Consolidated Statements Of Operations (USD $) In Thousands, except Share data	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Revenue:
Product sales	$ 30,833	$ 7,295	$ 65,587	$ 33,963
Manufacturing and development services	2,747	5,677	19,011	15,177
Research and development collaborative agreements	442	37,810	854	86,948
Total revenue	34,022	50,782	85,452	136,088
Costs and expenses:
Cost of product sales	12,419	8,434	34,026	23,529
Cost of manufacturing and development services	4,950	3,338	23,290	7,364
Research and development expenses	38,758	42,471	156,645	151,331
Selling, general and administrative expenses	42,135	26,365	116,692	68,456
Commercial collaboration expenses	11,755		17,004
Facility-related exit credits			(1,717)
Total costs and expenses	110,017	80,608	345,940	250,680
Income (loss) from operations	(75,995)	(29,826)	(260,488)	(114,592)
Investment income	2,839	3,794	9,014	13,497
Interest expense	(14,831)	(14,949)	(45,559)	(44,409)
Other income (expense)	(442)	122	(3,051)	(95)
Income (loss) before taxes	(88,429)	(40,859)	(300,084)	(145,599)
Provision for income taxes
Net income (loss)	$ (88,429)	$ (40,859)	$ (300,084)	$ (145,599)
Basic and diluted net income (loss) per share	$ (0.45)	$ (0.22)	$ (1.56)	$ (0.78)
Weighted average shares outstanding, basic and diluted	196,462,631	188,420,580	191,965,763	187,418,995