such announcement has been made, and (iii) promptly deliver to Dealer following the making of any such announcement a certificate indicating (A) Counterparty’s average daily Rule 10b-18 purchases (as defined in Rule 10b-18) during the three full calendar months preceding the date of the announcement of such transaction and (B) Counterparty’s block purchases (as defined in Rule 10b-18) effected pursuant to paragraph (b)(4) of Rule 10b-18 during the three full calendar months preceding the date of the announcement of such transaction. In addition, Counterparty shall promptly notify Dealer of the earlier to occur of the completion of such transaction and the completion of the vote by target stockholders. Counterparty acknowledges that any such public announcement may cause Dealer to elect to treat one or more Scheduled Trading Days as Disrupted Days pursuant to the provisions of “Regulatory Disruption” above. Accordingly, Counterparty acknowledges that its actions in relation to any such announcement or transaction must comply with the standards set forth in subclause (c) immediately below.

11

(c) Counterparty shall not enter into or alter any hedging transaction relating to the Shares corresponding to or offsetting the Transaction. Counterparty also acknowledges and agrees that any amendment, modification, waiver or termination of this Confirmation or the Agreement must be effected in accordance with the requirements for the amendment or termination of a “plan” as defined in Rule 10b5-1(c) under the Exchange Act. Without limiting the generality of the foregoing, any such amendment, modification, waiver or termination shall be made in good faith and not as part of a plan or scheme to evade the prohibitions of Rule 10b-5 under the Exchange Act.

(d) Each of Dealer and Counterparty agrees and represents that it is an “eligible contract participant” as defined in Section 1a(12) of the U.S. Commodity Exchange Act, as amended, and is entering into the Transaction as principal (and not as agent or in any other capacity, fiduciary or otherwise) and not for the benefit of any third party.

(e) Each of Dealer and Counterparty acknowledges that the offer and sale of the Transaction to it is intended to be exempt from registration under the Securities Act by virtue of Section 4(2) thereof. Accordingly, Counterparty represents and warrants to Dealer and Dealer represents to Counterparty that (i) it has the financial ability to bear the economic risk of its investment in the Transaction and is able to bear a total loss of its investment and its investments in and liabilities in respect of the Transaction, which it understands are not readily marketable, are not disproportionate to its net worth, (ii) it is an “accredited investor” as that term is defined in Regulation D as promulgated under the Securities Act, (iii) it is entering into the Transaction for its own account and without a view to the distribution or resale thereof, (iv) the assignment, transfer or other disposition of the Transaction has not been and will not be registered under the Securities Act and is restricted under this Confirmation, the Securities Act and state securities laws and (v) its financial condition is such that it has no need for liquidity with respect to its investment in the Transaction and no need to dispose of any portion thereof to satisfy any existing or contemplated undertaking or indebtedness and is capable of assessing the merits of and understanding (on its own behalf or through independent professional advice), and understands and accepts, the terms, conditions and risks of the Transaction.

(f) Each of Dealer and Counterparty agrees and acknowledges that Dealer is a “financial institution,” “swap participant” and “financial participant” within the meaning of Sections 101(22), 101(53C) and 101(22A) of the Bankruptcy Code. The parties hereto further agree and acknowledge that it is the intent of the parties (A) that this Confirmation is (i) a “securities contract,” as such term is defined in Section 741(7) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “settlement payment,” within the meaning of Section 546 of the Bankruptcy Code, and (ii) a “swap agreement,” as such term is defined in Section 101(53B) of the Bankruptcy Code, with respect to which each payment and delivery hereunder or in connection herewith is a “termination value,” “payment amount,” or “other transfer obligation” within the meaning of Section 362 of the Bankruptcy Code and a “transfer,” as such term is defined in Section 101(54) of the Bankruptcy Code and a “payment or other transfer of property” within the meaning of Sections 362 and 546 of the Bankruptcy Code, and (B) that Dealer is entitled to the protections afforded by, among other sections, Sections 362(b)(6), 362(b)(17), 362(o),546(e), 546(g), 548(d)(2), 555, 560 and 561 of the Bankruptcy Code.

(g) Counterparty shall deliver to Dealer an opinion of counsel, dated as of the Effective Date and reasonably acceptable to Dealer in form and substance, with respect to the matters set forth in Section 3(a) of the Agreement.

(h) Counterparty hereby agrees and acknowledges that the Transaction has not been registered with the Securities and Exchange Commission or any state securities commission and that the Options are being written by Dealer to Counterparty in reliance upon exemptions from any such registration requirements. Counterparty acknowledges that all Options acquired from Dealer will be acquired for investment purposes only and not for the purpose of resale or other transfer except in compliance with the requirements of the Securities Act. Counterparty will not sell or otherwise transfer any Option or any interest therein except in compliance with the requirements of the Securities Act and any subsequent offer or sale of the Options will be solely for Counterparty’s account and not as part of a distribution that would be in violation of the Securities Act.

12

(i) Each party acknowledges and agrees to be bound by the Conduct Rules of the Financial Industry Regulatory Authority, Inc. applicable to transactions in options, and further agrees not to violate the position and exercise limits set forth therein.

8. Other Provisions:

(a) Alternative Calculations and Payment on Early Termination and on Certain Extraordinary Events. If (i) Dealer shall owe Counterparty, or (ii) Counterparty shall owe Dealer, any amount pursuant to Section 12.2 of the Equity Definitions and “Consequences of Merger Events” above, or Sections 12.3, 12.6, 12.7 or 12.9 of the Equity Definitions (except in the event of a Tender Offer or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash) or pursuant to Section 6(d)(ii) of the Agreement (except in the event of an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, that resulted from an event or events within Counterparty’s control) (in the case of (i) or (ii), a “Payment Obligation”), Counterparty shall have the right, in its sole discretion, to (i) require Dealer to satisfy any such Payment Obligation by the Share Termination Alternative (as defined below), or (ii) elect to settle any Payment Obligation owed by Counterparty by the Share Termination Alternative (as defined below), by giving irrevocable telephonic notice to Dealer, confirmed in writing within one Scheduled Trading Day, no later than 9:30 A.M. New York City time on the Merger Date, Tender Offer Date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable (“Notice of Share Termination”); provided that if Counterparty does not elect to require Dealer to satisfy its Payment Obligation by the Share Termination Alternative, Dealer shall have the right, in its good faith and reasonable discretion, to elect to satisfy its Payment Obligation by the Share Termination Alternative, notwithstanding Counterparty’s failure to elect or election to the contrary; and provided further that Counterparty shall not have the right to so elect (but, for the avoidance of doubt, Dealer shall have the right to so elect) in the event of (i) an Insolvency, a Nationalization or a Merger Event, in each case, in which the consideration or proceeds to be paid to holders of Shares consists solely of cash or (ii) an Event of Default in which Counterparty is the Defaulting Party or a Termination Event in which Counterparty is the Affected Party, which Event of Default or Termination Event resulted from an event or events within Counterparty’s control. Upon such Notice of Share Termination, the following provisions shall apply on the Scheduled Trading Day immediately following the relevant merger date, Announcement Date, Early Termination Date or date of cancellation or termination in respect of an Extraordinary Event, as applicable:

Share Termination Alternative:	Applicable and means that Dealer shall deliver to Counterparty the Share Termination Delivery Property on the date on which the Payment Obligation would otherwise be due pursuant to “Consequences of Merger Events” above, Section 12.7 or 12.9 of the Equity Definitions or Section 6(d)(ii) of the Agreement, as applicable, or such later date as the Calculation Agent may reasonably determine (the “Share Termination Payment Date”), in satisfaction of the Payment Obligation.
Share Termination Delivery
Property:	A number of Share Termination Delivery Units, as calculated by the Calculation Agent, equal to the Payment Obligation divided by the Share Termination Unit Price. The Calculation Agent shall adjust the Share Termination Delivery Property by replacing any fractional portion of the aggregate amount of a security therein with an amount of cash equal to the value of such fractional security based on the values used to calculate the Share Termination Unit Price.
Share Termination Unit Price:	The value of property contained in one Share Termination Delivery Unit on the date such Share Termination Delivery Units are to be delivered as Share Termination Delivery Property, as determined by the Calculation Agent in its good faith discretion by commercially reasonable means and notified by the Calculation Agent to Dealer at the time of notification of the Payment Obligation.

13

Share Termination Delivery Unit:	In the case of a Termination Event, Event of Default, Delisting or Additional Disruption Event, one Share or, in the case of an Insolvency, Nationalization, Merger Event or Tender Offer, one Share or a unit consisting of the number or amount of each type of property received by a holder of one Share (without consideration of any requirement to pay cash or other consideration in lieu of fractional amounts of any securities) in such Insolvency, Nationalization, Merger Event or Tender Offer, as applicable. If such Insolvency, Nationalization, Merger Event or Tender Offer involves a choice of consideration to be received by holders, such holder shall be deemed to have elected to receive the maximum possible amount of cash.
Failure to Deliver:	Applicable
Other applicable provisions:	If Share Termination Alternative is applicable, the provisions of Sections 9.8, 9.9, 9.10, 9.11 (except that the Representation and Agreement contained in Section 9.11 of the Equity Definitions shall be modified by excluding any representations therein relating to restrictions, obligations, limitations or requirements under applicable securities laws arising as a result of the fact that Counterparty is the issuer of the Shares or any portion of the Share Termination Delivery Units) and 9.12 of the Equity Definitions will be applicable as if “Physical Settlement” applied to the Transaction, except that all references to “Shares” shall be read as references to “Share Termination Delivery Units.”

(b) Disposition of Hedge Shares. Counterparty hereby agrees that if, in the reasonable judgment of Dealer, any Shares (the “Hedge Shares”) acquired by Dealer for the purpose of hedging its obligations pursuant to the Transaction cannot be sold in the public market by Dealer without registration under the Securities Act, Counterparty shall, at its election: (i) in order to allow Dealer to sell the Hedge Shares in a registered offering, make available to Dealer an effective registration statement under the Securities Act to cover the resale of such Hedge Shares and (A) enter into an agreement, in form and substance reasonably satisfactory to Dealer and the Counterparty, substantially in the form of an underwriting agreement for a registered offering, (B) provide accountant’s “comfort” letters in customary form for registered offerings of equity securities, (C) provide disclosure opinions of nationally recognized outside counsel to Counterparty reasonably acceptable to Dealer, (D) provide other customary opinions, certificates and closing documents customary in form for registered offerings of equity securities and (E) afford Dealer a reasonable opportunity to conduct a “due diligence” investigation with respect to Counterparty customary in scope for underwritten offerings of equity securities; provided, however, that if Dealer, in its good faith reasonable discretion, is not satisfied with access to due diligence materials, the results of its due diligence investigation, or the procedures and documentation for the registered offering referred to above, then clause (ii) or clause (iii) of this Section 8(b) shall apply at the election of Counterparty; (ii) in order to allow Dealer to sell the Hedge Shares in a private placement, enter into a private placement agreement substantially similar to private placement purchase agreements customary for private placements of equity offerings of similar size, securities, in form and substance reasonably satisfactory to Dealer and Counterparty, including customary representations, covenants, blue sky and other governmental filings and/or registrations, indemnities to Dealer, due diligence rights (for Dealer or any designated buyer of the Hedge Shares from Dealer), opinions and certificates and such other documentation as is customary for private placements agreements, equity offerings of similar size all reasonably acceptable to Dealer (in which case, the Calculation Agent shall make any adjustments to the terms of the Transaction that are necessary, in its reasonable judgment, to compensate Dealer for any discount from the public market price of the Shares incurred on the sale of Hedge Shares in a private placement); or (iii) purchase the Hedge Shares from Dealer at the VWAP Price on such Exchange Business Days, and in the amounts, requested by Dealer. “VWAP Price” means, on any Exchange Business Day, the per Share volume-weighted average price as displayed under the heading “Bloomberg VWAP” on Bloomberg page HGSI <equity> VAP (or any successor thereto) in respect of the period from 9:30 a.m. to 4:00 p.m. (New York City time) on such Exchange Business Day (or if such volume-weighted average price is unavailable or is manifestly incorrect, the market value of one Share on such Exchange Business Day, as determined by the Calculation Agent using a volume-weighted method). This

14

Section 8(b) shall survive the termination, expiration or early unwind of the Transaction. For the avoidance of doubt, unless Counterparty elects to purchase the Hedge Shares pursuant to clause (iii) of this paragraph (c), nothing in this Confirmation shall be interpreted as requiring Counterparty to repurchase Hedge Shares or otherwise to pay any amount of cash to Dealer pursuant to this paragraph (c) and under no circumstances shall Counterparty be required to repurchase Hedge Shares or otherwise to pay any cash to Dealer pursuant to this paragraph (c), other than any cash payment required by an underwriting agreement entered into pursuant to clause (i)(A) or a private placement agreement entered into pursuant to clause (ii).

(c) Amendment to Equity Definitions. (i) The following amendment shall be made to the Equity Definitions:

Section 12.6(a)(ii) of the Equity Definitions is hereby amended by (1) deleting from the fourth line thereof the word “or” after the word “official” and inserting a comma therefor, and (2) deleting the semi-colon at the end of subsection (B) thereof and inserting the following words therefor “or (C) at Dealer’s option, the occurrence of any of the events specified in Section 5(a)(vii) (1) through (9) of the ISDA Master Agreement with respect to that Issuer, provided however that any reference to 15 days in Section 5(a)(vii), shall instead be a reference to 60 days.

(ii) Solely for purposes of applying the Equity Definitions and for purposes of this Confirmation, any reference in the Equity Definitions to a Strike Price shall be deemed to be a reference to either of the Strike Price or the Cap Price, or both, as appropriate.

(d) Repurchase Notices. Counterparty shall, at least five Scheduled Trading Days prior to effecting any repurchase of Shares or consummating or otherwise executing or engaging in any transaction or event that would lead to an increase in the Conversion Rate (as such term is defined in the Indenture) (a “Conversion Rate Adjustment Event”), give Dealer a written notice of such repurchase or Conversion Rate Adjustment Event (a “Repurchase Notice”) if, following such repurchase or Conversion Rate Adjustment Event, the Notice Percentage as determined on the date of such Repurchase Notice is (i) greater than 8.0% and (ii) greater by 0.5% than the Notice Percentage included in the immediately preceding Repurchase Notice (or, in the case of the first such Repurchase Notice, greater than 8.0%). The “Notice Percentage” as of any day is the fraction (A) the numerator of which is the aggregate of the Number of Shares for all Components under the Transaction and the number of Shares underlying any other capped call transactions between Counterparty and Dealer and (B) the denominator of which is the number of Shares outstanding on such day. In the event that Counterparty fails to provide Dealer with a Repurchase Notice on the day and in the manner specified in this Section 8(d) then Counterparty agrees to indemnify and hold harmless Dealer, its affiliates and their respective directors, officers, employees, agents and controlling persons (Dealer and each such person being an “Indemnified Party”) from and against any and all losses (including losses relating to Dealer’s hedging activities as a consequence of becoming, or of the risk of becoming, a Section 16 “insider,” including without limitation any forbearance from hedging activities or cessation of hedging activities and any losses in connection therewith with respect to the Transaction), claims, damages and liabilities (or actions in respect thereof), joint or several, to which such Indemnified Party may become subject under applicable securities laws, including without limitation, Section 16 of the Exchange Act relating to or arising out of such failure. If for any reason the foregoing indemnification is unavailable to any Indemnified Party or insufficient to hold harmless any Indemnified Party, then Counterparty shall contribute, to the maximum extent permitted by law, to the amount paid or payable by the Indemnified Party as a result of such loss, claim, damage or liability. In addition, Counterparty will reimburse any Indemnified Party for all expenses (including reasonable counsel fees and expenses) as they are incurred (after notice to Counterparty) in connection with the investigation of, preparation for or defense or settlement of any pending or threatened claim or any action, suit or proceeding arising therefrom, whether or not such Indemnified Party is a party thereto and whether or not such claim, action, suit or proceeding is initiated or brought by or on behalf of Counterparty. This indemnity shall survive the completion of the Transaction contemplated by this Confirmation and any assignment and delegation of the Transaction made pursuant to this Confirmation or the Agreement shall inure to the benefit of any permitted assignee of Dealer.

(e) Transfer and Assignment. Either party may transfer any of its rights or obligations under the Transaction with the prior written consent of the non-transferring party, such consent not to be unreasonably withheld or delayed; provided that notwithstanding any provision of the Agreement to the contrary, Dealer may, subject to applicable law, freely transfer and assign all of its rights and obligations under the Transaction

15

without the consent of Counterparty to any affiliate of Dealer of equal or better credit rating than Dealer or affiliate of Dealer whose obligations are guaranteed by the parent or holding company of Dealer, provided further that (I) if (x) Counterparty has not consented to a transfer proposed by Dealer that requires Counterparty’s consent as determined by Dealer, and (y) Dealer determines, in its commercially reasonable discretion, that such transfer would be reasonably necessary or prudent to (i) preserve Dealer’s hedging or hedge unwind activity (or anticipated hedging or hedge unwind activity) hereunder in light of existing liquidity conditions in the cash market or any other relevant market, (ii) to enable Dealer to effect transactions in Shares or cash-settled swaps in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is in compliance with applicable laws, regulations, policies and procedures applicable to Dealer or (iii) to avoid an Excess Ownership Position, or (II) if (x) any Excess Ownership Position exists and (y) Dealer, in its discretion, is unable to effect a transfer or assignment to a third party in accordance with the requirements set forth above after using its commercially reasonable efforts on pricing terms and within a time period reasonably acceptable to Dealer such that an Excess Ownership Position no longer exists, then in each case Dealer may designate a Scheduled Trading Day as an Early Termination Date with respect to all or a portion (the “Terminated Portion”) of the Transaction. In the event that Dealer so designates an Early Termination Date, a payment or delivery shall be made pursuant to Section 6 of the Agreement and/or Section 8(b) of this Confirmation as if (i) an Early Termination Date had been designated in respect of a Transaction having terms identical to the Terminated Portion of the Transaction, (ii) Counterparty shall be the sole Affected Party with respect to such partial termination and (iii) such portion of the Transaction shall be the only Terminated Transaction. “Excess Ownership Position” means any of the following: (i) the Equity Percentage exceeds 4.0%, (ii) Dealer or any “affiliate” or “associate” of Dealer would own in excess of 8.0% of the outstanding Shares for purposes of Section 203 of the Delaware General Corporation Law, (iii) Dealer or any affiliate thereof owns, directly or indirectly, in excess of 4.0% of the outstanding Shares for purposes of Section 382 of the Internal Revenue Code of 1986, as determined in accordance with Treasury Regulation Section 1.382-2T(g), (h), (j) and (k) (or any successor provisions), including any ownership by application of constructive ownership rules, or (iv) Dealer, Dealer Group (as defined below) or any person whose ownership position would be aggregated with that of Dealer or Dealer Group (Dealer, Dealer Group or any such person, a “Dealer Person”) under any federal, state or local laws, regulations or regulatory orders applicable to ownership of Shares (“Applicable Laws”), owns, beneficially owns, constructively owns, controls, holds the power to vote or otherwise meets a relevant definition of ownership in excess of a number of Shares equal to (x) the number of Shares that would give rise to reporting or registration obligations or other requirements (including obtaining prior approval by a state or federal regulator) of a Dealer Person under Applicable Laws and with respect to which such requirements have not been met or the relevant approval has not been received or that would give rise to any consequences adverse to Dealer (including that any transfer of Shares or any distribution of dividends to Dealer or any of its affiliates would be prohibited or void) under the constitutive documents of Counterparty or any contract or agreement to which Counterparty is a party, in each case minus (y) 1% of the number of Shares outstanding on the date of determination. The “Equity Percentage” as of any day is the fraction, expressed as a percentage, (A) the numerator of which is the number of Shares that Dealer and any of its affiliates or any other person subject to aggregation with Dealer, for purposes of the “beneficial ownership” test under Section 13 of the Exchange Act, or of any “group” (within the meaning of Section 13) of which Dealer is or may be deemed to be a part (Dealer and any such affiliates, persons and groups, collectively, “Dealer Group”), beneficially owns (within the meaning of Section 13 of the Exchange Act), without duplication, on such day and (B) the denominator of which is the number of Shares outstanding on such day. In the case of a transfer or assignment by Counterparty of its rights and obligations hereunder and under the Agreement, in whole or in part (any such Options so transferred or assigned, the “Transfer Options”), to any party, withholding of such consent by Dealer shall not be considered unreasonable if such transfer or assignment does not meet the reasonable conditions that Dealer may impose including, but not limited to, the following conditions:

(A) With respect to any Transfer Options, Counterparty shall not be released from its notice and indemnification obligations pursuant to Section 8(d) of this Confirmation or any obligations under Section 2 (regarding Extraordinary Events) or 8(b) of this Confirmation;

(B) Any Transfer Options shall only be transferred or assigned to a third party that is a U.S. person (as defined in the Internal Revenue Code of 1986, as amended);

16

(C) Such transfer or assignment shall be effected on terms, including any reasonable undertakings by such third party (including, but not limited to, undertakings with respect to compliance with applicable securities laws in a manner that, in the reasonable judgment of Dealer, will not expose Dealer to material risks under applicable securities laws) and execution of any documentation and delivery of legal opinions with respect to securities laws and other matters by such third party and Counterparty as are requested and reasonably satisfactory to Dealer;

(D) Neither Dealer nor Counterparty will, as a result of such transfer and assignment, be required to pay the transferee an amount under Section 2(d)(i)(4) of the Agreement greater than an amount that such party would have been required to pay in the absence of such transfer and assignment;

(E) An Event of Default, Potential Event of Default or Termination Event shall not occur as a result of such transfer and assignment; and

(F) Without limiting the generality of clause (B), Counterparty shall have caused the transferee to make such Payee Tax Representations and to provide such tax documentation as may be reasonably requested by Dealer to permit Dealer to determine that results described in clauses (D) and (E) will not occur upon or after such transfer and assignment.

(f) Staggered Settlement. (A) Upon a Settlement Method Election, if Dealer is required to deliver any Shares upon settlement, or (B) if Dealer is required, or elects, to satisfy any Payment Obligation by the Share Termination Alternative, then, in either case, Dealer may elect, on one or more occasions, to deliver to Counterparty all or any portion of the Shares or Share Termination Delivery Units, as the case may be, that Dealer would otherwise be required to deliver on the relevant Settlement Date or Share Termination Payment Date (each, a “Nominal Settlement Date”) on a date (an “Early Settlement Date”) prior to such Nominal Settlement Date, provided that:

(i) Dealer must deliver written notice to Counterparty at least three Business Days prior to such Early Settlement Date, specifying (x) such Early Settlement Date, and (y) the number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty on such Early Settlement Date; and

(ii) the aggregate number of Shares or Share Termination Delivery Units that Dealer will deliver to Counterparty hereunder on all such Early Settlement Dates and the Nominal Settlement Date shall not be less than the number of Shares or Share Termination Delivery Units that Dealer would otherwise have been required to deliver on such Nominal Settlement Date.

For the avoidance of doubt, any such delivery by Dealer of Shares or Share Termination Delivery Units will satisfy Dealer’s obligation to deliver the number of Shares or Share Termination Delivery Units so delivered on the relevant Nominal Settlement Date. If the number of Shares, or Share Termination Delivery Units, so delivered exceeds the number of Shares required to be delivered under the Transaction, Counterparty shall promptly return the excess number of Shares, or Share Termination Delivery Units to Dealer; provided that Dealer may by notice to Counterparty elect to receive such excess number of Shares or Share Termination Delivery Units on two or more dates over a commercially reasonable period of time; provided further that Counterparty may elect in its sole discretion, in lieu of returning such excess number of Shares or Share Termination Delivery Units, to pay to Dealer an amount of cash equal to the value of such Shares or Share Termination Delivery Units, as reasonably determined by the Calculation Agent based on the Settlement Price on the Expiration Date for the relevant Component.

(g) Right to Extend. Dealer, acting in good faith and in a commercially reasonable manner, may postpone any Exercise Date, Settlement Date or Cash Settlement Payment Date or any other date of valuation or delivery by Dealer, with respect to some or all of the relevant Options, if Dealer determines, in its reasonable discretion, that such extension is reasonably necessary or appropriate to (i) preserve Dealer’s or its affiliate’s hedging or hedge unwind activity hereunder in light of existing liquidity conditions in the cash market, the stock loan market or any other relevant market or (ii) to enable Dealer or its affiliate to effect purchases of Shares in connection with its hedging, hedge unwind or settlement activity hereunder in a manner that is or would, if Dealer or such affiliate were Counterparty or an affiliated purchaser of Counterparty, be in compliance with applicable legal, regulatory or self-regulatory requirements, or with related policies and procedures applicable to Dealer and/or such affiliate; provided, however, that Counterparty shall not be required to make any payment to Dealer on account of such extension.

17

(h) Cross-Default. It shall be an Event of Default under the Agreement with Counterparty as the Defaulting Party if Counterparty defaults (i) in any scheduled payment of principal of any indebtedness of Counterparty or of any of its subsidiaries, aggregating more than $25.0 million in principal amount, when due and payable after giving effect to any applicable grace period or (ii) in the performance of any other term or provision of any indebtedness of Counterparty or of any of its subsidiaries in excess of $25.0 million principal amount that results in such indebtedness becoming or being declared due and payable before the date on which it would otherwise become due and payable, and such acceleration is not rescinded or annulled, or such indebtedness is not discharged, within a period of five days after there has been given, by registered or certified mail, to Counterparty by Dealer, a written notice specifying such default or defaults and stating that such notice is a “Notice of Default” and referencing this Confirmation.

(i) Notice of Event of Default. Promptly upon becoming aware of any Event of Default or Potential Event of Default where Counterparty is or would be the Defaulting Party, Counterparty will notify Dealer, specifying the nature of such Event of Default or Potential Event of Default, and will give to Dealer such other information about such Event of Default or Potential Event of Default as Dealer may reasonably require.

(j) Adjustments. For the avoidance of doubt, whenever the Calculation Agent is called upon to make an adjustment pursuant to the terms of this Confirmation or the Definitions to take into account the effect of an event, the Calculation Agent shall make such adjustment by reference to the effect of such event on the Hedging Party, assuming that the Hedging Party maintains a commercially reasonable hedge position.

(k) Disclosure. Effective from the date of commencement of discussions concerning the Transaction, Counterparty and each of its employees, representatives, or other agents may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of the Transaction and all materials of any kind (including opinions or other tax analyses) that are provided to Counterparty relating to such tax treatment and tax structure.

(l) Designation by Dealer. Notwithstanding any other provision in this Confirmation to the contrary requiring or allowing Dealer to purchase, sell, receive or deliver any Shares or other securities to or from Counterparty, Dealer may designate any of its affiliates to purchase, sell, receive or deliver such Shares or other securities and otherwise to perform Dealer’s obligations in respect of the Transaction and any such designee may assume such obligations. Dealer shall not be discharged of any of its obligations to Counterparty except to the extent of actual full and final performance of its obligations to Counterparty by the designee.

(m) Set-off. The parties agree to amend Section 6 of the Agreement by replacing Section 6(f) in its entirety with the following:

“(f) Upon the occurrence of an Event of Default or Termination Event with respect to a party who is the Defaulting Party or the Affected Party (“X”), the other party (“Y”) will have the right (but not be obliged) without prior notice to X or any other person to set-off or apply any obligation of X under an Equity Contract owed to Y (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation) against any obligation of Y under an Equity Contract owed to X (whether or not matured or contingent and whether or not arising under the Agreement, and regardless of the currency, place of payment or booking office of the obligation). Y will give notice to the other party of any set-off effected under this Section 6(f).

“Equity Contract” shall mean for purposes of this Section 6(f) any transaction relating to Shares between X and Y that qualifies as ‘equity’ under applicable accounting rules.

Amounts (or the relevant portion of such amounts) subject to set-off may be converted by Y into the Termination Currency at the rate of exchange at which such party would be able, acting in a reasonable manner and in good faith, to purchase the relevant amount of such currency.

18

If any obligation is unascertained, Y may in good faith estimate that obligation and set-off in respect of the estimate, subject to the relevant party accounting to the other when the obligation is ascertained.

Nothing in this Section 6(f) shall be effective to create a charge or other security interest. This Section 6(f) shall be without prejudice and in addition to any right of set-off, combination of accounts, lien or other right to which any party is at any time otherwise entitled (whether by operation of law, contract or otherwise).”

(n) Equity Rights. Dealer acknowledges and agrees that this Confirmation is not intended to convey to it rights with respect to the Transaction that are senior to the claims of common stockholders in the event of Counterparty’s bankruptcy. For the avoidance of doubt, the parties agree that the preceding sentence shall not apply at any time other than during Counterparty’s bankruptcy to any claim arising as a result of a breach by Counterparty of any of its obligations under this Confirmation or the Agreement. For the avoidance of doubt, the parties acknowledge that this Confirmation is not secured by any collateral that would otherwise secure the obligations of Counterparty herein under or pursuant to any other agreement.

(o) Early Unwind. In the event the sale by Counterparty of the Convertible Notes is not consummated with the underwriters pursuant to the Underwriting Agreement for any reason by the close of business in New York on the Effective Date (or such later date as agreed upon by the parties, which in no event shall be later than November 17, 2011) (the Effective Date or such later date being the “Early Unwind Date”), the Transaction shall automatically terminate, on the Early Unwind Date and (i) the Transaction and all of the respective rights and obligations of Dealer and Counterparty thereunder shall be cancelled and terminated and (ii) each party shall be released and discharged by the other party from and agrees not to make any claim against the other party with respect to any obligations or liabilities of either party arising out of and to be performed in connection with the Transaction either prior to or after the Early Unwind Date.

(p) No Waiver of Rights. (i) Without limiting Section 9(d) or (f) of the Agreement, the parties hereby agree that no payment or delivery by a party made pursuant to this Confirmation shall be presumed to preclude such party’s right under this Confirmation or the Agreement to challenge the determination of the amount of such payment or delivery obligation at a later date or be deemed to be a waiver of any Event of Default or Termination Event that exists as of the date of any such payment or delivery.

(ii) Section 9(f) of the Agreement shall be amended by the addition of the following at the end of the provision: “(1) Failure by a party to expressly reserve any right, power or privilege it has under the Agreement, and/or (2) continued performance by a party of its obligations or enjoyment of any rights under the Agreement shall not in any way undermine or prejudice the effectiveness of this Section.”

(q) The Agreement is further supplemented by the following provisions:

1. The “Automatic Early Termination” provisions of Section 6(a) will not apply to Dealer or Counterparty.

2. Netting. The provisions of Section 2(c) of the Agreement will apply, provided that each occurrence of the word “Transaction” shall be replaced with “Equity Contract” and each occurrence of the word “Transactions” shall be replaced with “Equity Contracts”, and clause (ii) of Section 2(c) shall be replaced in its entirety with “(ii) in respect of Equity Contracts”.

(r) Tax Representations and Forms. Each of Dealer and Counterparty (x) represents that for the purpose of Section 3(f) of the Agreement, it is a “U.S. Person” (as that term is used in Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended), and (y) for purposes of Sections 4(a)(i) and 4(a)(iii) of the Agreement, agrees to deliver U.S. Internal Revenue Service Form W-9 (A) prior to execution of the Agreement,

19

promptly upon reasonable demand by the other party and promptly upon learning that any form or other document previously provided by either Dealer or Counterparty, as applicable, has become obsolete or incorrect.

(s) Illegality. The parties agree that for the avoidance of doubt, for purposes of Section 5(b)(i) of the Agreement, “any applicable law” shall include the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (“Dodd-Frank”), without regard to Section 739 of Dodd-Frank or any similar legal certainty provision in any legislation enacted, or rule or regulation promulgated, on or after the date on which a Transaction is entered into, and the consequences specified in the Agreement, including without limitation, the consequences specified in Section 6 of the Agreement, shall apply to any Illegality arising from any such act, rule or regulation.

(t) Waiver of Trial by Jury. EACH OF COUNTERPARTY AND DEALER HEREBY IRREVOCABLY WAIVES (ON ITS OWN BEHALF AND, TO THE EXTENT PERMITTED BY APPLICABLE LAW, ON BEHALF OF ITS STOCKHOLDERS) ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THE TRANSACTION OR THE ACTIONS OF DEALER OR ITS AFFILIATES IN THE NEGOTIATION, PERFORMANCE OR ENFORCEMENT HEREOF.

(u) Governing Law; Jurisdiction. THIS CONFIRMATION AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS CONFIRMATION SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REFERENCE TO CONFLICT OF LAW PRINCIPLES. THE PARTIES HERETO IRREVOCABLY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK AND THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK IN CONNECTION WITH ALL MATTERS RELATING HERETO AND WAIVE ANY OBJECTION TO THE LAYING OF VENUE IN, AND ANY CLAIM OF INCONVENIENT FORUM WITH RESPECT TO, THESE COURTS.

(v) Amendment. This Confirmation and the Agreement may not be modified, amended or supplemented, except in a written instrument signed by Counterparty and Dealer.

(w) Counterparts. This Confirmation may be executed in several counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument.

(x) Credit Support Provider and Credit Support Document. Credit Support Provider and Credit Support Document means, in relation to either Dealer or Counterparty: None.

20

Yours faithfully,
GOLDMAN, SACHS & CO.
By:	/s/ Daniel Kopper
	Name: Daniel Kopper
	Title: Vice President

Agreed and Accepted By:
HUMAN GENOME SCIENCES, INC.
By:	/s/ David P. Southwell
	Name: David P. Southwell
	Title: Executive Vice President and Chief           Financial Officer

EX-12.1

EXHIBIT 12.1

	Ratio of Earnings to Fixed Charges (dollars in thousands, except ratio data)
	Year ended December 31,
	2011			2010			2009		2008			2007
Earnings (Loss):
Earnings (loss) before provision for income taxes	$	(381,106	)	$	(233,231	)	$	4,385	$	(268,891	)	$	(284,371	)
Fixed Charges		79,788			78,108			77,780		82,930			80,927
Total Earnings (Loss)	$	(301,318	)	$	(155,123	)	$	82,165	$	(185,961	)	$	(203,444	)
Fixed Charges:
Interest expense on indebtedness (including amortization of debt expense and discount)	$	62,056		$	59,500		$	58,424	$	62,912		$	60,716
Interest expense on portion of rent expense representative of interest		17,732			18,608			19,356		20,018			20,211
Total Fixed Charges	$	79,788		$	78,108		$	77,780	$	82,930		$	80,927
Ratio of Earnings to Fixed Charges		—			—			1.06		—			—
Coverage deficiency (1) (2) (3)	$	(381,106	)	$	(233,231	)	$	—	$	(268,891	)	$	(284,371	)

(1) The Company’s Coverage deficiency for 2011 includes a $50,000 upfront license fee payment to FivePrime Therapeutics, Inc., which is reflected in research and development expenses in the consolidated statement of operations.

(2) The Company’s Ratio of Earnings to Fixed Charges for 2009 includes a gain on extinguishment of debt of $38,873, a gain on sale of an equity investment of $5,259 and reflects revenues received in connection with the delivery of raxibacumab to the Strategic National Stockpile. These amounts should not be considered indicative of the Company’s future performance.

(3) The Company’s Coverage deficiency for 2008 includes a gain on the sale of an equity investment of $32,518 partially offset by a charge for impaired investment of $6,284.

EX-21.1

EXHIBIT 21.1

Subsidiaries

Name	Jurisdiction of Incorporation
HGS France S.à r.l.	France
HGS International S.à r.l	Luxembourg
HGS Luxembourg LLC	Delaware
HGS Luxembourg LLC, S.C.S	Luxembourg
HGS Germany GmbH	Germany
Human Genome Sciences Pacific Pty Ltd.	Australia
Human Genome Sciences Spain, S.L.	Spain

EX-23.1

EXHIBIT 23.1

CONSENT OF ERNST & YOUNG LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form S-3 No. 333-128874) of Human Genome Sciences, Inc.,

(2) Registration Statement (Form S-3 No. 333-162731) of Human Genome Sciences, Inc.,

(3) Registration Statement (Form S-8 No. 333-44798) of Human Genome Sciences, Inc. 2000 Stock Incentive Plan and Human Genome Sciences, Inc. Employee Stock Purchase Plan,

(4) Registration Statement (Form S-8 No. 333-66670) of Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive Plan,

(5) Registration Statement (Form S-8 No. 333-89392) of Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive Plan,

(6) Registration Statement (Form S-8 No. 333-104219) of Human Genome Sciences, Inc. Amended and Restated 2000 Stock Incentive Plan,

(7) Registration Statement (Form S-8 No. 333-142713) of Human Genome Sciences, Inc. Employee Stock Purchase Plan and Non-Employee Director Equity Compensation Plan,

(8) Registration Statement (Form S-8 No. 333-156334) of Human Genome Sciences, Inc. Employee Stock Purchase Plan,

(9) Registration Statement (Form S-8 No. 333-159003) of Human Genome Sciences, Inc. Amended and Restated Stock Incentive Plan

(10) Registration Statement (Form S-8 No. 333-175833) of Human Genome Sciences, Inc. Second Amended and Restated Stock Incentive Plan

of our reports dated February 28, 2012, with respect to the consolidated financial statements of Human Genome Sciences, Inc., and the effectiveness of internal control over financial reporting of Human Genome Sciences, Inc., included in this Annual Report (Form 10-K) for the year ended December 31, 2011.

/s/ Ernst & Young LLP

Baltimore, Maryland

February 28, 2012

EX-31.1

EXHIBIT 31.1

I, H. Thomas Watkins, certify that:

1. I have reviewed this Annual Report on Form 10-K for the period ended December 31, 2011 of Human Genome Sciences, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

/s/ H. Thomas Watkins

H. Thomas Watkins

President and Chief Executive Officer

(Principal Executive Officer)

Date: February 28, 2012

EX-31.2

EXHIBIT 31.2

I, David P. Southwell, certify that:

1. I have reviewed this Annual Report on Form 10-K for the period ended December 31, 2011 of Human Genome Sciences, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

/s/ David P. Southwell

David P. Southwell

Chief Financial Officer and Executive Vice President

(Principal Financial Officer)

Date: February 28, 2012

EX-32.1

EXHIBIT 32.1

Certification of Principal Executive Officer

Pursuant to 18 U.S.C. 1350

(Section 906 of the Sarbanes-Oxley Act of 2002)

I, H. Thomas Watkins, President and Chief Executive Officer (principal executive officer) of Human Genome Sciences, Inc. (the “Registrant”), certify, to the best of my knowledge, based upon a review of the Annual Report on Form 10-K for the period ended December 31, 2011 of the Registrant (the “Report”), that:

(1) The Report fully complies with the requirements of Section 13(a) of the Securities Exchange Act of 1934, as amended; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

/s/ H. Thomas Watkins

Name: H. Thomas Watkins

Date: February 28, 2012

EX-32.2

EXHIBIT 32.2

Certification of Principal Financial Officer

Pursuant to 18 U.S.C. 1350

(Section 906 of the Sarbanes-Oxley Act of 2002)

I, David P. Southwell, Executive Vice President and Chief Financial Officer (principal financial officer) of Human Genome Sciences, Inc. (the “Registrant”), certify, to the best of my knowledge, based upon a review of the Annual Report on Form 10-K for the period ended December 31, 2011 of the Registrant (the “Report”), that:

(1) The Report fully complies with the requirements of Section 13(a) of the Securities Exchange Act of 1934, as amended; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

/s/ David P. Southwell

Name: David P. Southwell

Date: February 28, 2012

XML

Investments (Available-For-Sale Investments, Including Accrued Interest) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	$ 474,843	$ 770,574
Gross Unrealized Gains	5,517	8,207
Gross Unrealized Losses	(975)	(1,090)
Marketable securities, Fair Value	119,234	282,016
Marketable securities, non-current, Fair Value	279,958	416,165
Total, Fair Value	479,385	777,691
Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	117,846	279,540
Gross Unrealized Gains	1,453	2,508
Gross Unrealized Losses	(65)	(32)
Marketable securities, Fair Value	119,234	282,016
Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	276,994	412,329
Gross Unrealized Gains	3,703	4,859
Gross Unrealized Losses	(739)	(1,023)
Marketable securities, non-current, Fair Value	279,958	416,165
Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	80,003	78,705
Gross Unrealized Gains	361	840
Gross Unrealized Losses	(171)	(35)
Restricted assets, Fair Value	80,193	79,510
Cash And Cash Equivalents [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	11,649	7,455
Gross Unrealized Gains	1
Restricted assets, Fair Value	11,650	7,455
U.S. Treasury And Agencies [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	1,304	1,302
Gross Unrealized Gains	2	10
Restricted assets, Fair Value	1,306	1,312
Corporate Debt Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	94,669	125,708
Gross Unrealized Gains	1,123	1,655
Gross Unrealized Losses	(63)	(19)
Marketable securities, Fair Value	95,729	127,344
Corporate Debt Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	177,725	248,500
Gross Unrealized Gains	2,866	3,611
Gross Unrealized Losses	(726)	(881)
Marketable securities, non-current, Fair Value	179,865	251,230
Corporate Debt Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	51,773	45,931
Gross Unrealized Gains	316	620
Gross Unrealized Losses	(145)	(29)
Restricted assets, Fair Value	51,944	46,522
Government-Sponsored Enterprise Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost		86,905
Gross Unrealized Gains		61
Marketable securities, Fair Value		86,966
Government-Sponsored Enterprise Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	5,230	25,402
Gross Unrealized Gains	51	3
Gross Unrealized Losses		(120)
Marketable securities, non-current, Fair Value	5,281	25,285
Government-Sponsored Enterprise Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	4,641	13,237
Gross Unrealized Gains	9	72
Gross Unrealized Losses	(1)	(6)
Restricted assets, Fair Value	4,649	13,303
Residential Mortgage-Backed Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	20,681	53,944
Gross Unrealized Gains	329	787
Gross Unrealized Losses	(2)	(13)
Marketable securities, Fair Value	21,008	54,718
Residential Mortgage-Backed Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	47,158	79,605
Gross Unrealized Gains	737	1,161
Gross Unrealized Losses	(4)	(20)
Marketable securities, non-current, Fair Value	47,891	80,746
Residential Mortgage-Backed Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	5,977	6,368
Gross Unrealized Gains	30	128
Gross Unrealized Losses	(21)
Restricted assets, Fair Value	5,986	6,496
Asset-Backed Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	2,496	12,983
Gross Unrealized Gains	1	5
Marketable securities, Fair Value	2,497	12,988
Asset-Backed Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	46,881	58,822
Gross Unrealized Gains	49	84
Gross Unrealized Losses	(9)	(2)
Marketable securities, non-current, Fair Value	46,921	58,904
Asset-Backed Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	4,659	4,412
Gross Unrealized Gains	3	10
Gross Unrealized Losses	(4)
Restricted assets, Fair Value	$ 4,658	$ 4,422

XML

Commitments And Other Matters (Future Minimum Operating Lease Payments) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011
Commitments And Other Matters [Abstract]
2012	$ 21,305
2013	21,843
2014	21,973
2015	22,113
2016	22,431
2017 and thereafter	214,881
Total	$ 324,546

XML

Long-Term Debt (Narrative) (Details) (USD $)	12 Months Ended			12 Months Ended		3 Months Ended	12 Months Ended				12 Months Ended				12 Months Ended
	Dec. 31, 2011 years	Dec. 31, 2009	Dec. 31, 2010	Dec. 31, 2011 3% Convertible Senior Notes Due 2018 [Member]	Nov. 30, 2011 3% Convertible Senior Notes Due 2018 [Member]	Sep. 30, 2011 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2011 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2004 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2009 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2011 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2005 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2009 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2009 2.25% Convertible Subordinated Notes Due 2011 And 2011 [Member]	Dec. 31, 2011 Traville Lease [Member]
Debt Instrument [Line Items]
Total annual maturities of long-term debt	$ 754,197,000
Remaining term of the lease financing arrangement, in years	14
Total aggregate amount of remaining lease financing payments	421,504,000
Percentage of annual lease escalation																2.00%
Interest expense associated with this debt	11.00%
Lease financing, principal balance in year four	254,699,000
Term of lease financing arrangement	20
Debt remaining amount, at end of lease	201,738,000
Long-term debt, interest rate percentage				3.00%			2.25%	2.25%			2.25%	2.25%
Debt instrument, year of maturity				2018			2011				2012
Debt instrument conversion price, per share				$ 13.33			$ 15.55				$ 17.78
Minimum make-whole premium threshold, per share				$ 10.25							$ 14.82
Long-term debt	813,840,000
Convertible debt	561,735,000		372,851,000	363,698,000	361,340,000			191,804,000	188,620,000		198,037,000	143,266,000	184,231,000
Equity component of convertible debt					133,160,000			88,196,000				86,734,000
Debt issuance costs	14,270,000			10,428,000				5,924,000				4,220,000			855,000
Maximum make-whole premium	114,116,000										21,334,000
Maximum make-whole premium, percentage of face value				23.00%							10.00%
Minimum make-whole premium threshold, per share				$ 10.25							$ 14.82
Maximum make-whole premium threshold, per share				$ 75.00							$ 100.00
Cap price of call transactions, per share, range minimum	$ 13.33
Cap price of call transactions, per share, range maximum	$ 18.45
Capped call expenses recorded to additional paid in capital	50,933,000
Common stock shares issued in exchange of notes						7,614,000
Number of shares underlying the capped call contracts				37,110,692
Principal amount repaid	78,348,000						78,000,000
Unamortized discount	139,501,000	16,424,000	30,989,000	130,802,000		1,200,000			8,480,000		8,699,000		22,509,000
Interest expense	808,000						808,000
Extinguishment of debt						116,600,000
Face amount of debt	701,236,000		403,840,000	494,500,000	494,500,000			280,000,000	197,100,000	82,900,000	206,736,000	230,000,000	206,740,000	23,250,000
Extinguishment of long-term debt		49,998,000
Gain on extinguishment of debt		$ 38,873,000

XML

Earnings Per Share (Narrative) (Details)	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Stock Options [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Common stock equivalents excluded from calculation of diluted net loss per share	25,068,812	24,028,688	24,601,174
Convertible Debt Securities [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Common stock equivalents excluded from calculation of diluted net loss per share	48,735,519	24,302,742	24,303,304

XML

Stockholders' Equity (Narrative) (Details) (USD $) In Thousands, except Share data, unless otherwise specified	1 Months Ended		12 Months Ended
	Dec. 31, 2009	Aug. 31, 2009	Dec. 31, 2011		Dec. 31, 2010	Dec. 31, 2009
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Issuance of common stock pursuant to public offerings						$ 812,869
Issuance of common stock pursuant to public offerings, shares	17,825,000	26,697,250
Issuance of common stock pursuant to public offerings, price per share	$ 26.75	$ 14.00				$ 26.75
Proceeds from public offerings of common stock	456,400	356,500
Stock-based compensation expense capitalized as part of inventory production			3,373
Option expiration, maximum years			10 years
Vesting period of options, years			4 years
Outstanding common stock percentage			50.00%
Authorized number of shares under the Incentive Plan			59,845,420
Options available for future grant			6,478,055
Cash proceeds received from exercise of stock options			16,982		37,841	48,147
Unrecognized compensation cost related to stock options			104,153
Weighted-average period, unrecognized compensation cost, years			2.5
Non-vested stock options outstanding			8,064,257
Total intrinsic value of stock options exercised			32,946	[1]
Total fair value of stock options which vested			38,830		20,286	12,353
Weighted-average grant-date fair value of stock options, per share			$ 14.26		$ 17.31	$ 0.91
Weighted average volatility used			61.70%		63.50%	55.90%
RSUs granted			280,906
Weighted-average grant date fair value price per share of RSU's			$ 26.59
Compensation expense related to both RSUs and restricted stock awards			1,995		1,153	589
Shares issued pursuant to Purchase Plan			68,025
Common stock par value			$ 0.01		$ 0.01
Stock Purchase Plan discount rate			15.00%
Weighted-average fair value of the Employee Stock Purchase Plan price per share			$ 5.81		$ 6.65	$ 0.53
Employee stock purchase plan, shares reserved for future employee purchase			596,625
Stock Option Exercised [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares issued			1,954,840		3,600,641	4,584,767
Total intrinsic value of stock options exercised			32,946		66,779	51,205
Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense related to Employee Stock Purchase Plan			$ 758
Employee stock purchase plan, authorized shares			2,000,000

[1] Aggregate intrinsic value includes only options in which the exercise price of the option is less than the market value of the Company's stock on December 31, 2011, or for exercised options, the intrinsic value on the exercise date.

XML

Other Financial Information (Property, Plant And Equipment) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	$ 426,192	$ 409,746
Less: accumulated depreciation	(175,166)	(156,624)
Property, plant and equipment, net, total	251,026	253,122
Buildings [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	204,151	204,151
Laboratory And Production Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	100,400	96,462
Computer Equipment And Software [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	42,033	39,296
Land And Improvements [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	30,521	30,521
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	32,414	26,678
Furniture And Office Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	8,427	7,274
Construction-In-Progress [Member]
Property, Plant and Equipment [Line Items]
Property, plant and equipment, gross, total	$ 8,246	$ 5,364

XML

Quarterly Financial Information (Tables)

12 Months Ended

Dec. 31, 2011

Quarterly Financial Information [Abstract]

Schedule Of Quarterly Financial Information

	1st Quarter			2nd Quarter			3rd Quarter			4th Quarter
2011
Revenue	$	26,573		$	24,858		$	34,022		$	45,522
Loss from operations		(115,999	)		(68,494	)		(75,995	)		(69,063	)
Net loss		(130,995	)		(80,660	)		(88,429	)		(81,022	)
Net loss per share, basic and diluted		(0.69	)		(0.42	)		(0.45	)		(0.41	)
2010
Revenue	$	46,514		$	38,792		$	50,782		$	21,263
Loss from operations		(37,773	)		(46,992	)		(29,826	)		(76,182	)
Net loss		(47,877	)		(56,863	)		(40,859	)		(87,632	)
Net loss per share, basic and diluted		(0.26	)		(0.30	)		(0.22	)		(0.46	)

XML

Quarterly Financial Information (Schedule Of Quarterly Financial Information) (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2010	Sep. 30, 2010	Jun. 30, 2010	Mar. 31, 2010	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Quarterly Financial Information [Abstract]
Revenue	$ 45,522	$ 34,022	$ 24,858	$ 26,573	$ 21,263	$ 50,782	$ 38,792	$ 46,514	$ 130,975	$ 157,351	$ 275,749
Loss from operations	(69,063)	(75,995)	(68,494)	(115,999)	(76,182)	(29,826)	(46,992)	(37,773)	(329,551)	(190,773)	6,188
Net loss	$ (81,022)	$ (88,429)	$ (80,660)	$ (130,995)	$ (87,632)	$ (40,859)	$ (56,863)	$ (47,877)	$ (381,106)	$ (233,231)	$ 5,659
Net loss per share, basic and diluted	$ (0.41)	$ (0.45)	$ (0.42)	$ (0.69)	$ (0.46)	$ (0.22)	$ (0.30)	$ (0.26)	$ (1.97)	$ (1.24)	$ 0.04

XML

Stockholders' Equity (Summary Of Stock Option Activity) (Details) (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011
Stockholders' Equity [Abstract]
Shares, Outstanding at January 1, 2011	24,028,688
Shares, Granted	4,404,965
Shares, Exercised	(1,954,840)
Shares, Forfeited	(429,950)
Shares, Expired	(980,051)
Shares, Outstanding at December 31, 2011	25,068,812
Shares, Vested and expected to vest at December 31, 2011	24,331,795
Shares, Exercisable at December 31, 2011	17,017,555
Weighted-Average Exercise Price, Outstanding at January 1, 2011	$ 14.55
Weighted-Average Exercise Price, Granted	$ 25.57
Weighted-Average Exercise Price, Exercised	$ 8.69
Weighted-Average Exercise Price, Forfeited	$ 22.40
Weighted-Average Exercise Price, Expired	$ 39.28
Weighted-Average Exercise Price, Outstanding at December 31, 2011	$ 15.84
Weighted-Average Exercise Price, Vested and expected to vest at December 31, 2011	$ 15.66
Weighted-Average Exercise Price, Exercisable at December 31, 2011	$ 12.40
Weighted-Average Remaining Contractual Term (years), Outstanding at January 1, 2011	6.32
Weighted-Average Remaining Contractual Term (years), Outstanding at December 31, 2011	6.24
Weighted-Average Remaining Contractual Term (years), Vested and expected to vest at December 31, 2011	6.17
Weighted-Average Remaining Contractual Term (years), Exercisable at December 31, 2011	5.14
Aggregate Intrinsic Value, Outstanding at January 1, 2011	$ 275,278	[1]
Aggregate Intrinsic Value, Exercised	32,946	[1]
Aggregate Intrinsic Value, Outstanding at December 31, 2011	25,815	[1]
Aggregate Intrinsic Value, Vested and expected to vest at December 31, 2011	24,941	[1]
Aggregate Intrinsic Value, Exercisable at December 31, 2011	$ 18,023	[1]

[1] Aggregate intrinsic value includes only options in which the exercise price of the option is less than the market value of the Company's stock on December 31, 2011, or for exercised options, the intrinsic value on the exercise date.

XML

Earnings Per Share (Computation Of Diluted Net Income (Loss) Per Share) (Details) (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2010	Sep. 30, 2010	Jun. 30, 2010	Mar. 31, 2010	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Earnings Per Share [Abstract]
Net income (loss)	$ (81,022)	$ (88,429)	$ (80,660)	$ (130,995)	$ (87,632)	$ (40,859)	$ (56,863)	$ (47,877)	$ (381,106)	$ (233,231)	$ 5,659
Weighted average shares outstanding									193,667,672	187,791,437	149,334,426
Employee stock options and restricted stock units											5,719,047
Weighted average shares used for diluted net income (loss) per share									193,667,672	187,791,437	155,053,473
Diluted net income (loss) per share	$ (0.41)	$ (0.45)	$ (0.42)	$ (0.69)	$ (0.46)	$ (0.22)	$ (0.30)	$ (0.26)	$ (1.97)	$ (1.24)	$ 0.04

XML

Other Financial Information (Tables)

12 Months Ended

Dec. 31, 2011

Other Financial Information [Abstract]

Inventory

	December 31, 2011				December 31, 2010
	Current		Non-current		Current		Non-current
Raw materials	$	12,183	$	4,852	$	12,641	$	—
Work-in-process		22,567		102,887		23,426		—
Finished goods		6,909		4,083		7,024		—
Total	$	41,659	$	111,822	$	43,091	$	—

Property, Plant And Equipment

	December 31,
	2011			2010
Building (LSM)	$	204,151		$	204,151
Laboratory and production equipment		100,400			96,462
Computer equipment and software		42,033			39,296
Land and improvements		30,521			30,521
Leasehold improvements		32,414			26,678
Furniture and office equipment		8,427			7,274
Construction-in-progress		8,246			5,364
		426,192			409,746
Less: accumulated depreciation		(175,166	)		(156,624	)
	$	251,026		$	253,122

Accounts Payable And Accrued Expenses

	December 31,
	2011		2010
Accounts payable	$	4,442	$	6,364
Accrued clinical trial costs		9,302		13,665
Sales deductions and returns allowance		4,345		—
Other accrued expenses		29,364		21,769
	$	47,453	$	41,798

XML

Long-Term Debt (Annual Maturities Of All Long-Term Debt) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011
Long-Term Debt [Abstract]
2012	$ 206,736
2013
2014
2015	187
2016	671
2017 and thereafter	546,603
Total	$ 754,197

XML

Investments (Realized Gains And Losses On Investments Sold Before Maturity And Respective Net Proceeds) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Investments [Abstract]
Proceeds on sale and maturities of investments	$ 728,185	$ 708,896	$ 368,560
Realized gains	1,652	1,673	7,026
Realized losses	$ (1,416)	$ (1,976)	$ (2,522)

XML

Summary Of Significant Accounting Policies (Components Of Accumulated Other Comprehensive Income) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Summary Of Significant Accounting Policies [Abstract]
Marketable securities	$ 4,352	$ 6,317
Restricted investments	189	805
Foreign currency translation	15	3
Accumulated other comprehensive income	$ 4,556	$ 7,125

XML

Long-Term Debt (Components Of Convertible Debt) (Details) (USD $)	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2011 3% Convertible Senior Notes Due 2018 [Member]	Nov. 30, 2011 3% Convertible Senior Notes Due 2018 [Member]	Sep. 30, 2011 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2009 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2004 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2011 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2009 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2005 2.25% Convertible Subordinated Notes Due 2012 [Member]
Debt Instrument [Line Items]
Face value, debt	$ 701,236,000	$ 403,840,000		$ 494,500,000	$ 494,500,000		$ 197,100,000	$ 82,900,000	$ 280,000,000	$ 206,736,000	$ 206,740,000	$ 23,250,000	$ 230,000,000
Unamortized Debt Discount	(139,501,000)	(30,989,000)	(16,424,000)	(130,802,000)		(1,200,000)	(8,480,000)			(8,699,000)	(22,509,000)
Carrying Amount, debt	$ 561,735,000	$ 372,851,000		$ 363,698,000	$ 361,340,000		$ 188,620,000		$ 191,804,000	$ 198,037,000	$ 184,231,000		$ 143,266,000

XML

Fair Value Measurements (Narrative) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Convertible debt	$ 561,735	$ 372,851
Fair value of BioMed lease financing	263,688
Book value of BioMed lease financing	252,105	250,516
Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Quoted market price of company's convertible senior and subordinated debt	634,458
Convertible debt	$ 561,735

XML

Income Taxes (Narrative) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011 years
Income Tax Contingency [Line Items]
Valuation allowance increased	$ 20,136
Valuation allowance	899,795
Carryforwards of tax credits	40,533
State net operating loss carryforward adjustments	60,010
The threshold for ownership change, percentage	50.00%
Testing period for ownership change, years	3
Decrease in uncertain tax positions	1,284
Net Operating Loss [Member]
Income Tax Contingency [Line Items]
Amount impacting valuation allowance	49,129
Carryforwards for federal income tax	2,051,487
Carryforwards related to stock-based compensation	$ 366,185

XML

Other Financial Information (Accounts Payable And Accrued Expenses) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Other Financial Information [Abstract]
Accounts payable	$ 4,442	$ 6,364
Accrued clinical trial costs	9,302	13,665
Sales deductions and returns allowance	4,345
Other accrued expenses	29,364	21,769
Total accounts payable and accrued expenses	$ 47,453	$ 41,798

XML

Summary Of Significant Accounting Policies

12 Months Ended

Dec. 31, 2011

Summary Of Significant Accounting Policies [Abstract]

Summary Of Significant Accounting Policies

(NOTE B) – Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial statements in conformity with U.S. generally accepted accounting principles ("GAAP") requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Such estimates are based on historical experience and on various assumptions that the Company believes to be reasonable under the circumstances. Actual results could differ from these estimates under different assumptions or conditions.

Principles of Consolidation

The consolidated financial statements include the accounts of Human Genome Sciences, Inc. and its subsidiaries, all of which are wholly-owned. All significant intercompany accounts and transactions have been eliminated.

Cash Equivalents, Marketable Securities and Restricted Investments

The Company considers all highly liquid investment instruments purchased with a maturity of three months or less to be cash equivalents.

The Company classifies its marketable securities with readily determinable fair values as "available-for-sale." Investments in securities that are classified as available-for-sale are measured at fair market value in the balance sheets, and unrealized holding gains and losses on investments are reported as a separate component of stockholders' equity until realized. Investments of less than 20% of privately-held companies are accounted for as cost-method investments. The Company reviews the carrying value of such investments on a periodic basis for indicators of impairment. Additionally, certain of the Company's investments are held as restricted investments. Restricted investments with maturities less than three months are not classified as cash in the Company's consolidated balance sheets. See Note C, Investments, for additional information.

Investment Risk

The Company has invested its cash in obligations of the U.S. Government ("USG"), government agencies and in high-grade debt securities and various money market instruments. The Company's investment policy limits investments to certain types of instruments issued by institutions with credit ratings of "A-" or better, and places restrictions on maturities and concentrations in certain industries and by issuer. The Company does not hold auction rate securities, loans held for sale or mortgage-backed securities backed by sub-prime or Alt-A collateral.

Other-Than-Temporary Impairment of Investments

Periodically, the Company evaluates whether any investments have incurred an other-than-temporary impairment, based on the criteria under Financial Accounting Standards Board ("FASB") Accounting Standards Codification ("FASB ASC") Topic 320, Investments – Debt and Equity Securities. This evaluation consists of a review of several factors, including but not limited to the length of time and extent that a security has been in an unrealized loss position, the existence of an event that would impair the issuer's future repayment potential, the near term prospects for recovery of the market value of a security and the intent of the Company to hold the security until the market value recovers and whether it is not more likely than not that the Company will be required to sell the security. If the Company determines that such impairment exists, the Company will recognize a charge in the consolidated statement of operations equal to the amount of such impairment. See Note D, Collaborations and Other Agreements – Aegera Agreement, for additional discussion.

Accounts Receivable

Trade accounts receivable are recorded net of allowances for prompt payment discounts and doubtful accounts.

Inventories

Inventories, which are recorded at the lower of cost or market, include materials, labor and other direct and indirect costs and are valued using the first-in, first-out method. The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. In the case of raxibacumab, manufacturing costs were capitalized after the Company received a follow-on order from the USG in July 2009. BENLYSTA manufacturing costs have been capitalized since the FDA Advisory Committee vote in November 2010 to recommend approval of the product.

Inventory that is not expected to be utilized until more than 12 months from the balance sheet date is classified as non-current. Estimating the level of inventory utilization for the upcoming 12 months requires management to exercise significant judgment. The Company maintains inventory levels in excess of 12 months to mitigate risks such as product shortage due to higher than anticipated product demand, long lead times for manufacturing finished goods, supply interruptions for raw materials and risks of production disruptions at its sole U.S. FDA-approved manufacturing site due to contamination, equipment failure or other facility-related issues. Carrying such levels of inventory impacts the Company's liquidity and cash flows since the inventory will not be converted to cash for more than one year from the balance sheet date.

Inventory is evaluated for impairment by consideration of factors such as lower of cost or market, net realizable value, obsolescence or expiry. Inventories have carrying values that do not exceed cost nor do they exceed net realizable value. The Company believes BENLYSTA has limited risk of obsolescence at this time based on market research, which is used to estimate future demand.

The Company evaluates expiry risk by evaluating current and future product demand relative to product shelf life. The Company builds demand forecasts by considering factors such as, but not limited to, overall market potential, market share, market acceptance and patient usage. Currently, the shelf life of raw materials and work in process is approximately one to five years and three years, respectively. The shelf life for finished goods is three years. The product shelf life resets as inventory moves through each stage of completion.

Depreciation

Depreciation is computed using the straight-line method over the estimated useful lives of the assets as follows:

Buildings	30 years
Land improvements	lesser of the lease term or the useful life
Production equipment	5- 10 years
Laboratory equipment	3- 10 years
Computer equipment and software	3- 5 years
Furniture and office equipment	3- 5 years
Leasehold improvements	lesser of the lease term or the useful life

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable based on the criteria for accounting for the impairment or disposal of long-lived assets under FASB ASC Topic 360, Property, Plant and Equipment.

Deferred revenue

Deferred revenue consists primarily of amounts related to raxibacumab and certain BENLYSTA shipments. The Company recognizes raxibacumab revenue based on the average contracted price as shipments occur and records the difference between the invoiced price and the average contracted price in deferred revenue. Revenue generated from BENLYSTA shipments to specialty distributors is deferred and recognized once product has been sold-through to healthcare providers.

Product sales

Product sales consist of U.S. sales of BENLYSTA and raxibacumab. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, delivery has occurred and title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, all performance obligations have been met and returns can be reasonably estimated. Product sales are recorded net of accruals for estimated rebates, chargebacks, discounts and other deductions (collectively, "sales deductions"), and returns. Amounts accrued for sales deductions and returns are adjusted when trends, significant events, or actual results indicate that adjustment is appropriate. With the exception of allowances for prompt payment, allowances for sales deductions and returns are included in accounts payable and accrued expenses in the accompanying consolidated balance sheet as of December 31, 2011.

The Company does not record sales deductions and returns for sales of raxibacumab due to the absence of discounts and rebates and no right of return under the contract with the USG. Aside from product recall, once delivery has occurred, product may not be returned to the Company for any reason, including failure to obtain FDA approval. Furthermore, the Company has no obligation to replace existing Strategic National Stockpile ("SNS") doses if the formulation changes during the FDA approval process.

The Company estimates BENLYSTA sales deductions and returns utilizing actual sales data, contracts with distributors and wholesalers and third-party market research. Company estimates and assumptions are subject to inherent limitations and may need to be adjusted accordingly on a prospective basis. Specific considerations for BENLYSTA sold in the U.S. are as follows:

• With respect to BENLYSTA, the Company has determined that it qualifies as the principal based on various elements of the Company's agreement with GlaxoSmithKline ("GSK"), including responsibility for manufacturing product for sale in the U.S., inventory risk and primary responsibility for changes to the product, including product specifications. The Company has an agreement with GSK whereby GSK provides distribution services.

• BENLYSTA is distributed in the U.S. through specialty distributors and wholesalers. Under this model, exclusive distributors purchase and take physical delivery and title of product, and then sell to physicians or their clinics. Because the Company received FDA approval in the first quarter of 2011, the Company currently cannot make a reasonable estimate of future product returns when product is delivered to distributors. Therefore, the Company currently does not recognize revenue upon product shipment to specialty distributors, even though the distributor is invoiced upon product shipment. Instead, the Company recognizes revenue through the specialty distributor channel at the time of shipment to the physicians or their clinics. Wholesalers supply product to all other healthcare providers (e.g. hospitals, pharmacies), however they do not take physical delivery of product. All wholesaler orders are drop-shipped directly to the healthcare providers. For wholesaler purchases, the Company currently recognizes revenue upon shipment to the healthcare provider.

• Product returns. BENLYSTA customers are not offered a general right of return. However, the Company will accept product that is damaged or defective when shipped directly from GSK or for expired product up to 12 months subsequent to its expiration date. Due to the price of BENLYSTA and limited contractual rights of return, healthcare providers generally only carry inventory quantities estimated to meet projected short-term demand. Once product has been delivered to healthcare providers, the risk of material returns is significantly mitigated, and the Company is able to make a reasonable estimate of future returns at that point. In developing estimates for sales returns, the Company considers shelf life of the product, expected demand based on market data and publicly available return rates used for other biologic drugs. In addition, the Company considers the price of the product, the nature of healthcare providers, the ability of healthcare providers to obtain product on a just-in-time basis, the predictability of patient infusion and dosing and the absence of financial incentives that would promote bulk or advance purchasing.

• Rebates. Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or legal requirements with public sector (e.g. Medicaid) benefit providers. The allowance for rebates is based on statutory discount rates and expected utilization. The Company's estimates for expected utilization of rebates are based in part on third party market research data. Rebates are generally invoiced and paid quarterly in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter's activity, plus an accrual balance for known prior quarters' unpaid rebates. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect revenue in the period of adjustment.

• Chargebacks. Chargebacks are discounts that occur when contracted customers purchase directly from an intermediary distributor or wholesaler. Contracted customers, which currently consist primarily of Public Health Service institutions and Federal government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The distributor or wholesaler in turn, charges back the difference between the price initially paid by the distributor or wholesaler and the discounted price paid to the distributor or wholesaler by the customer. The allowance for distributor/wholesaler chargebacks is based on known sales to contracted customers.

• Distributor / Wholesaler deductions. U.S. specialty distributors and wholesalers are offered various forms of consideration including allowances, service fees and prompt payment discounts. Distributor allowances and service fees arise from contractual agreements with distributors and are generally a fixed rate per vial purchased. Wholesale customers are offered a prompt pay discount for payment within a specified period. Distributor allowances and service fees and wholesaler prompt payment discounts recorded in the Company's 2011 statement of operations are based on actual product sales and are not estimates.

• Co-pay assistance. Patients who have commercial insurance and meet certain eligibility requirements may receive co-pay assistance. The Company accrues a liability for co-pay assistance based on actual program participation and estimates of program redemption using data provided by third-party administrators.

The Company is not the principal with respect to BENLYSTA sold outside of the U.S., i.e. in the rest of world ("ROW"). Therefore, the Company is not recording product sales with respect to this activity.

Manufacturing and development services

As part of its raxibacumab contract with the USG and the Biomedical Advanced Research and Development Authority ("BARDA"), the Company performed a variety of drug development services primarily relating to the conduct of animal and human studies. Upon BARDA's acceptance of the initial raxibacumab delivery, the Company billed the USG for the drug development work previously performed, and recorded this as manufacturing and development services revenue during 2009. The Company has been recording additional development revenue as services are performed.

The Company has entered into agreements with certain commercial parties for manufacturing process development, clinical and commercial supply of certain biopharmaceutical products. Revenue under these agreements is recognized as services are performed or products delivered, depending on the nature of the work contracted, using the proportional performance method of accounting. Performance is assessed using output measures such as units-of-work performed to date as compared to total units-of-work contracted. Advance payments received in excess of amounts earned are classified as deferred revenue until earned.

 

Research and development collaborative agreements

Collaborative research and development agreements can provide for one or more of up-front license fees, research payments and milestone payments. In October 2009, the FASB issued new revenue recognition standards for arrangements with multiple deliverables, which were effective for the Company as of January 1, 2011. These standards address the determination of the unit(s) of accounting for multiple-element arrangements and how the arrangement's consideration should be allocated to each unit of accounting. An item can generally be considered a separate unit of accounting if all of the following criteria are met: (1) the delivered item(s) has value to the customer on a stand-alone basis and (2) if the arrangement includes a general right of return relative to the delivered item(s), delivery or performance of the undelivered item(s) is considered probable and substantially in control of the Company. Items that cannot be divided into separate units are combined with other units of accounting, as appropriate. Consideration received is allocated among the separate units based on vendor-specific objective evidence ("VSOE") if available; third-party evidence, if VSOE is unavailable; and estimated selling prices if neither VSOE nor third-party evidence is available. Revenue is recognized when the following criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the sales price is fixed or determinable; and (4) collectability is probable. The Company deems service to have been rendered if no continuing obligation exists on the part of the Company.

Revenue associated with non-refundable up-front license fees under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting are deferred and recognized as revenue on a straight-line basis over the expected term of the Company's continued involvement in the research and development process. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved, and the milestone payments are due and collectible. If not deemed substantive, the Company would recognize such milestone as revenue on a straight-line basis over the remaining expected term of continued involvement in the research and development process. Milestones are considered substantive if all of the following conditions are met: (1) it is commensurate with either our performance to meet the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the our performance to achieve the milestone, (2) it relates solely to past performance, and (3) the value of the milestone is reasonable relative to all the deliverables and payment terms (including other potential milestone consideration) within the arrangement. Payments received in advance of work performed are recorded as deferred revenue.

The new accounting standards were adopted by the Company on a prospective basis on January 1, 2011. The Company did not enter into any new multiple-element arrangements or materially modify any existing arrangements during 2011. The adoption of these standards did not have a material effect on the Company's consolidated results of operations, financial position or liquidity.

Cost of product sales

The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. Prior to capitalization, the cost of manufacturing drug product is recognized as research and development expense in the period that the cost is incurred. Therefore, manufacturing costs incurred prior to capitalization are not included in cost of product sales when revenue is recognized from the sale of that drug product.

Prior to receiving a follow-on order for raxibacumab from the USG in July 2009, the Company did not capitalize inventory costs related to this product. Although authorization to ship to the SNS was received in January 2009, there continued to be uncertainty around future product orders. Beginning in July 2009, the cost of manufacturing raxibacumab is recognized as a cost of product sales (capitalized and then expensed when revenue is recognized), rather than research and development expenses in the period that the cost is incurred.

Prior to the BENLSYTA Advisory Committee meeting in November 2010, the Company did not capitalize inventory costs related to this product. Following the positive outcome of the Advisory Committee, the cost of manufacturing BENLYSTA is being capitalized and will be expensed as cost of product sales as revenue is recognized, rather than being recorded as research and development expenses in the period that the cost is incurred.

Cost of product sales also includes royalties paid or payable to third parties based on the sales levels of certain products, distribution services costs, any applicable unabsorbed costs as a result of not operating the Company's manufacturing facilities at full capacity and manufacturing-related period expenses.

Cost of manufacturing and development services

Cost of manufacturing and development services represents costs associated with the Company's contract manufacturing arrangements and other development services. The costs associated with work previously performed to conduct animal and human studies for raxibacumab were recognized as research and development expenses in the period that the costs were incurred. Therefore, these pre-acceptance development costs are not included in cost of manufacturing and development services for 2009. The

Company is recording additional raxibacumab development services costs as incurred. Cost of manufacturing and development services also includes any applicable unabsorbed costs as a result of not operating the Company's manufacturing facilities at full capacity and manufacturing-related period expenses.

Research and Development

Research and development costs are charged to expense as incurred, unless otherwise capitalized pursuant to FASB ASC Topic 730, Research and Development. Research and development costs include salaries and related benefits, outside services, licensing fees or milestones, materials and supplies, building costs and allocations of certain support costs. Research and development direct expenditures were $196,182, $196,370 and $173,709 for 2011, 2010 and 2009, respectively. Reimbursement of research and development expenses received in connection with collaborative cost-sharing agreements is recorded as a reduction of such expenses.

Leases

The Company accounts for its leases under FASB ASC Topic 840, Leases. The Company has a number of operating leases and has entered into sale-leaseback transactions for land and facilities. See Note G, Commitments and Other Matters, for additional discussion.

Stock-Based Compensation

The Company has a stock incentive plan (the "Incentive Plan") under which options to purchase shares of the Company's common stock may be granted to employees, consultants and directors with an exercise price no less than the quoted market value on the date of grant. The Incentive Plan also provides for the issuance of non-vested common stock (restricted stock) and other share-based compensation. The Company recognizes stock-based compensation expense related to employee stock options under FASB ASC Topic 718, Compensation – Stock Compensation. For income tax purposes, the Company follows the "with and without" method of accounting for the tax effect of excess tax benefits generated from stock-based compensation. See Note H, Stockholders' Equity, for additional discussion.

Financing Costs Related to Long-term Debt

Costs associated with obtaining long-term debt are allocated between the debt and equity components as required by FASB ASC Topic 470, Debt. Costs allocated to the equity component are charged to Additional paid-in capital. Costs allocated to debt are deferred and amortized over the term of the related debt on a straight-line basis, which approximates the effective interest method.

Patent Application Costs

Patent application costs are charged to expense as incurred.

Commercial collaboration expenses

Commercial collaboration expenses include GSK's share of the collaboration profit with respect to BENLYSTA sales in the United States. At this time, it also includes HGS' share of the ROW collaboration expense incurred by GSK. In the period when ROW results become profitable, the Company will begin to reflect such results as commercial collaboration income. Commercial collaboration expenses/income does not include any research and development expenses shared with GSK.

Net Income (Loss) Per Share

The Company follows the provisions under FASB ASC Topic 260, Earnings Per Share, which requires the Company to present basic and diluted earnings per share. The Company's basic and diluted income (loss) per share is calculated by dividing the net income (loss) by the weighted average number of shares of common stock outstanding during all periods presented. Shares issuable upon the conversion of the Company's convertible debt and shares due to the Company upon settlement of the Company's capped call contracts are excluded from diluted earnings per share calculations for 2011, 2010 and 2009 because the effects are anti-dilutive.

Major customers and concentration of credit risk

The Company sells BENLYSTA to a limited number of exclusive pharmaceutical specialty distributors and wholesalers in the U.S. and sells raxibacumab only to the USG. The Company periodically assesses the financial strength of its customers and establishes allowances for anticipated losses, if necessary. The following table includes those customers that represent more than 10% of total revenue of $130,975 for 2011:

Customer A	42	%
Customer B	14	%
Customer C	14	%

Two customers each having a balance of more than 10% of the Accounts receivable balance on the consolidated balance sheet as of December 31, 2011 represent an aggregate of 90% of Accounts receivable.

Foreign Currency

The functional currency of substantially all of the Company's wholly-owned foreign subsidiaries is the U.S. dollar. For these foreign subsidiaries, monetary balance sheet and related income statement accounts are re-measured, with exchange gains and losses recorded in the consolidated statement of income. Non-monetary balance sheet items and related income statement accounts, which do not result in a fixed future cash inflow or outflow of foreign currency units, are re-measured at their historical exchange rates. In 2011, 2010 and 2009, the Company recorded negligible foreign currency re-measurement gains (losses), which are included in Other income (expense), net in the consolidated statements of income.

Comprehensive Income (Loss)

FASB ASC Topic 220, Comprehensive Income, requires unrealized gains and losses on the Company's available-for-sale marketable securities and long-term equity investments and the activity for the cumulative translation adjustment to be included in other comprehensive income.

The components of accumulated other comprehensive income are as follows:

	December 31,
	2011		2010
Net unrealized gains on:
Marketable securities	$	4,352	$	6,317
Restricted investments		189		805
Foreign currency translation		15		3
Accumulated other comprehensive income	$	4,556	$	7,125

Accumulated other comprehensive income excludes net realized gains included in Net income (loss) of $236 and $4,504 for 2011 and 2009, respectively. Accumulated other comprehensive income excludes net realized losses included in Net income (loss) of $303 for 2010. The effect of income taxes on items in other comprehensive income is $0 for all periods presented.

Sources of Supply

The Company is currently able to obtain most of its raw materials, supplies and equipment from various sources, and generally has no dependence upon a single supplier. However, certain materials required for manufacturing are currently available only from single sources. The Company attempts to identify and qualify alternative sources of supply wherever possible.

Reclassifications

Within the December 31, 2010 consolidated balance sheet, long-term equity investments of $3,241 have been reclassified and are included in Other assets, and a lease termination liability that had been classified in Accrued exit expenses has been reclassified to Other current liabilities. Also within the December 31, 2010 consolidated balance sheet, deferred rent of $10,358, deferred revenue, non-current of $2,517 and accrued exit expenses, non-current of $700 have been reclassified and are included in Other liabilities. All of these reclassifications have been made to conform to current year presentation.

Recent Accounting Pronouncements

In January 2010, the FASB issued Accounting Standards Update ("ASU") 2010-06, Improving Disclosures about Fair Value Measurements ("ASU 2010-06"). ASU 2010-06 requires disclosing the amounts of significant transfers in and out of Levels 1 and 2 fair value measurements and to describe the reasons for the transfers. The disclosures were effective for the Company beginning January 1, 2010, and had no material impact on the Company's financial statements. Additionally, disclosures of the gross purchases, sales, issuances and settlements activity in Level 3 fair value measurements were required beginning January 1, 2011. The additional provisions of ASU 2010-06 did not have any effect on the Company's consolidated results of operations, financial position or liquidity.

In April 2010, the FASB issued ASU 2010-17, Milestone Method of Revenue Recognition ("ASU 2010-17"), which provides guidance on defining a milestone and determining when it may be appropriate to apply the milestone method of revenue recognition for research or development transactions. Research or development arrangements frequently include payment provisions whereby a portion or all of the consideration is contingent upon milestone events such as successful completion of phases in a study or achieving a specific result from the research or development efforts. The amendments in this ASU provide guidance on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. ASU 2010-17 was effective for the Company on January 1, 2011. The adoption of ASU 2010-17 did not have a material effect on the Company's consolidated results of operations, financial position or liquidity.

In December 2010, the FASB issued ASU 2010-27, Fees Paid to the Federal Government by Pharmaceutical Manufacturers ("ASU 2010-27"), which specifies that the liability for the new fee mandated by the Patient Protection and Affordable Care Act of 2010, as amended by the Health Care and Education Reconciliation Act, should be estimated and recorded in full upon the first qualifying sale with a corresponding deferred cost that is amortized to expense using a straight-line method of allocation unless another method better allocates the fee over the calendar year that it is payable. This ASU was effective for the Company beginning January 1, 2011. The adoption of ASU 2010-27 did not have a material effect on the Company's consolidated results of operations, financial position or liquidity.

In May 2011, the FASB issued ASU 2011-04, Fair Value Measurement (Topic 820) ("ASU 2011-04"), which contains amendments to achieve common fair value measurement and disclosures in U.S. GAAP and International Financial Reporting Standards. ASU 2011-04 explains how to measure fair value for financial reporting. The guidance does not require fair value measurements in addition to those already required or permitted by other Topics. This ASU is effective for the Company beginning January 1, 2012. The adoption of ASU 2011-04 is not expected to have a material effect on the Company's consolidated results of operation, financial position or liquidity.

In June 2011, the FASB issued ASU 2011-05, Comprehensive Income (Topic 220): Presentation of Comprehensive Income ("ASU 2011-05"). This guidance is intended to increase the prominence of other comprehensive income in financial statements by presenting it in either a single statement or two-statement approach. This ASU is effective for the Company beginning January 1, 2012. The adoption of ASU 2011-05 is not expected to have a material effect on the Company's consolidated results of operations, financial position or liquidity.

XML

Income Taxes (Federal Income Tax Rate To Income Before Taxes) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Income Taxes [Abstract]
Federal income tax provision at 35%	$ (133,331)	$ (77,112)	$ 1,491
State taxes, net of federal tax benefit	(7,342)	(7,324)	185
Foreign income tax rate differential	5,436
Permanent differences, net	8,749	3,247	(336)
Tax credits, principally for research and development	(5,917)	428	(1,813)
State net operating loss carryforward adjustments	60,010
Research and development credit refunds			(1,274)
Other	3,130	(183)	(2,967)
Change in valuation allowance on deferred tax asset	69,265	80,944	3,440
Total			$ (1,274)
Federal income tax provision percentage	35.00%

XML

Collaborations And Other Agreements (Details) (USD $)	12 Months Ended							1 Months Ended	12 Months Ended								3 Months Ended	12 Months Ended								156 Months Ended	12 Months Ended								96 Months Ended
	Dec. 31, 2011 years	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2011 HGS1036 [Member]	Dec. 31, 2011 GlaxoSmithKline [Member]	Dec. 31, 2010 GlaxoSmithKline [Member]	Dec. 31, 2009 GlaxoSmithKline [Member]	Jul. 31, 2009 US Government [Member]	Dec. 31, 2011 US Government [Member]	Dec. 31, 2010 US Government [Member]	Dec. 31, 2009 US Government [Member]	Dec. 31, 2006 US Government [Member]	Dec. 31, 2011 Aegera Therapeutics, Inc. [Member]	Dec. 31, 2010 Aegera Therapeutics, Inc. [Member]	Dec. 31, 2009 Aegera Therapeutics, Inc. [Member]	Dec. 31, 2011 Morphotek Agreement [Member]	Mar. 31, 2011 FivePrime Therapeutics Agreement [Member]	Dec. 31, 2011 FivePrime Therapeutics Agreement [Member]	Dec. 31, 2010 Novartis International Pharmaceutical Ltd. [Member]	Dec. 31, 2009 Novartis International Pharmaceutical Ltd. [Member]	Dec. 31, 2009 Teva Pharmaceuticals Industries Ltd [Member] years	Dec. 31, 2008 Teva Pharmaceuticals Industries Ltd [Member]	Dec. 31, 2011 MedImmune L L C [Member]	Dec. 31, 2010 MedImmune L L C [Member]	Dec. 31, 2009 MedImmune L L C [Member]	Dec. 31, 2011 MedImmune L L C [Member]	Dec. 31, 2011 Maximum [Member] GlaxoSmithKline [Member]	Dec. 31, 2010 BENLYSTA [Member] GlaxoSmithKline [Member]	Dec. 31, 2009 BENLYSTA [Member] GlaxoSmithKline [Member]	Dec. 31, 2006 BENLYSTA [Member] GlaxoSmithKline [Member]	Dec. 31, 2011 Albiglutide [Member] GlaxoSmithKline [Member]	Dec. 31, 2010 Albiglutide [Member] GlaxoSmithKline [Member]	Dec. 31, 2009 Albiglutide [Member] GlaxoSmithKline [Member]	Dec. 31, 2004 Albiglutide [Member] GlaxoSmithKline [Member]	Dec. 31, 2011 Albiglutide [Member] GlaxoSmithKline [Member]
Collaborations and Other Agreements [Line Items]
Non-refundable payment received																				$ 207,500,000										$ 24,000,000				$ 6,000,000
Co-promote option, percentage																											20.00%
Clinical development period, in years	8
Development milestones received and recognized																																	9,000,000		27,000,000
Number of doses of raxibacumab contract to purchase								45,000				20,001
Delivery period of raxibacumab in years											3
Expected proceeds as deliveries are completed											142,000,000
Product revenue recognized	104,863,000	47,159,000	154,074,000						52,529,000.000	47,159,000	154,074,000
Manufacturing and development services	24,840,000	22,695,000	50,653,000						2,829,000	1,438,000	26,146,000										2,100,000
Approximate amount entitled to receive upon FDA licensure of raxibacumab									20,000,000
Impairment charge of cost method investment													3,150,000
Carrying amount of cost method investment													240,000
Research costs incurred and expensed	196,182,000	196,370,000	173,709,000	2,218,000									2,453,000	2,364,000	2,321,000				663,000							8,000,000
Proceeds from divestitures													320,000									47,336,000
Gain on sale of investment													80,000								5,259,000
License costs																	50,000,000	50,000,000
Development and milestone payments due																		445,000,000
Collaboration revenue recognized	1,272,000	87,497,000	71,022,000																82,806,000	54,158,000								3,445,000	4,737,000		434,000	460,000	741,000
Costs reimbursed or reimbursable for research and development expenses					25,060,000	62,022,000	43,069,000									3,983,000				851,000
Manufacturing services agreement term, in years																					3
Royalty expenses to MedImmune																							$ 6,631,000	$ 2,389,000	$ 8,600,000

XML

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2011

Income Taxes [Abstract]

Federal Income Tax Rate To Income Before Taxes

	Year Ended December 31,
	2011			2010			2009
Federal income tax provision at 35%	$	(133,331	)	$	(77,112	)	$	1,491
State taxes, net of federal tax benefit		(7,342	)		(7,324	)		185
Foreign income tax rate differential		5,436			—			—
Permanent differences, net		8,749			3,247			(336	)
Tax credits, principally for research and development		(5,917	)		428			(1,813	)
State net operating loss carryforward adjustments		60,010			—			—
Research and development credit refunds		—			—			(1,274	)
Other		3,130			(183	)		(2,967	)
Change in valuation allowance on deferred tax asset		69,265			80,944			3,440
	$	—		$	—		$	(1,274	)

Significant Portion Of Deferred Tax Assets And Liabilities

	Current Asset			Long-Term Asset  (Liability)
December 31, 2011
Net operating loss carryforward	$	—		$	824,005
Research and development and other tax credit carryforwards		—			40,791
Capital loss carryforwards		—			315
Deferred revenue		2,910			—
Lease termination charges		—			2,644
Net unrealized gains on investments		—			(1,690	)
Intangible assets		1,613			20,037
Equity-based compensation		—			19,729
Depreciation		—			23,523
Unamortized debt discount		—			(51,924	)
Reserves and accruals		7,453			8,763
Other		—			1,626
		11,976			887,819
Less valuation allowance		(11,976	)		(887,819	)
	$	—		$	—
	Current Asset			Long-Term Asset  (Liability)
December 31, 2010
Net operating loss carryforward	$	—		$	796,645
Research and development and other tax credit carryforwards		—			34,854
Deferred revenue		2,182			761
Lease termination charges		—			3,302
Net unrealized gains on investments		—			(2,806	)
Intangible assets		385			4,104
Equity-based compensation		—			13,664
Depreciation		—			18,633
Unamortized debt discount		—			(11,922	)
Reserves and accruals		7,453			10,968
Other		—			1,436
		10,020			869,639
Less valuation allowance		(10,020	)		(869,639	)
	$	—		$	—

Provision For Income Taxes

	Year Ended December 31,
	2011		2010		2009
Current:
Federal	$	—	$	—	$	(1,274	)
State		—		—		—
Foreign taxes		—		—		—
Deferred		—		—		—
	$	—	$	—	$	(1,274	)

Reconciliation Of Unrecognized Tax Benefits

	2011			2010			2009
Balance as of January 1	$	29,523		$	30,022		$	30,282
Gross increases related to prior year tax positions		910			—			—
Gross decreases related to prior year tax positions		(635	)		(803	)		(1,108	)
Gross increases related to current year tax positions		1,133			304			848
Balance as of December 31	$	30,931		$	29,523		$	30,022

XML

Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2011

Stockholders' Equity [Abstract]

Summary Of Stock-Based Compensation Expense

	Year Ended December 31,
	2011		2010		2009
Employee stock option and employee stock purchase plan	$	33,920	$	24,277	$	11,935
Restricted stock units		1,903		1,068		589
Restricted stock awards		92		85		—
Total	$	35,915	$	25,430	$	12,524

Summary Of Stock Option Activity

	Shares			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (years)	Aggregate Intrinsic Value (1)
Outstanding at January 1, 2011		24,028,688		$	14.55	6.32	$	275,278
Granted		4,404,965			25.57
Exercised		(1,954,840	)		8.69			32,946
Forfeited		(429,950	)		22.40
Expired		(980,051	)		39.28
Outstanding at December 31, 2011		25,068,812			15.84	6.24		25,815
Vested and expected to vest at December 31, 2011		24,331,795			15.66	6.17		24,941
Exercisable at December 31, 2011		17,017,555			12.40	5.14		18,023

(1) Aggregate intrinsic value includes only options in which the exercise price of the option is less than the market value of the Company's stock on December 31, 2011, or for exercised options, the intrinsic value on the exercise date.

Summary Of Information About Stock Options Outstanding

	Options Outstanding					Options Exercisable
Range of Exercise Price	Number Outstanding		Weighted- Average Remaining Contractual Life (In Years)	Weighted- Average Exercise Price		Number Exercisable		Weighted- Average Exercise Price
$  0.52 to $10.00		6,545,064	6.34	$	3.68		5,160,920	$	4.19
$10.01 to $12.50		6,617,214	3.96		10.96		6,526,235		10.96
$12.51 to $15.00		2,320,924	3.82		13.03		2,055,903		12.87
$15.01 to $33.00		9,585,610	8.32		28.18		3,274,497		27.92
		25,068,812					17,017,555

Fair Values Of Employee Stock Options Granted, Assumptions Used

	Year Ended December 31,
	2011	2010	2009
Expected life:
Stock options	5.5 years	5.5 years	5.5 years
Employee stock purchase plan rights	1.0 years	1.0 years	1.0 years
Interest rate	1.1% - 2.4%	1.3% - 2.7%	1.4% - 2.8%
Volatility	52.6% - 66.2%	55.0% - 65.4%	53.0% - 83.5%
Dividend yield	0%	0%	0%

Status Of Company's Restricted Stock

	Shares			Weighted-Average Grant-Date Fair Value
Restricted stock at January 1, 2011		203,782		$	16.01
Granted		280,906			26.59
Vested		(97,421	)		12.81
Forfeited		(11,454	)		16.96
Restricted stock at December 31, 2011		375,813			24.72
Expected to vest at December 31, 2011		333,521			24.94

XML

Stockholders' Equity (Summary Of Stock-Based Compensation Expense) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	$ 35,915	$ 25,430	$ 12,524
Employee Stock Option And Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	33,920	24,277	11,935
Restricted Stock Units RSUs [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	1,903	1,068	589
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense	$ 92	$ 85

XML

Other Financial Information (Narrative) (Details) (USD $)	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Other Financial Information [Abstract]
Collaborative receivables, current	$ 23,013,000	$ 18,856,000
Unbilled receivables related to costs incurred to produce pre-launch commercial products	12,436,000	13,165,000
Unbilled receivables from GSK in connection with company's cost-sharing agreements	9,833,000	5,166,000
Collaboration receivables, non-current	22,630,000	29,225,000
BENLYSTA inventory prior to capitalization	92,824,000	112,822,000
Related inventories purchased or manufactured prior to the date the company began capitalizing BENLYSTA inventory	0
Collaboration payable	33,230,000	12,984,000
Prepaid expenses and other current assets	9,388,000	5,569,000
Depreciation expense	$ 20,337,000	$ 20,055,000	$ 19,960,000

XML

Facility-Related Exit Credits (Tables)

12 Months Ended

Dec. 31, 2011

Facility-Related Exit Credits [Abstract]

Liability For Exit Charges

Balance as of January 1, 2011	$	1,938
Accretion recorded		37
Cash items		(258	)
Reserve adjustment		(1,717	)
Balance as of December 31, 2011	$	—

XML

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2011

Fair Value Measurements [Abstract]

Assets And Liabilities Subject To Fair Value Measurements On Recurring Basis

	Fair Value as of December 31, 2011
	Level 1		Level 2		Level 3		Total
Cash and cash equivalents	$	402,049	$	—	$	—	$	402,049
Corporate debt securities	$	—	$	95,729	$	—	$	95,729
Residential mortgage-backed securities		—		21,008		—		21,008
Asset-backed securities		—		2,497		—		2,497
Marketable securities	$	—	$	119,234	$	—	$	119,234
Corporate debt securities	$	—	$	179,865	$	—	$	179,865
Residential mortgage-backed securities		—		47,891		—		47,891
Government-sponsored enterprise securities		—		5,281		—		5,281
Asset-backed securities		—		46,921		—		46,921
Marketable securities, non-current	$	—	$	279,958	$	—	$	279,958
Money market funds	$	11,650	$	—	$	—	$	11,650
U.S. Treasury securities		1,306		—		—		1,306
Corporate debt securities		—		51,944		—		51,944
Residential mortgage-backed securities		—		5,986		—		5,986
Government-sponsored enterprise securities		—		4,649		—		4,649
Asset-backed securities		—		4,658		—		4,658
Restricted investments	$	12,956	$	67,237	$	—	$	80,193

XML

The Company

12 Months Ended

Dec. 31, 2011

The Company [Abstract]

The Company

(NOTE A) – The Company

Human Genome Sciences, Inc. (the "Company") is a biopharmaceutical company that exists to place new therapies into the hands of those battling serious disease. Its lead products are BENLYSTA^® (belimumab) for systemic lupus erythematosus ("SLE") and raxibacumab for inhalation anthrax.

BENLYSTA was approved in March 2011 by the U.S. Food and Drug Administration ("FDA") for the treatment of adult patients with active, autoantibody-positive SLE who are receiving standard therapy. The Company launched BENLYSTA shortly thereafter and recognized revenue from its first BENLYSTA sales in March 2011. In July 2011, the European Commission granted marketing authorization for BENLYSTA in Europe as an add-on therapy in adult patients with active autoantibody-positive SLE, with a high degree of disease activity despite standard therapy.

The Company, which is located primarily in the United States, operates in a single business segment.

XML

Earnings Per Share (Tables)

12 Months Ended

Dec. 31, 2011

Earnings Per Share [Abstract]

Computation Of Diluted Net Income (Loss) Per Share

	Year Ended December 31,
	2011			2010			2009
Numerator:
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659
Denominator:
Weighted average shares outstanding		193,667,672			187,791,437			149,334,426
Effect of dilutive securities:
Employee stock options and restricted stock units		—			—			5,719,047
Weighted average shares used for diluted net income (loss) per share		193,667,672			187,791,437			155,053,473
Diluted net income (loss) per share	$	(1.97	)	$	(1.24	)	$	0.04

XML

Investments (Gross Unrealized Losses And Fair Value Of Investments With Unrealized Losses) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2010
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	$ 268,423
Loss Position for Less Than Twelve Months, Unrealized Losses	(1,089)
Loss Position for Greater Than Twelve Months, Fair Value	1,536
Loss Position for Greater Than Twelve Months, Unrealized Losses	(1)
Total, Fair Value	269,959
Total, Unrealized Losses	(1,090)
Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	93,436
Loss Position for Less Than Twelve Months, Unrealized Losses	(31)
Loss Position for Greater Than Twelve Months, Fair Value	1,536
Loss Position for Greater Than Twelve Months, Unrealized Losses	(1)
Total, Fair Value	94,972
Total, Unrealized Losses	(32)
Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	166,375
Loss Position for Less Than Twelve Months, Unrealized Losses	(1,023)
Total, Fair Value	166,375
Total, Unrealized Losses	(1,023)
Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	8,612
Loss Position for Less Than Twelve Months, Unrealized Losses	(35)
Total, Fair Value	8,612
Total, Unrealized Losses	(35)
Corporate Debt Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	35,432
Loss Position for Less Than Twelve Months, Unrealized Losses	(18)
Loss Position for Greater Than Twelve Months, Fair Value	1,536
Loss Position for Greater Than Twelve Months, Unrealized Losses	(1)
Total, Fair Value	36,968
Total, Unrealized Losses	(19)
Corporate Debt Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	56,992
Loss Position for Less Than Twelve Months, Unrealized Losses	(881)
Total, Fair Value	56,992
Total, Unrealized Losses	(881)
Corporate Debt Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	7,110
Loss Position for Less Than Twelve Months, Unrealized Losses	(29)
Total, Fair Value	7,110
Total, Unrealized Losses	(29)
Government-Sponsored Enterprise Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	20,237
Loss Position for Less Than Twelve Months, Unrealized Losses	(120)
Total, Fair Value	20,237
Total, Unrealized Losses	(120)
Government-Sponsored Enterprise Securities [Member] | Restricted Investments [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	1,502
Loss Position for Less Than Twelve Months, Unrealized Losses	(6)
Total, Fair Value	1,502
Total, Unrealized Losses	(6)
Asset-Backed Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	3,286
Total, Fair Value	3,286
Asset-Backed Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	8,400
Loss Position for Less Than Twelve Months, Unrealized Losses	(2)
Total, Fair Value	8,400
Total, Unrealized Losses	(2)
Residential Mortgage-Backed Securities [Member] | Marketable Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	54,718
Loss Position for Less Than Twelve Months, Unrealized Losses	(13)
Total, Fair Value	54,718
Total, Unrealized Losses	(13)
Residential Mortgage-Backed Securities [Member] | Marketable Securities, Non-Current [Member]
Schedule of Available-for-sale Securities [Line Items]
Loss Position for Less Than Twelve Months, Fair Value	80,746
Loss Position for Less Than Twelve Months, Unrealized Losses	(20)
Total, Fair Value	80,746
Total, Unrealized Losses	$ (20)

XML

Commitments And Other Matters (Narrative) (USD $) In Thousands, unless otherwise specified	1 Months Ended		12 Months Ended							12 Months Ended
	Dec. 31, 2011	Nov. 30, 2011	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2011 Traville Lease [Member]	Dec. 31, 2006 Traville Lease [Member]	Dec. 31, 2011 MEDCO Lease [Member]	Dec. 31, 2010 MEDCO Lease [Member]	Dec. 31, 2011 Minimum [Member] MEDCO Lease [Member]	Dec. 31, 2011 Maximum [Member] MEDCO Lease [Member]
Commitments and Other Matters [Line Items]
Operating lease commitment						$ 324,546	$ 16,653
Annual base rent under the leases during 2011								1,108
Estimated annual base rent under the leases in 2012								2,036
Aggregate rental payments	324,546		324,546			307,243
Percentage of annual lease escalation						2.00%
Purchase price option						303,000				21,000	34,000
Operating lease purchase option exercised					5,300
Number of long term leases								2
Number of new securities class actions filed in U.S. District Court against the Company	3	2
Long-term leases expiration								January 1, 2019
Letters of credit, expiration date								December 2012
Restricted investments, aggregate cost								35,900	35,400
Deferred rent liability	11,795		11,795	10,358
Rent expense aggregated			19,976	20,949	22,357
Employee contributions to 401(k), maximum			100.00%
Company's contribution to 401(k)			5,257	2,592	1,645
Current inventory of raw materials and work in process relating to anticipated future orders	10,785		10,785
Operating Leases, Future Minimum Payments Due, Current	$ 21,305		$ 21,305

XML

Quarterly Financial Information (Narrative) (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended	12 Months Ended	3 Months Ended
	Mar. 31, 2011 FivePrime Therapeutics Agreement [Member]	Dec. 31, 2011 FivePrime Therapeutics Agreement [Member]	Sep. 30, 2010 ZALBIN [Member]
Revenue Recognition, Multiple-deliverable Arrangements [Line Items]
License fee	$ 50,000	$ 50,000
License fee paid per share basic and diluted	$ 0.26
Revenue recognized, collaboration agreement			$ 34,126
Revenue per share recognized, collaboration agreement			$ 0.18

XML

Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Current assets:
Cash and cash equivalents	$ 402,049	$ 155,691
Marketable securities	119,234	282,016
Accounts receivable	54,758	25,958
Collaboration receivables	23,013	18,856
Inventory	41,659	43,091
Prepaid expenses and other current assets	9,388	5,569
Total current assets	650,101	531,181
Marketable securities, non-current	279,958	416,165
Property, plant and equipment (net of accumulated depreciation)	251,026	253,122
Restricted investments	80,193	79,510
Inventory, non-current	111,822
Collaboration receivables, non-current	22,630	29,225
Other assets	11,846	5,826
TOTAL ASSETS	1,407,576	1,315,029
Current liabilities:
Accounts payable and accrued expenses	47,453	41,798
Accrued payroll and related taxes	34,339	30,157
Convertible subordinated debt	198,037	188,620
Collaboration payable	33,230	12,984
Deferred revenues	9,452	5,134
Accrued exit expenses		1,238
Other current liabilities	1,038	1,013
Total current liabilities	323,549	280,944
Convertible senior debt, non-current	363,698
Convertible subordinated debt, non-current		184,231
Lease financing	252,105	250,516
Other liabilities	11,805	13,575
Total liabilities	951,157	729,266
Stockholders' equity:
Preferred stock - $0.01 par value; 20,000,000 shares authorized; none outstanding
Common stock - $0.01 par value; 400,000,000 shares authorized; 198,750,531 and 188,980,748 shares issued and outstanding at December 31, 2011 and 2010, respectively	1,988	1,890
Additional paid-in capital	3,250,878	2,996,645
Accumulated other comprehensive income	4,556	7,125
Accumulated deficit	(2,801,003)	(2,419,897)
Total stockholders' equity	456,419	585,763
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY	$ 1,407,576	$ 1,315,029

XML

Other Financial Information (Inventory) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Current [Member]
Other Financial Information by Period [Line Items]
Raw materials	$ 12,183	$ 12,641
Work-in-process	22,567	23,426
Finished goods	6,909	7,024
Total	41,659	43,091
Non-Current [Member]
Other Financial Information by Period [Line Items]
Raw materials	4,852
Work-in-process	102,887
Finished goods	4,083
Total	$ 111,822

XML

Consolidated Statements Of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Cash flows from operating activities:
Net income (loss)	$ (381,106)	$ (233,231)	$ 5,659
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Stock-based compensation expense	35,915	25,430	12,524
Depreciation and amortization	21,686	21,305	21,255
Amortization of debt discount	23,485	23,052	21,936
Charge for impaired investment	3,008
Facility-related exit (credits) charges	(1,717)		759
Accrued interest on marketable securities and restricted investments	1,309	5,552	(493)
Gain on extinguishment of long-term debt			(38,873)
Gain on sale of long-term equity investment			(5,259)
Other	3,132	2,177	3,759
Changes in operating assets and liabilities:
Accounts receivable	(28,800)	(2,066)	(21,021)
Collaboration receivables	2,438	(30,805)	4,800
Inventory	(107,017)	(22,942)	(20,149)
Prepaid expenses and other assets	(4,011)	2,110	(1,640)
Accounts payable and accrued expenses	6,315	3,444	(9,152)
Accrued payroll and related taxes	4,182	(840)	12,423
Collaboration payable	20,246	8,984	(4,000)
Deferred revenues	4,318	(82,892)	17,234
Accrued exit expenses	4	(1,533)	(1,953)
Other liabilities	(1,306)	1,566	1,859
Net cash used in operating activities	(397,919)	(280,689)	(332)
Cash flows from investing activities:
Purchase of marketable securities	(334,476)	(840,145)	(625,041)
Proceeds from sale and maturities of marketable securities	630,485	681,687	388,277
Capital expenditures - property, plant, and equipment	(18,989)	(9,782)	(10,019)
Proceeds from sale of long-term equity investment	319		5,259
Release of restricted investments		300	3,291
Net cash provided by (used in) investing activities	277,339	(167,940)	(238,233)
Cash flows from financing activities:
Purchase of restricted investments	(100,027)	(31,672)	(47,002)
Proceeds from sale and maturities of restricted investments	98,675	30,081	26,426
Proceeds from issuance of common stock	18,382	39,269	861,573
Payments on maturity of convertible debt	(78,348)
Proceeds from convertible senior note offering	494,500
Purchase of capped call contracts	(50,933)
Debt issuance costs	(14,270)
Purchase of treasury stock	(1,041)	(1,025)	(15)
Extinguishment of long-term debt			(49,998)
Net cash provided by financing activities	366,938	36,653	790,984
Net increase (decrease) in cash and cash equivalents	246,358	(411,976)	552,419
Cash and cash equivalents - beginning of period	155,691	567,667	15,248
Cash and cash equivalents - end of period	$ 402,049	$ 155,691	$ 567,667

XML

Stockholders' Equity (Fair Values Of Employee Stock Options Granted, Assumptions Used) (Details)	12 Months Ended
	Dec. 31, 2011 years	Dec. 31, 2010 years	Dec. 31, 2009 years
Stockholders' Equity [Abstract]
Stock options, Expected life, in years	5.5	5.5	5.5
Employee stock purchase plan rights, Expected life, in years	1.0	1.0	1.0
Interest rate, minimum	1.10%	1.30%	1.40%
Interest rate, maximum	2.40%	2.70%	2.80%
Volatility, minimum	52.60%	55.00%	53.00%
Volatility, maximum	66.20%	65.40%	83.50%
Dividend yield	0.00%	0.00%	0.00%

XML

Summary Of Significant Accounting Policies (Schedule Of Depreciation Using Straight Line Method Of Useful Lives Of The Assets) (Details)	12 Months Ended
	Dec. 31, 2011 years
Buildings [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, average years	30
Land Improvements [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, years	lesser of the lease term or the useful life
Production Equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, minimum, years	5
Estimated useful lives of the assets, maximum, years	10
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, minimum, years	3
Estimated useful lives of the assets, maximum, years	10
Computer Equipment And Software [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, minimum, years	3
Estimated useful lives of the assets, maximum, years	5
Furniture And Office Equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, minimum, years	3
Estimated useful lives of the assets, maximum, years	5
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Estimated useful lives of the assets, years	lesser of the lease term or the useful life

XML

Income Taxes (Reconciliation Of Unrecognized Tax Benefits) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Income Taxes [Abstract]
Balance as of January 1	$ 29,523	$ 30,022	$ 30,282
Gross increases related to prior year tax positions	910
Gross decreases related to prior year tax positions	(635)	(803)	(1,108)
Gross increases related to current year tax positions	1,133	304	848
Balance as of December 31	$ 30,931	$ 29,523	$ 30,022

XML

Summary Of Significant Accounting Policies (Policy)

12 Months Ended

Dec. 31, 2011

Summary Of Significant Accounting Policies [Abstract]

Use Of Estimates

Use of Estimates

The preparation of financial statements in conformity with U.S. generally accepted accounting principles ("GAAP") requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Such estimates are based on historical experience and on various assumptions that the Company believes to be reasonable under the circumstances. Actual results could differ from these estimates under different assumptions or conditions.

Principles Of Consolidation

Principles of Consolidation

The consolidated financial statements include the accounts of Human Genome Sciences, Inc. and its subsidiaries, all of which are wholly-owned. All significant intercompany accounts and transactions have been eliminated.

Cash Equivalents, Marketable Securities And Restricted Investments

Cash Equivalents, Marketable Securities and Restricted Investments

The Company considers all highly liquid investment instruments purchased with a maturity of three months or less to be cash equivalents.

The Company classifies its marketable securities with readily determinable fair values as "available-for-sale." Investments in securities that are classified as available-for-sale are measured at fair market value in the balance sheets, and unrealized holding gains and losses on investments are reported as a separate component of stockholders' equity until realized. Investments of less than 20% of privately-held companies are accounted for as cost-method investments. The Company reviews the carrying value of such investments on a periodic basis for indicators of impairment. Additionally, certain of the Company's investments are held as restricted investments. Restricted investments with maturities less than three months are not classified as cash in the Company's consolidated balance sheets. See Note C, Investments, for additional information.

Investment Risk

Investment Risk

The Company has invested its cash in obligations of the U.S. Government ("USG"), government agencies and in high-grade debt securities and various money market instruments. The Company's investment policy limits investments to certain types of instruments issued by institutions with credit ratings of "A-" or better, and places restrictions on maturities and concentrations in certain industries and by issuer. The Company does not hold auction rate securities, loans held for sale or mortgage-backed securities backed by sub-prime or Alt-A collateral.

Other-Than-Temporary Impairment Of Investments

Other-Than-Temporary Impairment of Investments

Periodically, the Company evaluates whether any investments have incurred an other-than-temporary impairment, based on the criteria under Financial Accounting Standards Board ("FASB") Accounting Standards Codification ("FASB ASC") Topic 320, Investments – Debt and Equity Securities. This evaluation consists of a review of several factors, including but not limited to the length of time and extent that a security has been in an unrealized loss position, the existence of an event that would impair the issuer's future repayment potential, the near term prospects for recovery of the market value of a security and the intent of the Company to hold the security until the market value recovers and whether it is not more likely than not that the Company will be required to sell the security. If the Company determines that such impairment exists, the Company will recognize a charge in the consolidated statement of operations equal to the amount of such impairment. See Note D, Collaborations and Other Agreements – Aegera Agreement, for additional discussion.

Accounts Receivable

Accounts Receivable

Trade accounts receivable are recorded net of allowances for prompt payment discounts and doubtful accounts.

Inventories

Inventories

Inventories, which are recorded at the lower of cost or market, include materials, labor and other direct and indirect costs and are valued using the first-in, first-out method. The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. In the case of raxibacumab, manufacturing costs were capitalized after the Company received a follow-on order from the USG in July 2009. BENLYSTA manufacturing costs have been capitalized since the FDA Advisory Committee vote in November 2010 to recommend approval of the product.

Inventory that is not expected to be utilized until more than 12 months from the balance sheet date is classified as non-current. Estimating the level of inventory utilization for the upcoming 12 months requires management to exercise significant judgment. The Company maintains inventory levels in excess of 12 months to mitigate risks such as product shortage due to higher than anticipated product demand, long lead times for manufacturing finished goods, supply interruptions for raw materials and risks of production disruptions at its sole U.S. FDA-approved manufacturing site due to contamination, equipment failure or other facility-related issues. Carrying such levels of inventory impacts the Company's liquidity and cash flows since the inventory will not be converted to cash for more than one year from the balance sheet date.

Inventory is evaluated for impairment by consideration of factors such as lower of cost or market, net realizable value, obsolescence or expiry. Inventories have carrying values that do not exceed cost nor do they exceed net realizable value. The Company believes BENLYSTA has limited risk of obsolescence at this time based on market research, which is used to estimate future demand.

The Company evaluates expiry risk by evaluating current and future product demand relative to product shelf life. The Company builds demand forecasts by considering factors such as, but not limited to, overall market potential, market share, market acceptance and patient usage. Currently, the shelf life of raw materials and work in process is approximately one to five years and three years, respectively. The shelf life for finished goods is three years. The product shelf life resets as inventory moves through each stage of completion.

Depreciation

Depreciation

Depreciation is computed using the straight-line method over the estimated useful lives of the assets as follows:

Buildings	30 years
Land improvements	lesser of the lease term or the useful life
Production equipment	5- 10 years
Laboratory equipment	3- 10 years
Computer equipment and software	3- 5 years
Furniture and office equipment	3- 5 years
Leasehold improvements	lesser of the lease term or the useful life

Impairment Of Long-Lived Assets

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable based on the criteria for accounting for the impairment or disposal of long-lived assets under FASB ASC Topic 360, Property, Plant and Equipment.

Deferred Revenue

Deferred revenue

Deferred revenue consists primarily of amounts related to raxibacumab and certain BENLYSTA shipments. The Company recognizes raxibacumab revenue based on the average contracted price as shipments occur and records the difference between the invoiced price and the average contracted price in deferred revenue. Revenue generated from BENLYSTA shipments to specialty distributors is deferred and recognized once product has been sold-through to healthcare providers.

Product Sales

Product sales

Product sales consist of U.S. sales of BENLYSTA and raxibacumab. Revenue from product sales is recognized when persuasive evidence of an arrangement exists, delivery has occurred and title to product and associated risk of loss have passed to the customer, the price is fixed or determinable, collection from the customer is reasonably assured, all performance obligations have been met and returns can be reasonably estimated. Product sales are recorded net of accruals for estimated rebates, chargebacks, discounts and other deductions (collectively, "sales deductions"), and returns. Amounts accrued for sales deductions and returns are adjusted when trends, significant events, or actual results indicate that adjustment is appropriate. With the exception of allowances for prompt payment, allowances for sales deductions and returns are included in accounts payable and accrued expenses in the accompanying consolidated balance sheet as of December 31, 2011.

The Company does not record sales deductions and returns for sales of raxibacumab due to the absence of discounts and rebates and no right of return under the contract with the USG. Aside from product recall, once delivery has occurred, product may not be returned to the Company for any reason, including failure to obtain FDA approval. Furthermore, the Company has no obligation to replace existing Strategic National Stockpile ("SNS") doses if the formulation changes during the FDA approval process.

The Company estimates BENLYSTA sales deductions and returns utilizing actual sales data, contracts with distributors and wholesalers and third-party market research. Company estimates and assumptions are subject to inherent limitations and may need to be adjusted accordingly on a prospective basis. Specific considerations for BENLYSTA sold in the U.S. are as follows:

• With respect to BENLYSTA, the Company has determined that it qualifies as the principal based on various elements of the Company's agreement with GlaxoSmithKline ("GSK"), including responsibility for manufacturing product for sale in the U.S., inventory risk and primary responsibility for changes to the product, including product specifications. The Company has an agreement with GSK whereby GSK provides distribution services.

• BENLYSTA is distributed in the U.S. through specialty distributors and wholesalers. Under this model, exclusive distributors purchase and take physical delivery and title of product, and then sell to physicians or their clinics. Because the Company received FDA approval in the first quarter of 2011, the Company currently cannot make a reasonable estimate of future product returns when product is delivered to distributors. Therefore, the Company currently does not recognize revenue upon product shipment to specialty distributors, even though the distributor is invoiced upon product shipment. Instead, the Company recognizes revenue through the specialty distributor channel at the time of shipment to the physicians or their clinics. Wholesalers supply product to all other healthcare providers (e.g. hospitals, pharmacies), however they do not take physical delivery of product. All wholesaler orders are drop-shipped directly to the healthcare providers. For wholesaler purchases, the Company currently recognizes revenue upon shipment to the healthcare provider.

• Product returns. BENLYSTA customers are not offered a general right of return. However, the Company will accept product that is damaged or defective when shipped directly from GSK or for expired product up to 12 months subsequent to its expiration date. Due to the price of BENLYSTA and limited contractual rights of return, healthcare providers generally only carry inventory quantities estimated to meet projected short-term demand. Once product has been delivered to healthcare providers, the risk of material returns is significantly mitigated, and the Company is able to make a reasonable estimate of future returns at that point. In developing estimates for sales returns, the Company considers shelf life of the product, expected demand based on market data and publicly available return rates used for other biologic drugs. In addition, the Company considers the price of the product, the nature of healthcare providers, the ability of healthcare providers to obtain product on a just-in-time basis, the predictability of patient infusion and dosing and the absence of financial incentives that would promote bulk or advance purchasing.

• Rebates. Allowances for rebates include mandated discounts under the Medicaid Drug Rebate Program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or legal requirements with public sector (e.g. Medicaid) benefit providers. The allowance for rebates is based on statutory discount rates and expected utilization. The Company's estimates for expected utilization of rebates are based in part on third party market research data. Rebates are generally invoiced and paid quarterly in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter's activity, plus an accrual balance for known prior quarters' unpaid rebates. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect revenue in the period of adjustment.

• Chargebacks. Chargebacks are discounts that occur when contracted customers purchase directly from an intermediary distributor or wholesaler. Contracted customers, which currently consist primarily of Public Health Service institutions and Federal government entities purchasing via the Federal Supply Schedule, generally purchase the product at a discounted price. The distributor or wholesaler in turn, charges back the difference between the price initially paid by the distributor or wholesaler and the discounted price paid to the distributor or wholesaler by the customer. The allowance for distributor/wholesaler chargebacks is based on known sales to contracted customers.

• Distributor / Wholesaler deductions. U.S. specialty distributors and wholesalers are offered various forms of consideration including allowances, service fees and prompt payment discounts. Distributor allowances and service fees arise from contractual agreements with distributors and are generally a fixed rate per vial purchased. Wholesale customers are offered a prompt pay discount for payment within a specified period. Distributor allowances and service fees and wholesaler prompt payment discounts recorded in the Company's 2011 statement of operations are based on actual product sales and are not estimates.

• Co-pay assistance. Patients who have commercial insurance and meet certain eligibility requirements may receive co-pay assistance. The Company accrues a liability for co-pay assistance based on actual program participation and estimates of program redemption using data provided by third-party administrators.

The Company is not the principal with respect to BENLYSTA sold outside of the U.S., i.e. in the rest of world ("ROW"). Therefore, the Company is not recording product sales with respect to this activity.

Manufacturing And Development Services

Manufacturing and development services

As part of its raxibacumab contract with the USG and the Biomedical Advanced Research and Development Authority ("BARDA"), the Company performed a variety of drug development services primarily relating to the conduct of animal and human studies. Upon BARDA's acceptance of the initial raxibacumab delivery, the Company billed the USG for the drug development work previously performed, and recorded this as manufacturing and development services revenue during 2009. The Company has been recording additional development revenue as services are performed.

The Company has entered into agreements with certain commercial parties for manufacturing process development, clinical and commercial supply of certain biopharmaceutical products. Revenue under these agreements is recognized as services are performed or products delivered, depending on the nature of the work contracted, using the proportional performance method of accounting. Performance is assessed using output measures such as units-of-work performed to date as compared to total units-of-work contracted. Advance payments received in excess of amounts earned are classified as deferred revenue until earned.

Research And Development Collaborative Agreements

Research and development collaborative agreements

Collaborative research and development agreements can provide for one or more of up-front license fees, research payments and milestone payments. In October 2009, the FASB issued new revenue recognition standards for arrangements with multiple deliverables, which were effective for the Company as of January 1, 2011. These standards address the determination of the unit(s) of accounting for multiple-element arrangements and how the arrangement's consideration should be allocated to each unit of accounting. An item can generally be considered a separate unit of accounting if all of the following criteria are met: (1) the delivered item(s) has value to the customer on a stand-alone basis and (2) if the arrangement includes a general right of return relative to the delivered item(s), delivery or performance of the undelivered item(s) is considered probable and substantially in control of the Company. Items that cannot be divided into separate units are combined with other units of accounting, as appropriate. Consideration received is allocated among the separate units based on vendor-specific objective evidence ("VSOE") if available; third-party evidence, if VSOE is unavailable; and estimated selling prices if neither VSOE nor third-party evidence is available. Revenue is recognized when the following criteria are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the sales price is fixed or determinable; and (4) collectability is probable. The Company deems service to have been rendered if no continuing obligation exists on the part of the Company.

Revenue associated with non-refundable up-front license fees under arrangements where the license fees and research and development activities cannot be accounted for as separate units of accounting are deferred and recognized as revenue on a straight-line basis over the expected term of the Company's continued involvement in the research and development process. Revenues from the achievement of research and development milestones, if deemed substantive, are recognized as revenue when the milestones are achieved, and the milestone payments are due and collectible. If not deemed substantive, the Company would recognize such milestone as revenue on a straight-line basis over the remaining expected term of continued involvement in the research and development process. Milestones are considered substantive if all of the following conditions are met: (1) it is commensurate with either our performance to meet the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the our performance to achieve the milestone, (2) it relates solely to past performance, and (3) the value of the milestone is reasonable relative to all the deliverables and payment terms (including other potential milestone consideration) within the arrangement. Payments received in advance of work performed are recorded as deferred revenue.

The new accounting standards were adopted by the Company on a prospective basis on January 1, 2011. The Company did not enter into any new multiple-element arrangements or materially modify any existing arrangements during 2011. The adoption of these standards did not have a material effect on the Company's consolidated results of operations, financial position or liquidity.

Cost Of Product Sales

Cost of product sales

The Company capitalizes inventories produced in preparation for product launches when the related product candidates are considered likely to receive regulatory approval and it is probable that the related costs will be recoverable through the commercialization of the product. Prior to capitalization, the cost of manufacturing drug product is recognized as research and development expense in the period that the cost is incurred. Therefore, manufacturing costs incurred prior to capitalization are not included in cost of product sales when revenue is recognized from the sale of that drug product.

Prior to receiving a follow-on order for raxibacumab from the USG in July 2009, the Company did not capitalize inventory costs related to this product. Although authorization to ship to the SNS was received in January 2009, there continued to be uncertainty around future product orders. Beginning in July 2009, the cost of manufacturing raxibacumab is recognized as a cost of product sales (capitalized and then expensed when revenue is recognized), rather than research and development expenses in the period that the cost is incurred.

Prior to the BENLSYTA Advisory Committee meeting in November 2010, the Company did not capitalize inventory costs related to this product. Following the positive outcome of the Advisory Committee, the cost of manufacturing BENLYSTA is being capitalized and will be expensed as cost of product sales as revenue is recognized, rather than being recorded as research and development expenses in the period that the cost is incurred.

Cost of product sales also includes royalties paid or payable to third parties based on the sales levels of certain products, distribution services costs, any applicable unabsorbed costs as a result of not operating the Company's manufacturing facilities at full capacity and manufacturing-related period expenses.

Cost Of Manufacturing And Development Services

Cost of manufacturing and development services

Cost of manufacturing and development services represents costs associated with the Company's contract manufacturing arrangements and other development services. The costs associated with work previously performed to conduct animal and human studies for raxibacumab were recognized as research and development expenses in the period that the costs were incurred. Therefore, these pre-acceptance development costs are not included in cost of manufacturing and development services for 2009. The

Company is recording additional raxibacumab development services costs as incurred. Cost of manufacturing and development services also includes any applicable unabsorbed costs as a result of not operating the Company's manufacturing facilities at full capacity and manufacturing-related period expenses.

Research And Development

Research and Development

Research and development costs are charged to expense as incurred, unless otherwise capitalized pursuant to FASB ASC Topic 730, Research and Development. Research and development costs include salaries and related benefits, outside services, licensing fees or milestones, materials and supplies, building costs and allocations of certain support costs. Research and development direct expenditures were $196,182, $196,370 and $173,709 for 2011, 2010 and 2009, respectively. Reimbursement of research and development expenses received in connection with collaborative cost-sharing agreements is recorded as a reduction of such expenses.

Leases

Leases

The Company accounts for its leases under FASB ASC Topic 840, Leases. The Company has a number of operating leases and has entered into sale-leaseback transactions for land and facilities. See Note G, Commitments and Other Matters, for additional discussion.

Stock-Based Compensation

Stock-Based Compensation

The Company has a stock incentive plan (the "Incentive Plan") under which options to purchase shares of the Company's common stock may be granted to employees, consultants and directors with an exercise price no less than the quoted market value on the date of grant. The Incentive Plan also provides for the issuance of non-vested common stock (restricted stock) and other share-based compensation. The Company recognizes stock-based compensation expense related to employee stock options under FASB ASC Topic 718, Compensation – Stock Compensation. For income tax purposes, the Company follows the "with and without" method of accounting for the tax effect of excess tax benefits generated from stock-based compensation. See Note H, Stockholders' Equity, for additional discussion.

Financing Costs Related To Long-Term Debt

Financing Costs Related to Long-term Debt

Costs associated with obtaining long-term debt are allocated between the debt and equity components as required by FASB ASC Topic 470, Debt. Costs allocated to the equity component are charged to Additional paid-in capital. Costs allocated to debt are deferred and amortized over the term of the related debt on a straight-line basis, which approximates the effective interest method.

Patent Application Costs

Patent Application Costs

Patent application costs are charged to expense as incurred.

Commercial Collaboration Expenses

Commercial collaboration expenses

Commercial collaboration expenses include GSK's share of the collaboration profit with respect to BENLYSTA sales in the United States. At this time, it also includes HGS' share of the ROW collaboration expense incurred by GSK. In the period when ROW results become profitable, the Company will begin to reflect such results as commercial collaboration income. Commercial collaboration expenses/income does not include any research and development expenses shared with GSK.

Net Income (Loss) Per Share

Net Income (Loss) Per Share

The Company follows the provisions under FASB ASC Topic 260, Earnings Per Share, which requires the Company to present basic and diluted earnings per share. The Company's basic and diluted income (loss) per share is calculated by dividing the net income (loss) by the weighted average number of shares of common stock outstanding during all periods presented. Shares issuable upon the conversion of the Company's convertible debt and shares due to the Company upon settlement of the Company's capped call contracts are excluded from diluted earnings per share calculations for 2011, 2010 and 2009 because the effects are anti-dilutive.

Major Customers And Concentration Of Credit Risk

Major customers and concentration of credit risk

The Company sells BENLYSTA to a limited number of exclusive pharmaceutical specialty distributors and wholesalers in the U.S. and sells raxibacumab only to the USG. The Company periodically assesses the financial strength of its customers and establishes allowances for anticipated losses, if necessary. The following table includes those customers that represent more than 10% of total revenue of $130,975 for 2011:

Customer A	42	%
Customer B	14	%
Customer C	14	%

Two customers each having a balance of more than 10% of the Accounts receivable balance on the consolidated balance sheet as of December 31, 2011 represent an aggregate of 90% of Accounts receivable.

Foreign Currency

Foreign Currency

The functional currency of substantially all of the Company's wholly-owned foreign subsidiaries is the U.S. dollar. For these foreign subsidiaries, monetary balance sheet and related income statement accounts are re-measured, with exchange gains and losses recorded in the consolidated statement of income. Non-monetary balance sheet items and related income statement accounts, which do not result in a fixed future cash inflow or outflow of foreign currency units, are re-measured at their historical exchange rates. In 2011, 2010 and 2009, the Company recorded negligible foreign currency re-measurement gains (losses), which are included in Other income (expense), net in the consolidated statements of income.

Comprehensive Income (Loss)

Comprehensive Income (Loss)

FASB ASC Topic 220, Comprehensive Income, requires unrealized gains and losses on the Company's available-for-sale marketable securities and long-term equity investments and the activity for the cumulative translation adjustment to be included in other comprehensive income.

The components of accumulated other comprehensive income are as follows:

	December 31,
	2011		2010
Net unrealized gains on:
Marketable securities	$	4,352	$	6,317
Restricted investments		189		805
Foreign currency translation		15		3
Accumulated other comprehensive income	$	4,556	$	7,125

Accumulated other comprehensive income excludes net realized gains included in Net income (loss) of $236 and $4,504 for 2011 and 2009, respectively. Accumulated other comprehensive income excludes net realized losses included in Net income (loss) of $303 for 2010. The effect of income taxes on items in other comprehensive income is $0 for all periods presented.

Sources Of Supply

Sources of Supply

The Company is currently able to obtain most of its raw materials, supplies and equipment from various sources, and generally has no dependence upon a single supplier. However, certain materials required for manufacturing are currently available only from single sources. The Company attempts to identify and qualify alternative sources of supply wherever possible.

Reclassifications

Reclassifications

Within the December 31, 2010 consolidated balance sheet, long-term equity investments of $3,241 have been reclassified and are included in Other assets, and a lease termination liability that had been classified in Accrued exit expenses has been reclassified to Other current liabilities. Also within the December 31, 2010 consolidated balance sheet, deferred rent of $10,358, deferred revenue, non-current of $2,517 and accrued exit expenses, non-current of $700 have been reclassified and are included in Other liabilities. All of these reclassifications have been made to conform to current year presentation.

XML

Summary Of Significant Accounting Policies (Major Customers And Concentration Of Credit Risk) (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2010	Sep. 30, 2010	Jun. 30, 2010	Mar. 31, 2010	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Concentration Risk [Line Items]
Revenue	$ 45,522	$ 34,022	$ 24,858	$ 26,573	$ 21,263	$ 50,782	$ 38,792	$ 46,514	$ 130,975	$ 157,351	$ 275,749
Total Revenue [Member]
Concentration Risk [Line Items]
Concentration risk, benchmark percentage	10.00%								10.00%
Total Revenue [Member] | Customer A [Member]
Concentration Risk [Line Items]
Concentration risk, benchmark percentage	42.00%								42.00%
Total Revenue [Member] | Customer B [Member]
Concentration Risk [Line Items]
Concentration risk, benchmark percentage	14.00%								14.00%
Total Revenue [Member] | Customer C [Member]
Concentration Risk [Line Items]
Concentration risk, benchmark percentage	14.00%								14.00%
Accounts Receivable [Member]
Concentration Risk [Line Items]
Concentration risk, percentage	90.00%								90.00%
Concentration risk, benchmark percentage	10.00%								10.00%

XML

Investments (Tables)

12 Months Ended

Dec. 31, 2011

Dec. 31, 2010

Investments [Abstract]

Available-For-Sale Investments, Including Accrued Interest

	December 31, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	94,669	$	1,123	$	(63	)	$	95,729
Residential mortgage-backed securities		20,681		329		(2	)		21,008
Asset-backed securities		2,496		1		—			2,497
Subtotal - Marketable securities		117,846		1,453		(65	)		119,234
Corporate debt securities		177,725		2,866		(726	)		179,865
Residential mortgage-backed securities		47,158		737		(4	)		47,891
Government-sponsored enterprise securities		5,230		51		—			5,281
Asset-backed securities		46,881		49		(9	)		46,921
Subtotal - Marketable securities, non-current		276,994		3,703		(739	)		279,958
Cash and cash equivalents		11,649		1		—			11,650
U.S. Treasury and agencies		1,304		2		—			1,306
Corporate debt securities		51,773		316		(145	)		51,944
Residential mortgage-backed securities		5,977		30		(21	)		5,986
Government-sponsored enterprise securities		4,641		9		(1	)		4,649
Asset-backed securities		4,659		3		(4	)		4,658
Subtotal - Restricted investments		80,003		361		(171	)		80,193
Total	$	474,843	$	5,517	$	(975	)	$	479,385

	December 31, 2010
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	125,708	$	1,655	$	(19	)	$	127,344
Residential mortgage-backed securities		53,944		787		(13	)		54,718
Government-sponsored enterprise securities		86,905		61		—			86,966
Asset-backed securities		12,983		5		—			12,988
Subtotal - Marketable securities		279,540		2,508		(32	)		282,016
Corporate debt securities		248,500		3,611		(881	)		251,230
Residential mortgage-backed securities		79,605		1,161		(20	)		80,746
Government-sponsored enterprise securities		25,402		3		(120	)		25,285
Asset-backed securities		58,822		84		(2	)		58,904
Subtotal - Marketable securities, non-current		412,329		4,859		(1,023	)		416,165
Cash and cash equivalents		7,455		—		—			7,455
U.S. Treasury and agencies		1,302		10		—			1,312
Corporate debt securities		45,931		620		(29	)		46,522
Residential mortgage-backed securities		6,368		128		—			6,496
Government-sponsored enterprise securities		13,237		72		(6	)		13,303
Asset-backed securities		4,412		10		—			4,422
Subtotal - Restricted investments		78,705		840		(35	)		79,510
Total	$	770,574	$	8,207	$	(1,090	)	$	777,691

Gross Unrealized Losses And Fair Value Of Investments With Unrealized Losses

	December 31, 2010
	Loss Position for Less Than Twelve Months					Loss Position for Greater Than Twelve Months					Total
	Fair Value		Unrealized Losses			Fair Value		Unrealized Losses			Fair Value		Unrealized Losses
Corporate debt securities	$	35,432	$	(18	)	$	1,536	$	(1	)	$	36,968	$	(19	)
Residential mortgage-backed securities		54,718		(13	)		—		—			54,718		(13	)
Asset-backed securities		3,286		—			—		—			3,286		—
Subtotal - Marketable securities		93,436		(31	)		1,536		(1	)		94,972		(32	)
Corporate debt securities		56,992		(881	)		—		—			56,992		(881	)
Residential mortgage-backed securities		80,746		(20	)		—		—			80,746		(20	)
Government-sponsored enterprise securities		20,237		(120	)		—		—			20,237		(120	)
Asset-backed securities		8,400		(2	)		—		—			8,400		(2	)
Subtotal - Marketable securities, non-current		166,375		(1,023	)		—		—			166,375		(1,023	)
Corporate debt securities		7,110		(29	)		—		—			7,110		(29	)
Government-sponsored enterprise securities		1,502		(6	)		—		—			1,502		(6	)
Subtotal - Restricted investments		8,612		(35	)		—		—			8,612		(35	)
Total	$	268,423	$	(1,089	)	$	1,536	$	(1	)	$	269,959	$	(1,090	)

Maturities Of Marketable Securities And Restricted Investment Securities

	Marketable Securities				Marketable Securities, non-current				Restricted Investments
	Amortized Cost		Fair Value		Amortized Cost		Fair Value		Amortized Cost		Fair Value
Less than one year	$	117,846	$	119,234	$	—	$	—	$	34,914	$	35,003
Due in year two through year three		—		—		219,106		221,040		41,663		41,813
Due in year four through year five		—		—		41,695		42,473		3,295		3,245
Due after five years		—		—		16,193		16,445		131		132
Total	$	117,846	$	119,234	$	276,994	$	279,958	$	80,003	$	80,193

Realized Gains And Losses On Investments Sold And Respective Net Proceeds

	Year Ended December 31,
	2011			2010			2009
Proceeds on sale and maturities of investments	$	728,185		$	708,896		$	368,560
Realized gains		1,652			1,673			7,026
Realized losses		(1,416	)		(1,976	)		(2,522	)

XML

Fair Value Measurements (Assets And Liabilities Subject To Fair Value Measurements On Recurring Basis) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2008
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents	$ 402,049	$ 155,691	$ 567,667	$ 15,248
Marketable securities, fair value	119,234	282,016
Marketable securities, non-current, fair value	279,958	416,165
Restricted investments	80,193	79,510
Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents	402,049
Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents
Marketable Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	119,234
Marketable Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	119,234
Marketable Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, fair value	119,234	282,016
Marketable Securities [Member] | Corporate Debt Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, fair value	95,729	127,344
Investments, fair value disclosure	95,729
Marketable Securities [Member] | Corporate Debt Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	95,729
Marketable Securities [Member] | Corporate Debt Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities [Member] | Residential Mortgage-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	21,008
Marketable Securities [Member] | Residential Mortgage-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	21,008
Marketable Securities [Member] | Residential Mortgage-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities [Member] | Government-Sponsored Enterprise Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, fair value		86,966
Marketable Securities [Member] | Asset-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	2,497
Marketable Securities [Member] | Asset-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	2,497
Marketable Securities [Member] | Asset-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities, Non-Current [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, non-current, fair value	279,958	416,165
Investments, fair value disclosure	279,958
Marketable Securities, Non-Current [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	279,958
Marketable Securities, Non-Current [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities, Non-Current [Member] | Corporate Debt Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, non-current, fair value	179,865	251,230
Investments, fair value disclosure	179,865
Marketable Securities, Non-Current [Member] | Corporate Debt Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	179,865
Marketable Securities, Non-Current [Member] | Corporate Debt Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities, Non-Current [Member] | Residential Mortgage-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	47,891
Marketable Securities, Non-Current [Member] | Residential Mortgage-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	47,891
Marketable Securities, Non-Current [Member] | Residential Mortgage-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities, Non-Current [Member] | Government-Sponsored Enterprise Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Marketable securities, non-current, fair value	5,281	25,285
Investments, fair value disclosure	5,281
Marketable Securities, Non-Current [Member] | Government-Sponsored Enterprise Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	5,281
Marketable Securities, Non-Current [Member] | Government-Sponsored Enterprise Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Marketable Securities, Non-Current [Member] | Asset-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	46,921
Marketable Securities, Non-Current [Member] | Asset-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	46,921
Marketable Securities, Non-Current [Member] | Asset-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	80,193
Restricted Investments [Member] | Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	12,956
Restricted Investments [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	67,237
Restricted Investments [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | Money Market Funds [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	11,650
Restricted Investments [Member] | Money Market Funds [Member] | Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	11,650
Restricted Investments [Member] | Money Market Funds [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | U.S. Treasury Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	1,306
Restricted Investments [Member] | U.S. Treasury Securities [Member] | Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	1,306
Restricted Investments [Member] | U.S. Treasury Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | Corporate Debt Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	51,944
Restricted Investments [Member] | Corporate Debt Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	51,944
Restricted Investments [Member] | Corporate Debt Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | Residential Mortgage-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	5,986
Restricted Investments [Member] | Residential Mortgage-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	5,986
Restricted Investments [Member] | Residential Mortgage-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | Government-Sponsored Enterprise Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	4,649
Restricted Investments [Member] | Government-Sponsored Enterprise Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	4,649
Restricted Investments [Member] | Government-Sponsored Enterprise Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure
Restricted Investments [Member] | Asset-Backed Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	4,658
Restricted Investments [Member] | Asset-Backed Securities [Member] | Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure	4,658
Restricted Investments [Member] | Asset-Backed Securities [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Investments, fair value disclosure

XML

Consolidated Statements Of Cash Flows (Parenthetical) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Cash paid (received) during the period for:
Interest	$ 32,547	$ 33,169	$ 33,609
Income taxes		(1,948)	809
Non-cash interest expense	808
Interest rate of convertible subordinated notes	2.25%
Restricted investments, released		9,014
Non-cash accretion recorded	37	277	1,384
Increase in lease financing with BioMed	$ 1,588	$ 1,889	$ 2,151

XML

Consolidated Balance Sheets (Parenthetical) (USD $)	Dec. 31, 2011	Dec. 31, 2010
Consolidated Balance Sheets [Abstract]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	20,000,000	20,000,000
Preferred stock, shares outstanding	0	0
Common stock par value	$ 0.01	$ 0.01
Common stock, shares authorized	400,000,000	400,000,000
Common stock, shares, issued	198,750,531	188,980,748
Common stock, shares, outstanding	198,750,531	188,980,748

XML

Facility-Related Exit Credits

12 Months Ended

Dec. 31, 2011

Facility-Related Exit Credits [Abstract]

Facility-Related Exit Credits

(NOTE J) – Facility-Related Exit Credits

During 2011, the Company decided to utilize certain headquarters space ("Wing C") which it had previously not used and was not expecting to use. In conjunction with this decision, the Company reversed the remaining reserve related to this space, recording a facility-related exit credit of $1,717 in the consolidated statement of operations during 2011.

The following table summarizes the activity related to the liability for exit charges for 2011, all of which is facilities-related:

Balance as of January 1, 2011	$	1,938
Accretion recorded		37
Cash items		(258	)
Reserve adjustment		(1,717	)
Balance as of December 31, 2011	$	—

XML

Document And Entity Information (USD $)	12 Months Ended
	Dec. 31, 2011	Jan. 31, 2012	Jun. 30, 2011
Document And Entity Information [Abstract]
Entity Registrant Name	HUMAN GENOME SCIENCES INC
Entity Central Index Key	0000901219
Document Type	10-K
Document Period End Date	Dec. 31, 2011
Amendment Flag	false
Document Fiscal Year Focus	2011
Document Fiscal Period Focus	FY
Company Fiscal Year End Date	--12-31
Entity Filer Category	Large Accelerated Filer
Entity Common Stock, Shares Outstanding		198,981,706
Entity Well-known Seasoned Issuer	Yes
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Public Float			$ 3,085,756,649

XML

Fair Value Measurements

12 Months Ended

Dec. 31, 2011

Fair Value Measurements [Abstract]

Fair Value Measurements

(NOTE K) – Fair Value Measurements

The FASB guidance regarding the fair value of all assets and liabilities defines fair value, provides guidance for measuring fair value and requires certain disclosures. This guidance does not require any new fair value measurements, but rather applies to all other accounting pronouncements that require or permit fair value measurements. This guidance does not apply to measurements related to share-based payments.

The FASB Codification discusses valuation techniques, such as the market approach (comparable market prices), the income approach (present value of future income or cash flow), and the cost approach (cost to replace the service capacity of an asset or replacement cost). The guidance utilizes a fair value hierarchy that prioritizes the inputs to valuation techniques used to measure fair value into three broad levels. The following is a brief description of those three levels:

Level 1:	Observable inputs such as quoted prices (unadjusted) in active markets for identical assets or liabilities.
Level 2:	Inputs other than quoted prices that are observable for the asset or liability, either directly or indirectly. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active.
Level 3:	Unobservable inputs that reflect the reporting entity's own assumptions.

Active markets are those in which transactions occur with sufficient frequency and volume to provide pricing information on an ongoing basis. Inactive markets are those in which there are few transactions for the asset, prices are not current, or price quotations vary substantially either over time or among market makers, or in which little information is released publicly. With regard to the Company's financial assets subject to fair value measurements, the Company believes that all of the assets it holds are actively traded because there is sufficient frequency and volume to obtain pricing information on an ongoing basis.

The Company's assets and liabilities subject to fair value measurements on a recurring basis and the related fair value hierarchy are as follows:

	Fair Value as of December 31, 2011
	Level 1		Level 2		Level 3		Total
Cash and cash equivalents	$	402,049	$	—	$	—	$	402,049
Corporate debt securities	$	—	$	95,729	$	—	$	95,729
Residential mortgage-backed securities		—		21,008		—		21,008
Asset-backed securities		—		2,497		—		2,497
Marketable securities	$	—	$	119,234	$	—	$	119,234
Corporate debt securities	$	—	$	179,865	$	—	$	179,865
Residential mortgage-backed securities		—		47,891		—		47,891
Government-sponsored enterprise securities		—		5,281		—		5,281
Asset-backed securities		—		46,921		—		46,921
Marketable securities, non-current	$	—	$	279,958	$	—	$	279,958
Money market funds	$	11,650	$	—	$	—	$	11,650
U.S. Treasury securities		1,306		—		—		1,306
Corporate debt securities		—		51,944		—		51,944
Residential mortgage-backed securities		—		5,986		—		5,986
Government-sponsored enterprise securities		—		4,649		—		4,649
Asset-backed securities		—		4,658		—		4,658
Restricted investments	$	12,956	$	67,237	$	—	$	80,193

The Company evaluates the types of securities in its investment portfolios to determine the proper classification in the fair value hierarchy based on trading activity and the observability of market inputs.

The Company generally obtains a single quote or price per instrument from independent third parties to help it determine the fair value of securities in Level 1 and Level 2 of the fair value hierarchy. The Company's Level 1 cash and money market instruments are valued based on quoted prices from third parties, and the Company's Level 1 U.S. Treasury securities are valued based on broker quotes. The Company's Level 2 assets are valued using a multi-dimensional pricing model that includes a variety of inputs including actual trade data, benchmark yield data, non-binding broker/dealer quotes, issuer spread data, monthly payment information, collateral performance and other reference information. These are all observable inputs. The Company reviews the values generated by the multi-dimensional pricing model for reasonableness, which could include reviewing other publicly available information.

The Company does not hold auction rate securities, loans held for sale, mortgage-backed securities backed by sub-prime or Alt-A collateral or any other investments which require the Company to determine fair value using a discounted cash flow approach. Therefore, the Company does not need to adjust its analysis or change its assumptions specifically to factor illiquidity in the markets into its fair values.

The fair value of the Company's accounts receivable, collaboration receivables, other assets, accounts payable, accrued expenses and collaboration payable approximate their carrying amount due to the relatively short maturity of these items. The fair value of the Company's convertible senior and subordinated debt is based on quoted market prices. The quoted market price of the Company's convertible senior and subordinated debt was approximately $634,458 (book value of $561,735) as of December 31, 2011. With respect to its lease financing, the Company evaluated its incremental borrowing rate as of December 31, 2011, based on the current interest rate environment and the Company's credit risk. The fair value of the BioMed lease financing was approximately $263,688 (book value of $252,105) as of December 31, 2011 based on a discounted cash flow analysis, and current rates for corporate debt having similar characteristics and companies with similar creditworthiness.

XML

Consolidated Statements Of Operations (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenue:
Product sales	$ 104,863	$ 47,159	$ 154,074
Manufacturing and development services	24,840	22,695	50,653
Research and development collaborative agreements	1,272	87,497	71,022
Total revenue	130,975	157,351	275,749
Costs and expenses:
Cost of product sales	47,061	29,941	15,805
Cost of manufacturing and development services	28,999	15,016	18,215
Research and development expenses	196,182	196,370	173,709
Selling, general and administrative expenses	158,779	106,797	61,073
Commercial collaboration expenses	31,222
Facility-related exit (credits) charges	(1,717)		759
Total costs and expenses	460,526	348,124	269,561
Income (loss) from operations	(329,551)	(190,773)	6,188
Investment income	12,175	16,966	12,727
Interest expense	(62,056)	(59,500)	(58,424)
Gain on extinguishment of debt			38,873
Gain on sale of long-term equity investment			5,259
Other income (expense)	(1,674)	76	(238)
Income (loss) before taxes	(381,106)	(233,231)	4,385
Income tax benefit			1,274
Net income (loss)	$ (381,106)	$ (233,231)	$ 5,659
Basic and diluted net income (loss) per share	$ (1.97)	$ (1.24)	$ 0.04
Weighted average shares outstanding, basic	193,667,672	187,791,437	149,334,426
Weighted average shares outstanding, diluted	193,667,672	187,791,437	155,053,473

XML

Other Financial Information

12 Months Ended

Dec. 31, 2011

Other Financial Information [Abstract]

Other Financial Information

(NOTE E) – Other Financial Information

Collaboration Receivables

Collaboration receivables of $23,013 as of December 31, 2011 include $12,436 due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which is expected to be sold within the next year. Collaboration receivables also include $9,833 in unbilled receivables from GSK in connection with Company's cost-sharing agreements and other unbilled receivables. Collaboration receivables of $18,856 as of December 31, 2010 include $13,165 due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which will be sold within the next year, $5,166 in unbilled receivables from GSK in connection with the Company's cost-sharing agreements and other unbilled receivables.

Collaboration receivables, non-current of $22,630 and $29,225 as of December 31, 2011 and 2010, respectively, relate to the amounts due to the Company from GSK for manufacturing costs incurred to produce pre-launch commercial product which is not expected to be sold within the next year.

Inventory

Inventories consist of the following:

	December 31, 2011				December 31, 2010
	Current		Non-current		Current		Non-current
Raw materials	$	12,183	$	4,852	$	12,641	$	—
Work-in-process		22,567		102,887		23,426		—
Finished goods		6,909		4,083		7,024		—
Total	$	41,659	$	111,822	$	43,091	$	—

Inventory that is not expected to be sold until more than 12 months from the balance sheet date is classified as non-current.

BENLYSTA-related inventories that were either purchased or manufactured prior to the date the Company began capitalizing BENLYSTA inventory (November 2010) were $92,824 and $112,822 as of December 31, 2011 and 2010, respectively. These inventories have a carrying value of zero, as the costs to purchase or produce this inventory were expensed as research and development expense in the period manufactured, and accordingly are not reflected in the inventory balances shown above. These inventories could be used in clinical trials, sold in the U.S. as commercial product or sold to GSK at cost for the ROW sale of BENLYSTA.

As of December 31, 2011, the Company has current raw material and work in process inventory relating to raxibacumab beyond that which is required to fulfill the second order from the USG. See Note G, Commitments and Other Matters, for additional discussion.

Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets of $9,388 and $5,569 as of December 31, 2011 and 2010, respectively, consisted primarily of deposits, deferred financing fees and insurance payments made in advance.

Property, Plant and Equipment

Property, plant and equipment are stated at cost and are summarized as follows:

	December 31,
	2011			2010
Building (LSM)	$	204,151		$	204,151
Laboratory and production equipment		100,400			96,462
Computer equipment and software		42,033			39,296
Land and improvements		30,521			30,521
Leasehold improvements		32,414			26,678
Furniture and office equipment		8,427			7,274
Construction-in-progress		8,246			5,364
		426,192			409,746
Less: accumulated depreciation		(175,166	)		(156,624	)
	$	251,026		$	253,122

Depreciation expense was $20,337, $20,055 and $19,960 for 2011, 2010 and 2009, respectively.

Accounts Payable and Accrued Expenses

Accounts payable and accrued expenses are comprised of the following:

	December 31,
	2011		2010
Accounts payable	$	4,442	$	6,364
Accrued clinical trial costs		9,302		13,665
Sales deductions and returns allowance		4,345		—
Other accrued expenses		29,364		21,769
	$	47,453	$	41,798

Accrued clinical trial costs consist primarily of investigator fees, contract research organization services and laboratory costs. Other accrued expenses consist primarily of interest payable, accrued royalties and miscellaneous accrued expenses.

Collaboration Payable

Collaboration payable of $33,230 as of December 31, 2011, represents cost reimbursements due to GSK in connection with BENLYSTA. Collaboration payable of $12,984 as of December 31, 2010 represents cost reimbursements due to GSK and Novartis in connection with the Company's cost sharing agreements.

XML

Collaborations And Other Agreements

12 Months Ended

Dec. 31, 2011

Collaborations And Other Agreements [Abstract]

Collaborations And Other Agreements

(NOTE D) – Collaborations and Other Agreements

GlaxoSmithKline Agreement

During 2006, the Company entered into a license agreement with GSK for the co-development and co-commercialization of BENLYSTA arising from an option GSK exercised in 2005, relating to an earlier collaboration agreement. The agreement grants GSK a co-development and co-commercialization license, under which both companies will jointly conduct activities related to the development and sale of products in the United States and abroad. The Company and GSK share Phase 3 and 4 development costs, and share sales and marketing expenses and profits of any product commercialized under the agreement. The Company has primary responsibility for bulk manufacturing and for commercial manufacturing of the finished drug product. In partial consideration of the rights granted to GSK in this agreement, the Company received a non-refundable payment of $24,000 during 2006 and recognized this payment as revenue over the remaining clinical development period, which ended in 2010. The Company recognized revenue of $3,445 and $4,737 in 2010 and 2009, respectively, relating to this payment. In March 2011, the FDA approved BENLYSTA and in July 2011 the European Commission granted marketing authorization for BENLYSTA.

The BENLYSTA agreement arises from a 1993 agreement, as amended, in which the Company entered into a collaboration agreement providing GSK a first right to develop and market products in human and animal health care ("GSK Products"), based upon human genes identified by the Company. In June 1996, this agreement was substantially amended (the "1996 GSK Agreement").

With respect to the Company's rights under the 1996 GSK Agreement, the Company is entitled to (1) royalties on the net sales of certain GSK Products developed pursuant to the agreement, (2) product development milestones and (3) the option to co-promote up to 20% of any product developed by GSK under the collaboration agreement. If the Company were to exercise its option to co-promote any GSK Products, it would be entitled to receive additional amounts from GSK in proportion to its level of co-promotion. The Company has been informed that GSK is pursuing research programs involving specific genes for the creation or development of small molecule drugs. The Company cannot provide any assurance that any of these programs will be continued or result in any approved drugs.

In 2004, the Company entered into an agreement with GSK under which GSK acquired exclusive worldwide rights to develop and commercialize albiglutide, a drug that had been in late-stage preclinical development by the Company for potential use in the treatment of diabetes. In 2004, the Company received an up-front fee of $6,000 and is recognizing this revenue ratably over the clinical development period, which is estimated to be eight years. With respect to this fee, the Company recognized $434, $460 and $741 as revenue in 2011, 2010 and 2009, respectively. As of December 31, 2011, the Company has received and recognized development milestones aggregating $27,000 under the agreement, including $9,000 received and recognized in 2009.

GSK's share of the collaboration profit with respect to BENLYSTA sales in the U.S. and HGS' share of the ROW collaboration expense incurred by GSK are included in the Commercial collaboration expenses line in the consolidated statement of operations for 2011.

Research and development expenses are net of $25,060, $62,022 and $43,069 for 2011, 2010 and 2009, respectively, of costs reimbursed by GSK. The Company shares certain research and development costs including personnel costs, outside services, clinical manufacturing and overhead with GSK under cost sharing provisions in the GSK collaboration agreement.

U.S. Government Agreement

During 2006, the USG exercised its option under the second phase of a 2005 contract to purchase 20,001 doses of raxibacumab for the SNS. Under this two-phase contract, the Company has supplied raxibacumab, a human monoclonal antibody developed for use in the treatment of anthrax disease, to the USG. Along with the cost to manufacture the 20,001 doses, the Company has incurred the cost to conduct several animal and human studies as part of this contract. During 2009, the Company received authorization from BARDA to ship raxibacumab to the SNS and delivered all of the 20,001 doses. In July 2009, the USG agreed to purchase 45,000 additional doses of raxibacumab for the SNS, to be delivered over a three-year period beginning in 2009. The Company expects to receive a total of approximately $142,000 from this order as deliveries are completed. The Company recognized $52,529, $47,159 and $154,074 in product revenue related to raxibacumab in 2011, 2010 and 2009, respectively. The Company recognized $2,829, $1,438 and $26,146 in manufacturing and development services revenue related to the work to conduct the animal and human studies and other raxibacumab activities in 2011, 2010 and 2009, respectively. The Company is entitled to receive approximately $20,000 under the contract with the USG if raxibacumab is licensed by the FDA.

MedImmune LLC Agreement

In 1999, the Company entered into a collaborative agreement with Cambridge Antibody Technology Ltd. (assumed by MedImmune LLC ("MedImmune") through acquisition) to jointly pursue the development of fully human monoclonal antibody therapeutics. MedImmune will receive milestone payments from the Company in connection with the development of any such antibodies as well as royalty payments on the Company's net sales of such licensed product following regulatory approval. In the event of the achievement of certain other milestones or successful product launch of other products, the Company would be obligated to pay MedImmune additional compensation. Since 1999, the Company has exercised one option and made milestone payments to MedImmune totaling $8,000 pursuant to this agreement.

In 2000, the Company entered into a second agreement with Cambridge Antibody Technology Ltd. The 2000 agreement provides the Company with rights to use MedImmune technology to develop and sell an unlimited number of fully human antibodies for therapeutic and diagnostic purposes. The Company will pay MedImmune clinical development milestones and royalties based on product sales. Since 2000, the Company has exercised several options and made certain payments.

During 2011, 2010 and 2009, the Company incurred aggregate royalty expenses under these agreements of approximately $6,631, $2,389 and $8,600, respectively, associated with U.S. sales of BENLYSTA and raxibacumab. These royalty expenses are included in cost of product sales on the consolidated statements of operations. Royalty expenses to MedImmune related to ROW sales of BENLYSTA are included in commercial collaboration expense on the 2011 consolidated statement of operations.

FivePrime Therapeutics Agreement

In 2011, the Company entered into an agreement with FivePrime Therapeutics, Inc. ("FivePrime") to develop and commercialize FivePrime's FP-1039 product candidate for multiple cancers. The Company paid FivePrime an upfront license fee of $50,000, which is reflected in research and development expenses in the consolidated statement of operations for 2011. The Company's policy is that upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified are expensed as incurred. The Company may be required to pay up to $445,000 in future development, regulatory and commercial milestone payments, as well as royalty payments on net sales if the product is commercialized. HGS has exclusive rights to develop and commercialize FP-1039, now known as HGS1036, for all indications in the United States, Canada and the European Union ("EU"). FivePrime has an option to co-promote HGS1036 and any next-generation products in the United States, and retains full development and commercialization rights in all other regions of the world outside the U.S., Canada and the EU. The Company incurred and expensed additional research and development costs of $2,218 related to HGS1036 development during 2011.

Morphotek Agreement

During 2009, the Company entered into an agreement with Morphotek, Inc. to discover, develop and commercialize therapeutic monoclonal antibodies in the fields of oncology and immunology that specifically target antigens discovered by the Company. With respect to each antibody candidate, the Company and Morphotek have the right to opt in to participate in development and commercialization. The Company and Morphotek currently share research and development costs with respect to one collaboration product and the Company has primary responsibility for manufacturing clinical supplies of that product. Research and development expenses for 2011 are net of $3,983 of costs reimbursed by Morphotek. No research and development expenses were shared during 2010 and 2009.

Novartis Agreement

During 2006, the Company entered into an agreement with Novartis International Pharmaceutical Ltd. ("Novartis") for the co-development and commercialization of ZALBIN^TM. In 2010, the Company and Novartis ended development of ZALBIN based upon the feedback contained in a Complete Response Letter received from the FDA.

Under the agreement, Novartis had paid the Company $207,500 through the end of 2009. The Company was recognizing these payments as revenue ratably over the estimated remaining development period. Based on the decision to end further development of ZALBIN, the Company recognized all remaining deferred revenue related to these payments in September 2010. The Company recognized revenue of $82,806 and $54,158 in 2010 and 2009, respectively, under this agreement. The Company's share of Novartis-incurred research and development expenses was $663 in 2010. Research and development expenses in 2009 are net of $851 of costs reimbursed by Novartis.

Aegera Agreement

During 2007, the Company entered into a collaboration and license agreement with Aegera of Montreal, Canada under which the Company acquired exclusive worldwide rights (excluding Japan) to develop and commercialize certain oncology molecules and related backup compounds to be chosen during a research period extended through 2011.

During March 2011, the Company determined that its investment in Aegera had incurred an other-than-temporary impairment based on changes in Aegera's business activities and wrote down its investment of approximately $3,150 to approximately $240. The impairment loss is included in Other income (expense) on the consolidated statement of operations for 2011. In May 2011, Aegera was acquired by Pharmascience, Inc. and the Company received proceeds of approximately $320 resulting in a gain on the sale of the investment of approximately $80, which is included in Other income (expense) on the consolidated statement of operations for 2011. The Company incurred and expensed research costs of $2,453, $2,364 and $2,321 related to the Aegera agreement during 2011, 2010 and 2009, respectively. In December 2011, the Company made the decision to discontinue further development of the early-stage product being developed under the Aegera collaboration.

Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys) License Agreement and Manufacturing Services Agreement

The Company sold its CoGenesys division in 2006 and entered into a license agreement, as amended, that is now with Teva Biopharmaceuticals USA, Inc. ("Teva Bio"). Under the license agreement, as amended, the Company is entitled to various milestone and royalty rights on certain products, if they are developed and commercialized. Teva Bio can obtain additional product rights by extending the initial seven-year research term upon the payment of additional consideration. In addition, the Company entered into a three-year manufacturing services agreement, as amended, which ended during 2009. The Company allocated the consideration received to both the product license and manufacturing services agreement, which was recognized ratably over the term of the manufacturing services agreement, as amended. The Company recognized approximately $2,100 of revenue during 2009 relating to these agreements. See Note L, Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys), for additional discussion.

XML

Summary Of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2011

Summary Of Significant Accounting Policies [Abstract]

Schedule Of Depreciation Using Straight Line Method Of Useful Lives Of Assets

Buildings	30 years
Land improvements	lesser of the lease term or the useful life
Production equipment	5- 10 years
Laboratory equipment	3- 10 years
Computer equipment and software	3- 5 years
Furniture and office equipment	3- 5 years
Leasehold improvements	lesser of the lease term or the useful life

Major Customers And Concentration Of Credit Risk

Customer A	42	%
Customer B	14	%
Customer C	14	%

Components Of Accumulated Other Comprehensive Income

	December 31,
	2011		2010
Net unrealized gains on:
Marketable securities	$	4,352	$	6,317
Restricted investments		189		805
Foreign currency translation		15		3
Accumulated other comprehensive income	$	4,556	$	7,125

XML

Teva Biopharmaceuticals USA, Inc. (Formerly Cogenesys)

12 Months Ended

Dec. 31, 2011

Teva Biopharmaceuticals USA, Inc. (Formerly Cogenesys) [Abstract]

Teva Biopharmaceuticals USA, Inc. (Formerly Cogenesys)

(NOTE L) – Teva Biopharmaceuticals USA, Inc. (formerly CoGenesys)

In 2008, Teva Pharmaceuticals Industries, Ltd. ("Teva") acquired all of the outstanding stock of CoGenesys and CoGenesys became a wholly-owned subsidiary of Teva called Teva Bio. CoGenesys had been a division of the Company until 2006, when the Company completed the sale of assets and concurrently entered into a license agreement and manufacturing services agreement.

As consideration for the assets conveyed, liabilities assumed and intellectual property licensed, the Company obtained an equity interest in CoGenesys. The Company allocated the consideration received to both the product license and manufacturing services agreement, which was recognized ratably over the term of the manufacturing services agreement, as amended, which ended in 2009.

Under the license agreement, as amended, the Company is entitled to various milestone and royalty rights on certain products, if they are developed and commercialized. Teva Bio can obtain additional product rights by extending the initial seven-year research term upon the payment of additional consideration.

As a result of Teva's acquisition of CoGenesys in 2008, the Company received $47,336 as partial payment for its equity investment in CoGenesys. The terms of the agreement between Teva and CoGenesys required an escrow account be established for 10% of the purchase price as security for CoGenesys' representations, warranties, and covenants. During 2009, the Company received the final payment for its equity investment in CoGenesys and recorded a gain of $5,259.

XML

Stockholders' Equity

12 Months Ended

Dec. 31, 2011

Stockholders' Equity [Abstract]

Stockholders' Equity

(NOTE H) – Stockholders' Equity

Public Offerings of Common Stock

During 2009, the Company completed two public offerings of its common stock. The Company issued 26,697,250 shares in August 2009 at a price of $14.00 per share, resulting in net proceeds of approximately $356,500. The Company also issued 17,825,000 shares in December 2009 at a price of $26.75 per share, resulting in net proceeds of approximately $456,400.

Stock-based Compensation Plans

The Company has two stock-based compensation plans as described below. The following is a summary of the stock-based compensation expense that has been recorded in the consolidated statements of operations for the years indicated:

	Year Ended December 31,
	2011		2010		2009
Employee stock option and employee stock purchase plan	$	33,920	$	24,277	$	11,935
Restricted stock units		1,903		1,068		589
Restricted stock awards		92		85		—
Total	$	35,915	$	25,430	$	12,524

Stock-based compensation expense for 2011 is net of $3,373 capitalized as part of inventory production. No income tax benefit was recognized in the consolidated statements of operations for stock-based compensation for the years presented due to the Company's net loss position.

Stock Incentive Plan

The Company has a stock incentive plan (the "Incentive Plan") under which options to purchase new shares of the Company's common stock may be granted to employees, consultants and directors at an exercise price no less than the quoted market value on the date of grant. The Incentive Plan also provides for awards in the form of stock appreciation rights, restricted (non-vested) or unrestricted stock awards, stock-equivalent units or performance-based stock awards. The Company issues both qualified and non-qualified options under the Incentive Plan. The vesting period of the options is determined by the Board of Directors and is generally four years. Upon acquisition by a person, or group of persons, of more than 50% of the Company's outstanding common stock, outstanding options shall immediately vest in full and be exercisable. The Company recognizes compensation expense for an award with only service conditions that has a graded vesting schedule on a straight-line basis over the requisite service period for the entire award. All options expire after ten years or earlier from the date of grant.

As of December 31, 2011, the total authorized number of shares under the Incentive Plan, including prior plans, was 59,845,420. Options available for future grant were 6,478,055 as of December 31, 2011.

Stock Options

A summary of stock option activity for 2011 is as follows:

	Shares			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term (years)	Aggregate Intrinsic Value (1)
Outstanding at January 1, 2011		24,028,688		$	14.55	6.32	$	275,278
Granted		4,404,965			25.57
Exercised		(1,954,840	)		8.69			32,946
Forfeited		(429,950	)		22.40
Expired		(980,051	)		39.28
Outstanding at December 31, 2011		25,068,812			15.84	6.24		25,815
Vested and expected to vest at December 31, 2011		24,331,795			15.66	6.17		24,941
Exercisable at December 31, 2011		17,017,555			12.40	5.14		18,023

(1) Aggregate intrinsic value includes only options in which the exercise price of the option is less than the market value of the Company's stock on December 31, 2011, or for exercised options, the intrinsic value on the exercise date.

The following table summarizes information about stock options outstanding as of December 31, 2011:

	Options Outstanding					Options Exercisable
Range of Exercise Price	Number Outstanding		Weighted- Average Remaining Contractual Life (In Years)	Weighted- Average Exercise Price		Number Exercisable		Weighted- Average Exercise Price
$  0.52 to $10.00		6,545,064	6.34	$	3.68		5,160,920	$	4.19
$10.01 to $12.50		6,617,214	3.96		10.96		6,526,235		10.96
$12.51 to $15.00		2,320,924	3.82		13.03		2,055,903		12.87
$15.01 to $33.00		9,585,610	8.32		28.18		3,274,497		27.92
		25,068,812					17,017,555

During 2011, 2010 and 2009, the Company issued 1,954,840, 3,600,641 and 4,584,767 shares of common stock, respectively, in conjunction with stock option exercises. The Company received cash proceeds from the exercise of these stock options of approximately $16,982, $37,841 and $48,147, for 2011, 2010 and 2009, respectively.

As of December 31, 2011, total unrecognized compensation cost related to stock options amounted to $104,153, which is expected to be recognized over a weighted-average period of 2.5 years as the options vest. There were non-vested stock options outstanding for 8,064,257 shares as of December 31, 2011.

The total intrinsic value of stock options exercised during 2011, 2010 and 2009 was approximately $32,946, $66,779 and $51,205, respectively. The total fair value of stock options which vested during 2011, 2010 and 2009 was approximately $38,830, $20,286 and $12,353, respectively. The weighted-average grant-date fair value of stock options granted during 2011, 2010 and 2009 was $14.26, $17.31 and $0.91 per share, respectively.

The fair values of employee stock options granted during 2011, 2010 and 2009 were determined based on the Black-Scholes-Merton option-pricing model using the following range of assumptions:

	Year Ended December 31,
	2011	2010	2009
Expected life:
Stock options	5.5 years	5.5 years	5.5 years
Employee stock purchase plan rights	1.0 years	1.0 years	1.0 years
Interest rate	1.1% - 2.4%	1.3% - 2.7%	1.4% - 2.8%
Volatility	52.6% - 66.2%	55.0% - 65.4%	53.0% - 83.5%
Dividend yield	0%	0%	0%

An explanation of the above assumptions is as follows:

Expected Life of Stock-based Awards – The expected life of stock-based awards is the period of time for which the stock-based award is expected to be outstanding. This estimate is based on historical exercise data.

Interest Rate – The risk-free rate over the expected life of the option is based on the U.S. Treasury yield curve in effect at the time of grant.

Volatility – Volatility is a measure of the amount by which a financial variable such as a share price has fluctuated (historical volatility) or is expected to fluctuate (implied volatility) during a period. The Company uses a combination of historical volatility and the implied volatility of its traded convertible notes as the basis for its expected volatility. In 2010, because the Company's then outstanding traded convertible notes were nearing maturity, the Company added historical volatility to its overall volatility calculation. The weighted average volatility used was 61.7%, 63.5% and 55.9% for 2011, 2010 and 2009, respectively.

Dividend Yield – The Company has never declared or paid dividends and has no plans to do so in the foreseeable future.

Restricted Stock

Under the Incentive Plan, the Company has granted both restricted stock awards and restricted stock units ("RSUs"). RSUs have service conditions and vest ratably on an annual basis over a four-year period. During 2011, the Company awarded 280,906 RSUs at a weighted-average grant date fair value of $26.59 per share. The Company incurred $1,995, $1,153 and $589 of compensation expense for 2011, 2010 and 2009, respectively, related to both RSUs and restricted stock awards.

A summary of the status of the Company's restricted stock as of December 31, 2011 and changes during 2011 is presented below:

	Shares			Weighted-Average Grant-Date Fair Value
Restricted stock at January 1, 2011		203,782		$	16.01
Granted		280,906			26.59
Vested		(97,421	)		12.81
Forfeited		(11,454	)		16.96
Restricted stock at December 31, 2011		375,813			24.72
Expected to vest at December 31, 2011		333,521			24.94

Stock-based compensation expense under FASB ASC Topic 718, Compensation – Stock Compensation, for 2011, 2010 and 2009 is not necessarily representative of the level of stock-based compensation expense in future years due to, among other things, (1) the vesting period of the stock-based compensation and (2) the number and fair value of additional stock-based grants in future years.

Employee Stock Purchase Plan

The Company has an Employee Stock Purchase Plan (the "Purchase Plan"), as amended, registering 2,000,000 shares of $0.01 par value common stock for issuance under this plan. Under the Purchase Plan, eligible employees may purchase shares of common stock on certain dates and at certain prices as set forth in the plan. The common stock is purchased under the Purchase Plan at a discounted rate, currently at 15%, which results in this plan qualifying as compensatory. During 2011, the Company issued 68,025 shares of common stock pursuant to the Purchase Plan and recorded compensation cost of approximately $758. The weighted-average fair value of the employee stock purchase plan rights granted during 2011, 2010 and 2009 was $5.81, $6.65 and $0.53 per share, respectively. Common stock reserved for future employee purchase under the Purchase Plan aggregated 596,625 shares as of December 31, 2011. There are no other investment options for participants.

XML

Stockholders' Equity (Status Of Company's Restricted Stock) (Details) (USD $)	12 Months Ended
	Dec. 31, 2011
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares, Granted	280,906
Weighted-Average Grant-Date Fair Value, Restricted stock at January 1, 2011	$ 16.01
Weighted-Average Grant-Date Fair Value, Granted	$ 26.59
Weighted-Average Grant-Date Fair Value, Vested	$ 12.81
Weighted-Average Grant-Date Fair Value, Forfeited	$ 16.96
Weighted-Average Grant-Date Fair Value, Restricted stock at December 31, 2011	$ 24.72
Weighted-Average Grant-Date Fair Value, Expected to vest at December 31, 2011	$ 24.94
Restricted Stock Units RSUs [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares, Restricted stock at January 1, 2011	203,782
Shares, Granted	280,906
Shares, Vested	(97,421)
Shares, Forfeited	(11,454)
Shares, Restricted stock at December 31, 2011	375,813
Shares, Expected to vest at December 31, 2011	333,521

XML

Long-Term Debt

12 Months Ended

Dec. 31, 2011

Long-Term Debt [Abstract]

Long-Term Debt

(NOTE F) – Long-term Debt

The components of short-term and long-term debt are as follows:

			December 31,
Debt	Interest Rate	Maturities	2011			2010
3% Convertible Senior Notes due 2018	3.0%	November 2018	$	363,698		$	—
2 1/4% Convertible Subordinated Notes due 2011	2.25%	October 2011		—			188,620
2 1/4% Convertible Subordinated Notes due 2012	2.25%	August 2012		198,037			184,231
				561,735			372,851
BioMed lease financing	11.0%	May 2026		252,105			250,516
				813,840			623,367
Less current portion				(198,037	)		(188,620	)
			$	615,803		$	434,747

Annual maturities of all long-term debt (representing cash to be paid) are as follows:

2012	$	206,736
2013		—
2014		—
2015		187
2016		671
2017 and thereafter		546,603
	$	754,197

The difference between total debt of $813,840 and annual maturities of $754,197 is due to the accounting for the sale-leaseback of the Company's headquarters land and LSM as a financing transaction and the debt discount relating to the convertible senior and subordinated notes. During 2006, the Company entered into a purchase and sale agreement with BioMed in connection with the Company's Traville headquarters land and LSM. The Company is accounting for the sale-leaseback as a financing transaction. Payments due for the BioMed debt resulting from this financing are based upon an allocation of fair value of the properties included in the transaction. Aggregate lease financing payments, including interest, over the remaining fourteen year period are approximately $421,504 including an annual lease escalation of 2%. Interest expense associated with this debt is being calculated at approximately 11%, which approximated the Company's incremental borrowing rate at the time of the agreement. For the first nine years of the leases, the payments are less than the amount of calculated interest expense, which results in an increase in the debt balance during this period, reaching $254,699 in 2015. Accordingly, the Company has classified the full amount of the debt outstanding as of December 31, 2011 as long-term. Beginning in 2015, the payments begin to reduce the debt balance and are reflected in the annual maturities shown herein. At the end of the twenty-year leases, the remaining debt will be approximately $201,738.

In November 2011, the Company completed the private placement of $494,500 of 3% Convertible Senior Notes due 2018 ("3% Notes due 2018"), convertible into common stock at approximately $13.33 per share. Under FASB ASC Topic 470, Debt ("ASC 470"), $361,340 of the proceeds from the 3% Notes due 2018 was allocated to long-term debt and $133,160 was allocated to equity based on the Company's non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $361,340 of 3% Notes due 2018 amounted to approximately $10,428, which are being amortized on a straight-line basis, which approximates the effective interest method, over the life of the 3% Notes due 2018. The 3% Notes due 2018 also contain a provision for a "make-whole" premium to be paid by the Company to holders of the 3% Notes due 2018 in the event of certain changes in control that could occur during the life of the 3% Notes due 2018. The premium is payable in the form of the Company's common stock by increasing the conversion rate to the holders of the notes who convert their notes. The premium, which is expressed as additional shares of common stock per one thousand dollars principal amount of notes, is based upon the price of the Company's stock as of the effective date of the change in control. The maximum premium possible is approximately $114,116, or approximately 23% of the aggregate face value of 3% Notes due 2018 outstanding, in the event a qualified change in control occurs with a stock price of at least $10.25 per share at such date. If the stock price on the effective date of a change in control is less than $10.25 per share or greater than $75.00 per share, no premium will be paid.

In connection with the issuance of the 3% Notes due 2018, the Company entered into capped call contracts with certain counterparties covering approximately 37,110,692 shares of the Company's common stock issuable upon the conversion of the 3% Notes due 2018. The capped call contracts have a strike price of $13.33 per share and a cap price of $18.45 per share, and are settled upon maturity of the capped call contracts ("Settlement Date"). If the price of the Company's common stock at the Settlement Date is above the strike price of the capped calls, the counterparties will deliver shares of the Company's common stock and/or cash, at the Company's option. In the event the Company elects to receive shares, the counterparties will deliver shares based on computing the aggregate value of the capped call contracts (number of underlying shares of the convertibles notes multiplied by the difference between the price of the Company's common stock at the Settlement date, up to the capped price per share, and the strike price) and then dividing such aggregate value by the price of the Company's common stock as of the Settlement Date. In the event the Company elects to receive cash, the counterparties will deliver cash equal to the aggregate value of the capped call contracts. If the price of the Company's common stock at the Settlement Date is below the strike price of the capped call contracts, the capped call contracts will expire with no shares and/or cash being delivered to the Company. The Company paid approximately $50,933 for these capped calls in 2011 and recorded this cost in Additional paid-in capital.

During 2004, the Company completed the private placement of $280,000 of 2 ¹/4% Convertible Subordinated Notes due 2011 ("2 ¹/4% Notes due 2011"), convertible into common stock at approximately $15.55 per share. Under ASC 470, $191,804 of the proceeds from the 2 ¹/4% Notes due 2011 was allocated to long-term debt and $88,196 was allocated to equity based on the Company's non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $191,804 of 2 ¹/4% Notes due 2011 amounted to approximately $5,924, which were being amortized on a straight-line basis, which approximated the effective interest method, over the life of the 2 ¹/4% Notes due 2011. During 2009, the Company repurchased 2 ¹/4% Notes due 2011 with a face value of $82,900 (as discussed below), and wrote off the related unamortized debt issuance costs and debt discount. During the third quarter of 2011, the Company issued an aggregate of 7,614,000 shares of common stock in several separate transactions in exchange for $116,600 aggregate principal amount (net of an unamortized discount of $1,200) of the 2 ¹/4% Notes due 2011. The Company also recorded approximately $808 of interest expense in 2011 related to exchange offers accepted by certain note holders. The remaining approximately $78,000 principal amount of these notes was repaid in October 2011 in cash.

During 2005, the Company completed an offering of $230,000 of 2 ¹/4% Convertible Subordinated Notes due 2012 ("2 ¹/4% Notes due 2012"), convertible into common stock at approximately $17.78 per share. Under ASC 470, $143,266 of the proceeds from the 2 ¹/4% Notes due 2012 was allocated to long-term debt and $86,734 was allocated to equity based on the Company's non-convertible borrowing rate in effect at the time the notes were issued. Debt issuance costs attributable to the $143,266 of 2 ¹/4% Notes due 2012 amounted to approximately $4,220, which are being amortized on a straight-line basis, which approximates the effective interest method, over the life of the 2 ¹/4% Notes due 2012. During 2009, the Company repurchased 2 ¹/4% Notes due 2012 with a face value of $23,250 (as discussed below), and wrote off the related unamortized debt issuance costs and debt discount. The 2 ¹/4% Notes due 2012 also contain a provision for a "make-whole" premium to be paid by the Company to holders of the 2 ¹/4% Notes due 2012 in the event of certain changes in control that could occur during the life of the 2 ¹/4% Notes due 2012. The premium is payable in the form of the Company's common stock by increasing the conversion rate to the

holders of the notes who convert their notes. The premium, which is expressed as additional shares of common stock per one thousand dollars principal amount of notes, is based upon the price of the Company's stock as of the effective date of the change in control. As of December 31, 2011, the maximum premium possible is approximately $21,334, or approximately 10% of the aggregate face value of 2 ¹/4% Notes due 2012 outstanding, in the event a qualified change in control occurs with a stock price of at least $14.82 per share at such date. If the stock price on the effective date of a change in control is less than $14.82 per share or greater than $100.00 per share, no premium will be paid.

During 2009, the Company repurchased 2 ¹/4% Notes due 2011 with a face value of $82,900 and 2 ¹/4% Notes due 2012 with a face value of $23,250 for an aggregate cost of approximately $50,000 plus accrued interest. The repurchase resulted in a gain on extinguishment of debt of $38,873, net of the related debt discount of $16,424 and debt issuance costs of $855.

The carrying amount and fair value of the Company's short-term and long-term debt are as follows:

	December 31,
	2011				2010
	Carrying Amount		Fair Value		Carrying Amount		Fair Value
3% Convertible Senior Notes due 2018	$	363,698	$	433,924	$	—	$	—
2 1/4% Convertible Subordinated Notes due 2011		—		—		188,620		320,311
2 1/4% Convertible Subordinated Notes due 2012		198,037		200,534		184,231		314,245
BioMed lease financing		252,105		263,688		250,516		266,016
	$	813,840	$	898,146	$	623,367	$	900,572

The fair value of the BioMed lease financing is determined using a discounted cash flow analysis and current rates for corporate debt having similar characteristics and companies with similar credit worthiness.

The components of the convertible debt are as follows:

	December 31, 2011
	Face Value		Unamortized Debt Discount			Carrying Amount
3% Convertible Senior Notes due 2018	$	494,500	$	(130,802	)	$	363,698
2 1/4% Convertible Subordinated Notes due 2012		206,736		(8,699	)		198,037
	$	701,236	$	(139,501	)	$	561,735

	December 31, 2010
	Face Value		Unamortized Debt Discount			Carrying Amount
2 1/4% Convertible Subordinated Notes due 2011	$	197,100	$	(8,480	)	$	188,620
2 1/4% Convertible Subordinated Notes due 2012		206,740		(22,509	)		184,231
	$	403,840	$	(30,989	)	$	372,851

The Company's 3% Notes due 2018 are unsecured obligations of the Company and rank equal in right of payment with all other senior indebtedness, if any, and senior in right of payment to the Company's existing and future subordinated indebtedness. The 3% Notes due 2018 are not redeemable prior to maturity, but can be repurchased by the Company on the open market. The indentures under which the 3% Notes due 2018 have been issued contain no financial covenants or any restriction on the payments of dividends, the incurrence of additional senior indebtedness, or other indebtedness, or the Company's issuance or repurchase of securities. There are no sinking fund requirements with respect to the 3% Notes due 2018.

The Company's 2 ¹/4% Notes due 2012 are unsecured obligations of the Company and rank junior in right of payment to the Company's existing and future senior indebtedness. The 2 ¹/4% Notes due 2012 are not redeemable prior to maturity, but can be repurchased by the Company on the open market. The indentures under which the 2 ¹/4% Notes due 2012 have been issued contain no financial covenants or any restriction on the payments of dividends, the incurrence of senior indebtedness, or other indebtedness, or the Company's issuance or repurchase of securities. There are no sinking fund requirements with respect to the 2 ¹/4% Notes due 2012.

XML

Commitments And Other Matters

12 Months Ended

Dec. 31, 2011

Commitments And Other Matters [Abstract]

Commitments And Other Matters

(NOTE G) – Commitments and Other Matters

Leases

The Company leases office and laboratory premises pursuant to operating leases expiring at various dates through 2026. Minimum annual rentals are as follows:

Year Ending December 31,
2012	$	21,305
2013		21,843
2014		21,973
2015		22,113
2016		22,431
2017 and thereafter		214,881
	$	324,546

The operating lease commitment of $324,546 includes lease payments associated with the Company's lease with BioMed for its Traville headquarters. During 2006 the Company entered into a lease with BioMed for its Traville headquarters following the termination of the Company's Traville lease with its former lessor. Based upon an allocation of fair value, the initial annual rent for Traville was approximately $16,653. The aggregate rental payments over the remaining lease term are approximately $307,243, including an annual escalation of 2% which is accounted for on a straight-line basis over the lease term. The Company has an option to purchase the Traville facility in 2016 for $303,000. There are no financial covenants with respect to the BioMed lease.

As part of its agreement with BioMed, the Company committed to exercise purchase options with respect to certain equipment currently used at the Traville facility at the end of the applicable equipment lease terms. The equipment was subject to several operating leases with an unrelated party. The Company exercised the purchase option related to the remaining leases in 2009 at a cost of approximately $5,300. The Company will transfer ownership of this facility-related equipment to BioMed at the earlier of the end of the Traville lease term or at certain other pre-specified events.

The Company has entered into two long-term leases, as amended, with MEDCO expiring January 1, 2019 for a small-scale manufacturing facility built to the Company's specifications. The Company has accounted for these leases as operating leases. The facility was financed primarily through a combination of MEDCO Bonds and loans issued to MEDCO by certain State of Maryland agencies. The Company has no equity interest in MEDCO.

Rent is based upon MEDCO's debt service obligations. Annual base rent under the leases during 2011 was approximately $1,108. Annual base rent under the leases in 2012 is expected to increase to approximately $2,036. The MEDCO Bonds are secured by letters of credit issued for the account of MEDCO which expire in December 2012. The Company has restricted investments of approximately $35,900 and $35,400 as of December 31, 2011 and 2010, respectively, associated with these leases which serve as security for the MEDCO letters of credit reimbursement obligation. Upon default or early lease termination, the MEDCO Bond indenture trustee can draw upon the letters of credit to pay the MEDCO Bonds as they are tendered. In such an event, the Company could lose part or all of its restricted investments and could record a charge to earnings for a corresponding amount. Alternatively, the Company has an option during or at the end of the lease term to purchase this facility for an aggregate amount that declines from approximately $34,000 in 2012 to approximately $21,000 in 2019. The amended leases contain no debt covenants with respect to the Company's financial condition. See Note C, Investments, for additional discussion of the Company's restricted investments.

The Company's leases for office and laboratory space provide for certain rent escalations on each anniversary of the lease commencement date. For financial reporting purposes, rent expense is charged to operations on a straight-line basis over the term of the lease, resulting in a liability for deferred rent of $11,795 and $10,358 as of December 31, 2011 and 2010, respectively.

Rent expense aggregated $19,976, $20,949 and $22,357 for 2011, 2010 and 2009, respectively. The decrease in rent expense each year is due to the expiration of certain equipment leases.

401(k) Plan

The Company has a 401(k) pension plan available to eligible full-time employees. Participating employees may contribute up to 100% of their total eligible compensation to the plan, subject to Internal Revenue Service limitations. The Company currently matches a portion of the employee contributions. The Company's contribution was $5,257, $2,592 and $1,645 for 2011, 2010 and 2009, respectively.

Contingent Liabilities

In the ordinary course of business, the Company is involved in various legal proceedings, including, among others, patent oppositions, patent revocations, patent infringement litigation, securities class actions, shareholder derivative litigation and other matters incidental to its business. While it is not possible to accurately predict or determine the eventual outcome of these matters or estimate a range of loss, one or more of these matters currently pending could have a material adverse effect on the Company's financial condition, results of operations or cash flows.

In November 2011, two securities class actions were filed in the U.S. District Court for the District of Maryland against the Company and a number of its current and former executive officers and directors, alleging violations of securities laws during 2010 and 2009. In addition, three shareholder derivative actions have been filed during December 2011 and January 2012 in the United States District Court for the District of Maryland that are related to essentially the same allegations made in the securities class actions. The Company believes these suits are without merit and plans to vigorously defend these claims. Currently, the Company cannot estimate any potential loss related to these claims. No reserve has been established for any potential liability relating to these suits.

Loss Contingencies

As of December 31, 2011, current inventory includes an aggregate of $10,785 of raw materials and work in process relating to anticipated future orders for raxibacumab beyond that which is required to fulfill the second order from the USG. The Company currently expects to recover the cost of this inventory through future sales of raxibacumab. If the Company does not receive additional orders for raxibacumab, it would need to record a charge to cost of product sales for this amount of inventory.

XML

Income Taxes

12 Months Ended

Dec. 31, 2011

Income Taxes [Abstract]

Income Taxes

(NOTE I) – Income Taxes

The Company provides for income taxes using the liability method. The difference between the tax provision and the amount that would be computed by applying the statutory Federal income tax rate to income before taxes is attributable to the following:

	Year Ended December 31,
	2011			2010			2009
Federal income tax provision at 35%	$	(133,331	)	$	(77,112	)	$	1,491
State taxes, net of federal tax benefit		(7,342	)		(7,324	)		185
Foreign income tax rate differential		5,436			—			—
Permanent differences, net		8,749			3,247			(336	)
Tax credits, principally for research and development		(5,917	)		428			(1,813	)
State net operating loss carryforward adjustments		60,010			—			—
Research and development credit refunds		—			—			(1,274	)
Other		3,130			(183	)		(2,967	)
Change in valuation allowance on deferred tax asset		69,265			80,944			3,440
	$	—		$	—		$	(1,274	)

The change in valuation allowance as reported above excludes the change in valuation allowance associated with the net deferred tax asset recorded in connection with the net unrealized gains on investments, as such amounts are recorded as a component of other comprehensive income. In 2011, the Company recorded a charge of $60,010, fully offset by valuation allowance release, to adjust the Company's deferred tax assets related to state net operating loss carryforwards. The charge was necessary to account for the adoption of a more favorable state income apportionment methodology provided to Maryland manufacturers and the impact of the Company's commercialization activities. The effective rate reconciliation now includes a foreign income tax rate differential to account for the Company's international operations and a line for net permanent differences.

Temporary differences and carryforwards that give rise to a significant portion of deferred tax assets and liabilities are as follows:

	Current Asset			Long-Term Asset  (Liability)
December 31, 2011
Net operating loss carryforward	$	—		$	824,005
Research and development and other tax credit carryforwards		—			40,791
Capital loss carryforwards		—			315
Deferred revenue		2,910			—
Lease termination charges		—			2,644
Net unrealized gains on investments		—			(1,690	)
Intangible assets		1,613			20,037
Equity-based compensation		—			19,729
Depreciation		—			23,523
Unamortized debt discount		—			(51,924	)
Reserves and accruals		7,453			8,763
Other		—			1,626
		11,976			887,819
Less valuation allowance		(11,976	)		(887,819	)
	$	—		$	—
	Current Asset			Long-Term Asset  (Liability)
December 31, 2010
Net operating loss carryforward	$	—		$	796,645
Research and development and other tax credit carryforwards		—			34,854
Deferred revenue		2,182			761
Lease termination charges		—			3,302
Net unrealized gains on investments		—			(2,806	)
Intangible assets		385			4,104
Equity-based compensation		—			13,664
Depreciation		—			18,633
Unamortized debt discount		—			(11,922	)
Reserves and accruals		7,453			10,968
Other		—			1,436
		10,020			869,639
Less valuation allowance		(10,020	)		(869,639	)
	$	—		$	—

The Company recognized a valuation allowance to the full extent of its deferred tax assets since the likelihood of realization of the benefit is not more likely than not. The valuation allowance increased by $20,136 during 2011 to $899,795 as of December 31, 2011. The increase is primarily related to the net operating loss carryforward generated in the current year, partially offset by valuation allowance release related to state net operating losses and $49,129 related to non-deductible debt discount on the Company's 2011 convertible debt offering that was allocated to equity.

Provision for income taxes is comprised of the following:

	Year Ended December 31,
	2011		2010		2009
Current:
Federal	$	—	$	—	$	(1,274	)
State		—		—		—
Foreign taxes		—		—		—
Deferred		—		—		—
	$	—	$	—	$	(1,274	)

The Company has available tax credit carryforwards of approximately $40,533 which expire, if unused, from the year 2012 through the year 2031. The Company has net operating loss ("NOL") carryforwards for federal income tax purposes of approximately $2,051,487, excluding stock-based compensation NOLs, which expire, if unused, from the year 2012 through the year 2031. In connection with the adoption of stock-based compensation guidance in 2006, the Company elected to follow the with-and-without approach to determine the sequence in which deductions and NOL carryforwards are utilized. As of December 31, 2011, the Company has approximately $366,185 of NOL carryforwards that relate to stock-based compensation for which future tax benefits, if any, will be credited to equity.

Internal Revenue Code Section 382 ("Section 382") imposes annual limitations on the utilization of NOL carryforwards and other tax attributes upon an ownership change. In general terms, an ownership change may result from transactions that increase the aggregate ownership of certain stockholders in the Company's stock by more than 50 percentage points over a testing period (generally three years). The Company updated a Section 382 analysis originally completed during 2010. Based on this analysis and other reviews of relevant shareholder activity, the Company's NOLs and other tax attributes are not limited under Section 382. The Company's future utilization of all of the Company's NOLs and other tax attributes is dependent upon the Company's ability to generate sufficient income during the carryforward periods and no further significant changes in ownership.

The Company accounts for uncertain tax positions pursuant to the guidance of FASB ASC Topic 740, Income Taxes. The Company recognizes interest and penalties related to uncertain tax positions, if any, in income tax expense. As of December 31, 2011 and 2010, the Company did not accrue any interest related to uncertain tax positions. The Company's income taxes have not been subject to examination by any tax jurisdictions since the Company's inception. Accordingly, all income tax returns filed by the Company are subject to examination by the taxing jurisdictions.

A reconciliation of the beginning and ending amount of gross unrecognized tax benefits is as follows:

	2011			2010			2009
Balance as of January 1	$	29,523		$	30,022		$	30,282
Gross increases related to prior year tax positions		910			—			—
Gross decreases related to prior year tax positions		(635	)		(803	)		(1,108	)
Gross increases related to current year tax positions		1,133			304			848
Balance as of December 31	$	30,931		$	29,523		$	30,022

The Company believes that any of its uncertain tax positions would not result in adjustments to its effective tax rate because likely corresponding adjustments to deferred tax assets would be offset by adjustments to recorded valuation allowances. It is reasonably possible that the balance of uncertain tax positions will decrease by up to $1,284 within the next 12 months due to the statutory expiration of certain tax carryforwards.

XML

Income Taxes (Provision For Income Taxes) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Income Taxes [Abstract]
Federal			$ (1,274)
State
Foreign taxes
Deferred
Provision for income taxes			$ (1,274)

XML

Facility-Related Exit Credits (Liability For Exit Charges) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Facility-Related Exit Credits [Abstract]
Balance as of January 1, 2011	$ 1,938
Accretion recorded	37	277	1,384
Cash items	(258)
Reserve adjustment	(1,717)
Balance as of December 31, 2011		1,938
Facility-related exit credits	$ 1,717		$ (759)

XML

Income Taxes (Significant Portion Of Deferred Tax Assets And Liabilities) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Current Asset [Member]
Deferred Income Tax Assets and Liabilities [Line Items]
Deferred revenue	$ 2,910	$ 2,182
Intangible assets	1,613	385
Reserves and accruals	7,453	7,453
Deferred tax assets, gross	11,976	10,020
Less valuation allowance	(11,976)	(10,020)
Long-Term Assets [Member]
Deferred Income Tax Assets and Liabilities [Line Items]
Net operating loss carryforward	824,005	796,645
Research and development and other tax credit carryforwards	40,791	34,854
Capital loss carryforwards	315
Deferred revenue		761
Lease termination charges	2,644	3,302
Net unrealized gains on investments	(1,690)	(2,806)
Intangible assets	20,037	4,104
Equity-based compensation	19,729	13,664
Depreciation	23,523	18,633
Unamortized debt discount	(51,924)	(11,922)
Reserves and accruals	8,763	10,968
Other	1,626	1,436
Deferred tax assets, gross	887,819	869,639
Less valuation allowance	$ (887,819)	$ (869,639)

XML

Summary Of Significant Accounting Policies (Narrative) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011 years	Dec. 31, 2010	Dec. 31, 2009
Summary of Significant Accounting Policies [Line Items]
Maximum ownership percentage of investments accounted for using the cost method	20.00%
Raw materials inventory minimum shelf life, years	1
Raw materials inventory maximum shelf life, years	5
Work-in-process inventory shelf life, years	3
Finished goods inventory shelf life, years	3
Research and development expenses	$ 196,182	$ 196,370	$ 173,709
Accumulated other comprehensive income excludes net realized gain (loss) included in net income	236	(303)	4,504
Effect of income taxes in other comprehensive income	0	0	0
Long-Term Equity Investments [Member]
Summary of Significant Accounting Policies [Line Items]
Balance sheet reclassified amount		(3,241)
Deferred Rent Liability [Member]
Summary of Significant Accounting Policies [Line Items]
Balance sheet reclassified amount		10,358
Deferred Revenue, Non-Current [Member]
Summary of Significant Accounting Policies [Line Items]
Balance sheet reclassified amount		2,517
Accrued Exit Expenses, Non-Current [Member]
Summary of Significant Accounting Policies [Line Items]
Balance sheet reclassified amount		$ 700

XML

Long-Term Debt (Schedule Of Fair Value Of The Long-Term And Short-Term Debt) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Debt Instrument [Line Items]
Notes, Carrying Value	$ 813,840	$ 623,367
Notes, Fair Value	898,146	900,572
3% Convertible Senior Notes Due 2018 [Member]
Debt Instrument [Line Items]
Notes, Carrying Value	363,698
Notes, Fair Value	433,924
2.25% Convertible Subordinated Notes Due 2011 [Member]
Debt Instrument [Line Items]
Notes, Carrying Value		188,620
Notes, Fair Value		320,311
2.25% Convertible Subordinated Notes Due 2012 [Member]
Debt Instrument [Line Items]
Notes, Carrying Value	198,037	184,231
Notes, Fair Value	200,534	314,245
BioMed Lease Financing [Member]
Debt Instrument [Line Items]
Notes, Carrying Value	252,105	250,516
Notes, Fair Value	$ 263,688	$ 266,016

XML

Quarterly Financial Information

12 Months Ended

Dec. 31, 2011

Quarterly Financial Information [Abstract]

Quarterly Financial Information

(NOTE N) – Quarterly Financial Information (unaudited)

Quarterly financial information for 2011 and 2010 is presented in the following table:

	1st Quarter			2nd Quarter			3rd Quarter			4th Quarter
2011
Revenue	$	26,573		$	24,858		$	34,022		$	45,522
Loss from operations		(115,999	)		(68,494	)		(75,995	)		(69,063	)
Net loss		(130,995	)		(80,660	)		(88,429	)		(81,022	)
Net loss per share, basic and diluted		(0.69	)		(0.42	)		(0.45	)		(0.41	)
2010
Revenue	$	46,514		$	38,792		$	50,782		$	21,263
Loss from operations		(37,773	)		(46,992	)		(29,826	)		(76,182	)
Net loss		(47,877	)		(56,863	)		(40,859	)		(87,632	)
Net loss per share, basic and diluted		(0.26	)		(0.30	)		(0.22	)		(0.46	)

The Company's results for the first quarter of 2011 include an upfront license fee paid to FivePrime of $50,000, or $0.26 per basic and diluted share. See Note D, Collaborations and Other Agreements for additional information.

The Company's results for the third quarter of 2010 include additional revenue recognized based on the decision to end future development of ZALBIN of $34,126, or $0.18 per basic and diluted share.

XML

Long-Term Debt (Tables)

12 Months Ended

Dec. 31, 2011

Dec. 31, 2010

Long-Term Debt [Abstract]

Components Of Long-Term Debt

			December 31,
Debt	Interest Rate	Maturities	2011			2010
3% Convertible Senior Notes due 2018	3.0%	November 2018	$	363,698		$	—
2 1/4% Convertible Subordinated Notes due 2011	2.25%	October 2011		—			188,620
2 1/4% Convertible Subordinated Notes due 2012	2.25%	August 2012		198,037			184,231
				561,735			372,851
BioMed lease financing	11.0%	May 2026		252,105			250,516
				813,840			623,367
Less current portion				(198,037	)		(188,620	)
			$	615,803		$	434,747

Annual Maturities Of All Long-Term Debt

2012	$	206,736
2013		—
2014		—
2015		187
2016		671
2017 and thereafter		546,603
	$	754,197

Schedule Of Fair Value Of The Long-Term And Short-Term Debt

	December 31,
	2011				2010
	Carrying Amount		Fair Value		Carrying Amount		Fair Value
3% Convertible Senior Notes due 2018	$	363,698	$	433,924	$	—	$	—
2 1/4% Convertible Subordinated Notes due 2011		—		—		188,620		320,311
2 1/4% Convertible Subordinated Notes due 2012		198,037		200,534		184,231		314,245
BioMed lease financing		252,105		263,688		250,516		266,016
	$	813,840	$	898,146	$	623,367	$	900,572

Components Of Convertible Debt

	December 31, 2011
	Face Value		Unamortized Debt Discount			Carrying Amount
3% Convertible Senior Notes due 2018	$	494,500	$	(130,802	)	$	363,698
2 1/4% Convertible Subordinated Notes due 2012		206,736		(8,699	)		198,037
	$	701,236	$	(139,501	)	$	561,735

	December 31, 2010
	Face Value		Unamortized Debt Discount			Carrying Amount
2 1/4% Convertible Subordinated Notes due 2011	$	197,100	$	(8,480	)	$	188,620
2 1/4% Convertible Subordinated Notes due 2012		206,740		(22,509	)		184,231
	$	403,840	$	(30,989	)	$	372,851

XML

Long-Term Debt (Components Of Long-Term Debt) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended		12 Months Ended		12 Months Ended			12 Months Ended			12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2011 3% Convertible Senior Notes Due 2018 [Member]	Nov. 30, 2011 3% Convertible Senior Notes Due 2018 [Member]	Dec. 31, 2011 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2004 2.25% Convertible Subordinated Notes Due 2011 [Member]	Dec. 31, 2011 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2010 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2005 2.25% Convertible Subordinated Notes Due 2012 [Member]	Dec. 31, 2011 BioMed Lease Financing [Member]	Dec. 31, 2010 BioMed Lease Financing [Member]
Debt Instrument [Line Items]
Carrying Amount, debt	$ 561,735	$ 372,851	$ 363,698	$ 361,340		$ 188,620	$ 191,804	$ 198,037	$ 184,231	$ 143,266
Senior convertible notes and convertible subordinated notes, current and non-current	561,735	372,851
Lease financing	252,105	250,516									252,105	250,516
Total long-term and short-term debt	813,840	623,367
Less current portion	(198,037)	(188,620)
Total long term debt, noncurrent	$ 615,803	$ 434,747
Long-term debt, Interest Rate			3.00%		2.25%		2.25%	2.25%		2.25%
Lease financing, Interest Rate	11.00%										11.00%
Debt instrument, month and year of maturity			November 2018		October 2011			August 2012			May 2026
Debt instrument, year of maturity			2018		2011			2012

XML

Investments (Maturities Of Marketable Securities And Restricted Investment Securities) (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011
Marketable Securities [Member]
Fair Value, Investments, Entities that Calculate Net Asset Value Per Share [Line Items]
Less than one year, Amortized Cost	$ 117,846
Total Amortized Cost	117,846
Less than one year, Fair Value	119,234
Total Fair Value	119,234
Marketable Securities, Non-Current [Member]
Fair Value, Investments, Entities that Calculate Net Asset Value Per Share [Line Items]
Due in year two through year three, Amortized Cost	219,106
Due in year four through year five, Amortized Cost	41,695
Due after five years, Amortized Cost	16,193
Total Amortized Cost	276,994
Due in year two through year three, Fair Value	221,040
Due in year four through year five, Fair Value	42,473
Due after five years, Fair Value	16,445
Total Fair Value	279,958
Restricted Investments [Member]
Fair Value, Investments, Entities that Calculate Net Asset Value Per Share [Line Items]
Less than one year, Amortized Cost	34,914
Due in year two through year three, Amortized Cost	41,663
Due in year four through year five, Amortized Cost	3,295
Due after five years, Amortized Cost	131
Total Amortized Cost	80,003
Less than one year, Fair Value	35,003
Due in year two through year three, Fair Value	41,813
Due in year four through year five, Fair Value	3,245
Due after five years, Fair Value	132
Total Fair Value	$ 80,193

XML

Consolidated Statements Of Stockholders' Equity (Deficit) (USD $) In Thousands, except Share data, unless otherwise specified	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total
Balance beginning at Dec. 31, 2008	$ 1,357	$ 2,059,154	$ (4,490)	$ (2,192,325)	$ (136,304)
Balance beginning, shares at Dec. 31, 2008	135,739,978
Comprehensive income (loss):
Net income (loss)				5,659	5,659
Unrealized gain (loss) on investments			11,264		11,264
Cumulative translation adjustment			591		591
Comprehensive income (loss)					17,514
Issuance of common stock pursuant to public offerings	446	812,423			812,869
Issuance of common stock pursuant to public offerings, shares	44,522,250
Shares of common stock issued pursuant to stock-based compensation plans	50	48,762			48,812
Shares of common stock issued pursuant to stock-based compensation plans, shares	4,992,432
Stock-based compensation		12,524			12,524
Ending balance at Dec. 31, 2009	1,853	2,932,863	7,365	(2,186,666)	755,415
Ending balance, shares at Dec. 31, 2009	185,254,660
Comprehensive income (loss):
Net income (loss)				(233,231)	(233,231)
Unrealized gain (loss) on investments			(212)		(212)
Cumulative translation adjustment			(28)		(28)
Comprehensive income (loss)					(233,471)
Issuance of common stock pursuant to bond redemption/note conversion		8			8
Issuance of common stock pursuant to bond redemption/note conversion, shares	562
Shares of common stock issued pursuant to stock-based compensation plans	37	38,344			38,381
Shares of common stock issued pursuant to stock-based compensation plans, shares	3,725,526
Stock-based compensation		25,430			25,430
Ending balance at Dec. 31, 2010	1,890	2,996,645	7,125	(2,419,897)	585,763
Ending balance, shares at Dec. 31, 2010	188,980,748
Comprehensive income (loss):
Net income (loss)				(381,106)	(381,106)
Unrealized gain (loss) on investments			(2,580)		(2,580)
Cumulative translation adjustment			11		11
Comprehensive income (loss)					(383,675)
Issuance of common stock pursuant to bond redemption/note conversion	77	119,098			119,175
Issuance of common stock pursuant to bond redemption/note conversion, shares	7,678,426
Issuance of convertible senior notes due 2018		129,317			129,317
Purchase of capped call contracts		(50,933)			(50,933)
Shares of common stock issued pursuant to stock-based compensation plans	21	17,463			17,484
Shares of common stock issued pursuant to stock-based compensation plans, shares	2,091,357
Stock-based compensation		39,288			39,288
Ending balance at Dec. 31, 2011	$ 1,988	$ 3,250,878	$ 4,556	$ (2,801,003)	$ 456,419
Ending balance, shares at Dec. 31, 2011	198,750,531

XML

Investments

12 Months Ended

Dec. 31, 2011

Investments [Abstract]

Investments

(NOTE C) – Investments

Available for sale investments, including accrued interest, as of December 31, 2011 and 2010 were as follows:

	December 31, 2011
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	94,669	$	1,123	$	(63	)	$	95,729
Residential mortgage-backed securities		20,681		329		(2	)		21,008
Asset-backed securities		2,496		1		—			2,497
Subtotal - Marketable securities		117,846		1,453		(65	)		119,234
Corporate debt securities		177,725		2,866		(726	)		179,865
Residential mortgage-backed securities		47,158		737		(4	)		47,891
Government-sponsored enterprise securities		5,230		51		—			5,281
Asset-backed securities		46,881		49		(9	)		46,921
Subtotal - Marketable securities, non-current		276,994		3,703		(739	)		279,958
Cash and cash equivalents		11,649		1		—			11,650
U.S. Treasury and agencies		1,304		2		—			1,306
Corporate debt securities		51,773		316		(145	)		51,944
Residential mortgage-backed securities		5,977		30		(21	)		5,986
Government-sponsored enterprise securities		4,641		9		(1	)		4,649
Asset-backed securities		4,659		3		(4	)		4,658
Subtotal - Restricted investments		80,003		361		(171	)		80,193
Total	$	474,843	$	5,517	$	(975	)	$	479,385

	December 31, 2010
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Corporate debt securities	$	125,708	$	1,655	$	(19	)	$	127,344
Residential mortgage-backed securities		53,944		787		(13	)		54,718
Government-sponsored enterprise securities		86,905		61		—			86,966
Asset-backed securities		12,983		5		—			12,988
Subtotal - Marketable securities		279,540		2,508		(32	)		282,016
Corporate debt securities		248,500		3,611		(881	)		251,230
Residential mortgage-backed securities		79,605		1,161		(20	)		80,746
Government-sponsored enterprise securities		25,402		3		(120	)		25,285
Asset-backed securities		58,822		84		(2	)		58,904
Subtotal - Marketable securities, non-current		412,329		4,859		(1,023	)		416,165
Cash and cash equivalents		7,455		—		—			7,455
U.S. Treasury and agencies		1,302		10		—			1,312
Corporate debt securities		45,931		620		(29	)		46,522
Residential mortgage-backed securities		6,368		128		—			6,496
Government-sponsored enterprise securities		13,237		72		(6	)		13,303
Asset-backed securities		4,412		10		—			4,422
Subtotal - Restricted investments		78,705		840		(35	)		79,510
Total	$	770,574	$	8,207	$	(1,090	)	$	777,691

The Company's investments in mortgage-backed securities have no single maturity date and accordingly, have been allocated on a pro rata basis to each maturity range based on each maturity range's percentage of the total value. See Note K, Fair Value Measurements, for the fair value of the Company's financial assets and liabilities.

The Company's restricted investments with respect to its headquarters ("Traville") lease serve as collateral for a letter of credit which serves as the security deposit for the duration of the lease, although the Company has the ability to reduce the restricted investments that are in the form of securities by substituting a cash security deposit in the amount of $19,750 to be maintained with the landlord. Presently, to secure the security deposit letter of credit, the Company is required to maintain margin value of the collateral of at least $19,750.

The Company's restricted investments with respect to its large-scale manufacturing facility ("LSM") lease, as amended, will serve as collateral in favor of the landlord in lieu of providing the landlord with either a cash deposit or a standby letter of credit. Under the LSM lease, the Company is required to pledge to the landlord a minimum of $20,000 in marketable securities or provide the landlord with a $19,750 cash security deposit. As of December 31, 2011 and 2010, the Company has pledged marketable securities.

In addition, the Company is also required to maintain $34,300 in restricted investments, with respect to two leases with the Maryland Economic Development Corporation ("MEDCO") for its small-scale manufacturing facility. The facility was financed primarily through a combination of bonds issued by MEDCO ("MEDCO Bonds") and loans issued to MEDCO by certain State of Maryland agencies. The MEDCO Bonds are secured by letters of credit issued for the account of MEDCO which expire in December 2012. The Company is required to maintain restricted investments which serve as security for the MEDCO letters of credit reimbursement obligation.

Marketable securities and Restricted investments – unrealized losses

The Company owned 343 available-for-sale securities as of December 31, 2011. Of these 343 securities, 77 had unrealized losses as of December 31, 2011. The Company did not have any investments in a loss position for greater than 12 months as of December 31, 2011. The Company has evaluated its marketable securities and restricted investments and has determined that none of these investments has an other-than-temporary impairment, as it has no intent to sell securities with unrealized losses and it is not more likely than not that the Company will be required to sell any securities with unrealized losses, given the Company's current and anticipated financial position. The Company's gross unrealized losses and fair value of investments with unrealized losses as of December 31, 2010 were as follows:

	December 31, 2010
	Loss Position for Less Than Twelve Months					Loss Position for Greater Than Twelve Months					Total
	Fair Value		Unrealized Losses			Fair Value		Unrealized Losses			Fair Value		Unrealized Losses
Corporate debt securities	$	35,432	$	(18	)	$	1,536	$	(1	)	$	36,968	$	(19	)
Residential mortgage-backed securities		54,718		(13	)		—		—			54,718		(13	)
Asset-backed securities		3,286		—			—		—			3,286		—
Subtotal - Marketable securities		93,436		(31	)		1,536		(1	)		94,972		(32	)
Corporate debt securities		56,992		(881	)		—		—			56,992		(881	)
Residential mortgage-backed securities		80,746		(20	)		—		—			80,746		(20	)
Government-sponsored enterprise securities		20,237		(120	)		—		—			20,237		(120	)
Asset-backed securities		8,400		(2	)		—		—			8,400		(2	)
Subtotal - Marketable securities, non-current		166,375		(1,023	)		—		—			166,375		(1,023	)
Corporate debt securities		7,110		(29	)		—		—			7,110		(29	)
Government-sponsored enterprise securities		1,502		(6	)		—		—			1,502		(6	)
Subtotal - Restricted investments		8,612		(35	)		—		—			8,612		(35	)
Total	$	268,423	$	(1,089	)	$	1,536	$	(1	)	$	269,959	$	(1,090	)

The Company's equity investment of less than 20% in privately-held companies, which consists of its investment in Aegera Therapeutics, Inc. ("Aegera"), is carried at cost and included in Other assets on the consolidated balance sheet as of December 31, 2010. As of December 31, 2011, the Company no longer owns this investment. See Note D, Collaborations and Other Agreements – Aegera Agreement, for additional information.

Other Information

The following table summarizes maturities of the Company's marketable securities and restricted investment securities as of December 31, 2011:

	Marketable Securities				Marketable Securities, non-current				Restricted Investments
	Amortized Cost		Fair Value		Amortized Cost		Fair Value		Amortized Cost		Fair Value
Less than one year	$	117,846	$	119,234	$	—	$	—	$	34,914	$	35,003
Due in year two through year three		—		—		219,106		221,040		41,663		41,813
Due in year four through year five		—		—		41,695		42,473		3,295		3,245
Due after five years		—		—		16,193		16,445		131		132
Total	$	117,846	$	119,234	$	276,994	$	279,958	$	80,003	$	80,193

The Company's net proceeds, realized gains and realized losses from its investments are as follows:

	Year Ended December 31,
	2011			2010			2009
Proceeds on sale and maturities of investments	$	728,185		$	708,896		$	368,560
Realized gains		1,652			1,673			7,026
Realized losses		(1,416	)		(1,976	)		(2,522	)

Realized gains and losses on securities are included in investment income in the consolidated statements of operations. The cost of the securities sold is based on the specific identification method. Realized gains shown above also include gains related to the sale of long-term equity investments, which are shown separately on the consolidated statements of operations.

During 2011, 2010 and 2009, the Company recognized interest income of $11,939, $17,269 and $13,506 respectively, in investment income.

XML

Stockholders' Equity (Summary Of Information About Stock Options Outstanding) (Details) (USD $)	12 Months Ended
	Dec. 31, 2011
$0.52 To $10.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Range of Exercise Price, minimum	$ 0.52
Range of Exercise Price, maximum	$ 10.00
$10.01 To $12.50 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Range of Exercise Price, minimum	$ 10.01
Range of Exercise Price, maximum	$ 12.50
$12.51 To $15.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Range of Exercise Price, minimum	$ 12.51
Range of Exercise Price, maximum	$ 15.00
$15.01 To $33.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Range of Exercise Price, minimum	$ 15.01
Range of Exercise Price, maximum	$ 33.00
Options Outstanding [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Outstanding, Number Outstanding	25,068,812
Options Outstanding [Member] | $0.52 To $10.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Outstanding, Number Outstanding	6,545,064
Options Outstanding, Weighted-Average Remaining Contractual Life (In Years)	6.34
Options Outstanding, Weighted-Average Exercise Price	$ 3.68
Options Outstanding [Member] | $10.01 To $12.50 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Outstanding, Number Outstanding	6,617,214
Options Outstanding, Weighted-Average Remaining Contractual Life (In Years)	3.96
Options Outstanding, Weighted-Average Exercise Price	$ 10.96
Options Outstanding [Member] | $12.51 To $15.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Outstanding, Number Outstanding	2,320,924
Options Outstanding, Weighted-Average Remaining Contractual Life (In Years)	3.82
Options Outstanding, Weighted-Average Exercise Price	$ 13.03
Options Outstanding [Member] | $15.01 To $33.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Outstanding, Number Outstanding	9,585,610
Options Outstanding, Weighted-Average Remaining Contractual Life (In Years)	8.32
Options Outstanding, Weighted-Average Exercise Price	$ 28.18
Options Exercisable [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Exercisable, Number Exercisable	17,017,555
Options Exercisable [Member] | $0.52 To $10.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Exercisable, Number Exercisable	5,160,920
Options Exercisable, Weighted-Average Exercise Price	$ 4.19
Options Exercisable [Member] | $10.01 To $12.50 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Exercisable, Number Exercisable	6,526,235
Options Exercisable, Weighted-Average Exercise Price	$ 10.96
Options Exercisable [Member] | $12.51 To $15.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Exercisable, Number Exercisable	2,055,903
Options Exercisable, Weighted-Average Exercise Price	$ 12.87
Options Exercisable [Member] | $15.01 To $33.00 [Member]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Options Exercisable, Number Exercisable	3,274,497
Options Exercisable, Weighted-Average Exercise Price	$ 27.92

XML

Teva Biopharmaceuticals USA, Inc. (Formerly Cogenesys) (Details) (Teva Pharmaceuticals Industries Ltd [Member], USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011 years	Dec. 31, 2009	Dec. 31, 2008
Teva Pharmaceuticals Industries Ltd [Member]
Related Party Transaction [Line Items]
Product rights obtained in years	7
Partial payment received for equity method investment			$ 47,336
Escrow account percentage of Teva and CoGenesys			10.00%
Gain on sale of investment		$ 5,259

XML

Commitments And Other Matters (Tables)

12 Months Ended

Dec. 31, 2011

Commitments And Other Matters [Abstract]

Future Minimum Operating Lease Payments

Year Ending December 31,
2012	$	21,305
2013		21,843
2014		21,973
2015		22,113
2016		22,431
2017 and thereafter		214,881
	$	324,546

XML

Investments (Narrative) (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Schedule of Available-for-sale Securities [Line Items]
Number of leases with the Maryland Economic Development Corporation	2
Number of available-for-sale securities owned	343
Number of securities with unrealized losses	77
Recognized interest income	$ 11,939	$ 17,269	$ 13,506
Other Assets [Member]
Schedule of Available-for-sale Securities [Line Items]
Percentage of cost investments in privately-held Companies		20.00%
Traville Lease [Member]
Schedule of Available-for-sale Securities [Line Items]
Cash security deposit to be maintained with the landlord with respect to the LSM lease	19,750
Margin value of the collateral, minimum	19,750
LSM Lease [Member]
Schedule of Available-for-sale Securities [Line Items]
Cash security deposit to be maintained with the landlord with respect to the LSM lease	19,750
Pledge to landlord in marketable securities, minimum	20,000
MEDCO Lease [Member]
Schedule of Available-for-sale Securities [Line Items]
Pledge to landlord in marketable securities, minimum	$ 34,300
Letters of credit, expiration date	December 2012

XML

Earnings Per Share

12 Months Ended

Dec. 31, 2011

Earnings Per Share [Abstract]

Earnings Per Share

(NOTE M) – Earnings Per Share

Diluted net income (loss) per share was determined as follows:

	Year Ended December 31,
	2011			2010			2009
Numerator:
Net income (loss)	$	(381,106	)	$	(233,231	)	$	5,659
Denominator:
Weighted average shares outstanding		193,667,672			187,791,437			149,334,426
Effect of dilutive securities:
Employee stock options and restricted stock units		—			—			5,719,047
Weighted average shares used for diluted net income (loss) per share		193,667,672			187,791,437			155,053,473
Diluted net income (loss) per share	$	(1.97	)	$	(1.24	)	$	0.04

Common stock issued in connection with the Company's Employee Stock Purchase Plan and through exercised options granted pursuant to the Incentive Plan are included in the Company's weighted average share balance based upon the issuance date of the related shares. As of December 31, 2011, 2010 and 2009, the Company had 25,068,812, 24,028,688 and 24,601,174, respectively, stock options outstanding. The Company had 48,735,519, 24,302,742 and 24,303,304 shares issuable upon the conversion of the

Company's convertible debt as of December 31, 2011, 2010 and 2009, respectively. The shares issuable upon the conversion of the Company's convertible debt and shares due to the Company upon settlement of the Company's capped call option contracts are excluded from the weighted average shares as they are anti-dilutive.